{"id":"https://openalex.org/W842205477","doi":null,"title":"An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies","display_name":"An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W842205477","mag":"842205477"},"language":"en","primary_location":{"id":"pmh:oai:dora.dmu.ac.uk:2086/5999","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2086/5999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400394","display_name":"DMU Open Research Archive (De Montfort University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66943878","host_organization_name":"De Montfort University","host_organization_lineage":["https://openalex.org/I66943878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103010175","display_name":"Parul Patel","orcid":"https://orcid.org/0000-0001-7002-4348","observed_orcids":["https://orcid.org/0000-0001-7002-4348"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Parul Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7002-4348","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103010175"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.2094999998807907,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7559999823570251},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.984000027179718},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9660000205039978},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.6190000176429749},{"id":"https://openalex.org/keywords/bioanalytical-method-validation","display_name":"bioanalytical method validation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/sample-stability","display_name":"sample stability","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7509999871253967},{"id":"https://openalex.org/keywords/method-transferability","display_name":"method transferability","score":0.7080000042915344},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.7940000295639038},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7069568037986755},{"id":"https://openalex.org/C2776597655","wikidata":"https://www.wikidata.org/wiki/Q5307389","display_name":"Dried blood spot","level":2,"score":0.5712107419967651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39821264147758484},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33452215790748596},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3217134475708008},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.28559646010398865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23614585399627686}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dora.dmu.ac.uk:2086/5999","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2086/5999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400394","display_name":"DMU Open Research Archive (De Montfort University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66943878","host_organization_name":"De Montfort University","host_organization_lineage":["https://openalex.org/I66943878"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},{"id":"mag:842205477","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.dmu.ac.uk/bitstream/handle/2086/5999/e-thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":294,"referenced_works":["https://openalex.org/W46581255","https://openalex.org/W95742513","https://openalex.org/W105671925","https://openalex.org/W166333077","https://openalex.org/W202225520","https://openalex.org/W207459251","https://openalex.org/W237900477","https://openalex.org/W386268369","https://openalex.org/W1120968769","https://openalex.org/W1508301208","https://openalex.org/W1515542254","https://openalex.org/W1527224580","https://openalex.org/W1528603850","https://openalex.org/W1531330393","https://openalex.org/W1552300475","https://openalex.org/W1563606060","https://openalex.org/W1566316934","https://openalex.org/W1577914040","https://openalex.org/W1585025003","https://openalex.org/W1601301295","https://openalex.org/W1620361783","https://openalex.org/W1700