{"id":"https://openalex.org/W841586012","doi":"https://doi.org/10.1371/journal.pone.0131908","title":"Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish","display_name":"Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish","publication_year":2015,"publication_date":"2015-07-10","ids":{"openalex":"https://openalex.org/W841586012","doi":"https://doi.org/10.1371/journal.pone.0131908","mag":"841586012","pmid":"https://pubmed.ncbi.nlm.nih.gov/26161877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4498767"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0131908","doi":"https://doi.org/10.1371/journal.pone.0131908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0131908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131908&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068290582","display_name":"Christoph Seiler","orcid":"https://orcid.org/0000-0002-3917-1689","observed_orcids":["https://orcid.org/0000-0002-3917-1689"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Seiler","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080496987","display_name":"Nichole Gebhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nichole Gebhart","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007650371","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0001-6316-2734","observed_orcids":["https://orcid.org/0000-0001-6316-2734"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026026841","display_name":"Susan A. Shinton","orcid":"https://orcid.org/0000-0003-2649-1904","observed_orcids":["https://orcid.org/0000-0003-2649-1904"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan A. Shinton","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101914941","display_name":"Yuesheng Li","orcid":"https://orcid.org/0000-0002-1393-3913","observed_orcids":["https://orcid.org/0000-0002-1393-3913"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue-sheng Li","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002949262","display_name":"Nicola L. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicola L. Ross","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101934176","display_name":"Xingjun Liu","orcid":"https://orcid.org/0000-0002-7012-7053","observed_orcids":["https://orcid.org/0000-0002-7012-7053"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingjun Liu","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438887","display_name":"Qin Li","orcid":"https://orcid.org/0000-0001-7942-6685","observed_orcids":["https://orcid.org/0000-0001-7942-6685"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Li","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013934515","display_name":"Alison n. Bilbee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison N. Bilbee","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007263489","display_name":"Gaurav K. Varshney","orcid":"https://orcid.org/0000-0002-0429-1904","observed_orcids":["https://orcid.org/0000-0002-0429-1904"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav K. Varshney","raw_affiliation_strings":["Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021958635","display_name":"Matthew C. LaFave","orcid":"https://orcid.org/0000-0001-9165-041X","observed_orcids":["https://orcid.org/0000-0001-9165-041X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew C. LaFave","raw_affiliation_strings":["Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087555842","display_name":"Shawn Michael Burgess","orcid":"https://orcid.org/0000-0003-1147-0596","observed_orcids":["https://orcid.org/0000-0003-1147-0596"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn M. Burgess","raw_affiliation_strings":["Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087020194","display_name":"Jorune Balciuniene","orcid":"https://orcid.org/0000-0001-8063-5302","observed_orcids":["https://orcid.org/0000-0001-8063-5302"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorune Balciuniene","raw_affiliation_strings":["Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080270907","display_name":"Darius Balciunas","orcid":"https://orcid.org/0000-0003-1938-3243","observed_orcids":["https://orcid.org/0000-0003-1938-3243"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darius Balciunas","raw_affiliation_strings":["Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103170575","display_name":"Richard R. Hardy","orcid":"https://orcid.org/0000-0002-9809-5583","observed_orcids":["https://orcid.org/0000-0002-9809-5583"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R. Hardy","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051146159","display_name":"Dietmar J. Kappes","orcid":"https://orcid.org/0000-0002-9112-509X","observed_orcids":["https://orcid.org/0000-0002-9112-509X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dietmar J. Kappes","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002152110","display_name":"David