{"id":"https://openalex.org/W84384989","doi":null,"title":"Efficacy of a nonadjuvanted, outer surface protein A, recombinant vaccine in dogs after challenge by ticks naturally infected with Borrelia burgdorferi.","display_name":"Efficacy of a nonadjuvanted, outer surface protein A, recombinant vaccine in dogs after challenge by ticks naturally infected with Borrelia burgdorferi.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W84384989","mag":"84384989","pmid":"https://pubmed.ncbi.nlm.nih.gov/19757556"},"language":"en","primary_location":{"id":"pmid:19757556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19757556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025963503","display_name":"Jennifer Conlon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Conlon","raw_affiliation_strings":["Merial Limited, Biological Division, 115 Transtech Drive, Athens, GA 30601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merial Limited, Biological Division, 115 Transtech Drive, Athens, GA 30601, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016846953","display_name":"Thomas N. Mather","orcid":"https://orcid.org/0000-0003-0609-8603","observed_orcids":["https://orcid.org/0000-0003-0609-8603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T N Mather","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000506485","display_name":"Patrick A. Tanner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Tanner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102777983","display_name":"Greta Gallo","orcid":"https://orcid.org/0000-0002-4583-5568","observed_orcids":["https://orcid.org/0000-0002-4583-5568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gallo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011104302","display_name":"Richard H. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H Jacobson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7225,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.81604921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"1","issue":"2","first_page":"96","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.640999972820282},{"id":"https://openalex.org/keywords/recombinant-vaccine","display_name":"recombinant vaccine","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tick-challenge","display_name":"tick challenge","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ixodes-scapularis","display_name":"Ixodes scapularis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/xenodiagnosis","display_name":"xenodiagnosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/spirochete-isolation","display_name":"spirochete isolation","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.850705087184906},{"id":"https://openalex.org/C2778335811","wikidata":"https://www.wikidata.org/wiki/Q4119199","display_name":"Xenodiagnosis","level":4,"score":0.7877497673034668},{"id":"https://openalex.org/C2781453105","wikidata":"https://www.wikidata.org/wiki/Q1497962","display_name":"Ixodes scapularis","level":4,"score":0.7283767461776733},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6223983764648438},{"id":"https://openalex.org/C2777553296","wikidata":"https://www.wikidata.org/wiki/Q201989","display_name":"Lyme disease","level":2,"score":0.5924140214920044},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5765186548233032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5472913384437561},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5212445855140686},{"id":"https://openalex.org/C2779553505","wikidata":"https://www.wikidata.org/wiki/Q845770","display_name":"Spirochaetaceae","level":4,"score":0.5160757899284363},{"id":"https://openalex.org/C2776397665","wikidata":"https://www.wikidata.org/wiki/Q1951212","display_name":"Ixodes","level":3,"score":0.4870186448097229},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.4245867133140564},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.41417765617370605},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.4123501181602478},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39780864119529724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26002269983291626},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018884","descriptor_name":"Ixodes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D022123","descriptor_name":"Lyme Disease Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D025065","descriptor_name":"Borrelia burgdorferi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:19757556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19757556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.uri.edu:pls_facpubs-1251","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.uri.edu/pls_facpubs/247","pdf_url":null,"source":{"id":"https://openalex.org/S2764761010","display_name":"Journal of Media Literacy