{"id":"https://openalex.org/W838429431","doi":null,"title":"Role of the two ClpP protease subunits in Mycobacterium tuberculosis","display_name":"Role of the two ClpP protease subunits in Mycobacterium tuberculosis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W838429431","mag":"838429431"},"language":"en","primary_location":{"id":"pmh:hdl:10068/997777","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/997777","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034787242","display_name":"Yoann Personne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yoann Personne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034787242"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clpp-protease","display_name":"ClpP protease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/caseinolytic-protease","display_name":"caseinolytic protease","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tmrna","display_name":"tmRNA","score":0.9259999990463257},{"id":"https://openalex.org/keywords/smpb","display_name":"SmpB","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.8949999809265137},{"id":"https://openalex.org/keywords/misfolded-protein-degradation","display_name":"misfolded protein degradation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/substrate-recognition","display_name":"substrate recognition","score":0.6309999823570251},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.6290000081062317},{"id":"https://openalex.org/keywords/ribosome-targeting-antibiotics","display_name":"ribosome-targeting antibiotics","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7523658275604248},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.675904393196106},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.629073441028595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4230096638202667},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.40244922041893005},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35876935720443726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3416537344455719},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23579543828964233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23189625144004822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18112382292747498},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/997777","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/997777","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/2962","doi":null,"is_oa":false,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/2962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:838429431","doi":null,"is_oa":false,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/2962","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":320,"referenced_works":["https://openalex.org/W12336293","https://openalex.org/W114727475","https://openalex.org/W116010092","https://openalex.org/W145215571","https://openalex.org/W846534069","https://openalex.org/W1500221063","https://openalex.org/W1525162460","https://openalex.org/W1532942255","https://openalex.org/W1540505601","https://openalex.org/W1542843760","https://openalex.org/W1546783991","https://openalex.org/W1549438168","https://openalex.org/W1555471479","https://openalex.org/W1571361882","https://openalex.org/W1573033932","https://openalex.org/W1577728302","https://openalex.org/W1592902260","https://openalex.org/W1596832151","https://openalex.org/W1597620505","https://openalex.org/W1597808424","https://openalex.org/W1598194603","https://openalex.org/W1602037468","https://openalex.org/W1719553848","https://openalex.org/W1743031149","https://openalex.org/W1799526184","https://openalex.org/W1822881903","https://openalex.org/W1826756319","https://openalex.org/W1839665474","https://openalex.org/W1844811650","https://openalex.org/W1906303910","https://openalex.org/W1910931001","https://openalex.org/W1926946171","https://openalex.org/W1942592304","https://openalex.org/W1943619333","https://openalex.org/W1946718856","https://openalex.org/W1963434023","https://openalex.org/W1964118366","https://openalex.org/W1964774325","https://openalex.org/W1965528542","https://openalex.org/W1966404058","https://openalex.org/W1966559223","https://openalex.org/W1967365559","https://openalex.org/W1967457339","https://openalex.org/W1967824952","https://openalex.org/W1968131355","https://openalex.org/W1969633963","https://openalex.org/W1970071348","https://openalex.org/W1970164033","https://openalex.org/W1971988433","https://openalex.org/W1974090018","https://openalex.org/W1974299093","https://openalex.org/W1975610050","https://openalex.org/W1978099201","https://openalex.org/W1981423406","https://openalex.org/W1983345237","https://openalex.org/W1983379128","https://openalex.org/W1984213404","https://openalex.org/W1984523365","https://openalex.org/W1985485693","https://openalex.org/W1986684620","https://openalex.org/W1988102426","https://openalex.org/W1988986229","https://openalex.org/W1989191904","https://openalex.org/W1990148399","https://openalex.org/W1991680871","https://openalex.org/W1994400533","https://openalex.org/W1995045090","https://openalex.org/W1995673848","https://openalex.org/W1996520342","https://openalex.org/W1997978648","https://openalex.org/W1998018574","https://openalex.org/W1999467171","https://openalex.org/W2001414564","https://openalex.org/W2003144529","https://openalex.org/W2004304744","https://openalex.org/W2004814352","https://openalex.org/W2005528894","https://openalex.org/W2005548636","https://openalex.org/W2005756027","https://openalex.org/W2007097682","https://openalex.org/W2009969297","https://openalex.org/W2010190199","https://openalex.org/W2010958487","https://openalex.org/W2011226772","https://openalex.org/W2011562799","https://openalex.org/W2012499122","https://openalex.org/W2012731700","https://openalex.org/W2013999085","https://openalex.org/W2014578355","https://openalex.org/W2015078576","https://openalex.org/W2016988498","https://openalex.org/W2017188875","https://openalex.org/W2017550427","https://openalex.org/W2018031259","https://openalex.org/W2018292120","https://openalex.org/W2020201637","https://openalex.org/W2021296798","https://openalex.org/W2022472102","https://openalex.org/W2023721865","https://openalex.org/W2024091788","https://openalex.org/W2027657858","https://openalex.org/W2028014530","https://openalex.org/W2028618437","https://openalex.org/W2029168963","https://openalex.org/W2029171915","https://openalex.org/W2031790892","https://openalex.org/W2031977279","https://openalex.org/W2033974483","https://openalex.org/W2034454594","https://openalex.org/W2036032145","https://openalex.org/W2037176629","https://openalex.org/W2038347400","https://openalex.org/W2038567250","https://openalex.org/W2038667329","https://openalex.org/W2038852478","https://openalex.org/W2039590408","https://openalex.org/W2040584799","https://openalex.org/W2040802012","https://openalex.org/W2045780223","https://openalex.org/W2045857220","https://openalex.org/W2045875106","https://openalex.org/W2046591395","https://openalex.org/W2047222464","https://openalex.org/W2047285451","https://openalex.org/W2047670590","https://openalex.org/W2049261534","https://openalex.org/W2051348529","https://openalex.org/W2051766634","https://openalex.org/W2052481735","https://openalex.org/W2053195173","https://openalex.org/W2053700342","https://openalex.org/W2054395426","https://openalex.org/W2054832549","https://openalex.org/W2054924586","https://openalex.org/W2056047407","https://openalex.org/W2056552659","https://openalex.org/W2056757378","https://openalex.org/W2058858340","https://openalex.org/W2058930723","https://openalex.org/W2059135418","https://openalex.org/W2059265460","https://openalex.org/W2061836311","https://openalex.org/W2062900004","https://openalex.org/W2063292959","https://openalex.org/W2063460342","https://openalex.org/W2065542724","https://openalex.org/W2066135800","https://openalex.org/W2066857552","https://openalex.org/W2066958748","https://openalex.org/W2067050590","https://openalex.org/W2067268586","https://openalex.org/W2067477145","https://openalex.org/W2067911054","https://openalex.org/W2068978822","https://openalex.org/W2069602560","https://openalex.org/W2069826477","https://openalex.org/W2070413611","https://openalex.org/W2071056869","https://openalex.org/W2071062657","https://openalex.org/W2073044683","https://openalex.org/W2074338643","https://openalex.org/W2074654002","https://openalex.org/W2074689569","https://openalex.