{"id":"https://openalex.org/W84123251","doi":"https://doi.org/10.4049/jimmunol.178.supp.36.1","title":"Regulation of Antigen Presentation by Amyloid Precursor-Like Protein 2 (36.1)","display_name":"Regulation of Antigen Presentation by Amyloid Precursor-Like Protein 2 (36.1)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W84123251","doi":"https://doi.org/10.4049/jimmunol.178.supp.36.1","mag":"84123251"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.36.1","doi":"https://doi.org/10.4049/jimmunol.178.supp.36.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.36.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068379719","display_name":"Amit Tuli","orcid":"https://orcid.org/0000-0001-5476-4127","observed_orcids":["https://orcid.org/0000-0001-5476-4127"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Tuli","raw_affiliation_strings":["Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","1Biochemistry and Molecular Biology,","2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1Biochemistry and Molecular Biology,","institution_ids":[]},{"raw_affiliation_string":"2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038205163","display_name":"Mahak Sharma","orcid":"https://orcid.org/0000-0002-4117-4790","observed_orcids":["https://orcid.org/0000-0002-4117-4790"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahak Sharma","raw_affiliation_strings":["Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","1Biochemistry and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"1Biochemistry and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045783904","display_name":"Miriam Rose Menezes","orcid":"https://orcid.org/0000-0001-6478-9600","observed_orcids":["https://orcid.org/0000-0001-6478-9600"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Rose Menezes","raw_affiliation_strings":["Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085276533","display_name":"Naava Naslavsky","orcid":"https://orcid.org/0009-0004-0965-3881","observed_orcids":["https://orcid.org/0009-0004-0965-3881"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naava Naslavsky","raw_affiliation_strings":["Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","1Biochemistry and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"1Biochemistry and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004821340","display_name":"Steve Caplan","orcid":"https://orcid.org/0000-0001-9445-4297","observed_orcids":["https://orcid.org/0000-0001-9445-4297"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Caplan","raw_affiliation_strings":["Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","1Biochemistry and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"1Biochemistry and Molecular Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005813820","display_name":"Mary M. McIlhaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary M McIlhaney","raw_affiliation_strings":["Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086505077","display_name":"Joyce C. Solheim","orcid":"https://orcid.org/0000-0002-6313-8213","observed_orcids":["https://orcid.org/0000-0002-6313-8213"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce C Solheim","raw_affiliation_strings":["Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","1Biochemistry and Molecular Biology,","2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I1307117695"]},{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center , 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1Biochemistry and Molecular Biology,","institution_ids":[]},{"raw_affiliation_string":"2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska, 68198","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S12","last_page":"S12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.4246000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplp2","display_name":"APLP2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.949999988079071},{"id":"https://openalex.org/keywords/beta2m","display_name":"beta2m","score":0.7379999756813049},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/peptide-binding-region","display_name":"peptide-binding region","score":0.5180000066757202},{"id":"https://openalex.org/keywords/alpha3-domain","display_name":"alpha3 domain","score":0.7609999775886536},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7020000219345093},{"id":"https://openalex.org/keywords/plasma-membrane-expression","display_name":"plasma membrane expression","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.60914546251297},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.587278425693512},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5782532691955566},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.5122917890548706},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.48119837045669556},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4310373067855835},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.4186924993991852},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36876970529556274},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3488563299179077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28245824575424194},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19154733419418335},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.120293527841568},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10580933094024658},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.07272472977638245}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.36.1","doi":"https://doi.org/10.4049/jimmunol.178.supp.36.1","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.36.1","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1533529945","https://openalex.org/W1974156090","https://openalex.org/W1969686812","https://openalex.org/W2072566106","https://openalex.org/W1967040338","https://openalex.org/W22154320","https://openalex.org/W2135344118","https://openalex.org/W2302481206","https://openalex.org/W2166175320","https://openalex.org/W2023194132"],"abstract_inverted_index":{"Abstract":[0],"The":[1,49],"amyloid":[2],"precursor-like":[3],"protein":[4,10],"2":[5],"(APLP2)":[6],"is":[7,12,108],"a":[8,185],"secreted":[9],"that":[11,18,41,105],"ubiquitously":[13],"expressed.":[14],"We":[15],"have":[16],"found":[17],"APLP2":[19,38,42,52,82,153,189],"over-expression":[20],"decreases":[21],"the":[22,28,99,113,117,121,143,173],"quantity":[23],"of":[24,51,78,95,120,136,145,172],"H2-Kd":[25],"molecules":[26,80,97],"on":[27,53,131],"plasma":[29],"membrane.":[30],"In":[31,151],"addition,":[32],"Kd":[33,44,54,73,79,96],"thermostability":[34,162],"was":[35,83],"improved":[36],"by":[37,110,163,167,180],"down-regulation,":[39],"suggesting":[40],"affects":[43,154],"peptide":[45],"selection":[46],"and/or":[47],"retention.":[48],"effects":[50],"are":[55],"likely":[56],"related":[57],"to":[58,69],"their":[59],"physical":[60],"association,":[61],"as":[62],"pulse-chase":[63],"experiments":[64],"demonstrated":[65],"interaction":[66,146,165],"for":[67],"up":[68],"two":[70],"hours":[71],"after":[72],"synthesis.":[74],"Furthermore,":[75],"significant":[76],"co-localization":[77],"with":[81],"observed":[84],"in":[85,112,187],"vesicular":[86],"structures":[87],"both":[88],"at":[89],"steady":[90],"state":[91],"and":[92,116,149,161,179,195,203],"during":[93],"endocytosis":[94],"from":[98],"cell":[100,158],"surface.":[101],"Mutagenesis":[102],"studies":[103],"revealed":[104],"APLP2/MHC":[106,132],"association":[107],"influenced":[109],"sequences":[111],"peptide-binding":[114],"region":[115],"\u03b13":[118],"domain":[119,171],"MHC":[122,155,174,191],"class":[123,156,175,192],"I":[124,157,176,193],"heavy":[125,177],"chain.":[126],"\u03b22m":[127,138],"has":[128],"an":[129,164],"impact":[130],"interaction,":[133],"since":[134],"introduction":[135],"human":[137],"into":[139],"mouse":[140],"fibroblasts":[141],"increased":[142],"level":[144],"between":[147],"H2-Dd":[148],"APLP2.":[150],"summary,":[152],"surface":[159],"expression":[160],"controlled":[166],"more":[168],"than":[169],"one":[170],"chain":[178],"\u03b22m.":[181],"These":[182],"data":[183],"support":[184],"model":[186],"which":[188],"regulates":[190],"trafficking,":[194],"thereby":[196],"antigen":[197],"presentation.":[198],"(NIH":[199],"Grants":[200],"AI54645,":[201],"GM57428,":[202],"GM74876)":[204]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}