{"id":"https://openalex.org/W8401236","doi":null,"title":"The activated clotting time (ACT) can be used to monitor enoxaparin and dalteparin after intravenous administration.","display_name":"The activated clotting time (ACT) can be used to monitor enoxaparin and dalteparin after intravenous administration.","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W8401236","mag":"8401236","pmid":"https://pubmed.ncbi.nlm.nih.gov/16079447"},"language":"en","primary_location":{"id":"pmid:16079447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16079447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of invasive cardiology","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015517634","display_name":"Erdal \u00c7avu\u015fo\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erdal Cavusoglu","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, the Bronx Veterans Administration Medical Center, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, the Bronx Veterans Administration Medical Center, Bronx, NY, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047161001","display_name":"Manish Lakhani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manish Lakhani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015559144","display_name":"Jonathan D. Marmur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan D Marmur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1969,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55694237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"8","first_page":"416","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activated-clotting-time","display_name":"activated clotting time","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dalteparin","display_name":"dalteparin","score":1.0},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/unfractionated-heparin","display_name":"unfractionated heparin","score":0.902999997138977},{"id":"https://openalex.org/keywords/anticoagulation-monitoring","display_name":"anticoagulation monitoring","score":0.9200000166893005},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9390000104904175},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9390000104904175},{"id":"https://openalex.org/keywords/anti-xa-activity","display_name":"anti-Xa activity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.652999997138977},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia-inhibitors","display_name":"glycoprotein IIb/IIIa inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cardiac-catheterization","display_name":"cardiac catheterization","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307738542556763},{"id":"https://openalex.org/C2777987278","wikidata":"https://www.wikidata.org/wiki/Q4677454","display_name":"Activated clotting time","level":3,"score":0.8534817099571228},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.8446084856987},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.711293637752533},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7058553099632263},{"id":"https://openalex.org/C2776884760","wikidata":"https://www.wikidata.org/wiki/Q2750727","display_name":"Low molecular weight heparin","level":3,"score":0.6080416440963745},{"id":"https://openalex.org/C2778825682","wikidata":"https://www.wikidata.org/wiki/Q416516","display_name":"Enoxaparin sodium","level":4,"score":0.5649598240852356},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.5581863522529602},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.49631625413894653},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49549400806427},{"id":"https://openalex.org/C77171857","wikidata":"https://www.wikidata.org/wiki/Q5135593","display_name":"Clotting time","level":3,"score":0.45820334553718567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3320789933204651},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.3179503083229065},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26699528098106384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19230520725250244},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.08102422952651978}],"mesh":[{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014914","descriptor_name":"Whole Blood Coagulation Time","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017984","descriptor_name":"Enoxaparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017985","descriptor_name":"Dalteparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16079447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16079447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of invasive cardiology","raw_type":"Comparative