{"id":"https://openalex.org/W835853404","doi":null,"title":"High-Throughput Analysis of the Intestinal Microbiota in Clostridium Difficile-Associated Disease","display_name":"High-Throughput Analysis of the Intestinal Microbiota in Clostridium Difficile-Associated Disease","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W835853404","mag":"835853404"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10147286","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","pdf_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069560490","display_name":"Adam M. Berg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069560490"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-difficile-associated-disease","display_name":"Clostridium difficile-associated disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antibiotic-associated-dysbiosis","display_name":"antibiotic-induced dysbiosis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/colonization-resistance","display_name":"colonization resistance","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.7960000038146973},{"id":"https://openalex.org/keywords/microbiota-composition","display_name":"microbiota composition","score":0.6150000095367432},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.671999990940094},{"id":"https://openalex.org/keywords/microbiome-profiling","display_name":"microbiome profiling","score":0.49399998784065247},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.8298954963684082},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5064119100570679},{"id":"https://openalex.org/C2781092032","wikidata":"https://www.wikidata.org/wiki/Q327663","display_name":"Clostridium","level":3,"score":0.48584267497062683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4846065938472748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4484104812145233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34511950612068176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24774619936943054},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1646597683429718},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16105961799621582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08416905999183655}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10147286","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","pdf_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/28143","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/28143","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:835853404","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579209","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10147286","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","pdf_url":"https://figshare.com/articles/thesis/High-Throughput_Analysis_of_the_Intestinal_Microbiota_in_Clostridium_Difficile-Associated_Disease/10147286","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W835853404.pdf","grobid_xml":"https://content.openalex.org/works/W835853404.grobid-xml"},"referenced_works_count":383,"referenced_works":["https://openalex.org/W43831812","https://openalex.org/W211910875","https://openalex.org/W419388793","https://openalex.org/W606987418","https://openalex.org/W1231996581","https://openalex.org/W1431584087","https://openalex.org/W1482554523","https://openalex.org/W1511823445","https://openalex.org/W1530269410","https://openalex.org/W1530832870","https://openalex.org/W1532327591","https://openalex.org/W1540359912","https://openalex.org/W1540397453","https://openalex.org/W1558982506","https://openalex.org/W1566458213","https://openalex.org/W1566973164","https://openalex.org/W1576056687","https://openalex.org/W1581592599","https://openalex.org/W1598363147","https://openalex.org/W1598574080","https://openalex.org/W1599516835","https://openalex.org/W1701869895","https://openalex.org/W1706992259","https://openalex.org/W1750708191","https://openalex.org/W1758131994","https://openalex.org/W1761524968","https://openalex.org/W1770972723","https://openalex.org/W1785063242","https://openalex.org/W1809561724","https://openalex.org/W1832474145","https://openalex.org/W1874668543","https://openalex.org/W1878193911","https://openalex.org/W1891948122","https://openalex.org/W1918745966","https://openalex.org/W1937965543","https://openalex.org/W1940704816","https://openalex.org/W1963573192","https://openalex.org/W1965895403","https://openalex.org/W1967821667","https://openalex.org/W1967850793","https://openalex.org/W1970428833","https://openalex.org/W1971415551","https://openalex.org/W1977431919","https://openalex.org/W1978673080","https://openalex.org/W1979080859","https://openalex.org/W1980914602","https://openalex.org/W1981592019","https://openalex.org/W1981890438","https://openalex.org/W1981939647","https://openalex.org/W1982302677","https://openalex.org/W1983086029","https://openalex.org/W1983972858","https://openalex.org/W1984412453","https://openalex.org/W1984474722","https://openalex.org/W1985197139","https://openalex.org/W1987184081","https://openalex.org/W1988112148","https://openalex.org/W1988925586","https://openalex.org/W1990405289","https://openalex.org/W1990487336","https://openalex.org/W1990853496","https://openalex.org/W1991486768","https://openalex.org/W1991829808","https