{"id":"https://openalex.org/W8453164","doi":null,"title":"Renal Humoral, Genetic and Genomic Mechanisms Underlying Spontaneous Hypertension","display_name":"Renal Humoral, Genetic and Genomic Mechanisms Underlying Spontaneous Hypertension","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W8453164","mag":"8453164"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:biology_etds-1022","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/biology_etds/24","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1022&context=biology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Biology","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1022&context=biology_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059657108","display_name":"Jason Andrieu Collett","orcid":"https://orcid.org/0000-0002-0492-0926","observed_orcids":["https://orcid.org/0000-0002-0492-0926"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jason A. Collett","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0492-0926","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059657108"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00042927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-hypertension","display_name":"spontaneous hypertension","score":0.9240000247955322},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8849999904632568},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.5820000171661377},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.39100000262260437},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pressure-natriuresis","display_name":"pressure natriuresis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sodium-detection","display_name":"sodium ion detection","score":0.8109999895095825},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mitochondrial-genome","display_name":"mitochondrial genome","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pathogenesis-of-hypertension","display_name":"hypertension pathogenesis","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6063054203987122},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5246265530586243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.506620466709137},{"id":"https://openalex.org/C57190642","wikidata":"https://www.wikidata.org/wiki/Q7144839","display_name":"Pathophysiology of hypertension","level":3,"score":0.49657732248306274},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4575132727622986},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4217481017112732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3871466815471649},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.380632609128952},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35120850801467896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3424493670463562},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:biology_etds-1022","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/biology_etds/24","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1022&context=biology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Biology","raw_type":"text"},{"id":"mag:8453164","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/biology_etds/24/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:biology_etds-1022","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/biology_etds/24","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1022&context=biology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Biology","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W8453164.pdf","grobid_xml":"https://content.openalex.org/works/W8453164.grobid-xml"},"referenced_works_count":269,"referenced_works":["https://openalex.org/W29568342","https://openalex.org/W41564383","https://openalex.org/W80391022","https://openalex.org/W85415543","https://openalex.org/W99356862","https://openalex.org/W121477089","https://openalex.org/W1490285206","https://openalex.org/W1493092704","https://openalex.org/W1554017667","https://openalex.org/W1596954550","https://openalex.org/W1597996024","https://openalex.org/W1650754258","https://openalex.org/W1745634660","https://openalex.org/W1775749144","https://openalex.org/W1781872636","https://openalex.org/W1782072969","https://openalex.org/W1798432044","https://openalex.org/W1821554906","https://openalex.org/W1838353535","https://openalex.org/W1887435369","https://openalex.org/W1963784744","https://openalex.org/W1963865377","https://openalex.org/W1964816832","https://openalex.org/W1965368873","https://openalex.org/W1966409424","https://openalex.org/W1967761082","https://openalex.org/W1970068637","https://openalex.org/W1970451374","https://openalex.org/W1971082641","https://openalex.org/W1971258752","https://openalex.org/W1974468195","https://openalex.org/W1976239472","https://openalex.org/W1978537011","https://openalex.org/W1978578097","https://openalex.org/W1980029817","https://openalex.org/W1980041972","https://openalex.org/W1982115147","https://openalex.org/W1983263976","https://openalex.org/W1986723837","https://openalex.org/W1987421178","https://openalex.org/W1990103489","https://openalex.org/W1990249744","https://openalex.org/W1992936955","https://openalex.org/W1995241593","https://openalex.org/W1999430544","https://openalex.org/W2000040025","https://openalex.org/W2000392454","https://openalex.org/W2001385601","https://openalex.org/W2002241222","https://openalex.org/W2003026064","https://openalex.org/W2004585452","https://openalex.org/W2004840558","https://openalex.org/W2005944335","https://openalex.org/W2006884514","https://openalex.org/W2007465587","https://openalex.org/W2008277503","https://openalex.org/W2008744043","https://openalex.org/W2009040654","https://openalex.org/W2009211065","https://openalex.org/W2010261215","https://openalex.org/W2011401201","https://openalex.org/W2012619772","https://openalex.org/W2012894694","https://openalex.org/W2012983628","https://openalex.org/W2013456543","https://openalex.org/W2015957571","https://openalex.org/W2016212892","https://openalex.org/W2018185503","https://openalex.org/W2018925356","https://openalex.org/W2019711354","https://openalex.org/W2021372992","https://openalex.org/W2023130470","https://openalex.org/W2024004416","https://openalex.org/W2025595360","https://openalex.org/W2028654235","https://openalex.org/W2028680679","https://openalex.org/W2029241765","https://openalex.org/W2030474974","https://openalex.org/W2031047412","https://openalex.org/W2031297231","https://openalex.org/W2033210506","https://openalex.org/W2035054035","https://openalex.org/W2035503549","https://openalex.org/W2036689966","https://openalex.org/W2036951068","https://openalex.org/W2036960544","https://openalex.org/W2037748805","https://openalex.org/W2037900311","https://openalex.org/W2039418330","https://openalex.org/W2039765184","https://openalex.org/W2040012879","https://openalex.org/W2040285032","https://openalex.org/W2040431225","https://openalex.org/W2041324535","https://openalex.org/W2042498523","https://openalex.org/W2044494908","https://openalex.org/W2044553476","https://openalex.org/W2044773944","https://openalex.org/W2045494721","https://openalex.org/W2045619262","https://openalex.org/W2046666672","https://openalex.org/W2047686677","https://openalex.org/W2048079557","https://openalex.org/W2048900216","https://openalex.org/W2049453613","https://openalex.org/W2049481764","https://openalex.org/W2049636133","https://openalex.org/W2050578838","https://openalex.org/W2051618380","https://openalex.org/W2052653818","https://openalex.org/W2054397100","https://openalex.org/W2054633565","https://openalex.org/W2054891539","https://openalex.org/W2054896364","https://openalex.org/W2055361528","https://openalex.org/W2056352596","https://openalex.org/W2058878434","https://openalex.org/W2059842928","https://openalex.org/W2060187831","https://openalex.org/W2060191609","https://openalex.org/W2060360315","https://openalex.org/W2061151366","https://openalex.org/W2061580910","https://openalex.org/W2061999616","https://openalex.org/W2062223494","https://openalex.org/W2063767047","https://openalex.org/W2065236378","https://openalex.org/W2065463667","https://openalex.org/W2066907492","https://openalex.org/W2067946831","https://openalex.org/W2068488537","https://openalex.org/W2070610716","https://openalex.org/W2070679128","https://openalex.org/W2073264424","https://openalex.org/W2073671242","https://openalex.org/W2076592280","https://openalex.org/W2077529465","https://openalex.org/W2077772456","https://openalex.org/W2077957402","