{"id":"https://openalex.org/W836476797","doi":null,"title":"ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER","display_name":"ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER","publication_year":2011,"publication_date":"2011-08-31","ids":{"openalex":"https://openalex.org/W836476797","mag":"836476797"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/8382","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/8382","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071845735","display_name":"Crystal S. Bethel-Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Crystal Bethel\u2010Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071845735"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.9810000061988831},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/astrocyte-endothelial-interactions","display_name":"astrocyte-endothelial interactions","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.9649999737739563},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.902999997138977},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.628000020980835},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hiv-neuropathogenesis","display_name":"HIV neuropathogenesis","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8203728199005127},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.668509840965271},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6670830845832825},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5361148715019226},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44933316111564636},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3514088988304138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34337419271469116},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3280148506164551},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27872321009635925},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1324925422668457},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09197476506233215}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/8382","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/8382","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:836476797","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/bitstream/1808/8382/1/BethelBrown_ku_0099D_11685_DATA_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W1174742","https://openalex.org/W43995647","https://openalex.org/W67377856","https://openalex.org/W87068116","https://openalex.org/W142867979","https://openalex.org/W1481786375","https://openalex.org/W1485043351","https://openalex.org/W1493414055","https://openalex.org/W1497214669","https://openalex.org/W1522823711","https://openalex.org/W1530364137","https://openalex.org/W1543006644","https://openalex.org/W1558962636","https://openalex.org/W1567881416","https://openalex.org/W1575891190","https://openalex.org/W1608043318","https://openalex.org/W1622758820","https://openalex.org/W1656832641","https://openalex.org/W1759955568","https://openalex.org/W1769783081","https://openalex.org/W1784761870","https://openalex.org/W1841952425","https://openalex.org/W1925136148","https://openalex.org/W1926035455","https://openalex.org/W1936351921","https://openalex.org/W1964795218","https://openalex.org/W1965560753","https://openalex.org/W1966700067","https://openalex.org/W1972635588","https://openalex.org/W1973010584","https://openalex.org/W1974702421","https://openalex.org/W1974835419","https://openalex.org/W1975126224","https://openalex.org/W1975195718","https://openalex.org/W1975258429","https://openalex.org/W1978223419","https://openalex.org/W1979476762","https://openalex.org/W1979800084","https://openalex.org/W1981478725","https://openalex.org/W1982713269","https://openalex.org/W1984767179","https://openalex.org/W1984987454","https://openalex.org/W1988766125","https://openalex.org/W1988932933","https://openalex.org/W1992644506","https://openalex.org/W1993264471","https://openalex.org/W1994600662","https://openalex.org/W1994662730","https://openalex.org/W1995254193","https://openalex.org/W1995924099","https://openalex.org/W1997653290","https://openalex.org/W1998907224","https://openalex.org/W2000366839","https://openalex.org/W2002818759","https://openalex.org/W2003545714","https://openalex.org/W2004560219","https://openalex.org/W2004703152","https://openalex.org/W2005221277","https://openalex.org/W2005416260","https://openalex.org/W2007338142","https://openalex.org/W2009969882","https://openalex.org/W2010358244","https://openalex.org/W2012911450","https://openalex.org/W2013357966","https://openalex.org/W2015983043","https://openalex.org/W2017210417","https://openalex.org/W2019425955","https://openalex.org/W2021061796","https://openalex.org/W2022412338","https://openalex.org/W2022978872","https://openalex.org/W2023653988","https://openalex.org/W2027580727","https://openalex.org/W2029353650","https://openalex.org/W2034928823","https://openalex.org/W2038418972","https://openalex.org/W2044177663","https://openalex.org/W2044458602","https://openalex.org/W2046468113","https://openalex.org/W2050999635","https://openalex.org/W2051172700","https://openalex.org/W2052537645","https://openalex.org/W2052747138","https://openalex.org/W2053953952","https://openalex.org/W2055770817","https://openalex.org/W2058476297","https://openalex.org/W2061494834","https://openalex.org/W2062200627","https://openalex.org/W2064612117","https://openalex.org/W2065752062","https://openalex.org/W2066650638","https://openalex.org/W2067105764","https://openalex.org/W2070665570","https://openalex.org/W2071366179","https://openalex.org/W2074661552","https://openalex.org/W2074811497","https://openalex.org/W2081464932","https://openalex.org/W2084426019","https://openalex.org/W2086237072","https://