{"id":"https://openalex.org/W84333434","doi":null,"title":"Perinatal glucocorticoid treatment and perspectives for antioxidat therapy","display_name":"Perinatal glucocorticoid treatment and perspectives for antioxidat therapy","publication_year":2014,"publication_date":"2014-01-30","ids":{"openalex":"https://openalex.org/W84333434","mag":"84333434"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/293052","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/293052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/293052","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088782632","display_name":"Deodata Tijsseling","orcid":"https://orcid.org/0000-0001-7391-3159","observed_orcids":["https://orcid.org/0000-0001-7391-3159"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deodata Tijsseling","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7391-3159","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088782632"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.09489999711513519,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antenatal-glucocorticoids","display_name":"antenatal glucocorticoids","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hippocampal-development","display_name":"hippocampal development","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9549999833106995},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.824999988079071},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.48399999737739563},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.41100001335144043},{"id":"https://openalex.org/keywords/arterial-pressure","display_name":"arterial pressure","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cardiovascular-function","display_name":"cardiovascular function","score":0.6320000290870667},{"id":"https://openalex.org/keywords/glucocorticoid-side-effects","display_name":"glucocorticoid adverse effects","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.8194729089736938},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7562995553016663},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7400140166282654},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.7362385988235474},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6882492899894714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6083686947822571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6010041236877441},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5902151465415955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5358608365058899},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.425446480512619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.269222229719162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/293052","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/293052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/293052","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/293052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/293052","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/293052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:84333434","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/bitstream/1874/293052/2/tijsseling.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/293052","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/293052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082745243","https://openalex.org/W1981252180","https://openalex.org/W2091405773","https://openalex.org/W186021234","https://openalex.org/W2090002569","https://openalex.org/W2025799133","https://openalex.org/W1980816520","https://openalex.org/W1980893110","https://openalex.org/W2131807459","https://openalex.org/W2569642032"],"abstract_inverted_index":{"Pre-":[0],"and":[1,127,151,167,173,192,196,205,226,230,281,284,298,326,351,366,432,451],"postnatal":[2,124,159,180],"glucocorticoids":[3,13,28,141],"are":[4],"a":[5,34,38,102,170,261,291,317,373,401,423,452],"life-saving":[6],"therapy":[7,164],"for":[8,416,429],"prematurely":[9,442,453],"born":[10,443,454,461],"infants.":[11],"However,":[12,238],"also":[14,241],"trigger":[15],"unwanted":[16],"side":[17,121],"effects.":[18,132],"In":[19,250,265],"part":[20],"I":[21],"we":[22,77,157,254,276,420],"investigated