Study"},{"id":"mag:8401236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16079447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W83211124","https://openalex.org/W114021389","https://openalex.org/W117662345","https://openalex.org/W168034184","https://openalex.org/W1003942490","https://openalex.org/W1220174878","https://openalex.org/W1531021320","https://openalex.org/W1606562396","https://openalex.org/W1813018921","https://openalex.org/W1976642167","https://openalex.org/W1976842164","https://openalex.org/W1981075857","https://openalex.org/W1981314048","https://openalex.org/W1984897675","https://openalex.org/W1987083415","https://openalex.org/W1989815577","https://openalex.org/W1990795196","https://openalex.org/W1993996998","https://openalex.org/W2000485058","https://openalex.org/W2001977643","https://openalex.org/W2007476535","https://openalex.org/W2013537866","https://openalex.org/W2028084368","https://openalex.org/W2028475631","https://openalex.org/W2040951514","https://openalex.org/W2055205093","https://openalex.org/W2056244769","https://openalex.org/W2056489010","https://openalex.org/W2059776109","https://openalex.org/W2064827504","https://openalex.org/W2065690551","https://openalex.org/W2071568552","https://openalex.org/W2072777707","https://openalex.org/W2075196907","https://openalex.org/W2075332638","https://openalex.org/W2075418079","https://openalex.org/W2076677620","https://openalex.org/W2079454363","https://openalex.org/W2079551829","https://openalex.org/W2085897604","https://openalex.org/W2091158776","https://openalex.org/W2091160459","https://openalex.org/W2091795351","https://openalex.org/W2094346862","https://openalex.org/W2094631472","https://openalex.org/W2101996111","https://openalex.org/W2103633180","https://openalex.org/W2109609988","https://openalex.org/W2113031661","https://openalex.org/W2116244986","https://openalex.org/W2123385876","https://openalex.org/W2149599987","https://openalex.org/W2161073476","https://openalex.org/W2283957630","https://openalex.org/W2316460201","https://openalex.org/W2399983266","https://openalex.org/W2470478854","https://openalex.org/W2499445311","https://openalex.org/W4300528032"],"related_works":["https://openalex.org/W2161073476","https://openalex.org/W2412827528","https://openalex.org/W32244358","https://openalex.org/W2072777707","https://openalex.org/W2059776109","https://openalex.org/W2056489010","https://openalex.org/W73556849","https://openalex.org/W2377341313","https://openalex.org/W2531078094","https://openalex.org/W2409532157"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,153,181,195],"use":[2],"of":[3,37,73,103,148,156,165],"low-molecular":[4],"weight":[5,67],"heparin":[6,42,68],"(LMWH)":[7],"during":[8,215],"percutaneous":[9],"coronary":[10],"intervention":[11],"(PCI)":[12],"has":[13],"been":[14],"limited":[15],"by":[16],"the":[17,35,45,54,95,136,146,159,228],"presumed":[18],"inability":[19],"to":[20,33,51,61,81,175,200,226],"monitor":[21,62],"its":[22],"anticoagulant":[23],"effect":[24],"using":[25,151],"bedside":[26],"assays.":[27],"OBJECTIVES:":[28],"This":[29],"study":[30],"was":[31,169],"designed":[32],"compare":[34],"dose-response":[36,143],"enoxaparin,":[38],"dalteparin":[39,86,130,168],"and":[40,50,119,129,138,161,167,183,203],"unfractionated":[41],"(UFH)":[43],"on":[44],"activated":[46,114],"clotting":[47],"time":[48,117,154],"(ACT),":[49],"determine":[52,227],"whether":[53],"ACT":[55,137,142,160,196,231],"or":[56,90],"aPTT":[57,162],"can":[58],"be":[59,224],"used":[60],"intravenous":[63,82],"(IV)":[64],"low":[65],"molecular":[66],"(LMWH).":[69],"METHODS:":[70],"A":[71],"total":[72],"130":[74,96],"patients":[75,185],"undergoing":[76],"cardiac":[77],"catheterization":[78],"were":[79],"assigned":[80],"enoxaparin":[83,128,166,182,202],"0.5":[84],"mg/kg,":[85],"50":[87,92],"international":[88],"units/kg":[89],"UFH":[91],"units/kg.":[93],"Of":[94],"patients,":[97],"46":[98],"(35%)":[99],"underwent":[100,187],"PCI,":[101],"all":[102],"whom":[104],"received":[105],"a":[106,132,173],"glycoprotein":[107],"(GP)":[108],"IIb/IIIa":[109],"inhibitor.":[110],"We":[111],"measured":[112],"ACT,":[113],"partial":[115],"thromboplastin":[116],"(aPTT)":[118],"plasma":[120],"anti-Xa":[121],"levels":[122],"after":[123,163],"serial":[124],"sampling.":[125],"RESULTS:":[126],"Both":[127],"induced":[131],"significant":[133],"rise":[134],"in":[135,158,234],"aPTT,":[139],"with":[140,172,189,219],"an":[141,208],"approximately":[144,178],"one-half":[145],"magnitude":[147],"that":[149],"obtained":[150],"UFH.":[152],"course":[155],"changes":[157],"administration":[164],"virtually":[170],"identical,":[171],"return":[174],"baseline":[176],"at":[177],"2":[179],"hours.":[180],"dalteparin-treated":[184],"successfully":[186],"PCI":[188],"no":[190],"major":[191],"hemorrhagic":[192],"complications.":[193],"CONCLUSIONS:":[194],"is":[197],"equally":[198],"sensitive":[199],"IV":[201],"dalteparin.":[204],"These":[205],"data":[206],"support":[207],"ACT-guided":[209],"strategy":[210],"for":[211,232],"intravenously":[212],"administered":[213],"LMWH":[214,233],"PCI.":[216,235],"Additional":[217],"studies":[218],"larger":[220],"patient":[221],"populations":[222],"may":[223],"indicated":[225],"ideal":[229],"target":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}