openalex.org/W2086652159","https://openalex.org/W2087423729","https://openalex.org/W2088624957","https://openalex.org/W2090458882","https://openalex.org/W2091058660","https://openalex.org/W2094066480","https://openalex.org/W2094891357","https://openalex.org/W2096482886","https://openalex.org/W2097146615","https://openalex.org/W2101607187","https://openalex.org/W2111606797","https://openalex.org/W2111838184","https://openalex.org/W2112697998","https://openalex.org/W2117524864","https://openalex.org/W2118391212","https://openalex.org/W2119515863","https://openalex.org/W2120658132","https://openalex.org/W2122731907","https://openalex.org/W2124347712","https://openalex.org/W2126327738","https://openalex.org/W2131286622","https://openalex.org/W2133071375","https://openalex.org/W2133636845","https://openalex.org/W2133655326","https://openalex.org/W2135761260","https://openalex.org/W2136193758","https://openalex.org/W2137321682","https://openalex.org/W2137740515","https://openalex.org/W2144251330","https://openalex.org/W2146014199","https://openalex.org/W2148595561","https://openalex.org/W2150141957","https://openalex.org/W2153325989","https://openalex.org/W2154009147","https://openalex.org/W2155214429","https://openalex.org/W2155226726","https://openalex.org/W2155968662","https://openalex.org/W2155989785","https://openalex.org/W2156905839","https://openalex.org/W2161017525","https://openalex.org/W2161533323","https://openalex.org/W2163017758","https://openalex.org/W2167557753","https://openalex.org/W2168144334","https://openalex.org/W2169241566","https://openalex.org/W2328570866","https://openalex.org/W2470618196"],"related_works":["https://openalex.org/W2143564316","https://openalex.org/W1971433653","https://openalex.org/W2155226726","https://openalex.org/W1991504591","https://openalex.org/W2885095866","https://openalex.org/W3133778887","https://openalex.org/W2797413178","https://openalex.org/W2052041838","https://openalex.org/W2135520652","https://openalex.org/W7134888120"],"abstract_inverted_index":{"During":[0],"the":[1,28,33,42,46,54,70,81,83,112,121,129,178,188,198,202,210,226,238,253,259,272,294,321],"course":[2],"of":[3,36,64,80,85,123,128,137,195,197,201,225,240,252,263,274,285,296,315,323],"HIV-1":[4],"disease,":[5,82],"virus":[6,30,43],"neuroinvasion":[7],"occurs":[8,62],"as":[9,100,134,141,157,300,328],"an":[10,101,193],"early":[11],"event,":[12],"within":[13],"weeks":[14],"following":[15],"infection.":[16],"Intriguingly,":[17],"subsequent":[18],"central":[19,280],"nervous":[20],"system":[21],"(CNS)":[22],"complications":[23],"manifest":[24],"only":[25],"decades":[26],"after":[27],"initial":[29],"exposure.":[31],"In":[32],"current":[34],"era":[35],"combined":[37],"anti-retroviral":[38],"therapy":[39],"(cART),":[40],"while":[41,69],"replication":[44],"in":[45,53,162,187,206,221,248,277,293,326],"periphery":[47],"is":[48,90,97,116,231,237,282],"brought":[49],"under":[50],"complete":[51],"control,":[52],"CNS":[55,96,113],"owing":[56],"to":[57,183,245,287,306,319,331],"poor":[58],"drug":[59],"penetrance,":[60],"there":[61],"development":[63],"increasing":[65],"neurocognitive":[66,87],"complications.":[67],"So":[68],"HIV-infected":[71],"patients":[72],"are":[73],"living":[74],"longer":[75],"and":[76,235,250,270,309],"have":[77],"decreased":[78],"incidence":[79],"prevalence":[84],"HIV-associated":[86],"disorders":[88],"(HAND)":[89],"actually":[91],"on":[92],"a":[93,117,138,149,158,181,184],"rise.":[94],"Although":[95],"commonly":[98],"regarded":[99],"immune-privileged":[102],"site,":[103],"emerging":[104],"evidence":[105],"indicates":[106],"that":[107,212,283],"innate":[108,204],"immunity":[109,205],"elicited":[110],"by":[111,169],"glial":[114],"cells":[115],"critical":[118,232],"determinant":[119],"for":[120,233],"establishment":[122],"protective":[124,130,182],"immunity.":[125],"Sustained":[126],"expression":[127,136],"immune":[131,160],"responses":[132],"manifested":[133],"increased":[135],"mediator,":[139,161],"such":[140,299],"platelet-derived":[142,213],"growth":[143,214,297],"factor":[144,215],"(PDGF),":[145],"however,":[146],"can":[147,176],"be":[148],"double-edged":[150],"sword.":[151],"While":[152],"PDGF":[153,228],"has":[154,220],"been":[155],"defined":[156],"neuroprotective":[159],"concert":[163],"with":[164],"other":[165],"inflammatory":[166],"mediators":[167],"(elicited":[168],"HIV":[170,207,288],"or":[171],"its":[172],"protein":[173,290],"products),":[174],"it":[175,329],"tip":[177],"balance":[179],"from":[180,218],"toxic":[185],"state":[186],"CNS.":[189],"Herein,":[190],"we":[191],"present":[192],"overview":[194],"some":[196],"essential":[199],"elements":[200],"cerebral":[203],"neuropathogenesis":[208],"including":[209],"role":[211,273],"(PDGF)":[216],"released":[217],"astrocytes":[219,234,246,286,327],"exacerbating":[222],"HAND.":[223,264],"Out":[224],"various":[227],"isoforms,":[229],"PDGF-BB":[230,243,275,324],"hence":[236],"focus":[239],"our":[241,279],"study.":[242],"exposure":[244,284],"results":[247,292],"astrogliosis":[249,308],"release":[251,295],"chemokine":[254],"monocyte":[255],"chemotactic":[256],"protein-1":[257],"(MCP-1),":[258],"two":[260],"hallmark":[261],"features":[262],"To":[265],"further":[266],"understand":[267],"these":[268],"observations":[269],"explore":[271,320],"regulation":[276,325],"HAND,":[278],"hypothesis":[281],"transactivating":[289],"Tat":[291],"factors":[298],"PDGF-BB,":[301],"which":[302],"could":[303],"ultimately":[304],"lead":[305],"enhanced":[307],"blood-brain":[310],"barrier(BBB)":[311],"disruption.":[312],"The":[313],"aim":[314],"this":[316],"study":[317],"was":[318],"mechanism":[322],"relates":[330],"HAND":[332],"pathogenesis.":[333]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}