":[23,78,174],"the":[24,50,54,85,107,111,190,202,206,210,236,248,251,268,279,323,334,368],"effects":[25,79,122,146,175,269,341,378,467],"of":[26,42,64,80,110,113,123,186,199,209,220,233,244,270,302,320,329,339,459],"antenatal":[27,43,81],"on":[29,84,120,176,272,395,471],"hippocampal":[30],"development.":[31],"First":[32],"in":[33,49,106,169,189,201,235,247,278,293,322,333,404,410,422],"mice":[35],"model":[36,172],"using":[37,260],"clinically":[39],"relevant":[40],"dose":[41],"dexamethasone.":[44],"Dexamethasone":[45,183],"treatment":[46,83,126,161,213,288,310,383,387],"increased":[47,57,68,184,242,327,359,367],"apoptosis":[48],"hippocampus":[51,112],"until":[52],"birth.During":[53],"phase":[55],"with":[56,162,258,384,447],"apoptosis,":[58],"proliferation":[59],"was":[60,67,71],"reduced.":[61],"The":[62],"number":[63,319],"proliferative":[65],"cells":[66,332],"postnatally,":[69],"but":[70,216,398],"decreased":[72,103,193,318,363,389],"at":[73,179],"adult":[74],"stage.":[75],"Thereafter,":[76],"glucocorticoid":[82,114,125],"human":[86],"hippocampus.":[87,211,237],"Included":[88],"were":[89,342,379,463,468],"preterms":[90],"who":[91],"died":[92],"during":[93,309],"or":[94,449],"within":[95],"4":[96],"days":[97],"after":[98],"delivery.":[99],"We":[100],"detected":[101],"neuronal":[104],"density":[105,328],"CA":[108,203],"zones":[109],"treated":[115,446],"neonates.":[116],"Part":[117],"II":[118],"focuses":[119],"how":[128],"to":[129,223,267,290,344,400,437],"reduce":[130],"these":[131,340],"Accumulating":[133],"evidence":[134],"suggests":[135],"that":[136,275],"one":[137],"pathway":[138],"by":[139,312,347,381,465],"which":[140],"may":[142,413],"promote":[143],"their":[144],"deleterious":[145],"is":[147],"increasing":[148],"oxidative":[149,187,221,245],"stress":[150,188,222,246],"decreasing":[152],"nitric":[153],"oxide":[154],"bioavailability.":[155],"Therefore":[156],"combined":[158,257,349,382],"dexamethasone":[160,256,271,280,287,350,358,448],"antioxidant":[163],"(vitamins":[165],"C":[166,283],"E)":[168],"rat":[171,263],"brain":[177,194,228,273,396],"development":[178,274,397],"day":[181],"21.":[182],"indices":[185,219,243,301],"cortex":[191,325],"volume":[195,229],"soma":[197,231],"volumes":[198,232],"neurons":[200,234,321],"1":[204],"dentate":[207],"gyrus":[208],"Combined":[212],"restored":[214,343],"some":[215],"not":[217],"all":[218],"control":[224,345],"levels":[225,346],"improved":[227],"vitamins":[239,282],"alone":[240,388],"cortex.":[249],"following":[252],"chapters,":[253],"tested":[255],"pravastatin":[259,352],"comparable":[262],"model.":[264],"addition":[266],"found":[277],"E":[285],"study,":[286],"led":[289,399],"fall":[292,403],"plasma":[294],"NOx":[295,390],"concentrations":[296],"(nitrates":[297],"nitrites,well":[299],"established":[300],"circulating":[303],"NO":[304],"bioavailability),":[305],"impaired":[306],"weight":[307,314],"gain":[308,315],"followed":[311],"accelerated":[313],"thereafter,":[316],"cerebral":[324],"GFAP":[330],"positive":[331],"cingulate":[335],"white":[336],"matter.":[337],"Most":[338],"giving":[348],"treatment.":[353],"As":[354,408],"regards":[355],"cardiovascular":[356],"function;":[357],"basal":[360],"arterial":[361],"pressure,":[362],"vascular":[364,405],"reactivity":[365],"rate":[369],"pressure":[370],"product":[371],"indicating":[372],"higher":[374],"myocardial":[375],"workload.":[376],"These":[377],"ameliorated":[380],"pravastatin.":[385],"Pravastatin":[386],"concentrations,":[391],"had":[392],"no":[393],"effect":[394],"significant":[402],"relaxation":[406],"sensitivity.":[407],"changes":[409],"growth":[411,427,472],"patterns":[412,428,458],"have":[414],"consequences":[415],"long":[417],"term":[418],"health":[419],"compared":[421],"retrospective":[424],"cohort":[425],"study":[426],"weight,":[430],"height":[431],"head":[433],"circumference":[434],"from":[435],"birth":[436],"age":[438],"four":[439],"years,":[440],"between":[441],"children":[444],"postnatally":[445],"hydrocortisone":[450],"reference":[455],"group.":[456],"Growth":[457],"preterm":[460],"infants":[462],"affected":[464],"glucocorticoid-treatment,":[466],"observed":[469],"mainly":[470],"velocities.":[473]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}