L. Wiest","orcid":"https://orcid.org/0000-0002-0792-3188","observed_orcids":["https://orcid.org/0000-0002-0792-3188"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Wiest","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103242762","display_name":"Jennifer Rhodes","orcid":"https://orcid.org/0000-0001-7298-1213","observed_orcids":["https://orcid.org/0000-0001-7298-1213"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210122924","display_name":"Temple University Health System","ror":"https://ror.org/02fhvxj45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer Rhodes","raw_affiliation_strings":["Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Cell Development and Function Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103242762"],"corresponding_institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.9602,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70230204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"7","first_page":"e0131908","last_page":"e0131908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.8299999833106995},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.828000009059906},{"id":"https://openalex.org/keywords/mutagenesis-screen","display_name":"mutagenesis screen","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gfp-tagging","display_name":"GFP tagging","score":0.4659999907016754},{"id":"https://openalex.org/keywords/hematopoietic-development","display_name":"hematopoietic development","score":0.6629999876022339},{"id":"https://openalex.org/keywords/t-cell-immunodeficiency","display_name":"T cell deficiency","score":0.5400000214576721},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.9480000138282776},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8665069341659546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7744051218032837},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.7158862352371216},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6096108555793762},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5318282246589661},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5027627944946289},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5002713203430176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47604823112487793},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46880534291267395},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4379523694515228},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.41228264570236206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3718017339706421},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3700650930404663},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3606761693954468}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0131908","doi":"https://doi.org/10.1371/journal.pone.0131908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0131908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4498767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4498767","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26161877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26161877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.918","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.918","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/15/4f/pone.0131908.PMC4498767.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1f7bec41e2a44af78a4f88d4a9b2264a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f7bec41e2a44af78a4f88d4a9b2264a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 7, p e0131908 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1480215","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Mutagenesis_Screen_Identifies_agtpbp1_and_eps15L1_as_Essential_for_T_lymphocyte_Development_in_Zebrafish/1480215","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:null:20.500.12613/5218","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/5218","pdf_url":null,"source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0131908","doi":"https://doi.org/10.1371/journal.pone.0131908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0131908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5148824087","display_name":"Transposon-based Platform for Insertional Mutagenesis and Genome Engineering","funder_award_id":"R01HD061749","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7815557280","display_name":null,"funder_award_id":"HD061749","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332523","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W841586012.pdf","grobid_xml":"https://content.openalex.org/works/W841586012.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W167332595","https://openalex.org/W1548893012","https://openalex.org/W1556198965","https://openalex.org/W1855382658","https://openalex.org/W1879493681","https://openalex.org/W1959595138","https://openalex.org/W1965255669","https://openalex.org/W1965940508","https://openalex.org/W1966175518","https://openalex.org/W1969631366","https://openalex.org/W1970315917","https://openalex.org/W1972259766","https://openalex.org/W1977099733","https://openalex.org/W1979606683","https://openalex.org/W1986142361","https://openalex.org/W1988869829","https://openalex.org/W1992938999","https://openalex.org/W1998512131","https://openalex.org/W2002602023","https://openalex.org/W2003021320","https://openalex.org/W2003653198","https://openalex.org/W2006273621","https://openalex.org/W2008052698","https://openalex.org/W2016471469","https://openalex.org/W2016487192","https://openalex.org/W2017689311","https://openalex.org/W2026117399","https://openalex.org/W2026916094","https://openalex.org/W2032417286","https://openalex.org/W2033853537","https://openalex.org/W2034118113","https://openalex.org/W2048630989","https://openalex.org/W2049578737","https://openalex.org/W2051397980","https://openalex.org/W2053326752","https://openalex.org/W2059774715","https://openalex.org/W2061016502","https://openalex.org/W2061740109","https://openalex.org/W2064404284","https://openalex.org/W2065406525","https://openalex.org/W2066336965","https://openalex.org/W2075249856","https://openalex.org/W2075524647","https://openalex.org/W2084531609","https://openalex.org/W2096251733","https://openalex.org/W2112915311","https://openalex.org/W2116371846","https://openalex.org/W2118995117","https://openalex.org/W2122751183","https://openalex.org/W2123938765","https://openalex.org/W2137450484","https://openalex.org/W2139193085","https://openalex.org/W2142610302","https://openalex.org/W2143611128","https://openalex.org/W2161533644","https://openalex.org/W2161922597","https://openalex.org/W2164445141","https://openalex.org/W2167279371","https://openalex.org/W2168027290","https://openalex.org/W2169684967","https://openalex.org/W2169863448","https://openalex.org/W2359794409"],"related_works":["https://openalex.org/W7097572896","https://openalex.org/W7096755967","https://openalex.org/W2137450484","https://openalex.org/W2516645960","https://openalex.org/W4309001834","https://openalex.org/W2057257335","https://openalex.org/W2061740109","https://openalex.org/W2175548761","https://openalex.org/W2593867842","https://openalex.org/W1990770660"],"abstract_inverted_index":{"Genetic":[0],"screens":[1],"are":[2,10],"a":[3,34,43,76,110],"powerful":[4,35],"tool":[5],"to":[6,47,197,206],"discover":[7],"genes":[8,213,262],"that":[9,69,127,144],"important":[11],"in":[12,50,87,113,136,158,178,214,231,268,283],"immune":[13,215],"cell":[14,116,216,238,266,285],"development":[15,21,239],"and":[16,67,74,171,256,281],"function.":[17],"The":[18],"evolutionarily":[19],"conserved":[20],"of":[22,30,63,78,105,118,129,163,169,190,243,247,260,279],"lymphoid":[23],"cells":[24,66,157,183],"paired":[25],"with":[26,222],"the":[27,51,60,71,80,208,211,220,248,252,264,269,274],"genetic":[28],"tractability":[29],"zebrafish":[31,52],"make":[32],"this":[33,39],"model":[36],"system":[37],"for":[38,167,210],"purpose.":[40],"We":[41,83],"used":[42,205],"Tol2-based":[44],"gene-breaking":[45],"transposon":[46,193],"induce":[48],"mutations":[49],"(Danio":[53],"rerio,":[54],"AB":[55],"strain)":[56],"genome,":[57],"which":[58,88,114,179,232],"served":[59],"dual":[61],"purpose":[62],"fluorescently":[64,185],"tagging":[65],"tissues":[68,90],"express":[70],"disrupted":[72,81,212,253],"gene":[73,199],"provided":[75],"means":[77],"identifying":[79],"gene.":[82],"identified":[84,175,228,251],"12":[85],"lines":[86,131,143,177,202,221,230,249],"hematopoietic":[89,150,225],"expressed":[91],"green":[92],"fluorescent":[93],"protein":[94],"(GFP)":[95],"during":[96],"embryonic":[97,148,223],"development,":[98],"as":[99],"detected":[100],"by":[101,123,152],"microscopy.":[102],"Subsequent":[103],"analysis":[104,162],"young":[106,137,159],"adult":[107,138],"fish,":[108],"using":[109],"novel":[111],"approach":[112],"single":[115],"suspensions":[117],"whole":[119],"fish":[120],"were":[121,184],"analyzed":[122],"flow":[124],"cytometry,":[125],"revealed":[126],"8":[128],"these":[130,201,261],"also":[132],"exhibited":[133,155,235],"GFP":[134],"expression":[135,168],"cells.":[139],"An":[140],"additional":[141],"15":[142],"did":[145],"not":[146],"have":[147],"GFP+":[149,156,165,224],"tissue":[151],"microscopy,":[153],"nevertheless":[154],"adults.":[160],"RT-PCR":[161],"purified":[164],"populations":[166],"T":[170,180,237,265,284],"B":[172,182],"cell-specific":[173],"markers":[174],"18":[176],"and/or":[181],"tagged":[186],"at":[187,240],"6":[188,241],"weeks":[189],"age.":[191,244],"As":[192],"insertion":[194],"is":[195],"expected":[196],"cause":[198],"disruption,":[200],"can":[203],"be":[204],"assess":[207],"requirement":[209],"development.":[217,286],"Focusing":[218],"on":[219],"tissue,":[226],"we":[227,250],"three":[229],"homozygous":[233],"mutants":[234],"impaired":[236],"days":[242],"In":[245],"two":[246],"genes,":[254],"agtpbp1":[255,280],"eps15L1.":[257],"Morpholino-mediated":[258],"knockdown":[259],"mimicked":[263],"defects":[267],"corresponding":[270],"mutant":[271],"embryos,":[272],"demonstrating":[273],"previously":[275],"unrecognized,":[276],"essential":[277],"roles":[278],"eps15L1":[282]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}