{"id":"https://openalex.org/W83708510","doi":"https://doi.org/10.1023/a:1010605625538","title":"Gene Expression Profiling of Exposure to TZT-1027, a Novel Microtubule-Interfering Agent, in Non-Small Cell Lung Cancer PC-14 Cells and Astrocytes","display_name":"Gene Expression Profiling of Exposure to TZT-1027, a Novel Microtubule-Interfering Agent, in Non-Small Cell Lung Cancer PC-14 Cells and Astrocytes","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W83708510","doi":"https://doi.org/10.1023/a:1010605625538","mag":"83708510","pmid":"https://pubmed.ncbi.nlm.nih.gov/11561688"},"language":"en","primary_location":{"id":"doi:10.1023/a:1010605625538","doi":"https://doi.org/10.1023/a:1010605625538","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010605625538","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067947584","display_name":"Tsugitaka Natsume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsugitaka Natsume","raw_affiliation_strings":["Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan","Pharmacology Division, National Cancer Center Research Institute, Tokyo","Teikoku Hormone Mfg. Co., Ltd., Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Teikoku Hormone Mfg. Co., Ltd., Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780482","display_name":"Takashi Nakamura","orcid":"https://orcid.org/0000-0002-6124-061X","observed_orcids":["https://orcid.org/0000-0002-6124-061X"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakamura","raw_affiliation_strings":["Pharmacology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054386489","display_name":"Yasuhiro Koh","orcid":"https://orcid.org/0000-0002-8758-8980","observed_orcids":["https://orcid.org/0000-0002-8758-8980"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Koh","raw_affiliation_strings":["Pharmacology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069774952","display_name":"Motohiro Kobayashi","orcid":"https://orcid.org/0000-0002-7607-0801","observed_orcids":["https://orcid.org/0000-0002-7607-0801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motohiro Kobayashi","raw_affiliation_strings":["Teikoku Hormone Mfg. Co., Ltd., Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teikoku Hormone Mfg. Co., Ltd., Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111842962","display_name":"N Saijo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nagahiro Saijo","raw_affiliation_strings":["Pharmacology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004282323","display_name":"Kazuto Nishio","orcid":"https://orcid.org/0000-0002-8275-0846","observed_orcids":["https://orcid.org/0000-0002-8275-0846"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuto Nishio","raw_affiliation_strings":["Pharmacology Division, National Cancer Center Research Institute, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, National Cancer Center Research Institute, Tokyo","institution_ids":["https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.6348,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62411348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"4","first_page":"293","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.12960000336170197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubulin-polymerization-inhibition","display_name":"tubulin polymerization inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cytokines-and-growth-factors","display_name":"cytokines and growth factors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor","display_name":"TNF receptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cytokeratin-8","display_name":"cytokeratin 8","score":0.9549999833106995},{"id":"https://openalex.org/keywords/xpg","display_name":"XPG","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6257150769233704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5565478801727295},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.511735200881958},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42809635400772095},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42033258080482483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36532557010650635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1336161196231842}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1010605625538","doi":"https://doi.org/10.1023/a:1010605625538","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010605625538","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:11561688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11561688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W141235770","https://openalex.org/W238668910","https://openalex.org/W1547132539","https://openalex.org/W1580605592","https://openalex.org/W1911989431","https://openalex.org/W1981558181","https://openalex.org/W1983251310","https://openalex.org/W1987176233","https://openalex.org/W2001669607","https://openalex.org/W2025003664","https://openalex.org/W2044153685","https://openalex.org/W2049109311","https://openalex.org/W2114918609"],"related_works":["https://openalex.org/W2087331499","https://openalex.org/W614644891","https://openalex.org/W1580605592","https://openalex.org/W2016222769","https://openalex.org/W1987176233","https://openalex.org/W2415954795","https://openalex.org/W2037258477","https://openalex.org/W1981214883","https://openalex.org/W3014822181","https://openalex.org/W2044131371"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}