{"id":"https://openalex.org/W843025282","doi":null,"title":"The Role of Angiotensin II on Human and Partial Bladder Outlet Obstructed Rabbit Corpus Cavernosal Contractility: Modulation of Nitric Oxide-Mediated Relaxation and Relevance to Erectile Dysfunction","display_name":"The Role of Angiotensin II on Human and Partial Bladder Outlet Obstructed Rabbit Corpus Cavernosal Contractility: Modulation of Nitric Oxide-Mediated Relaxation and Relevance to Erectile Dysfunction","publication_year":2013,"publication_date":"2013-10-28","ids":{"openalex":"https://openalex.org/W843025282","mag":"843025282"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1409849","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1409849/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009190658","display_name":"Hani Ertemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H. Ertemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009190658"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/corpus-cavernosum-smooth-muscle","display_name":"corpus cavernosum smooth muscle","score":0.8119999766349792},{"id":"https://openalex.org/keywords/partial-bladder-outlet-obstruction","display_name":"partial bladder outlet obstruction","score":0.875},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9129999876022339},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.8289999961853027},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vardenafil","display_name":"vardenafil","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.574999988079071},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.8429986238479614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7163480520248413},{"id":"https://openalex.org/C2777209548","wikidata":"https://www.wikidata.org/wiki/Q414754","display_name":"Apocynin","level":4,"score":0.7075647711753845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6826990842819214},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.6589785814285278},{"id":"https://openalex.org/C2778509035","wikidata":"https://www.wikidata.org/wiki/Q664698","display_name":"Erectile tissue","level":3,"score":0.6015048623085022},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5622154474258423},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5533982515335083},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.5376151204109192},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5373652577400208},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5011875629425049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4886517822742462},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4438466429710388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28480011224746704},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.28408563137054443},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.2375614047050476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21069860458374023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11205413937568665},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1409849","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1409849/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:843025282","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1409849/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W39364382","https://openalex.org/W85096918","https://openalex.org/W113042798","https://openalex.org/W120379914","https://openalex.org/W185152087","https://openalex.org/W198934061","https://openalex.org/W206662292","https://openalex.org/W1494508678","https://openalex.org/W1495512269","https://openalex.org/W1498403236","https://openalex.org/W1518058648","https://openalex.org/W1546689954","https://openalex.org/W1551301272","https://openalex.org/W1591510379","https://openalex.org/W1595582953","https://openalex.org/W1776140948","https://openalex.org/W1801334961","https://openalex.org/W1809208208","https://openalex.org/W1821918060","https://openalex.org/W1822622598","https://openalex.org/W1824937346","https://openalex.org/W1857709346","https://openalex.org/W1917071897","https://openalex.org/W