{"id":"https://openalex.org/W84095845","doi":null,"title":"Reduction of DABS-L-methionine-dl-sulfoxide by protein methionine sulfoxide reductase from polymorphonuclear leukocytes: stereospecificity towards the l-sulfoxide.","display_name":"Reduction of DABS-L-methionine-dl-sulfoxide by protein methionine sulfoxide reductase from polymorphonuclear leukocytes: stereospecificity towards the l-sulfoxide.","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W84095845","mag":"84095845","pmid":"https://pubmed.ncbi.nlm.nih.gov/7759220"},"language":"en","primary_location":{"id":"pmid:7759220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7759220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Italian journal of biochemistry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057582349","display_name":"Giampaolo Minetti","orcid":"https://orcid.org/0000-0003-3063-4613","observed_orcids":["https://orcid.org/0000-0003-3063-4613"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Minetti","raw_affiliation_strings":["Dipartimento di Biochimica, Sezione di Scienze, Universit\u00e0 di Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biochimica, Sezione di Scienze, Universit\u00e0 di Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108536941","display_name":"Carlo L. Balduini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Balduini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015098230","display_name":"Augusta BROVELLI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Brovelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1062,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.28612522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"6","first_page":"273","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methionine-sulfoxide-reductase","display_name":"methionine sulfoxide reductase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/stereospecificity","display_name":"stereospecificity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.75},{"id":"https://openalex.org/keywords/artificial-substrates","display_name":"artificial substrates","score":0.6980000138282776},{"id":"https://openalex.org/keywords/methionine-sulfoxide-reduction","display_name":"methionine sulfoxide reduction","score":0.5529999732971191},{"id":"https://openalex.org/keywords/dithiothreitol","display_name":"dithiothreitol","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dithioerythritol","display_name":"dithioerythritol","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C2777568990","wikidata":"https://www.wikidata.org/wiki/Q6823656","display_name":"Methionine sulfoxide","level":4,"score":0.9501546025276184},{"id":"https://openalex.org/C2778448320","wikidata":"https://www.wikidata.org/wiki/Q408395","display_name":"Sulfoxide","level":2,"score":0.9346440434455872},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9037346243858337},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.8095569610595703},{"id":"https://openalex.org/C2778813780","wikidata":"https://www.wikidata.org/wiki/Q3663244","display_name":"Methionine sulfoxide reductase","level":4,"score":0.7266173362731934},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5446261167526245},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.5137227773666382},{"id":"https://openalex.org/C2778452553","wikidata":"https://www.wikidata.org/wiki/Q407927","display_name":"Dimethyl sulfoxide","level":2,"score":0.512122631072998},{"id":"https://openalex.org/C2778806918","wikidata":"https://www.wikidata.org/wiki/Q411193","display_name":"Sulfone","level":2,"score":0.4911003112792969},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43270143866539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31530654430389404},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24471205472946167},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19049835205078125},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.14885371923446655}],"mesh":[{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013454","descriptor_name":"Sulfoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051150","descriptor_name":"Methionine Sulfoxide Reductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7759220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7759220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Italian journal of biochemistry","raw_type":"Journal Article"},{"id":"mag:84095845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7759220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4018999934196472}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006903305","https://openalex.org/W979329105","https://openalex.org/W1507343928","https://openalex.org/W7161776128","https://openalex.org/W2066556630","https://openalex.org/W1965507089","https://openalex.org/W2948059122","https://openalex.org/W2089626228","https://openalex.org/W2148497496","https://openalex.org/W3043141230"],"abstract_inverted_index":{"A":[0],"new":[1],"synthetic":[2],"substrate":[3],"for":[4],"protein":[5],"methionine":[6,26],"sulfoxide":[7],"reductase":[8],"is":[9],"proposed.":[10],"We":[11,98],"show":[12],"that":[13,102],"extracts":[14],"from":[15],"human":[16],"polymorphonuclear":[17,95],"leukocytes":[18,96],"can":[19],"reduce":[20],"4-dimethylaminoazobenzene-4'-sulfonyl-L-methionine-dl-sulfoxide":[21],"[DABS-L-Met-dl-(O)]":[22],"to":[23,56],"the":[24,29,38,50,57,60,64,78,84,92,100,103,111,114],"corresponding":[25],"derivative,":[27],"in":[28,63,110],"presence":[30],"of":[31,37,59,68,77,83,91,113,117],"dithiothreitol":[32],"or":[33],"dithioerythritol.":[34],"The":[35],"product":[36],"reaction":[39],"(DABS-Met)":[40],"was":[41],"separated":[42],"by":[43,48,94],"reversed-phase":[44],"HPLC":[45],"and":[46,73,81],"detected":[47],"reading":[49],"absorbance":[51],"at":[52],"436":[53],"nm.":[54],"Due":[55],"chirality":[58],"sulfur":[61],"atom":[62],"sulfoxide,":[65],"two":[66,79],"diastereomers":[67],"Met(O)":[69],"exist,":[70],"namely":[71],"Met-l-sulfoxide":[72],"Met-d-sulfoxide.":[74],"After":[75],"separation":[76],"forms":[80],"preparation":[82],"DABS-derivatives,":[85],"we":[86],"observed":[87,104],"a":[88],"preferential":[89],"reduction":[90],"l-sulfoxide":[93],"extracts.":[97],"discuss":[99],"possibility":[101],"stereospecificity":[105],"might":[106],"have":[107],"physiological":[108],"relevance":[109],"field":[112],"oxidative":[115],"modifications":[116],"proteins.":[118]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}