Education","issn_l":"2167-8715","issn":["2167-8715"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310316378","host_organization_name":"National Association for Media Literacy Education","host_organization_lineage":["https://openalex.org/P4310316378"],"host_organization_lineage_names":["National Association for Media Literacy Education"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plant Sciences and Entomology Faculty Publications","raw_type":"text"},{"id":"mag:84384989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19757556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W72024240","https://openalex.org/W72433188","https://openalex.org/W167482968","https://openalex.org/W182113194","https://openalex.org/W1542649482","https://openalex.org/W1591963452","https://openalex.org/W1906832098","https://openalex.org/W1950464255","https://openalex.org/W1974798214","https://openalex.org/W1976449167","https://openalex.org/W1983831412","https://openalex.org/W2027226830","https://openalex.org/W2039693432","https://openalex.org/W2062634915","https://openalex.org/W2078543094","https://openalex.org/W2114759766","https://openalex.org/W2129198648","https://openalex.org/W2131646187","https://openalex.org/W2160953240","https://openalex.org/W2161366931","https://openalex.org/W2163533527","https://openalex.org/W2301710502","https://openalex.org/W2320088211","https://openalex.org/W2337700516","https://openalex.org/W2415340862","https://openalex.org/W2419351527"],"related_works":["https://openalex.org/W1788215479","https://openalex.org/W2896265749","https://openalex.org/W1975560805","https://openalex.org/W2511026750","https://openalex.org/W2114759766","https://openalex.org/W2326559180","https://openalex.org/W1542880530","https://openalex.org/W2134555004","https://openalex.org/W2379129879","https://openalex.org/W2046202646"],"abstract_inverted_index":{"In":[0],"a":[1,33,87,256],"blinded,":[2],"controlled":[3],"study,":[4],"thirty":[5],"purpose-bred,":[6],"Borrelia":[7],"burgdorferi":[8,37,89,210],"negative,":[9],"mixed-breed":[10],"dogs":[11,70,146,149,214,217],"10":[12],"to":[13,118,128,142,269],"12":[14],"weeks":[15,74],"of":[16,24,31,53,111,158,182,198,224,231,240,251,262],"age":[17],"were":[18,71,116,150],"randomly":[19],"divided":[20],"into":[21],"three":[22],"groups":[23,49],"ten":[25],"animals":[26],"each":[27],"for":[28,44],"the":[29,62,76,130,134,148,204],"purpose":[30],"evaluating":[32],"recombinant":[34,60],"nonadjuvanted":[35,245],"B.":[36,88,209,227,246],"OspA":[38,188,266],"vaccine":[39,120,205,248,267],"(Recombitek":[40],"Lyme":[41],"[Merial":[42],"Limited])":[43],"efficacy":[45],"and":[46,104,106,137,163,195,234,273],"safety.":[47],"Two":[48],"received":[50],"two":[51,54],"doses":[52],"different":[55],"lots":[56],"ofa":[57],"nonadjuvanted,":[58],"OspA,":[59],"vaccine;":[61],"third":[63],"group":[64],"served":[65],"as":[66],"nonvaccinated":[67],"controls.":[68],"All":[69],"challenged":[72],"3":[73],"after":[75,147,173,255],"second":[77],"vaccination":[78],"with":[79,155,208,226],"blacklegged":[80],"deer":[81],"ticks":[82,136,140],"(Ixodes":[83],"scapularis)":[84],"harvested":[85],"from":[86,113],"endemic":[90],"area":[91],"in":[92,133,138,211,275],"Rhode":[93],"Island.":[94],"Clinical":[95],"signs,":[96,179],"antibody":[97,124,189],"titers":[98],"by":[99,161,165],"ELISA,":[100],"Western":[101,192],"blot":[102,193],"assays,":[103],"isolation":[105,181,197,230],"polymerase":[107,235],"chain":[108,236],"reaction":[109,237],"analyses":[110],"spirochetes":[112,183,199,232,241],"biopsy":[114],"specimens":[115],"used":[117,127],"evaluate":[119,129],"efficacy.":[121],"Direct":[122],"fluorescent":[123],"assay":[125],"was":[126],"infection":[131,207,225,254],"rate":[132],"challenge":[135,258],"na\u00efve":[139],"allowed":[141],"feed":[143],"on":[144,184,191,200],"study":[145],"infected":[151,260],"(xenodiagnosis).":[152],"Vaccinates":[153,175],"responded":[154],"high":[156],"levels":[157],"antibodies":[159,222],"(determined":[160],"ELISA":[162],"measured":[164],"optical":[166],"density":[167],"[OD]),":[168],"which":[169],"did":[170],"not":[171],"rise":[172],"challenge.":[174],"demonstrated":[176,218],"no":[177],"clinical":[178,219],"negative":[180,196],"biopsy,":[185,201],"only":[186],"an":[187],"pattern":[190],"assay,":[194],"confirming":[202],"that":[203,259],"blocked":[206],"all":[212],"vaccinated":[213],"(20/20).":[215],"Control":[216],"signs":[220],"(2/10),":[221],"characteristic":[223],"burgdoferi":[228,247],"(10/10),":[229,233],"(PCR)":[238],"detection":[239],"(9/10).":[242],"The":[243,265],"recombinant,":[244],"protected":[249],"100%":[250,261],"vaccinates":[252],"against":[253],"severe":[257],"control":[263],"dogs.":[264],"proved":[268],"be":[270],"highly":[271],"safe":[272],"effective":[274],"this":[276],"study.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
