{"id":"https://openalex.org/W84014473","doi":null,"title":"Histone Deacetylases as Targets for Melanoma Immunotherapy","display_name":"Histone Deacetylases as Targets for Melanoma Immunotherapy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W84014473","mag":"84014473"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-6052","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=6052&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067364305","display_name":"David Michael Woods","orcid":"https://orcid.org/0000-0002-6328-8107","observed_orcids":["https://orcid.org/0000-0002-6328-8107"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David M. Woods","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6328-8107","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067364305"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hdac11","display_name":"HDAC11","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.765999972820282},{"id":"https://openalex.org/keywords/mhc-class-i-and-ii-expression","display_name":"MHC class I and II expression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cd80-cd86","display_name":"CD80/CD86","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/t-cell-anergy","display_name":"T cell anergy","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.583849310874939},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.571506917476654},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.45121386647224426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4032065272331238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34469565749168396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32512056827545166},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2706053853034973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26485180854797363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2553291618824005},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22288525104522705}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-6052","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=6052&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-6052","doi":null,"is_oa":false,"landing_page_url":"https://scholarcommons.usf.edu/etd/4856","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:84014473","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/etd/4856/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2326519486","https://openalex.org/W1999782534","https://openalex.org/W7034435570","https://openalex.org/W2319416639","https://openalex.org/W2147601959","https://openalex.org/W2331369838","https://openalex.org/W2889564529","https://openalex.org/W2543055468","https://openalex.org/W2766093455","https://openalex.org/W1484654930"],"abstract_inverted_index":{"Cancer":[0],"represents":[1],"the":[2,9,63,69,79,129,149,153,158,194,263,266,272,275,278,373,387,395],"second":[3],"leading":[4],"cause":[5,413],"of":[6,57,62,71,81,95,131,137,152,160,175,181,185,197,203,222,229,238,250,265,268,277,337,349,386,427,439],"death":[7],"in":[8,54,102,112,126,157,177,217,233,247,256,271,296],"United":[10],"States.":[11],"For":[12],"many":[13,42],"malignancies,":[14],"currently":[15],"available":[16],"treatment":[17,159,228],"options":[18],"offer":[19],"little":[20],"long-lasting":[21],"survival":[22,255],"benefits":[23],"to":[24,33,38,76,109,143,219,361,412,433],"patients.":[25,58],"However,":[26,115],"recent":[27],"studies":[28],"have":[29,98,324,346,405],"shown":[30,290],"immunotherapeutic":[31,44],"approaches":[32],"be":[34,443],"an":[35,234,307,325,417,444],"attractive":[36,445],"strategy":[37,446],"cancer":[39,85,434],"treatment.":[40],"While":[41],"current":[43,82],"strategies":[45],"convey":[46],"durable":[47],"responses,":[48],"such":[49],"responses":[50,73],"are":[51,123],"only":[52],"seen":[53],"a":[55,172,178,369,406,430],"minority":[56],"An":[59],"increased":[60,333,347],"understanding":[61,264],"mechanisms":[64],"governing":[65],"tumor":[66,132],"immunogenicity":[67,130],"and":[68,83,134,139,189,241,252,299,319,335,340,353,365,391,398,409,415,436],"biology":[70,276],"immune":[72,135,195,205,230],"is":[74,171,289,293,301,314,377,429],"crucial":[75],"improving":[77],"upon":[78,145],"efficacy":[80,151,450],"future":[84],"immunotherapies.":[86],"Histone":[87],"deacetylases":[88],"(HDACs),":[89],"enzymes":[90],"classically":[91],"associated":[92,206],"with":[93],"regulation":[94],"gene":[96],"expression,":[97],"been":[99],"therapeutic":[100,150],"targets":[101],"various":[103],"cancers":[104],"for":[105,372,447],"several":[106,204],"years":[107],"due":[108],"their":[110],"involvement":[111],"cell":[113,186,207],"growth.":[114],"it":[116,288,313,376],"has":[117],"become":[118],"increasingly":[119],"clear":[120],"that":[121,169,291,316,380,425,437],"HDACs":[122,270,428,441],"intimately":[124],"involved":[125],"regulating":[127],"both":[128,239,317,350,393],"cells":[133,199,231],"response":[136],"leukocytes":[138],"lymphocytes.":[140],"In":[141,400],"order":[142],"expand":[144],"this":[146,286],"growing":[147],"knowledge,":[148],"pan-HDAC":[154],"inhibitor":[155,174],"LBH589":[156,170,192,227,257],"melanoma":[161,198,223],"was":[162,282],"studied.":[163],"The":[164],"results":[165,232,423],"presented":[166],"here":[167],"demonstrate":[168,358,424],"potent":[173,408],"growth":[176],"wide":[179],"variety":[180],"melanomas":[182],"through":[183],"induction":[184],"cycle":[187],"arrest":[188],"apoptosis.":[190],"Additionally,":[191,342],"increases":[193],"visibility":[196],"by":[200,332,363],"increasing":[201],"expression":[202,221,300,348],"surface":[208],"markers":[209],"(e.g.":[210],"MHC":[211,213],"I,":[212],"II,":[214],"CD80,":[215],"CD86)":[216],"addition":[218],"upregulating":[220],"differentiation":[224],"antigens.":[225],"Furthermore,":[226],"enhanced":[235,326,359,418],"pro-inflammatory":[236],"phenotype":[237],"APCs":[240],"T-cells.":[242],"These":[243],"combined":[244],"effects":[245],"result":[246],"better":[248],"activation":[249],"T-cells":[251,321,345,356,382,402],"ultimately":[253],"prolonged":[254],"treated,":[258],"melanoma-baring":[259],"mice.":[260],"To":[261,285],"further":[262,283],"role":[267],"individual":[269],"T-cell":[273,297],"response,":[274],"newest":[279],"HDAC,":[280],"HDAC11,":[281],"assessed.":[284],"end,":[287],"HDAC11":[292,308,323,404],"differentially":[294],"expressed":[295],"populations,":[298],"rapidly":[302],"decreased":[303],"following":[304],"activation.":[305],"Utilizing":[306],"knockout":[309],"(HDAC11KO)":[310],"mouse":[311],"strain,":[312],"found":[315],"CD4+":[318],"CD8+":[320,344],"lacking":[322,403],"type":[327],"1":[328],"effector":[329],"function":[330],"characterized":[331],"proliferation":[334],"secretion":[336],"IL-2,":[338],"TNF":[339],"IFN-\u03b3.":[341],"HDAC11KO":[343,355,381],"granzyme":[351],"B":[352],"perforin.":[354],"also":[357,378],"resistance":[360],"inhibition":[362],"Tregs":[364],"anergy":[366],"formation.":[367],"As":[368],"possible":[370],"mechanism":[371],"observed":[374],"phenotype,":[375],"demonstrated":[379],"produce":[383],"elevated":[384],"levels":[385],"transcription":[388],"factors":[389],"Eomes":[390],"T-bet,":[392],"at":[394],"basal":[396],"state":[397],"post-activation.":[399],"vivo,":[401],"more":[407],"robust":[410],"ability":[411],"GvHD":[414],"mediate":[416],"anti-tumor":[419],"response.":[420],"Collectively,":[421],"these":[422],"targeting":[426,438],"viable":[431],"approach":[432],"immunotherapy,":[435],"specific":[440],"may":[442],"optimizing":[448],"immunotherapy":[449],"while":[451],"minimizing":[452],"side":[453],"effects.":[454]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
