{"id":"https://openalex.org/W84128797","doi":null,"title":"Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments.","display_name":"Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to treatments.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W84128797","mag":"84128797","pmid":"https://pubmed.ncbi.nlm.nih.gov/11495003"},"language":"en","primary_location":{"id":"pmid:11495003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11495003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107484481","display_name":"Fran\u00e7oise Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120235","display_name":"H\u00f4pitaux Universitaires Paris-Ouest","ror":"https://ror.org/01v676463","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Gray","raw_affiliation_strings":["Laboratoire de Neuropathologie, Facult\u00e9 de M\u00e9decine Paris-Ouest, Garches, France. francoise.gray@rpc.ap-hop-paris.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Neuropathologie, Facult\u00e9 de M\u00e9decine Paris-Ouest, Garches, France. francoise.gray@rpc.ap-hop-paris.fr","institution_ids":["https://openalex.org/I4210120235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006332501","display_name":"Homa Adle\u2010Biassette","orcid":"https://orcid.org/0000-0001-9446-8306","observed_orcids":["https://orcid.org/0000-0001-9446-8306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Adle-Biassette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113603598","display_name":"Fabrice Chr\u00e9tien","orcid":"https://orcid.org/0000-0002-2794-1383","observed_orcids":["https://orcid.org/0000-0002-2794-1383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Chretien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080651297","display_name":"Geoffroy Lorin de la Grandmaison","orcid":"https://orcid.org/0000-0002-1681-2746","observed_orcids":["https://orcid.org/0000-0002-1681-2746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Lorin de la Grandmaison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112870691","display_name":"Gilles Force","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Force","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011270386","display_name":"Catherine Keohane","orcid":"https://orcid.org/0000-0002-4088-2242","observed_orcids":["https://orcid.org/0000-0002-4088-2242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Keohane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7657,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.90698393,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"146","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hiv-encephalitis","display_name":"HIV encephalitis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.7850000262260437},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.5220000147819519},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.39500001072883606},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.5360000133514404},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.6891317367553711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6630745530128479},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5399932265281677},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.513690173625946},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5002150535583496},{"id":"https://openalex.org/C2778583010","wikidata":"https://www.wikidata.org/wiki/Q3237081","display_name":"Leukoencephalopathy","level":3,"score":0.461044043302536},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4397828280925751},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4317816495895386},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4179244041442871},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4151243567466736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40975651144981384},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3051903247833252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1900818645954132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1899399757385254},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15608707070350647},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.10819905996322632},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020833","descriptor_name":"Diffuse Axonal Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11495003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11495003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Journal Article"},{"id":"mag:84128797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11495003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2182036820","https://openalex.org/W2000366874","https://openalex.org/W2065752062","https://openalex.org/W2056459216","https://openalex.org/W2429536988","https://openalex.org/W2050639689","https://openalex.org/W2143326565","https://openalex.org/W2102273738","https://openalex.org/W2035807473","https://openalex.org/W2045301606"],"abstract_inverted_index":{"A":[0],"variety":[1],"of":[2,5,27,54,93,159,175,179,185,202,211,219,224,237],"HIV-induced":[3,249],"lesions":[4],"the":[6,91,106,155,172,198,209,217],"central":[7],"nervous":[8],"system":[9],"(CNS)":[10],"have":[11],"been":[12],"described,":[13],"including":[14],"HIV":[15,17,48,55,80],"encephalitis,":[16],"leukoencephalopathy,":[18],"axonal":[19],"damage,":[20,115],"and":[21,47,72,109,151,200],"diffuse":[22],"poliodystrophy":[23],"with":[24,99,112],"neuronal":[25,61,87,128,132,145,168],"loss":[26,133],"variable":[28],"severity":[29],"resulting,":[30],"at":[31],"least":[32],"partly,":[33],"from":[34,171],"an":[35],"apoptotic":[36],"process.":[37],"However,":[38],"no":[39],"correlation":[40],"could":[41],"be":[42,135,182,254],"established":[43],"between":[44],"these":[45],"changes":[46,251],"dementia":[49,162],"(HIVD).":[50],"From":[51],"our":[52,97,207],"study":[53],"infected":[56],"patients,":[57],"it":[58],"appeared":[59],"that":[60,144],"apoptosis":[62,88,146],"is":[63,147,241],"probably":[64],"not":[65,153],"related":[66,78],"to":[67,79,118,122,127],"a":[68,83,148,166,222,242],"single":[69],"cause.":[70],"Microglial":[71],"glial":[73],"activation,":[74,120],"directly":[75],"or":[76,121],"indirectly":[77],"infection,":[81],"plays":[82],"major":[84],"role":[85],"in":[86,105,139],"possibly":[89],"through":[90],"mediation":[92],"oxidative":[94],"stress.":[95],"In":[96,206],"patients":[98],"full-blown":[100],"AIDS,":[101],"this":[102],"mechanism":[103],"predominated":[104],"basal":[107],"ganglia":[108],"correlated":[110],"well":[111],"HIVD.":[113,160],"Axonal":[114],"either":[116],"secondary":[117],"microglial":[119],"systemic":[123],"factors":[124],"also":[125,253],"contributes":[126],"apoptosis.":[129],"Although":[130],"massive":[131],"may":[134,181,252],"responsible":[136],"for":[137],"HIVD":[138,203],"occasional":[140],"cases,":[141],"we":[142],"conclude":[143],"late":[149],"event":[150],"does":[152],"represent":[154],"main":[156],"pathological":[157],"substrate":[158],"The":[161,233],"more":[163],"likely":[164],"reflects":[165],"specific":[167],"dysfunction":[169],"resulting":[170],"combined":[173],"effects":[174],"several":[176],"mechanisms,":[177],"some":[178],"which":[180],"reversible.":[183],"Introduction":[184],"highly":[186],"active":[187],"antiretroviral":[188,239],"therapy":[189],"dramatically":[190,214],"improved":[191],"patient":[192],"survival,":[193],"however,":[194],"its":[195],"impact":[196],"on":[197],"incidence":[199,210],"course":[201],"remains":[204],"debatable.":[205],"series,":[208],"HIVE":[212],"has":[213],"decreased":[215],"since":[216],"introduction":[218],"multitherapies,":[220],"but":[221,245],"number":[223],"cases":[225],"remain":[226],"whose":[227],"cognitive":[228],"disorders":[229],"persist,":[230],"despite":[231],"HAART.":[232],"poor":[234],"CNS":[235,250],"penetration":[236],"many":[238],"agents":[240],"possible":[243],"explanation,":[244],"irreversible":[246],"\"burnt":[247],"out\"":[248],"responsible.":[255]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
