{"id":"https://openalex.org/W846029848","doi":null,"title":"Mechanisms of catecholamine secretion from adrenal chromaffin cells.","display_name":"Mechanisms of catecholamine secretion from adrenal chromaffin cells.","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W846029848","mag":"846029848","pmid":"https://pubmed.ncbi.nlm.nih.gov/8527809"},"language":"en","primary_location":{"id":"pmid:8527809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8527809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005167203","display_name":"Robert D. Burgoyne","orcid":"https://orcid.org/0000-0002-9219-0387","observed_orcids":["https://orcid.org/0000-0002-9219-0387"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R D Burgoyne","raw_affiliation_strings":["Physiological Laboratory, University of Liverpool, UK","University of Liverpool, Crown Street, Liverpool L69 3BX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiological Laboratory, University of Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"University of Liverpool, Crown Street, Liverpool L69 3BX, UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005167203"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":null,"apc_paid":null,"fwci":0.5402,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.574412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"3","first_page":"273","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catecholamine-release","display_name":"catecholamine release","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.925000011920929},{"id":"https://openalex.org/keywords/regulated-exocytosis","display_name":"regulated exocytosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.9819999933242798},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8240000009536743},{"id":"https://openalex.org/keywords/calcium-binding-proteins","display_name":"calcium-binding proteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuroendocrine-secretion","display_name":"neuroendocrine secretion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.7559999823570251},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.7733669877052307},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7282333374023438},{"id":"https://openalex.org/C2780910648","wikidata":"https://www.wikidata.org/wiki/Q919689","display_name":"Chromaffin cell","level":4,"score":0.5251959562301636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4490339756011963},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.4300508201122284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41175565123558044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36356812715530396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3027360439300537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21486333012580872}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002838","descriptor_name":"Chromaffin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8527809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8527809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:846029848","doi":null,"is_oa":false,"landing_page_url":"http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.agro-article-92cf14e5-fd97-46fd-82f4-982452960091","pdf_url":null,"source":{"id":"https://openalex.org/S4363607192","display_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","issn_l":"0867-5910","issn":["0867-5910"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physiology and Pharmacology","raw_type":null},{"id":"mag:2418456065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8527809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417762732","https://openalex.org/W2010114917","https://openalex.org/W3099729563","https://openalex.org/W6980544949","https://openalex.org/W413882458","https://openalex.org/W21589909","https://openalex.org/W2425175746","https://openalex.org/W2114254682","https://openalex.org/W3103469982","https://openalex.org/W2436137340"],"abstract_inverted_index":{"Adrenaline":[0],"and":[1,35,74,102],"noradrenaline":[2],"are":[3,30,97,117],"released":[4],"from":[5,13],"adrenal":[6],"medullary":[7],"chromaffin":[8,28],"cells":[9,29,37],"by":[10,22,54,80],"regulated":[11],"exocytosis":[12,24,96],"stored":[14],"secretory":[15],"granules.":[16],"Many":[17],"aspects":[18],"of":[19,46,85,92,110,114],"the":[20,44,86,103,108,111],"mechanisms":[21],"which":[23,57],"is":[25,52],"activated":[26],"in":[27,33,49,95,99],"now":[31],"understood":[32],"detail":[34],"these":[36,93],"have":[38,77],"provided":[39],"an":[40],"important":[41],"model":[42],"for":[43,107],"study":[45],"neuroendocrine":[47],"secretion":[48],"general.":[50],"Exocytosis":[51],"triggered":[53],"Ca2+":[55,70],"influx":[56],"activates":[58],"a":[59],"multistep":[60],"process":[61],"involving":[62],"at":[63],"least":[64],"two":[65],"Ca(2+)-binding":[66],"proteins":[67,76,94],"with":[68],"distinct":[69],"affinities.":[71],"Several":[72],"cytosolic":[73],"membrane":[75],"been":[78],"implicated":[79],"functional":[81],"studies":[82],"as":[83],"components":[84],"exocytotic":[87],"machinery.":[88],"The":[89],"likely":[90],"roles":[91],"discussed":[98],"this":[100],"review":[101],"questions":[104],"that":[105],"remain":[106],"understanding":[109],"molecular":[112],"basis":[113],"catecholamine":[115],"release":[116],"highlighted.":[118]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}