{"id":"https://openalex.org/W842094027","doi":"https://doi.org/10.1038/nrc3986","title":"APC restores order","display_name":"APC restores order","publication_year":2015,"publication_date":"2015-07-09","ids":{"openalex":"https://openalex.org/W842094027","doi":"https://doi.org/10.1038/nrc3986","mag":"842094027","pmid":"https://pubmed.ncbi.nlm.nih.gov/26156639"},"language":"en","primary_location":{"id":"doi:10.1038/nrc3986","doi":"https://doi.org/10.1038/nrc3986","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc3986","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082537529","display_name":"Sarah E. Seton-Rogers","orcid":"https://orcid.org/0000-0002-3699-3847","observed_orcids":["https://orcid.org/0000-0002-3699-3847"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah Seton-Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082537529"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4615,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57637107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"8","first_page":"454","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6660000085830688},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oncogenic-mutations","display_name":"oncogenic mutations","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.5}],"concepts":[{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.8906369805335999},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7383965253829956},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6871742010116577},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.6119382977485657},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5668452978134155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5147337913513184},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4966171383857727},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.469482958316803},{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.4517461955547333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40190693736076355},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32179418206214905},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2817704677581787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27516093850135803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21119698882102966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1389230489730835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09832462668418884},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrc3986","doi":"https://doi.org/10.1038/nrc3986","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc3986","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:26156639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26156639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1655178001"],"related_works":["https://openalex.org/W2335060263","https://openalex.org/W1655178001","https://openalex.org/W4231915854","https://openalex.org/W2503180330","https://openalex.org/W7098969787","https://openalex.org/W7099787053","https://openalex.org/W2105552492","https://openalex.org/W1986249506","https://openalex.org/W1971697506","https://openalex.org/W1967237032"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