org/W2075105102","https://openalex.org/W2076272826","https://openalex.org/W2077540472","https://openalex.org/W2078481295","https://openalex.org/W2079583942","https://openalex.org/W2079630207","https://openalex.org/W2079757735","https://openalex.org/W2081541337","https://openalex.org/W2081661863","https://openalex.org/W2084140927","https://openalex.org/W2084488581","https://openalex.org/W2085347178","https://openalex.org/W2087006403","https://openalex.org/W2088436037","https://openalex.org/W2088550607","https://openalex.org/W2088593000","https://openalex.org/W2088931841","https://openalex.org/W2090410768","https://openalex.org/W2090837541","https://openalex.org/W2092231589","https://openalex.org/W2093301236","https://openalex.org/W2094126923","https://openalex.org/W2094222845","https://openalex.org/W2094566796","https://openalex.org/W2096966529","https://openalex.org/W2097424323","https://openalex.org/W2097593226","https://openalex.org/W2097743105","https://openalex.org/W2097817417","https://openalex.org/W2097919434","https://openalex.org/W2098157904","https://openalex.org/W2099102896","https://openalex.org/W2099196052","https://openalex.org/W2100975834","https://openalex.org/W2102545353","https://openalex.org/W2104850768","https://openalex.org/W2104938413","https://openalex.org/W2106765673","https://openalex.org/W2107133310","https://openalex.org/W2107196115","https://openalex.org/W2107235830","https://openalex.org/W2107900269","https://openalex.org/W2108500436","https://openalex.org/W2108989983","https://openalex.org/W2109545101","https://openalex.org/W2109560982","https://openalex.org/W2109817270","https://openalex.org/W2110437187","https://openalex.org/W2110678358","https://openalex.org/W2112034821","https://openalex.org/W2113265821","https://openalex.org/W2114071486","https://openalex.org/W2115786035","https://openalex.org/W2118060907","https://openalex.org/W2118804480","https://openalex.org/W2118868063","https://openalex.org/W2119612051","https://openalex.org/W2119784689","https://openalex.org/W2119839519","https://openalex.org/W2120842435","https://openalex.org/W2121523774","https://openalex.org/W2122135250","https://openalex.org/W2122574306","https://openalex.org/W2122964795","https://openalex.org/W2123084649","https://openalex.org/W2123266729","https://openalex.org/W2125089546","https://openalex.org/W2125112523","https://openalex.org/W2125273006","https://openalex.org/W2126674289","https://openalex.org/W2128482141","https://openalex.org/W2128702974","https://openalex.org/W2129381218","https://openalex.org/W2129414300","https://openalex.org/W2129606026","https://openalex.org/W2129907243","https://openalex.org/W2130710889","https://openalex.org/W2131731929","https://openalex.org/W2132581401","https://openalex.org/W2133273161","https://openalex.org/W2133942178","https://openalex.org/W2134915935","https://openalex.org/W2135745367","https://openalex.org/W2136758639","https://openalex.org/W2137668223","https://openalex.org/W2138892732","https://openalex.org/W2139531099","https://openalex.org/W2140337827","https://openalex.org/W2140354550","https://openalex.org/W2140981202","https://openalex.org/W2142351039","https://openalex.org/W2143335657","https://openalex.org/W2144010612","https://openalex.org/W2145035030","https://openalex.org/W2145571109","https://openalex.org/W2145573096","https://openalex.org/W2145719148","https://openalex.org/W2146882256","https://openalex.org/W2147404160","https://openalex.org/W2148318714","https://openalex.org/W2149181646","https://openalex.org/W2149189278","https://openalex.org/W2149876284","https://openalex.org/W2150342978","https://openalex.org/W2152050001","https://openalex.org/W2152888107","https://openalex.org/W2153418857","https://openalex.org/W2153767036","https://openalex.org/W2154039684","https://openalex.org/W2154717249","https://openalex.org/W2154995327","https://openalex.org/W2156136970","https://openalex.org/W2156285140","https://openalex.org/W2156389983","https://openalex.org/W2156938363","https://openalex.org/W2157318559","https://openalex.org/W2157559696","https://openalex.org/W2157638040","https://openalex.org/W2158023121","https://openalex.org/W2159586303","https://openalex.org/W2160790441","https://openalex.org/W2