{"id":"https://openalex.org/W83880277","doi":null,"title":"Genetic modification of T cells for cancer therapy.","display_name":"Genetic modification of T cells for cancer therapy.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W83880277","mag":"83880277","pmid":"https://pubmed.ncbi.nlm.nih.gov/15323362"},"language":"en","primary_location":{"id":"pmid:15323362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15323362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078761978","display_name":"Chihaya Imai","orcid":"https://orcid.org/0000-0001-7435-3464","observed_orcids":["https://orcid.org/0000-0001-7435-3464"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Imai","raw_affiliation_strings":["Departments of Hematology-Oncology, University of Tennessee College of Medicine, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Hematology-Oncology, University of Tennessee College of Medicine, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065331155","display_name":"Dario Campana","orcid":"https://orcid.org/0000-0001-9980-3230","observed_orcids":["https://orcid.org/0000-0001-9980-3230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Campana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1838,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56339581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"1","first_page":"62","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.847000002861023},{"id":"https://openalex.org/keywords/t-cell-engineering","display_name":"T cell engineering","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9110000133514404},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.843999981880188},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.5649999976158142},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7714757919311523},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7060135006904602},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5725577473640442},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5660789608955383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5606102347373962},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5334123969078064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48254531621932983},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4639105200767517},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43184274435043335},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.43170982599258423},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4300042986869812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42514553666114807},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4184494912624359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3795425295829773},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3242732286453247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3145469129085541},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.14816981554031372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10836341977119446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07506203651428223}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053261","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:15323362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15323362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3301032526","display_name":"Beta CELL PROGENITORS AND BONE MARROW MICROENVIRONMENT","funder_award_id":"R01CA058297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W43972213","https://openalex.org/W105534366","https://openalex.org/W115808898","https://openalex.org/W122280273","https://openalex.org/W151068973","https://openalex.org/W210195154","https://openalex.org/W1492642877","https://openalex.org/W1524274652","https://openalex.org/W1540969335","https://openalex.org/W1545918761","https://openalex.org/W1548735291","https://openalex.org/W1574443686","https://openalex.org/W1595135214","https://openalex.org/W1598217555","https://openalex.org/W1624657716","https://openalex.org/W1647478418","https://openalex.org/W1707184873","https://openalex.org/W1730447863","https://openalex.org/W1737344958","https://openalex.org/W1873141201","https://openalex.org/W1943676235","https://openalex.org/W1966496772","https://openalex.org/W1966747978","https://openalex.org/W1967597135","https://openalex.org/W1975664608","https://openalex.org/W1979574709","https://openalex.org/W1979857614","https://openalex.org/W1983056774","https://openalex.org/W1984275578","https://openalex.org/W1984961927","https://openalex.org/W1986686677","https://openalex.org/W1987891097","https://openalex.org/W1990005899","https://openalex.org/W1991385476","https://openalex.org/W1991447766","https://openalex.org/W1993783506","https://openalex.org/W1993858544","https://openalex.org/W1996628620","https://openalex.org/W1998006783","https://openalex.org/W2001327683","https://openalex.org/W2003572398","https://openalex.org/W2003624697","https://openalex.org/W2005354199","https://openalex.org/W2007855451","https://openalex.org/W2010607826","https://openalex.org/W2017056242","https://openalex.org/W2019921823","https://openalex.org/W2020073768","https://openalex.org/W2024120152","https://openalex.org/W2024281858","https://openalex.org/W2024875691","https://openalex.org/W2024997807","https://openalex.org/W2025208931","https://openalex.org/W2025271699","https://openalex.org/W2028460943","https://openalex.org/W2029287277","https://openalex.org/W2030077709","https://openalex.org/W2031813404","https://openalex.org/W2033614281","https://openalex.org/W2037243028","https://openalex.org/W2038814077","https://openalex.org/W2039849294","https://openalex.org/W2041698571","https://openalex.org/W2043830286","https://openalex.org/W2045339312","https://openalex.org/W2047205338","https://openalex.org/W2047420649","https://openalex.org/W2052332203","https://openalex.org/W2055393026","https://openalex.org/W2057127443","https://openalex.org/W2057623400","https://openalex.org/W2067575839","https://openalex.org/W2081570576","https://openalex.org/W2088102742","https://openalex.org/W2089894429","https://openalex.org/W2090010312","https://openalex.org/W2091110863","https://openalex.org/W2095220820","https://openalex.org/W2098116001","https://openalex.org/W2099241614","https://openalex.org/W2105053973","https://openalex.org/W2113802879","https://openalex.org/W2114358743","https://openalex.org/W2128746406","https://openalex.org/W2137440275","https://openalex.org/W2140048036","https://openalex.org/W2156754275","https://openalex.org/W2159888718","https://openalex.org/W2160989461","https://openalex.org/W2165984958","https://openalex.org/W2171026458","https://openalex.org/W2171653261","https://openalex.org/W2177410450","https://openalex.org/W2180651989","https://openalex.org/W2292087673","https://openalex.org/W2297816245","https://openalex.org/W2315098267","https://openalex.org/W2326477218","https://openalex.org/W2335166576","https://openalex.org/W2335277148","https://openalex.org/W2340547456","https://openalex.org/W2399726719","https://openalex.org/W2406035635","https://openalex.org/W2413034195","https://openalex.org/W4313377003"],"related_works":["https://openalex.org/W3016467003","https://openalex.org/W2605884542","https://openalex.org/W2048308930","https://openalex.org/W3188235617","https://openalex.org/W1982764471","https://openalex.org/W2075149514","https://openalex.org/W1964304569","https://openalex.org/W7098121310","https://openalex.org/W7074000518","https://openalex.org/W2081228087"],"abstract_inverted_index":{"The":[0,50],"use":[1],"of":[2,11,18,24,29,44,52,59,95,139,147,176,184],"immune":[3,48,81,120,170],"cells":[4,85,121,142],"with":[5,181],"restricted":[6],"specificities":[7],"for":[8,89,162],"the":[9,25,42,57,93,103,158,177],"treatment":[10],"cancer":[12,65,84],"is":[13,143,153],"a":[14,37],"rapidly":[15],"emerging":[16],"area":[17],"clinical":[19,133,151],"research.":[20],"Chimeric":[21],"receptors":[22,105,124,165],"composed":[23],"single-chain":[26],"variable":[27],"domain":[28],"murine":[30],"antibodies":[31],"and":[32,70,79,114,132,160,166],"human":[33],"signaling":[34],"molecules":[35,61,96],"are":[36],"promising":[38],"tool":[39],"to":[40,76,102],"redirect":[41],"specificity":[43],"autologous":[45],"or":[46,100],"allogeneic":[47],"cells.":[49,66],"success":[51],"this":[53,148,182],"approach":[54,149],"depends":[55],"on":[56,64],"identification":[58],"target":[60],"expressed":[62],"preferentially":[63],"Moreover,":[67],"appropriate":[68],"primary":[69],"secondary":[71],"stimuli":[72],"must":[73],"be":[74],"delivered":[75],"generate":[77],"vigorous":[78],"durable":[80],"responses.":[82],"Since":[83],"often":[86],"lack":[87],"ligands":[88],"key":[90],"co-stimulatory":[91],"molecules,":[92],"addition":[94],"such":[97],"as":[98,172,174],"CD28":[99],"4-1BB":[101],"chimeric":[104,123,164],"can":[106,125],"significantly":[107],"improve":[108],"their":[109],"function.":[110],"Studies":[111],"in":[112,115,150],"vitro":[113],"animal":[116],"models":[117],"indicate":[118,135],"that":[119,136],"expressing":[122],"have":[126],"remarkable":[127],"anti-cancer":[128],"activity,":[129],"while":[130],"experimental":[131],"data":[134],"long-term":[137],"persistence":[138],"adoptively":[140],"transferred":[141],"feasible.":[144],"Therefore,":[145],"testing":[146],"trials":[152],"warranted.":[154],"We":[155],"here":[156],"review":[157],"principles":[159],"methodologies":[161],"designing":[163],"delivering":[167],"them":[168],"into":[169],"cells,":[171],"well":[173],"some":[175],"potential":[178],"complications":[179],"associated":[180],"form":[183],"cell":[185],"therapy.":[186]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