https://openalex.org/W2077983561","https://openalex.org/W2079276564","https://openalex.org/W2083077388","https://openalex.org/W2083747813","https://openalex.org/W2085111073","https://openalex.org/W2085970646","https://openalex.org/W2088230441","https://openalex.org/W2090790150","https://openalex.org/W2092824385","https://openalex.org/W2093754226","https://openalex.org/W2095566192","https://openalex.org/W2095855118","https://openalex.org/W2096583106","https://openalex.org/W2097334774","https://openalex.org/W2097446827","https://openalex.org/W2097532633","https://openalex.org/W2097805169","https://openalex.org/W2098291803","https://openalex.org/W2098763069","https://openalex.org/W2098884306","https://openalex.org/W2101668095","https://openalex.org/W2101918999","https://openalex.org/W2103695431","https://openalex.org/W2105404724","https://openalex.org/W2105754268","https://openalex.org/W2108373013","https://openalex.org/W2109812957","https://openalex.org/W2110144897","https://openalex.org/W2110927915","https://openalex.org/W2112154387","https://openalex.org/W2112793962","https://openalex.org/W2113515610","https://openalex.org/W2113531489","https://openalex.org/W2114402699","https://openalex.org/W2114547396","https://openalex.org/W2114614037","https://openalex.org/W2114814810","https://openalex.org/W2115041849","https://openalex.org/W2117434927","https://openalex.org/W2117760506","https://openalex.org/W2119494775","https://openalex.org/W2119608885","https://openalex.org/W2119968370","https://openalex.org/W2120213122","https://openalex.org/W2121198137","https://openalex.org/W2123150238","https://openalex.org/W2124612466","https://openalex.org/W2124663880","https://openalex.org/W2125060032","https://openalex.org/W2125236275","https://openalex.org/W2125518431","https://openalex.org/W2126109643","https://openalex.org/W2126125759","https://openalex.org/W2126337135","https://openalex.org/W2126637481","https://openalex.org/W2127120893","https://openalex.org/W2127817308","https://openalex.org/W2129162046","https://openalex.org/W2129695314","https://openalex.org/W2131196992","https://openalex.org/W2131505519","https://openalex.org/W2132871581","https://openalex.org/W2134066661","https://openalex.org/W2134270369","https://openalex.org/W2134507595","https://openalex.org/W2134587415","https://openalex.org/W2134662886","https://openalex.org/W2134899427","https://openalex.org/W2135943575","https://openalex.org/W2137490131","https://openalex.org/W2138009367","https://openalex.org/W2138268741","https://openalex.org/W2138753483","https://openalex.org/W2139886472","https://openalex.org/W2140466892","https://openalex.org/W2140546667","https://openalex.org/W2141910024","https://openalex.org/W2144184072","https://openalex.org/W2144851538","https://openalex.org/W2145701818","https://openalex.org/W2146172783","https://openalex.org/W2146436291","https://openalex.org/W2148888640","https://openalex.org/W2149258163","https://openalex.org/W2149408586","https://openalex.org/W2151458434","https://openalex.org/W2152701586","https://openalex.org/W2153835671","https://openalex.org/W2154207789","https://openalex.org/W2154308192","https://openalex.org/W2154630777","https://openalex.org/W2155557800","https://openalex.org/W2156585674","https://openalex.org/W2156850243","https://openalex.org/W2157498064","https://openalex.org/W2162008550","https://openalex.org/W2162583612","https://openalex.org/W2164444293","https://openalex.org/W2165268250","https://openalex.org/W2165456329","https://openalex.org/W2165752453","https://openalex.org/W2166190242","https://openalex.org/W2166664098","https://openalex.org/W2166791505","https://openalex.org/W2167014117","https://openalex.org/W2167077408","https://openalex.org/W2169230483","https://openalex.org/W2169685512","https://openalex.org/W2171815293","https://openalex.org/W2172060077","https://openalex.org/W2184870906","https://openalex.org/W2225273165","https://openalex.org/W2271077068","https://openalex.org/W2275546552","https://openalex.org/W2314183680","https://openalex.org/W2322342868","https://openalex.org/W2327063007","https://openalex.org/W2330293803","https://openalex.org/W2332965800","https://openalex.org/W2336490398","https://openalex.org/W2338902100","https://openalex.org/W2409