{"id":"https://openalex.org/W83993786","doi":null,"title":"Impact of Neisseria gonorrhoeae on HIV-1 Replication and Immune Cell Activity in Co-infected Peripheral Blood Mononuclear Cells","display_name":"Impact of Neisseria gonorrhoeae on HIV-1 Replication and Immune Cell Activity in Co-infected Peripheral Blood Mononuclear Cells","publication_year":2011,"publication_date":"2011-08-30","ids":{"openalex":"https://openalex.org/W83993786","mag":"83993786"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/29704","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29704","pdf_url":"https://utoronto.scholaris.ca/bitstreams/1353b7c2-0ddb-467c-aa97-dbc6ac32e0b3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/1353b7c2-0ddb-467c-aa97-dbc6ac32e0b3/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033411603","display_name":"Wendy N. Dobson-Belaire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wendy N. Dobson-Belaire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033411603"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sexually-transmitted-infections","display_name":"sexually transmitted infections","score":0.7450000047683716},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.8820000290870667},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.8205165863037109},{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.6929585933685303},{"id":"https://openalex.org/C2778082588","wikidata":"https://www.wikidata.org/wiki/Q101896","display_name":"Gonorrhea","level":3,"score":0.6870856285095215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6311119794845581},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6196996569633484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5069580078125},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4869776666164398},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4156007468700409},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.41279691457748413},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39127805829048157},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.33182454109191895},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.32840240001678467},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1811886429786682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08800983428955078},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/29704","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29704","pdf_url":"https://utoronto.scholaris.ca/bitstreams/1353b7c2-0ddb-467c-aa97-dbc6ac32e0b3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/29704","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/29704","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:83993786","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/29704/3/DobsonBelaire_Wendy_N_20116_PhD_Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/29704","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/29704","pdf_url":"https://utoronto.scholaris.ca/bitstreams/1353b7c2-0ddb-467c-aa97-dbc6ac32e0b3/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W83993786.pdf","grobid_xml":"https://content.openalex.org/works/W83993786.grobid-xml"},"referenced_works_count":266,"referenced_works":["https://openalex.org/W2372988","https://openalex.org/W49920453","https://openalex.org/W105900776","https://openalex.org/W145413137","https://openalex.org/W176235732","https://openalex.org/W1483894580","https://openalex.org/W1486393097","https://openalex.org/W1487921725","https://openalex.org/W1500217023","https://openalex.org/W1500930352","https://openalex.org/W1511825494","https://openalex.org/W1517310071","https://openalex.org/W1517807534","https://openalex.org/W1518977559","https://openalex.org/W1527004061","https://openalex.org/W1531840529","https://openalex.org/W1535411667","https://openalex.org/W1536777415","https://openalex.org/W1549430246","https://openalex.org/W1555512065","https://openalex.org/W1557860493","https://openalex.org/W1571249274","https://openalex.org/W1594514074","https://openalex.org/W1599767906","https://openalex.org/W1604828028","https://openalex.org/W1633472206","https://openalex.org/W1642082766","https://openalex.org/W1646912334","https://openalex.org/W1655510925","https://openalex.org/W1752881710","https://openalex.org/W1781725180","https://openalex.org/W1793907231","https://openalex.org/W1806998329","https://openalex.org/W1842548364","https://openalex.org/W1858240683","https://openalex.org/W1865716530","https://openalex.org/W1868667984","https://openalex.org/W1895843741","https://openalex.org/W1896763970","https://openalex.org/W1903227718","https://openalex.org/W1947255956","https://openalex.org/W1965283063","https://openalex.org/W1966343819","https://openalex.org/W1968873679","https://openalex.org/W1970587354","https://openalex.org/W1971510734","https://openalex.org/W1975586435","https://openalex.org/W1976513589","https://openalex.org/W1977282539","https://openalex.org/W1977540238","https://openalex.org/W1978741561","https://openalex.org/W1980137252","https://openalex.org/W1980507393","https://openalex.org/W1980657682","https://openalex.org/W1981164507","https://openalex.org/W1981756981","https://openalex.org/W1982