1964562856","https://openalex.org/W1964620208","https://openalex.org/W1965484721","https://openalex.org/W1966415714","https://openalex.org/W1967069595","https://openalex.org/W1967428357","https://openalex.org/W1971137611","https://openalex.org/W1973501606","https://openalex.org/W1974380064","https://openalex.org/W1975581032","https://openalex.org/W1980146451","https://openalex.org/W1982642768","https://openalex.org/W1984494359","https://openalex.org/W1985235031","https://openalex.org/W1985959562","https://openalex.org/W1986031402","https://openalex.org/W1986699779","https://openalex.org/W1988449390","https://openalex.org/W1989064235","https://openalex.org/W1989265626","https://openalex.org/W1989818009","https://openalex.org/W1990001566","https://openalex.org/W2006705030","https://openalex.org/W2006847107","https://openalex.org/W2007541306","https://openalex.org/W2007655935","https://openalex.org/W2009639166","https://openalex.org/W2010140850","https://openalex.org/W2013287037","https://openalex.org/W2015104052","https://openalex.org/W2015518057","https://openalex.org/W2015623606","https://openalex.org/W2016482528","https://openalex.org/W2017039090","https://openalex.org/W2018398381","https://openalex.org/W2018858967","https://openalex.org/W2023512511","https://openalex.org/W2026836366","https://openalex.org/W2026893793","https://openalex.org/W2031548942","https://openalex.org/W2034832260","https://openalex.org/W2040126239","https://openalex.org/W2040619094","https://openalex.org/W2047042164","https://openalex.org/W2049704766","https://openalex.org/W2051693929","https://openalex.org/W2052518051","https://openalex.org/W2053608868","https://openalex.org/W2054631954","https://openalex.org/W2056147576","https://openalex.org/W2058137293","https://openalex.org/W2058348904","https://openalex.org/W2059656768","https://openalex.org/W2061011041","https://openalex.org/W2061676860","https://openalex.org/W2065727360","https://openalex.org/W2076669420","https://openalex.org/W2078361267","https://openalex.org/W2078773224","https://openalex.org/W2081938413","https://openalex.org/W2082291507","https://openalex.org/W2083597942","https://openalex.org/W2085203979","https://openalex.org/W2085790267","https://openalex.org/W2087840221","https://openalex.org/W2089258822","https://openalex.org/W2090404009","https://openalex.org/W2091660987","https://openalex.org/W2095224007","https://openalex.org/W2095244032","https://openalex.org/W2097091663","https://openalex.org/W2100342988","https://openalex.org/W2100628831","https://openalex.org/W2102509609","https://openalex.org/W2103154123","https://openalex.org/W2103760597","https://openalex.org/W2105767037","https://openalex.org/W2108471380","https://openalex.org/W2109536751","https://openalex.org/W2111494287","https://openalex.org/W2111745105","https://openalex.org/W2114547396","https://openalex.org/W2115259899","https://openalex.org/W2118783073","https://openalex.org/W2119869567","https://openalex.org/W2122740041","https://openalex.org/W2123339944","https://openalex.org/W2126136540","https://openalex.org/W2129572120","https://openalex.org/W2129876214","https://openalex.org/W2133921510","https://openalex.org/W2135586734","https://openalex.org/W2136252004","https://openalex.org/W2137146936","https://openalex.org/W2138944514","https://openalex.org/W2139491374","https://openalex.org/W2141633506","https://openalex.org/W2141849555","https://openalex.org/W2146426387","https://openalex.org/W2147934559","https://openalex.org/W2149636968","https://openalex.org/W2150676717","https://openalex.org/W2151899022","https://openalex.org/W2154496348","https://openalex.org/W2155169902","https://openalex.org/W2155207996","https://openalex.org/W2156121263","https://openalex.org/W2158582607","https://openalex.org/W2160059959","https://openalex.org/W2161399617","https://openalex.org/W2163768086","https://openalex.org/W2164189667","https://openalex.org/W2164930319","https://openalex.org/W2166507618","https://openalex.org/W2168643678","https://openalex.org/W2171065949","https://openalex.org/W2171236476","https://openalex.org/W2235720900