390948","https://openalex.org/W2412982725","https://openalex.org/W2416654311","https://openalex.org/W2431997096","https://openalex.org/W2438560904","https://openalex.org/W2472310606","https://openalex.org/W2475303041","https://openalex.org/W2970463493","https://openalex.org/W6931824552"],"related_works":["https://openalex.org/W2083614383","https://openalex.org/W2259770850","https://openalex.org/W1971906307","https://openalex.org/W3139662839","https://openalex.org/W646564173","https://openalex.org/W1607819873","https://openalex.org/W2099553671","https://openalex.org/W2479681784","https://openalex.org/W2420587577","https://openalex.org/W2332127685"],"abstract_inverted_index":{"In":[0],"spite":[1],"of":[2,8,16,19,44,69,87,123,147,160,171,175,192,204,239,283,309,315,322,336],"significant":[3],"progress":[4],"in":[5,164,201,212,242,280,294,303,312,331],"our":[6,14,165,213],"knowledge":[7],"mechanisms":[9,97,146,321],"that":[10,41,183,210,269],"control":[11,27],"blood":[12,28,263],"pressure,":[13,29],"understanding":[15],"the":[17,32,85,116,120,124,136,148,158,161,169,172,176,184,188,193,202,253,258,281,307,310,313,323,332,337],"pathogenesis":[18,314],"hypertension,":[20,100],"its":[21,151],"genetics,":[22],"and":[23,59,61,111,144,150,190,219,287,319,334],"population":[24],"efforts":[25],"to":[26,71,108,115,153,229,244,257,326],"hypertension":[30,82],"remains":[31],"leading":[33],"risk":[34,54],"factor":[35,55],"for":[36,56,272],"mortality":[37],"worldwide.":[38],"It\u2019s":[39],"estimated":[40],"1":[42],"out":[43],"every":[45,304],"3":[46,179],"adults":[47],"has":[48,83],"hypertension.":[49,154,206,284,316],"Hypertension":[50],"is":[51,62],"a":[52,64,101,129,226,277,328],"major":[53],"cardiovascular":[57],"disease":[58],"stroke,":[60],"considered":[63],"primary":[65],"or":[66],"contributing":[67,114],"cause":[68],"death":[70],"more":[72],"than":[73],"2.4":[74],"million":[75],"US":[76],"deaths":[77],"each":[78],"year.":[79],"Although":[80],"spontaneous":[81,99,205],"been":[84],"subject":[86],"substantial":[88],"research,":[89],"many":[90],"critical":[91,278],"questions":[92],"remain":[93],"unanswered.":[94],"To":[95],"investigate":[96],"underlying":[98],"unique":[102],"rodent":[103,166,214],"breeding":[104],"approach":[105],"was":[106],"used":[107],"isolate":[109],"nuclear":[110,121,173,286],"mitochondrial":[112,138,288],"genes":[113,270,291],"disease.":[117,338],"By":[118],"diluting":[119],"genome":[122,174],"Spontaneously":[125],"Hypertensive":[126],"Rat":[127],"on":[128],"normotensive":[130,299],"Brown":[131],"Norway":[132],"background":[133],"while":[134],"maintaining":[135],"SHR":[137],"genome,":[139],"I":[140],"investigated":[141],"both":[142],"intrinsic":[143],"extrinsic":[145],"kidney":[149,220,311,324],"relationship":[152,251],"Chapter":[155,178,207,265],"2":[156],"documents":[157],"dominance":[159],"hypertensive":[162,223,295],"phenotype":[163],"colony,":[167],"despite":[168],"dilution":[170],"SHR.":[177],"presents":[180,209,267],"data":[181,268],"indicating":[182],"renin-angiotensin":[185],"system,":[186],"particularly":[187],"location":[189],"abundance":[191],"AT1":[194],"receptor":[195],"may":[196,275],"play":[197,276,327],"an":[198],"important":[199,271],"role":[200,279,330],"manifestation":[203],"4":[208],"rats":[211,224,296],"colony":[215],"exhibited":[216],"normal":[217],"pressure-natriuresis":[218,250],"function;":[221],"however,":[222],"had":[225],"reduced":[227],"ability":[228],"sense":[230],"orally":[231],"ingested":[232],"sodium":[233,246],"chloride,":[234],"thus":[235,260],"necessitating":[236],"chronic":[237,249],"elevations":[238],"arterial":[240],"pressure":[241],"order":[243],"maintain":[245],"balance.":[247],"This":[248],"shifts":[252],"renal":[254],"function":[255],"curve":[256],"right,":[259],"sustaining":[261],"elevated":[262],"pressure.":[264],"5":[266],"oxidative":[273,289],"phosphorylation":[274,290],"development":[282,333],"Both":[285],"were":[292],"downregulated":[293],"compared":[297],"with":[298],"rats.":[300],"Data":[301],"presented":[302],"chapter":[305],"highlights":[306],"importance":[308],"Humoral,":[317],"genetic":[318],"genomic":[320],"appear":[325],"dominant":[329],"maintenance":[335]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