762969","https://openalex.org/W1761934797","https://openalex.org/W1776063828","https://openalex.org/W1818045902","https://openalex.org/W1836660334","https://openalex.org/W1852542300","https://openalex.org/W1875055464","https://openalex.org/W1888057860","https://openalex.org/W1894873888","https://openalex.org/W1898325617","https://openalex.org/W1911366939","https://openalex.org/W1930059357","https://openalex.org/W1930427755","https://openalex.org/W1957034755","https://openalex.org/W1964084236","https://openalex.org/W1964182026","https://openalex.org/W1965987183","https://openalex.org/W1966054392","https://openalex.org/W1966941751","https://openalex.org/W1968079906","https://openalex.org/W1969673834","https://openalex.org/W1969830608","https://openalex.org/W1972200239","https://openalex.org/W1973810905","https://openalex.org/W1974541545","https://openalex.org/W1975206137","https://openalex.org/W1976663895","https://openalex.org/W1976932199","https://openalex.org/W1977537246","https://openalex.org/W1978655276","https://openalex.org/W1980476299","https://openalex.org/W1983253990","https://openalex.org/W1984669404","https://openalex.org/W1985137868","https://openalex.org/W1985206081","https://openalex.org/W1985704757","https://openalex.org/W1985848675","https://openalex.org/W1987997716","https://openalex.org/W1989473417","https://openalex.org/W1990302608","https://openalex.org/W1990647320","https://openalex.org/W1991671417","https://openalex.org/W1991794864","https://openalex.org/W1993113937","https://openalex.org/W1993120507","https://openalex.org/W1993780682","https://openalex.org/W1994731787","https://openalex.org/W1996275102","https://openalex.org/W1996399352","https://openalex.org/W1996756103","https://openalex.org/W1997828059","https://openalex.org/W1997961043","https://openalex.org/W1999292228","https://openalex.org/W1999367008","https://openalex.org/W2000138983","https://openalex.org/W2000742403","https://openalex.org/W2001013152","https://openalex.org/W2001030316","https://openalex.org/W2001248503","https://openalex.org/W2001324129","https://openalex.org/W2001356545","https://openalex.org/W2002592708","https://openalex.org/W2002642430","https://openalex.org/W2004275170","https://openalex.org/W2005216712","https://openalex.org/W2005473897","https://openalex.org/W2005517690","https://openalex.org/W2006200797","https://openalex.org/W2006600600","https://openalex.org/W2007501521","https://openalex.org/W2008096422","https://openalex.org/W2008683503","https://openalex.org/W2010214586","https://openalex.org/W2011319389","https://openalex.org/W2012436282","https://openalex.org/W2013336432","https://openalex.org/W2014176889","https://openalex.org/W2015369755","https://openalex.org/W2015503275","https://openalex.org/W2015679604","https://openalex.org/W2015775078","https://openalex.org/W2016465069","https://openalex.org/W2016719205","https://openalex.org/W2017459399","https://openalex.org/W2018358374","https://openalex.org/W2018544205","https://openalex.org/W2019140910","https://openalex.org/W2019423867","https://openalex.org/W2020803142","https://openalex.org/W2021861946","https://openalex.org/W2022569579","https://openalex.org/W2022576911","https://openalex.org/W2023097384","https://openalex.org/W2023373993","https://openalex.org/W2023723680","https://openalex.org/W2023950153","https://openalex.org/W2024033874","https://openalex.org/W2024127724","https://openalex.org/W2025223638","https://openalex.org/W2025349244","https://openalex.org/W2025752875","https://openalex.org/W2027321121","https://openalex.org/W2027508859","https://openalex.org/W2028000157","https://openalex.org/W2028574914","https://openalex.org/W2029081959","https://openalex.org/W2029096263","https://openalex.org/W2029705184","https://openalex.org/W2030723776","https://openalex.org/W2032358261","https://openalex.org/W2032443014","https://openalex.org/W2032471407","https://openalex.org/W2034389382","https