","https://openalex.org/W2290796593","https://openalex.org/W2297358297","https://openalex.org/W2312672091","https://openalex.org/W2324174526","https://openalex.org/W2331157584","https://openalex.org/W2398850634","https://openalex.org/W2402399220","https://openalex.org/W2411624213","https://openalex.org/W2413911436","https://openalex.org/W2529434526","https://openalex.org/W2615684303","https://openalex.org/W3141957964"],"related_works":["https://openalex.org/W1824937346","https://openalex.org/W2078773224","https://openalex.org/W2313707234","https://openalex.org/W1016867027","https://openalex.org/W2042066304","https://openalex.org/W1938155937","https://openalex.org/W2076057051","https://openalex.org/W1970190657","https://openalex.org/W2061011041","https://openalex.org/W2050947502"],"abstract_inverted_index":{"The":[0,43,148,190,264],"interaction":[1],"between":[2],"angiotensin":[3],"II":[4,84,134,192,236,252],"(Ang":[5],"II),":[6],"a":[7,16,58,73,151,277,289],"smooth":[8,67,246],"muscle":[9,68,247],"constrictor":[10],"peptide":[11,85,149],"and":[12,32,57,61,106,119,145,166,204,209,221,227,237,243,259],"nitric":[13],"oxide":[14],"(NO)":[15],"vasodilator,":[17],"as":[18,20],"well":[19],"the":[21,97,123,127,138,141,250,255,260,281,293],"role":[22],"of":[23,64,112,129,155,257,262,280,295],"oxidative":[24],"stress":[25],"(OS),":[26],"have":[27],"been":[28],"investigated":[29],"in":[30,52,87,137,197,218,266],"human":[31,88,242],"chronic":[33],"partial":[34],"bladder":[35],"outlet":[36],"obstructed":[37],"(PBOO)":[38],"rabbit":[39,45,244],"corpus":[40,53,65,89],"cavernosal":[41,54,66,90],"tissue.":[42],"PBOO":[44,202,272],"model":[46,75,220],"is":[47,273],"characterised":[48],"by":[49,161,173,188,206,214,223],"an":[50,178],"increase":[51,265],"collagen":[55],"deposition":[56],"marked":[59],"reduction":[60],"impaired":[62,217],"relaxation":[63,171,212],"(CCSM)":[69],"cells,":[70],"making":[71],"it":[72],"useful":[74],"for":[76,292],"erectile":[77],"dysfunction":[78],"(ED).":[79],"Immunohistochemical":[80],"analysis":[81],"identified":[82],"Ang":[83,98,133,191,235,251,267],"distribution":[86],"tissue,":[91],"while":[92],"organ":[93],"bath":[94],"studies":[95],"determined":[96,103],"II/NO":[99],"interaction.":[100],"OS":[101],"was":[102,135,159,186,195,216],"using":[104],"apocynin":[105],"diphenylene":[107],"iodonium":[108],"chloride":[109],"(DPI),":[110],"inhibitors":[111],"NAD(P)H":[113],"oxidase,":[114],"which":[115],"inhibit":[116],"superoxide":[117,120,258],"production":[118,256],"dismutase":[121],"(SOD,":[122],"enzyme":[124],"that":[125,158,234],"accelerates":[126],"breakdown":[128],"superoxide).":[130],"Human":[131],"penile":[132,245],"distributed":[136],"arteriolar":[139],"endothelium,":[140],"endothelium":[142],"lining":[143],"sinusoids":[144],"CCSM":[146,156,170,198,211,269],"cells.":[147],"caused":[150],"dose":[152],"dependent":[153],"contraction":[154,270],"strips":[157,199],"inhibited":[160,205],"losartan":[162],"(AT1":[163],"receptor":[164,285],"antagonist)":[165],"apocynin.":[167],"In":[168],"contrast,":[169],"induced":[172,213],"either":[174],"sodium":[175],"nitroprusside":[176],"(SNP,":[177],"NO":[179,238],"donor)":[180],"or":[181],"electrical":[182],"field":[183],"stimulation":[184],"(EFS)":[185],"potentiated":[187],"losartan.":[189,228],"contractile":[193],"response":[194,253],"enhanced":[196],"taken":[200],"from":[201],"rabbits":[203],"losartan,":[207],"DPI":[208],"SOD.":[210],"SNP/EFS":[215],"this":[219],"improved":[222],"vardenafil":[224],"(PDE5":[225],"inhibitor)":[226],"Taken":[229],"together,":[230],"these":[231],"findings":[232],"suggest":[233],"interact":[239],"to":[240,275],"modulate":[241],"tone.":[248],"Moreover,":[249],"involves":[254],"development":[261],"OS.":[263],"II-mediated":[268],"following":[271],"likely":[274],"be":[276,288],"pathological":[278],"consequence":[279],"condition.":[282],"Importantly,":[283],"AT1":[284],"inhibition":[286],"may":[287],"therapeutic":[290],"target":[291],"treatment":[294],"ED":[296],"associated":[297],"with":[298],"PBOO.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