506988","https://openalex.org/W1984999783","https://openalex.org/W1985604746","https://openalex.org/W1986277933","https://openalex.org/W1987128366","https://openalex.org/W1989417613","https://openalex.org/W1990291720","https://openalex.org/W1991192668","https://openalex.org/W1991670386","https://openalex.org/W1991974890","https://openalex.org/W1992031061","https://openalex.org/W1993386412","https://openalex.org/W1993426832","https://openalex.org/W1993452562","https://openalex.org/W1993894494","https://openalex.org/W1994534621","https://openalex.org/W1995048832","https://openalex.org/W1996253790","https://openalex.org/W1996964330","https://openalex.org/W1997719382","https://openalex.org/W1999396723","https://openalex.org/W2000175632","https://openalex.org/W2001375348","https://openalex.org/W2001675486","https://openalex.org/W2003797329","https://openalex.org/W2004580525","https://openalex.org/W2006285210","https://openalex.org/W2006772331","https://openalex.org/W2006918586","https://openalex.org/W2008011267","https://openalex.org/W2008457983","https://openalex.org/W2010458160","https://openalex.org/W2010623178","https://openalex.org/W2011701477","https://openalex.org/W2016199862","https://openalex.org/W2018712964","https://openalex.org/W2019202919","https://openalex.org/W2021661436","https://openalex.org/W2022069273","https://openalex.org/W2023420720","https://openalex.org/W2025481552","https://openalex.org/W2027567211","https://openalex.org/W2028648297","https://openalex.org/W2029995183","https://openalex.org/W2032026535","https://openalex.org/W2032232188","https://openalex.org/W2033111275","https://openalex.org/W2033320393","https://openalex.org/W2034360565","https://openalex.org/W2035112855","https://openalex.org/W2035166969","https://openalex.org/W2037478466","https://openalex.org/W2039824458","https://openalex.org/W2040064814","https://openalex.org/W2040128029","https://openalex.org/W2041442788","https://openalex.org/W2044296969","https://openalex.org/W2045891404","https://openalex.org/W2047269867","https://openalex.org/W2047422912","https://openalex.org/W2048280539","https://openalex.org/W2049192527","https://openalex.org/W2054233015","https://openalex.org/W2055181136","https://openalex.org/W2055844502","https://openalex.org/W2058279766","https://openalex.org/W2059015859","https://openalex.org/W2059337777","https://openalex.org/W2059389569","https://openalex.org/W2059841928","https://openalex.org/W2061534215","https://openalex.org/W2062350041","https://openalex.org/W2063700930","https://openalex.org/W2064163367","https://openalex.org/W2065366476","https://openalex.org/W2066029873","https://openalex.org/W2066754037","https://openalex.org/W2067874984","https://openalex.org/W2067997434","https://openalex.org/W2068963175","https://openalex.org/W2070643372","https://openalex.org/W2072018350","https://openalex.org/W2074279699","https://openalex.org/W2074620757","https://openalex.org/W2075256922","https://openalex.org/W2075394423","https://openalex.org/W2077197137","https://openalex.org/W2078995134","https://openalex.org/W2079504777","https://openalex.org/W2079981443","https://openalex.org/W2080510429","https://openalex.org/W2080990030","https://openalex.org/W2081648804","https://openalex.org/W2082314789","https://openalex.org/W2083298792","https://openalex.org/W2083752778","https://openalex.org/W2087133492","https://openalex.org/W2087946368","https://openalex.org/W2088014625","https://openalex.org/W2089242226","https://openalex.org/W2090640877","https://openalex.org/W2091180924","https://openalex.org/W2091183230","https://openalex.org/W2091560314","https://openalex.org/W2092512319","https://openalex.org/W2094174707","https://openalex.org/W2096972275","https://openalex.org/W2097301807","https://openalex.org/W2098985784","https://openalex.org/W2099046061","https://openalex.org/W2101550682","https://openalex.org/W2102344946","https://openalex.org/W2103182811","https://openalex.org/W2103565638","https://openalex.org/W2104586170","https://openalex.org/W2104904748","https://openalex.org/W2104994844","https://openalex.org/W2106424493","https://openalex.org/W2106521582","https://openalex.org/W2107277218","https://openalex.org/W2108256128","https://openalex.org/W2108399976","https://openalex.org/W2108798315","https://openalex.org/W2109194095","https://openalex.org/W2109403608","https://openalex.org/W2109992855","https://openalex.org/W2110553275","https://openalex.org/W2112299473","https://openalex.org/W2112969174","https://openalex.org/W2113071805","https://openalex.org/W2113098047","https://openalex.org/W2113282092","https://openalex.org/W2114951959","https://openalex.org/W2114967009","https://openalex.org/W2114981005","https://openalex.org/W2115238816","https://openalex.org/W2117779089","https://openalex.org/W2118537722","https://openalex.org/W2121803603","https://openalex.org/W2122039690","https://openalex.org/W2122160475","https://openalex.org/W2125493508","https://openalex.org/W2128119821","https://openalex.org/W2128536797","https://openalex.org/W2129035692","https://openalex.org/W2129613580","https://openalex.org/W2129716106","https://openalex.org/W2130030124","https://openalex.org/W2130351826","