{"id":"https://openalex.org/W83809916","doi":"https://doi.org/10.1007/978-3-642-78530-6_3","title":"Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Responses to Structural Proteins","display_name":"Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Responses to Structural Proteins","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W83809916","doi":"https://doi.org/10.1007/978-3-642-78530-6_3","mag":"83809916","pmid":"https://pubmed.ncbi.nlm.nih.gov/7523033"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-78530-6_3","doi":"https://doi.org/10.1007/978-3-642-78530-6_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-78530-6_3","pdf_url":null,"source":{"id":"https://openalex.org/S192937065","display_name":"Current topics in microbiology and immunology","issn_l":"0070-217X","issn":["0070-217X","2196-9965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Microbiology and Immunology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W639461386","display_name":"Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018205846","display_name":"R. Paul Johnson","orcid":"https://orcid.org/0000-0002-2600-120X","observed_orcids":["https://orcid.org/0000-0002-2600-120X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. P. Johnson","raw_affiliation_strings":["Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114","Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. D. Walker","raw_affiliation_strings":["Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5479,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.98373984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"189","issue":null,"first_page":"35","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/viral-replication-control","display_name":"viral replication control","score":0.6389999985694885},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7789999842643738},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.897443413734436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7176861763000488},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6791286468505859},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6766526699066162},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6667324304580688},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.5532127618789673},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5101640224456787},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4579346179962158},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4575809836387634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4472254514694214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3409024775028229},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2979939579963684},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.28359299898147583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08606669306755066},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06276670098304749}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015678","descriptor_name":"Viral Structural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-642-78530-6_3","doi":"https://doi.org/10.1007/978-3-642-78530-6_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-78530-6_3","pdf_url":null,"source":{"id":"https://openalex.org/S192937065","display_name":"Current topics in microbiology and immunology","issn_l":"0070-217X","issn":["0070-217X","2196-9965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Microbiology and Immunology","raw_type":"book-chapter"},{"id":"pmid:7523033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7523033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in microbiology and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W169792345","https://openalex.org/W236267061","https://openalex.org/W1233534743","https://openalex.org/W1484135921","https://openalex.org/W1487204939","https://openalex.org/W1492241828","https://openalex.org/W1492773221","https://openalex.org/W1497763226","https://openalex.org/W1498853706","https://openalex.org/W1500421682","https://openalex.org/W1504631955","https://openalex.org/W1514857866","https://openalex.org/W1517682435","https://openalex.org/W1519407700","https://openalex.org/W1523002822","https://openalex.org/W1524156873","https://openalex.org/W1525840776","https://openalex.org/W1530272116","https://openalex.org/W1537746263","https://openalex.org/W1545404903","https://openalex.org/W1560893038","https://openalex.org/W1561535474","https://openalex.org/W1579412383","https://openalex.org/W1589616946","https://openalex.org/W1590495117","https://openalex.org/W1593069798","https://openalex.org/W1601291490","https://openalex.org/W1743004630","https://openalex.org/W1789164989","https://openalex.org/W1915484414","https://openalex.org/W1919528337","https://openalex.org/W1946377768","https://openalex.org/W1951932735","https://openalex.org/W1963956083","https://openalex.org/W1964620549","https://openalex.org/W1966311223","https://openalex.org/W1968299739","https://openalex.org/W1968873679","https://openalex.org/W1971302107","https://openalex.org/W1972966267","https://openalex.org/W1973635674","https://openalex.org/W1974138678","https://openalex.org/W1976348539","https://openalex.org/W1977282539","https://openalex.org/W1979296983","https://openalex.org/W1981026726","https://openalex.org/W1985838249","https://openalex.org/W1987843295","https://openalex.org/W1988053484","https://openalex.org/W1989938774","https://openalex.org/W1990118428","https://openalex.org/W1990806106","https://openalex.org/W1995377723","https://openalex.org/W1996464851","https://openalex.org/W2000251753","https://openalex.org/W2000886748","https://openalex.org/W2000919244","https://openalex.org/W2000985920","https://openalex.org/W2001267374","https://openalex.org/W2003227439","https://openalex.org/W2005150291","https://openalex.org/W2006597943","https://openalex.org/W2012987505","https://openalex.org/W2014997725","https://openalex.org/W2017172508","https://openalex.org/W2018073475","https://openalex.org/W2019007714","https://openalex.org/W2019372457","https://openalex.org/W2020205111","https://openalex.org/W2021989026","https://openalex.org/W2022852420","https://openalex.org/W2023651173","https://openalex.org/W2025392129","https://openalex.org/W2026078176","https://openalex.org/W2030242831","https://openalex.org/W2030641724","https://openalex.org/W2034298592","https://openalex.org/W2038354376","https://openalex.org/W2039596527","https://openalex.org/W2039725698","https://openalex.org/W2041204705","https://openalex.org/W2044058829","https://openalex.org/W2049932413","https://openalex.org/W2059684015","https://openalex.org/W2063841466","https://openalex.org/W2074508421","https://openalex.org/W2077348914","https://openalex.org/W2082814103","https://openalex.org/W2083177852","https://openalex.org/W2085101289","https://openalex.org/W2085244301","https://openalex.org/W2085831528","https://openalex.org/W2086104438","https://openalex.org/W2091735849","https://openalex.org/W2092985132","https://openalex.org/W2102093684","https://openalex.org/W2102154787","https://openalex.org/W2108142790","https://openalex.org/W2111235578","https://openalex.org/W2116557650","https://openalex.org/W2120573262","https://openalex.org/W2136045513","https://openalex.org/W2136850348","https://openalex.org/W2145860359","https://openalex.org/W2146438815","https://openalex.org/W2157588998","https://openalex.org/W2163972742","https://openalex.org/W2170908973","https://openalex.org/W2238350270","https://openalex.org/W2394526106","https://openalex.org/W2396470748","https://openalex.org/W2418178753","https://openalex.org/W2470032245","https://openalex.org/W4237369806"],"related_works":["https://openalex.org/W2411152052","https://openalex.org/W2088308807","https://openalex.org/W141088424","https://openalex.org/W2218340142","https://openalex.org/W2181455570","https://openalex.org/W1977629382","https://openalex.org/W4244766088","https://openalex.org/W2026807072","https://openalex.org/W2006597943","https://openalex.org/W2504249268"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}