{"id":"https://openalex.org/W84004767","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","title":"Abstract 4952: Differential Expression in the Determinants of Extracellular Matrix Remodeling in Pediatric and Adult Dilated Cardiomyopathy","display_name":"Abstract 4952: Differential Expression in the Determinants of Extracellular Matrix Remodeling in Pediatric and Adult Dilated Cardiomyopathy","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W84004767","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","mag":"84004767"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_963-b","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039995990","display_name":"Tain\u2010Yen Hsia","orcid":"https://orcid.org/0000-0003-4151-8060","observed_orcids":["https://orcid.org/0000-0003-4151-8060"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tain-Yen Hsia","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060650486","display_name":"Jeremy M. Ringewald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy M Ringewald","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029674413","display_name":"Robert E. Stroud","orcid":"https://orcid.org/0009-0000-5969-1924","observed_orcids":["https://orcid.org/0009-0000-5969-1924"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E Stroud","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael C Graves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Graves","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108370365","display_name":"Scott M. Bradley","orcid":"https://orcid.org/0000-0003-2105-1950","observed_orcids":["https://orcid.org/0000-0003-2105-1950"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M Bradley","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041498326","display_name":"Francis G. Spinale","orcid":"https://orcid.org/0000-0003-0529-5605","observed_orcids":["https://orcid.org/0000-0003-0529-5605"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis G Spinale","raw_affiliation_strings":["MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-dilated-cardiomyopathy","display_name":"idiopathic dilated cardiomyopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pediatric-dilated-cardiomyopathy","display_name":"pediatric dilated cardiomyopathy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.972000002861023},{"id":"https://openalex.org/keywords/mmp-8","display_name":"MMP-8","score":0.9950000047683716},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.953000009059906},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.800000011920929},{"id":"https://openalex.org/keywords/mt1-mmp","display_name":"MT1-MMP","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.7059999704360962},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7149999737739563},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8759152889251709},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7159199714660645},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.6655831336975098},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6459554433822632},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48599275946617126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4714680016040802},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4383618235588074},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40698719024658203},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35690927505493164},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.29887592792510986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0966295599937439},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_963-b","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_963-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011059662","https://openalex.org/W2901724560","https://openalex.org/W2093032251","https://openalex.org/W2894425411","https://openalex.org/W2793807894","https://openalex.org/W2022526789","https://openalex.org/W3014621541","https://openalex.org/W4407239252","https://openalex.org/W2043831105","https://openalex.org/W2134376215"],"abstract_inverted_index":{"Ventricular":[0],"phenotype":[1],"of":[2,29,48,120,174,221,234],"idiopathic":[3],"dilated":[4],"cardiomyopathy":[5],"(DCM)":[6],"can":[7],"appear":[8],"similar":[9],"in":[10,61,147,168,181,195,213,219,236],"pediatric":[11,24,62,73,148,152,196,214],"and":[12,45,63,78,108,135,137,141,178,225],"adult":[13,64,79],"patients,":[14],"but":[15],"a":[16,39,165,179,207],"more":[17,231],"aggressive":[18,192],"clinical":[19],"course":[20],"often":[21],"occurs":[22],"with":[23,115],"DCM.":[25,89,197,215],"A":[26],"structural":[27,116],"underpinning":[28],"DCM":[30,65,121,162,235],"is":[31,200],"extracellular":[32,176],"matrix":[33,42,193,223],"changes,":[34],"which":[35,170,183],"are":[36],"determined":[37],"by":[38,130,157,203],"balance":[40],"between":[41],"metalloproteinases":[43],"(MMPs)":[44],"tissue":[46],"inhibitors":[47],"MMPs":[49],"(TIMPs).":[50],"This":[51,186],"study":[52],"tests":[53],"the":[54,175,230],"hypothesis":[55],"that":[56],"different":[57],"MMP/TIMP":[58],"profiles":[59],"occur":[60],"patients.":[66,149],"Left":[67],"ventricular":[68],"samples":[69],"were":[70,92,122,145,155],"taken":[71],"from":[72],"(age":[74,80],"12\u00b14":[75],"yr;":[76,82],"n=5)":[77],"63\u00b13":[81],"n=11)":[83],"patients":[84,163],"during":[85],"heart":[86],"transplantation":[87],"for":[88,94,109],"Myocardial":[90],"levels":[91,128,139,154],"quantified":[93],"all":[95,110,172],"MMP":[96],"classes:":[97],"gelatinases":[98],"(MMP-2,":[99],"-9),":[100],"collagenases":[101],"(MMP-8,":[102],"-13),":[103],"lysins":[104],"(MMP-7),":[105],"membrane-type":[106],"(MT1-MMP),":[107],"4":[111],"known":[112],"TIMPs.":[113],"Patients":[114],"or":[117],"ischemic":[118],"etiologies":[119],"excluded.":[123],"Compared":[124],"to":[125,229],"adults,":[126],"MMP-8":[127,199],"increased":[129],"over":[131,158],"350%":[132],"(Figure":[133],"),":[134],"MMP-7":[136],"MT1-MMP":[138],"(75\u00b19%":[140],"76\u00b19%,":[142],"respectively;":[143],"p<0.05)":[144],"lower":[146],"In":[150],"contrast,":[151],"TIMP-1":[153],"reduced":[156],"50%":[159],"(Figure).":[160],"Pediatric":[161],"manifest":[164],"robust":[166],"increase":[167],"MMP-8,":[169],"degrades":[171],"components":[173],"matrix,":[177],"decrease":[180],"TIMP-1,":[182],"inhibits":[184],"MMP-8.":[185],"heightened":[187],"MMP-8/TIMP-1":[188],"ratio":[189],"would":[190],"favor":[191],"remodeling":[194],"Since":[198],"primarily":[201],"expressed":[202],"macrophage":[204],"cell":[205],"lineage,":[206],"unique":[208],"proteolytic":[209],"program":[210],"may":[211],"exist":[212],"These":[216],"distinct":[217],"differences":[218],"determinants":[220],"myocardial":[222],"structure":[224],"function":[226],"likely":[227],"contribute":[228],"progressive":[232],"nature":[233],"children.":[237]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