https://openalex.org/W2130448025","https://openalex.org/W2131961351","https://openalex.org/W2131982022","https://openalex.org/W2133289974","https://openalex.org/W2135420926","https://openalex.org/W2136791076","https://openalex.org/W2136921311","https://openalex.org/W2139142827","https://openalex.org/W2140175211","https://openalex.org/W2141661308","https://openalex.org/W2143300095","https://openalex.org/W2144504691","https://openalex.org/W2145067766","https://openalex.org/W2145677917","https://openalex.org/W2146667353","https://openalex.org/W2146788036","https://openalex.org/W2146840680","https://openalex.org/W2147169218","https://openalex.org/W2147413871","https://openalex.org/W2147945419","https://openalex.org/W2149835504","https://openalex.org/W2150484278","https://openalex.org/W2150608326","https://openalex.org/W2150702503","https://openalex.org/W2152204052","https://openalex.org/W2156141826","https://openalex.org/W2156178056","https://openalex.org/W2156345163","https://openalex.org/W2156643487","https://openalex.org/W2158154269","https://openalex.org/W2159402147","https://openalex.org/W2159454585","https://openalex.org/W2161299455","https://openalex.org/W2162535416","https://openalex.org/W2162976535","https://openalex.org/W2163819348","https://openalex.org/W2164259862","https://openalex.org/W2164743819","https://openalex.org/W2167003486","https://openalex.org/W2167366928","https://openalex.org/W2167829181","https://openalex.org/W2170263258","https://openalex.org/W2171305498","https://openalex.org/W2172148966","https://openalex.org/W2197446195","https://openalex.org/W2216785249","https://openalex.org/W2274972818","https://openalex.org/W2314893245","https://openalex.org/W2320150009","https://openalex.org/W2336115893","https://openalex.org/W2398181636","https://openalex.org/W2398791388","https://openalex.org/W2401714868","https://openalex.org/W2402239345","https://openalex.org/W2414918809","https://openalex.org/W2417086746","https://openalex.org/W2474521317","https://openalex.org/W2897034676","https://openalex.org/W2994877751","https://openalex.org/W3005648189","https://openalex.org/W3026107450"],"related_works":["https://openalex.org/W1966128930","https://openalex.org/W1486393097","https://openalex.org/W1793907231","https://openalex.org/W2123120695","https://openalex.org/W1964961805","https://openalex.org/W3033502071","https://openalex.org/W2790686124","https://openalex.org/W2102344946","https://openalex.org/W7095381237","https://openalex.org/W4416223148"],"abstract_inverted_index":{"Clinical":[0],"and":[1,16,29,79,113,152,176,208,215,222],"epidemiological":[2],"studies":[3,102],"have":[4,22,68,200],"provided":[5,69],"a":[6,12,49,104],"large":[7],"body":[8],"of":[9,32,46,52,86,106,141,147,155,187],"evidence":[10],"supporting":[11],"link":[13],"between":[14,165,206],"HIV":[15,27,77,128],"other":[17],"sexually":[18],"transmitted":[19],"co-infections.":[20],"Co-infections":[21],"been":[23],"associated":[24],"with":[25,40,72],"promoting":[26],"transmission":[28],"acquisition.":[30],"One":[31],"the":[33,38,43,82,139,153,172,188,204],"closest":[34],"studied":[35],"interactions":[36,217],"is":[37,55,89,135],"co-infection":[39,75,101,125],"N.":[41,63],"gonorrhoeae,":[42],"etiological":[44],"agent":[45],"gonorrhea,":[47],"yet":[48],"clear":[50],"understanding":[51,203],"this":[53,87,198],"relationship":[54,205],"still":[56],"elusive.":[57],"Studies":[58],"aimed":[59],"at":[60],"deciphering":[61],"how":[62],"gonorrhoeae":[64],"mediates":[65],"these":[66,96],"effects":[67],"mixed":[70,107],"results":[71,97,119,190,196],"some":[73,186],"suggesting":[74,81],"promotes":[76],"replication,":[78],"others":[80],"opposite.":[83],"The":[84,118,195],"aim":[85],"thesis":[88,199],"to":[90,137,226],"uncover":[91],"molecular":[92,214],"mechanisms":[93],"that":[94,123,163,218],"explain":[95,185],"through":[98],"in":[99,130,192,197],"vitro":[100],"using":[103],"combination":[105],"peripheral":[108],"mononuclear":[109],"blood":[110],"cells":[111,150,180],"(PBMCs)":[112],"isolated":[114],"human":[115],"cell":[116,168,174],"types.":[117],"presented":[120],"here":[121],"demonstrate":[122],"gonococcal":[124],"profoundly":[126],"inhibits":[127],"replication":[129],"co-infected":[131],"PBMCs.":[132],"This":[133],"inhibition":[134],"due":[136],"both":[138],"release":[140],"anti-HIV":[142],"IFN\uf061\uf02c":[143],"via":[144],"TLR9-mediated":[145],"activation":[146,154],"plasmacytoid":[148],"dendritic":[149],"(pDCs),":[151],"\uf067\uf064":[156],"T":[157,167,179],"cells.":[158],"In":[159],"addition,":[160],"I":[161],"show":[162],"responses":[164],"CD4+":[166,178],"lines,":[169],"such":[170],"as":[171],"Jurkat":[173],"line,":[175],"primary":[177],"can":[181],"differ,":[182],"which":[183],"may":[184],"contrasting":[189],"seen":[191],"published":[193],"literature.":[194],"implications":[201],"for":[202],"gonococci":[207],"HIV,":[209],"providing":[210],"new":[211,224],"insight":[212],"into":[213],"immunological":[216],"influence":[219],"viral":[220],"transmission,":[221],"reveal":[223],"opportunities":[225],"combat":[227],"HIV.":[228]},"counts_by_year":[],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2016-06-24T00:00:00"}