161292266","https://openalex.org/W2161312954","https://openalex.org/W2161688176","https://openalex.org/W2161809782","https://openalex.org/W2162519786","https://openalex.org/W2162524966","https://openalex.org/W2163014180","https://openalex.org/W2163562422","https://openalex.org/W2163852009","https://openalex.org/W2164263846","https://openalex.org/W2164698321","https://openalex.org/W2165005042","https://openalex.org/W2165412123","https://openalex.org/W2165509846","https://openalex.org/W2165732172","https://openalex.org/W2165885466","https://openalex.org/W2166635511","https://openalex.org/W2167420567","https://openalex.org/W2167790893","https://openalex.org/W2168066272","https://openalex.org/W2169024001","https://openalex.org/W2169414320","https://openalex.org/W2170342148","https://openalex.org/W2170377094","https://openalex.org/W2170598748","https://openalex.org/W2171154810","https://openalex.org/W2171814990","https://openalex.org/W2178503716","https://openalex.org/W2252690754","https://openalex.org/W2338652248","https://openalex.org/W2400315638","https://openalex.org/W2411807956","https://openalex.org/W2415325035","https://openalex.org/W2469323919","https://openalex.org/W2525818956","https://openalex.org/W2613703036"],"related_works":["https://openalex.org/W2025849119","https://openalex.org/W7099681920","https://openalex.org/W2081589091","https://openalex.org/W2132242403","https://openalex.org/W2077885055","https://openalex.org/W7096101028","https://openalex.org/W2075105102","https://openalex.org/W1889873746","https://openalex.org/W7098315714","https://openalex.org/W4229016381"],"abstract_inverted_index":{"Caseinolytic":[0],"(Clp)":[1],"proteases":[2,8,39],"are":[3,12,106],"the":[4,37,41,47,121,167,178,183,186,192,213,223],"most":[5,69],"widespread":[6],"energy-dependent":[7],"in":[9,14,28,46],"bacteria.":[10],"They":[11],"involved":[13],"protein":[15,65],"quality":[16],"control":[17],"by":[18,57,60,174],"degrading":[19],"misfolded":[20],"and":[21,24,83,97,104,132,150],"aggregated":[22],"proteins":[23,170],"have":[25,71],"a":[26,64],"role":[27],"regulatory":[29],"proteolysis.":[30],"The":[31,112],"main":[32],"group":[33],"of":[34,36,49,89,95,115,182,185,191],"substrates":[35],"Clp":[38],"is":[40,54,198,203,206],"SsrA-tagged":[42,153],"proteins,":[43],"which":[44],"arise":[45],"presence":[48],"defective":[50],"translation.":[51],"SsrA":[52,142],"tagging":[53],"carried":[55],"out":[56],"tmRNA,":[58],"encoded":[59],"ssrA,":[61],"together":[62,119],"with":[63,85,120,171],"partner":[66],"SmpB.":[67],"While":[68],"organisms":[70],"only":[72,156],"one":[73,88],"ClpP,":[74],"Mycobacterium":[75],"tuberculosis":[76],"has":[77],"two":[78,168],"ClpP":[79,169],"protease":[80],"subunits":[81],"(ClpP1":[82],"ClpP2)":[84],"at":[86],"least":[87],"them":[90],"essential":[91,199],"for":[92,166,209],"growth.":[93],"Co-expression":[94],"clpP1":[96,103],"clpP2":[98,105],"was":[99,117,136,217],"demonstrated":[100,195],"showing":[101],"that":[102,147,196],"not":[107,207],"expressed":[108],"under":[109],"different":[110,163],"conditions.":[111],"promoter":[113],"region":[114],"clpP1P2":[116],"identified,":[118],"potential":[122],"ClgR":[123],"binding":[124],"site.":[125],"A":[126],"reporter":[127],"system":[128],"to":[129,220,227],"assay":[130],"ClpP1":[131,149,175],"ClpP2":[133,151,157],"enzymatic":[134],"activities":[135],"developed":[137],"based":[138],"on":[139,177],"LacZ":[140],"incorporating":[141],"tag":[143,187],"sequences.":[144],"This":[145,161],"showed":[146],"both":[148],"degrade":[152],"LacZ,":[154],"whilst":[155],"degrades":[158],"untagged":[159],"proteins.":[160],"suggests":[162],"pattern":[164],"recognition":[165,173],"substrate":[172],"dependent":[176],"last":[179],"three":[180],"residues":[181],"C-terminus":[184],"sequence.":[188],"Mutagenesis":[189],"analysis":[190],"accessory":[193],"components":[194],"ssrA":[197],"but":[200,212],"SmpB":[201,205],"deletion":[202],"viable.":[204],"required":[208],"aerobic":[210],"growth":[211],"smpB\u0394":[214],"mutant":[215],"strain":[216],"more":[218],"sensitive":[219],"antibiotics":[221],"targeting":[222],"ribosome":[224],"as":[225],"compared":[226],"wildtype":[228],"cells.":[229]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}