://openalex.org/W2035404970","https://openalex.org/W2036452928","https://openalex.org/W2041881230","https://openalex.org/W2044103929","https://openalex.org/W2044324900","https://openalex.org/W2044788142","https://openalex.org/W2045278104","https://openalex.org/W2046615298","https://openalex.org/W2048114154","https://openalex.org/W2048718351","https://openalex.org/W2048871686","https://openalex.org/W2049333580","https://openalex.org/W2049606866","https://openalex.org/W2049658135","https://openalex.org/W2049937121","https://openalex.org/W2050253715","https://openalex.org/W2050862250","https://openalex.org/W2051969713","https://openalex.org/W2052885250","https://openalex.org/W2053707359","https://openalex.org/W2053936196","https://openalex.org/W2054558564","https://openalex.org/W2055871388","https://openalex.org/W2056382904","https://openalex.org/W2058071755","https://openalex.org/W2058211369","https://openalex.org/W2059185356","https://openalex.org/W2059529385","https://openalex.org/W2059703542","https://openalex.org/W2060116490","https://openalex.org/W2060763377","https://openalex.org/W2060967796","https://openalex.org/W2061790725","https://openalex.org/W2063143853","https://openalex.org/W2063467309","https://openalex.org/W2064206433","https://openalex.org/W2064646765","https://openalex.org/W2065219498","https://openalex.org/W2065244409","https://openalex.org/W2066250067","https://openalex.org/W2066410117","https://openalex.org/W2066584349","https://openalex.org/W2067175105","https://openalex.org/W2067600971","https://openalex.org/W2068861236","https://openalex.org/W2069275102","https://openalex.org/W2069756383","https://openalex.org/W2070013574","https://openalex.org/W2073632755","https://openalex.org/W2073696270","https://openalex.org/W2073729167","https://openalex.org/W2074104343","https://openalex.org/W2074504885","https://openalex.org/W2075110706","https://openalex.org/W2076364543","https://openalex.org/W2076765615","https://openalex.org/W2077824951","https://openalex.org/W2077996245","https://openalex.org/W2079195253","https://openalex.org/W2081046742","https://openalex.org/W2085021668","https://openalex.org/W2085093423","https://openalex.org/W2085694070","https://openalex.org/W2088996598","https://openalex.org/W2090267724","https://openalex.org/W2090434577","https://openalex.org/W2091458190","https://openalex.org/W2091838980","https://openalex.org/W2092469024","https://openalex.org/W2093442618","https://openalex.org/W2094277512","https://openalex.org/W2094514326","https://openalex.org/W2094530591","https://openalex.org/W2097496935","https://openalex.org/W2097550443","https://openalex.org/W2104428172","https://openalex.org/W2105621974","https://openalex.org/W2106679929","https://openalex.org/W2107845287","https://openalex.org/W2108639749","https://openalex.org/W2108741491","https://openalex.org/W2109964513","https://openalex.org/W2110928488","https://openalex.org/W2113331331","https://openalex.org/W2114235313","https://openalex.org/W2114903378","https://openalex.org/W2115156600","https://openalex.org/W2115571073","https://openalex.org/W2116418471","https://openalex.org/W2117373363","https://openalex.org/W2119227173","https://openalex.org/W2120957560","https://openalex.org/W2121129723","https://openalex.org/W2122233999","https://openalex.org/W2122527560","https://openalex.org/W2123024846","https://openalex.org/W2123141619","https://openalex.org/W2123869017","https://openalex.org/W2125697166","https://openalex.org/W2126922950","https://openalex.org/W2129088775","https://openalex.org/W2129483958","https://openalex.org/W2129745823","https://openalex.org/W2130033605","https://openalex.org/W2130752680","https://openalex.org/W2131755635","https://openalex.org/W2132158620","https://openalex.org/W2132788265","https://openalex.org/W2133171370","https://openalex.org/W2133597621","https://openalex.org/W2133640666","https://openalex.org/W2134823797","https://openalex.org/W2135270007","https://openalex.org/W2137490212","https://openalex.org/W2141215569","https://openalex.org/W2141954010","https://openalex.org/W2144462910","https://openalex.org/W2145435092","https://openalex.org/W2146556358","https://openalex.org/W2146993893","https://openalex.org/W2147458817","https://openalex.org/W2151125631","https://openalex.org/W2151692106","https://openalex.org/W2152279809","https://openalex.org/W2152602593","https://openalex.org/W2153681048","https://openalex.org/W2155916653","https://openalex.org/W2156769465","https://openalex.org/W2157009638","https://openalex.org/W2157937301","https://openalex.org/W2159205993","https://openalex.org/W2160587450","https://openalex.org/W2161446377","https://openalex.org/W2161653495","https://openalex.org/W2161824000","https://openalex.org/W2162252433","https://openalex.org/W2165330647","https://openalex.org/W2165730367","https://openalex.org/W2166182148","https://openalex.org/W2166607402","https://openalex.org/W2167847793","https://openalex.org/W2167950368","https://openalex.org/W2168500684","https://openalex.org/W2169101968","https://openalex.org/W2170277712","https://openalex.org/W2171261526","https://openalex.org/W2171697855","https://openalex.org/W2240258872","https://openalex.org/W2257579179","https://openalex.org/W2264567420","https://openalex.org/W2321741145","https://openalex.org/W2409481285","https://openalex.org/W2411444793","https://openalex.org/W2489082462","https://openalex.org/W2601271328","https://openalex.org/W2655704018","https://openalex.org/W2887143207","https://openalex.org/W2913904064","https://openalex.org/W3135185800","https://openalex.org/W4294305256"],"related_works":["https://openalex.org/W2253035067","https://openalex.org/W2088269022","https://openalex.org/W2069756383","https://openalex.org/W2116406458","https://openalex.org/W2784765845","https://openalex.org/W2353705399","https://openalex.org/W2091251586","https://openalex.org/W2182289218","https://openalex.org/W7053095393","https://openalex.org/W2090629603"],"abstract_inverted_index":{"The":[0,63,333,383],"ethical":[1],"and":[2,21,75,90,95,121,133,148,155,229,264,289,326,345,351,418,442,455,473,554],"practical":[3,503],"issues":[4],"of":[5,31,49,54,77,97,117,135,163,182,225,236,251,254,276,328,348,386,420,447,457,548,557,572],"obtaining":[6],"a":[7,11,32,46,262,286,313,412,465,502,509],"blood":[8,24,34,56,79,107,128,176,195,256,335,365,406,429,498,550,559],"sample":[9,35,226,231],"pose":[10],"significant":[12,506],"challenge":[13],"to":[14,38,71,114,204,247,285,317,341,371,403,445,531,539,544],"performing":[15],"pharmacokinetic":[16,61,101,115,308,320,516,563],"studies":[17,64,102,116,380,517],"in":[18,59,66,103,150,174,197,200,297,356,381,393,469,481,487,514,518,552],"children,":[19],"infants":[20],"neonates.":[22,105,198,382,396],"Dried":[23,106],"spot":[25,57,80,108,257,366,430,499],"analysis,":[26],"based":[27,374],"on":[28,51,126,160,189,527,562],"the":[29,52,73,93,127,136,153,161,175,180,190,206,223,252,279,361,405,416,421,477,482,546,555,573],"collection":[30,129,196],"micro":[33],"has":[36],"potential":[37,362,507,537],"overcome":[39],"these":[40],"difficulties.":[41],"There":[42],"are":[43],"at":[44],"present":[45],"limited":[47],"number":[48],"reports":[50],"utility":[53],"dried":[55,78,255,364,428,497],"analysis":[58,367,500],"clinical":[60,515],"studies.":[62,492],"described":[65],"this":[67,98,536],"thesis":[68],"were":[69,110,124,145,167,269,310,339,433,443,476],"undertaken":[70,244],"investigate":[72],"accuracy":[74],"precision":[76,436],"sampling":[81,191,551],"coupled":[82],"with":[83,152,218,245,271,278,435,489,505],"mass":[84,267],"spectrometry":[85],"detection":[86,137,290],"for":[87,100,112,303,363,376,512,534],"drug":[88,431,560],"quantification,":[89],"clinically":[91],"validate":[92],"robustness":[94,253,417],"feasibility":[96],"technique":[99,281,414,574],"preterm":[104,299,395],"methods":[109,144