{"id":"https://openalex.org/W84243993","doi":null,"title":"Pleiotropy and genotype by diet interaction: A multivariate genetic analysis of HDL-C subfractions","display_name":"Pleiotropy and genotype by diet interaction: A multivariate genetic analysis of HDL-C subfractions","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W84243993","mag":"84243993"},"language":"en","primary_location":{"id":"mag:84243993","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/133914-pleiotropy-genotype-diet-interaction-multivariate-genetic-analysis-hdl-subfractions","pdf_url":null,"source":{"id":"https://openalex.org/S134425043","display_name":"The American Journal of Human Genetics","issn_l":"0002-9297","issn":["0002-9297","1537-6605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The American Journal of Human Genetics","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014408985","display_name":"MC Mahaney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MC Mahaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723","observed_orcids":["https://orcid.org/0000-0001-6250-5723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6250-5723","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111238899","display_name":"A.G. Comuzzie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.G. Comuzzie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5150,"currency":"USD","value_usd":5150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01113069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.18979999423027039,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdl-subfractions","display_name":"HDL subfractions","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/genotype-by-diet-interaction","display_name":"genotype by diet interaction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.9129999876022339},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.6000000238418579},{"id":"https://openalex.org/keywords/papio-hamadryas","display_name":"Papio hamadryas","score":0.9610000252723694},{"id":"https://openalex.org/keywords/atherosclerosis-model","display_name":"atherosclerosis model","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hdl2-c","display_name":"HDL2-C","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6631139516830444},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.6193633675575256},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6045812964439392},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5587730407714844},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5525752902030945},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5496481657028198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4974992573261261},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.490151971578598},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.47590145468711853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.441409170627594},{"id":"https://openalex.org/C17966761","wikidata":"https://www.wikidata.org/wiki/Q68947","display_name":"Subspecies","level":2,"score":0.4158439636230469},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4121435284614563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.275751531124115},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.23113220930099487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08790317177772522},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:84243993","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/133914-pleiotropy-genotype-diet-interaction-multivariate-genetic-analysis-hdl-subfractions","pdf_url":null,"source":{"id":"https://openalex.org/S134425043","display_name":"The American Journal of Human Genetics","issn_l":"0002-9297","issn":["0002-9297","1537-6605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The American Journal of Human Genetics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099130001","https://openalex.org/W2113595490","https://openalex.org/W2114347061","https://openalex.org/W2276495252","https://openalex.org/W2105037838","https://openalex.org/W2046844111","https://openalex.org/W2017899333","https://openalex.org/W2123403695","https://openalex.org/W1994640703","https://openalex.org/W2170662528"],"abstract_inverted_index":{"Reduced":[0],"high":[1,81],"density":[2],"lipoprotein":[3],"cholesterol":[4],"(HDL-C)":[5],"is":[6],"a":[7,41,74,78],"risk":[8],"factor":[9],"for":[10,27,44,100,146,216,234],"cardiovascular":[11],"disease":[12],"in":[13,58,69,248],"humans.":[14],"Both":[15],"major":[16,19],"genes":[17,53,245],"and":[18,66,77,123,136,178,200,267],"genotype":[20,230],"by":[21,96,231],"diet":[22,76,232],"interaction":[23,233],"have":[24],"been":[25],"reported":[26],"HDL-C,":[28],"but":[29],"the":[30,33,49,186,190,194,219,243,252,259,268],"genetics":[31],"of":[32,52,128,218,262],"HDL-C":[34,60,92],"subfractions":[35,61,149,166,221,271],"are":[36],"less":[37],"well":[38],"known.":[39],"In":[40],"baboon":[42],"model":[43],"human":[45],"atherosclerosis,":[46],"we":[47,158,228],"investigated":[48,275],"pleiotropic":[50],"effects":[51,127],"on":[54,90,150,185,255],"normal":[55],"quantitative":[56],"variation":[57,247],"three":[59,148,165,220],"(HDL{sub":[62],"1}-C,":[63,236],"HDL{sub":[64,67,176,179,198,201,235,237,240,265],"2}-C,":[65],"3}-C)":[68],"two":[70,270],"dietary":[71,156],"environments":[72],"--":[73],"basal":[75,187],"7":[79],"week":[80],"cholesterol,":[82],"saturated":[83],"fat":[84],"(HCSF)":[85],"diet.":[86,257],"We":[87,110],"analyzed":[88],"data":[89],"serum":[91],"subfraction":[93,250],"levels,":[94],"quantified":[95],"gradient":[97],"gel":[98],"eletrophoresis,":[99],"942":[101],"baboons":[102],"(Papo":[103],"hamadryas,":[104],"sensu":[105],"lato)":[106],"from":[107],"17":[108],"pedigrees.":[109],"used":[111],"multivariate":[112],"maximum":[113],"likelihood":[114],"methods":[115],"to":[116,251,273],"simultaneously":[117],"estimate":[118],"phenotypic":[119],"means,":[120],"standard":[121],"deviations,":[122],"heritabilities":[124],"(h{sup":[125],"2});":[126],"sex,":[129],"age-by-sex,":[130],"age{sup":[131],"2}-by-sex,":[132],"percent":[133],"subspecies":[134],"admixture,":[135],"infant":[137],"feeding":[138],"modality;":[139],"plus":[140],"estimated":[141],"significant":[142,160,208],"h{sup":[143],"2}":[144],"values":[145],"all":[147,164],"both":[151,223],"diets.":[152,224],"When":[153],"tested":[154],"within":[155],"environments,":[157],"obtained":[159],"genetic":[161,195],"correlations":[162],"between":[163,175,197,222,264],"[i.e.,":[167],"P({rho}{sub":[168],"G}":[169,182],"=":[170,183,205],"0)":[171],"0.1]":[174],"1}-C":[177,199],"3}-C":[180,202],"({rho}{sub":[181,203],"0.81)":[184],"diet.more\u00a0\u00bb":[188],"On":[189],"HCSF":[191],"diet,":[192],"only":[193],"correlation":[196],"g}":[204],"0.61)":[206],"was":[207,214],"(p":[209],">":[210],"0.1).":[211],"Complete":[212],"pleiotropy":[213,263],"observed":[215],"each":[217,249],"Given":[225],"these":[226],"results,":[227],"reject":[229],"2}-C":[238,266],"or":[239],"3}-C;":[241],"i.e.,":[242],"same":[244,253],"influence":[246],"degree":[254],"either":[256],"However,":[258],"apparent":[260],"disruption":[261],"other":[269],"needs":[272],"be":[274],"further.\u00ab\u00a0less":[276]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}