{"id":"https://openalex.org/W8441624","doi":null,"title":"A 102-center prospective study of seizure in association with bupropion.","display_name":"A 102-center prospective study of seizure in association with bupropion.","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W8441624","mag":"8441624","pmid":"https://pubmed.ncbi.nlm.nih.gov/1744061"},"language":"en","primary_location":{"id":"pmid:1744061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1744061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015927873","display_name":"Joseph A. Johnston","orcid":"https://orcid.org/0000-0003-3913-9256","observed_orcids":["https://orcid.org/0000-0003-3913-9256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Johnston","raw_affiliation_strings":["Burroughs Wellcome Co., Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burroughs Wellcome Co., Research Triangle Park, NC 27709","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110093476","display_name":"Charles G. Lineberry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C G Lineberry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109196825","display_name":"John A. Ascher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Ascher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864584","display_name":"Jonathan R. T. Davidson","orcid":"https://orcid.org/0000-0002-8387-8913","observed_orcids":["https://orcid.org/0000-0002-8387-8913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Davidson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040146624","display_name":"Moise A. Khayrallah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Khayrallah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112713695","display_name":"J P Feighner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Feighner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P Stark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Stark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2096,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.74169377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"52","issue":"11","first_page":"450","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":1.0},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.824999988079071},{"id":"https://openalex.org/keywords/drug-induced-seizures","display_name":"drug-induced seizures","score":0.6380000114440918},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.824999988079071},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8059999942779541},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/seizure-incidence","display_name":"seizure incidence","score":0.7749999761581421},{"id":"https://openalex.org/keywords/antidepressant-tolerability","display_name":"antidepressant tolerability","score":0.6140000224113464},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779908668","wikidata":"https://www.wikidata.org/wiki/Q834280","display_name":"Bupropion","level":3,"score":0.9543870687484741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.654366672039032},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6122528314590454},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49067628383636475},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4697461724281311},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4447510540485382},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.41048258543014526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34655362367630005},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.1261688768863678},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016642","descriptor_name":"Bupropion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016642","descriptor_name":"Bupropion","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1744061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1744061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Clinical Trial"},{"id":"mag:8441624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1744061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080593090","https://openalex.org/W2338977821","https://openalex.org/W2072584094","https://openalex.org/W2272596311","https://openalex.org/W2009409297","https://openalex.org/W2745227316","https://openalex.org/W2417500023","https://openalex.org/W2766842088","https://openalex.org/W1999660555","https://openalex.org/W2078665523"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1,177],"trial":[2,178],"was":[3,54,114],"conducted":[4],"to":[5,43,61,76,99,139,153,157],"determine":[6],"the":[7,13,36,89,106,117,123,187],"incidence":[8],"of":[9,15,20,50,79,84,96,137,146,189],"seizures":[10],"associated":[11],"with":[12,133],"use":[14],"bupropion.":[16,80],"METHOD:":[17],"A":[18,82],"total":[19,83],"3341":[21],"depressed":[22],"patients":[23,40,86,132],"from":[24],"102":[25],"sites":[26],"were":[27],"enrolled":[28],"in":[29,45,105],"this":[30],"8-week,":[31],"prospective,":[32],"open":[33],"trial.":[34],"Following":[35],"8-week":[37,90,127],"treatment":[38,91,104,118],"phase,":[39,92],"could":[41],"elect":[42],"enroll":[44],"a":[46,134,143,183],"humanitarian":[47,107],"continuation":[48,108],"phase":[49,119],"unlimited":[51],"duration.":[52],"Dosing":[53],"initiated":[55],"at":[56],"225":[57],"mg/day":[58,63,141],"and":[59,71,77,93,120,158,169],"increased":[60],"450":[62,140],"as":[64,182],"tolerated.":[65],"Investigators":[66],"carefully":[67],"monitored":[68],"seizure":[69,112,167],"occurrences":[70],"rated":[72],"their":[73],"patients'":[74],"response":[75],"tolerance":[78],"RESULTS:":[81],"1986":[85],"(61%)":[87],"completed":[88],"1616":[94],"(81%)":[95],"these":[97],"elected":[98],"be":[100],"maintained":[101],"on":[102,131],"bupropion":[103,160],"phase.":[109],"The":[110],"observed":[111],"rate":[113,145],"0.24%":[115],"for":[116,122,174,186],"0.40%":[121],"entire":[124],"study.":[125],"An":[126],"survival":[128],"analysis":[129],"performed":[130],"dosing":[135],"regimen":[136],"300":[138],"yielded":[142],"cumulative":[144],"0.36%.":[147],"Patients,":[148],"including":[149],"those":[150],"previously":[151],"resistant":[152],"antidepressant":[154,175],"treatment,":[155],"responded":[156],"tolerated":[159],"well.":[161],"CONCLUSION:":[162],"These":[163],"rates":[164],"confirm":[165],"earlier":[166],"estimates":[168],"fall":[170],"within":[171],"accepted":[172],"parameters":[173],"drugs.":[176],"enhances":[179],"bupropion's":[180],"position":[181],"valuable":[184],"alternative":[185],"management":[188],"depression.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}