,375],"developed":[111,143,422],"application":[113],"test":[118],"drugs":[119],"dexamethasone":[120,293,377],"caffeine.":[122],"Investigations":[123],"focused":[125],"system,":[130],"analyte":[131],"recovery":[132],"optimisation":[134,379],"system.":[138],"In-vitro":[139],"validation":[140],"results":[141,494],"indicated":[142],"precise,":[146],"accurate":[147],"selective":[149],"accordance":[151],"Food":[154],"Drug":[156],"Administration":[157],"regulatory":[158],"guidelines":[159],"assessment":[162,250],"bioanalytical":[164],"methods.":[165],"Results":[166,259],"not":[168],"significantly":[169],"affected":[170],"by":[171,216],"small":[172],"variations":[173],"volume":[177,327,346,456],"spotted":[178],"or":[179],"presence":[181],"petroleum":[183],"jelly,":[184],"which":[185,485],"is":[186,486,501,538,575],"often":[187],"used":[188,402],"site":[192],"during":[193],"capillary":[194,549],"Variability":[199],"haematocrit":[201],"was":[202,243,295,391,401],"determined":[203,296,392],"be":[205,532,540,567],"single":[207,263],"most":[208,282,478],"important":[209],"factor":[210],"affecting":[211],"assay":[212],"accuracy.":[213],"Stability":[214],"assessments":[215],"comparison":[217],"freshly":[219],"prepared":[220],"samples":[221],"verified":[222],"suitability":[224],"drying,":[227],"storage":[228],"post":[230],"extraction":[232],"conditions.":[233],"An":[234],"investigation":[235],"method":[237,511],"transferability":[238],"between":[239],"different":[240],"analytical":[241],"instruments":[242],"caffeine":[246,390],"provide":[248],"an":[249,272,369],"analysis.":[258],"generated":[260],"from":[261,427,464],"triple":[265],"quadrupole":[266],"spectrometer":[268],"comparable":[270,444],"expected":[273],"lower":[274],"limit":[275],"quantification":[277],"latter":[280],"likely":[283],"due":[284],"greater":[287],"ionisation":[288],"efficiency.":[291],"Intravenous":[292],"pharmacokinetics":[294,385],"5":[298],"neonates":[300,357,470,553],"receiving":[301],"treatment":[302],"chronic":[304],"lung":[305],"disease.":[306],"Individual":[307],"analyses":[309],"performed":[311],"using":[312,411,558],"one":[314,398],"compartment":[315,399],"model":[316,400,484],"estimate":[318],"primary":[319],"parameters,":[321],"clearance":[322,344,449,483],"(mean,":[323,330,450,459],"0.18":[324],"l/h/kg)":[325],"distribution":[329,458],"1.33":[331],"l/kg).":[332],"whole":[334],"derived":[336,426],"mean":[337],"estimates":[338,347,446],"similar":[340],"previous":[342,466,490],"plasma":[343,373,448],"0.14":[349],"l/h/kg":[350],"1.91":[352],"l/kg,":[353],"respectively":[354],"reported":[355],"(n=7).":[358],"This":[359],"highlights":[360],"as":[368,508,522],"alternative":[370],"conventional":[372],"dose":[378],"population":[384,467,491],"oral":[387],"/":[388],"intravenous":[389],"67":[394],"A":[397],"describe":[404],"concentration-time":[407],"data.":[408],"Model":[409],"evaluation":[410],"bootstrapping":[413],"confirmed":[415],"stability":[419],"model.":[423],"Pharmacokinetic":[424],"parameters":[425],"measurements":[432,561],"estimated":[434],"(relative":[437],"standard":[438],"error":[439],"<":[440],"10%)":[441],"7.3":[451],"vs.":[452,461],"7.0":[453],"ml/h/kg)":[454],"593":[460],"851":[462],"ml/kg)":[463],"study":[468],"(n=110).":[471],"Weight":[472],"postnatal":[474],"age":[475],"influential":[479],"covariates":[480],"agreement":[488],"These":[493],"demonstrate":[495],"that":[496],"technique,":[504],"robust":[510],"use":[513,571],"vulnerable":[519],"populations":[520],"such":[521],"preterms.":[523],"Haematocrit":[524],"related":[525],"effects":[526],"paper":[528],"will":[529,566],"need":[530],"accounted":[533],"if":[535],"realised.":[541],"Further":[542],"investigations":[543],"determine":[545],"reproducibility":[547],"impact":[556],"parameter":[564],"estimation":[565],"necessary":[568],"before":[569],"widespread":[570],"possible.":[576]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
