{"id":"https://openalex.org/W84484870","doi":"https://doi.org/10.1007/978-0-387-77498-5_54","title":"Emerging Therapeutic Targets for Pancreatic Cancer","display_name":"Emerging Therapeutic Targets for Pancreatic Cancer","publication_year":2009,"publication_date":"2009-11-27","ids":{"openalex":"https://openalex.org/W84484870","doi":"https://doi.org/10.1007/978-0-387-77498-5_54","mag":"84484870"},"language":"en","primary_location":{"id":"doi:10.1007/978-0-387-77498-5_54","doi":"https://doi.org/10.1007/978-0-387-77498-5_54","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-0-387-77498-5_54","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreatic Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4213234618","display_name":"Pancreatic Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachna T. Shroff","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087376683","display_name":"James L. Abbruzzese","orcid":"https://orcid.org/0000-0001-9223-2965","observed_orcids":["https://orcid.org/0000-0001-9223-2965"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Abbruzzese","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07283091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1319","last_page":"1335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9810000061988831},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8949999809265137},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9279999732971191},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.824999988079071},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8889999985694885},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.8759999871253967},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6263543367385864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42457717657089233},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33830106258392334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3239690661430359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21403932571411133}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-0-387-77498-5_54","doi":"https://doi.org/10.1007/978-0-387-77498-5_54","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-0-387-77498-5_54","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreatic Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1490888974","https://openalex.org/W1514547987","https://openalex.org/W1544246953","https://openalex.org/W1552481161","https://openalex.org/W1627231359","https://openalex.org/W1784261519","https://openalex.org/W1785779992","https://openalex.org/W1839039174","https://openalex.org/W1970820773","https://openalex.org/W1972769310","https://openalex.org/W1973268287","https://openalex.org/W1973515006","https://openalex.org/W1974423029","https://openalex.org/W1979123513","https://openalex.org/W1983774507","https://openalex.org/W1985804387","https://openalex.org/W1991958238","https://openalex.org/W2000932071","https://openalex.org/W2001333573","https://openalex.org/W2005483847","https://openalex.org/W2006124032","https://openalex.org/W2009007206","https://openalex.org/W2018672261","https://openalex.org/W2018944333","https://openalex.org/W2019264784","https://openalex.org/W2022899234","https://openalex.org/W2029339363","https://openalex.org/W2035653659","https://openalex.org/W2036776072","https://openalex.org/W2037191150","https://openalex.org/W2048451721","https://openalex.org/W2053560716","https://openalex.org/W2056041663","https://openalex.org/W2061876263","https://openalex.org/W2062070329","https://openalex.org/W2068671045","https://openalex.org/W2076150416","https://openalex.org/W2077462602","https://openalex.org/W2086692663","https://openalex.org/W2093750998","https://openalex.org/W2096844786","https://openalex.org/W2099198727","https://openalex.org/W2108696990","https://openalex.org/W2111406172","https://openalex.org/W2113794558","https://openalex.org/W2115808409","https://openalex.org/W2116821087","https://openalex.org/W2117271731","https://openalex.org/W2121120744","https://openalex.org/W2121812224","https://openalex.org/W2124863710","https://openalex.org/W2125923072","https://openalex.org/W2126583326","https://openalex.org/W2127287125","https://openalex.org/W2128077493","https://openalex.org/W2129515878","https://openalex.org/W2131612416","https://openalex.org/W2132127571","https://openalex.org/W2133425838","https://openalex.org/W2136111611","https://openalex.org/W2147406814","https://openalex.org/W2148457804","https://openalex.org/W2152697120","https://openalex.org/W2155131748","https://openalex.org/W2155139733","https://openalex.org/W2156442575","https://openalex.org/W2158134441","https://openalex.org/W2164733896","https://openalex.org/W2166378792","https://openalex.org/W2166994863","https://openalex.org/W2169365607","https://openalex.org/W2170241782","https://openalex.org/W2242211041","https://openalex.org/W2316067769","https://openalex.org/W2402499910","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2011098594","https://openalex.org/W2095483969","https://openalex.org/W2041150663","https://openalex.org/W2400100592","https://openalex.org/W2384577546","https://openalex.org/W1994542980","https://openalex.org/W3161124279","https://openalex.org/W2024377584","https://openalex.org/W2055106140","https://openalex.org/W4402847463"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}