://openalex.org/W1991882532","https://openalex.org/W1992563129","https://openalex.org/W1993351732","https://openalex.org/W1995962575","https://openalex.org/W1996374882","https://openalex.org/W1996796956","https://openalex.org/W1997484087","https://openalex.org/W1998601670","https://openalex.org/W1998902908","https://openalex.org/W1999195817","https://openalex.org/W2000072710","https://openalex.org/W2000259070","https://openalex.org/W2000545144","https://openalex.org/W2000550931","https://openalex.org/W2001531805","https://openalex.org/W2001561218","https://openalex.org/W2001616480","https://openalex.org/W2002128729","https://openalex.org/W2002941870","https://openalex.org/W2003485756","https://openalex.org/W2003788503","https://openalex.org/W2005089459","https://openalex.org/W2006512810","https://openalex.org/W2007268783","https://openalex.org/W2009358143","https://openalex.org/W2009635585","https://openalex.org/W2010421806","https://openalex.org/W2010995019","https://openalex.org/W2013032478","https://openalex.org/W2014444740","https://openalex.org/W2016376041","https://openalex.org/W2016854628","https://openalex.org/W2017027430","https://openalex.org/W2017425843","https://openalex.org/W2017428076","https://openalex.org/W2017529960","https://openalex.org/W2017598603","https://openalex.org/W2018599132","https://openalex.org/W2018964155","https://openalex.org/W2020913417","https://openalex.org/W2025069365","https://openalex.org/W2025583382","https://openalex.org/W2025986883","https://openalex.org/W2026074634","https://openalex.org/W2026476601","https://openalex.org/W2027941603","https://openalex.org/W2028030178","https://openalex.org/W2028082957","https://openalex.org/W2030154486","https://openalex.org/W2030165415","https://openalex.org/W2030364983","https://openalex.org/W2031611770","https://openalex.org/W2031932327","https://openalex.org/W2032605132","https://openalex.org/W2032678548","https://openalex.org/W2033699060","https://openalex.org/W2034082915","https://openalex.org/W2034313449","https://openalex.org/W2034469347","https://openalex.org/W2034987674","https://openalex.org/W2035907483","https://openalex.org/W2036562107","https://openalex.org/W2036647435","https://openalex.org/W2037013509","https://openalex.org/W2037833069","https://openalex.org/W2038838030","https://openalex.org/W2039079048","https://openalex.org/W2039381534","https://openalex.org/W2040556005","https://openalex.org/W2040693077","https://openalex.org/W2041054643","https://openalex.org/W2042411241","https://openalex.org/W2044219890","https://openalex.org/W2047666712","https://openalex.org/W2047703946","https://openalex.org/W2049094395","https://openalex.org/W2049480710","https://openalex.org/W2050153593","https://openalex.org/W2051163560","https://openalex.org/W2052313066","https://openalex.org/W2052969143","https://openalex.org/W2053235173","https://openalex.org/W2053462745","https://openalex.org/W2055043387","https://openalex.org/W2055615060","https://openalex.org/W2056010853","https://openalex.org/W2056857250","https://openalex.org/W2057198053","https://openalex.org/W2057290520","https://openalex.org/W2057876155","https://openalex.org/W2058746265","https://openalex.org/W2058839892","https://openalex.org/W2059850119","https://openalex.org/W2061016076","https://openalex.org/W2064187509","https://openalex.org/W2064641442","https://openalex.org/W2064642161","https://openalex.org/W2065605458","https://openalex.org/W2065854492","https://openalex.org/W2066452478","https://openalex.org/W2066684304","https://openalex.org/W2067537975","https://openalex.org/W2067665219","https://openalex.org/W2068619078","https://openalex.org/W2068687524","https://openalex.org/W2072315314","https://openalex.org/W2072417345","https://openalex.org/W2072556768","https://openalex.org/W2072812562","https://openalex.org/W2073332363","https://openalex.org/W2073539942","https://openalex.org/W2075833753","https://openalex.org/W2075892592","https://openalex.org/W2076621797","https://openalex.org/W2078225590","https://openalex.org/W2078336838","https://openalex.org/W2080283023","https://openalex.org/W2080370020","https://openalex.org/W2081218339","https://openalex.org/W2081411589","https://openalex.org/W2082092506","https://openalex.org/W2082682265","https://openalex.org/W2083089709","https://openalex.org/W2083770905","https://openalex.org/W2084193745","https://openalex.org/W2084443943","https://openalex.org/W2085331813","https://openalex.org/W2086219374","https://openalex.org/W2087292184","https://openalex.org/W2087484128","https://openalex.org/W2088170018","https://openalex.org/W2088170171","https://openalex.org/W2088974713","https://openalex.org/W2090925778","https://openalex.org/W2091922579","https://openalex.org/W2092534111","https://openalex.org/W2092696502","https://openalex.org/W2092800150","https://openalex.org/W2093069928","https://openalex.org/W2093917326","https://openalex.org/W2095040140","https://openalex.org/W2095132285","https://openalex.org/W2096625211","https://openalex.org/W2097146199","https://openalex.org/W2097383747","https://openalex.org/W2097457987","https://openalex.org/W2097673919","https://openalex.org/W2098757354","https://openalex.org/W2099119185","https://openalex.org/W2099198339","https://openalex.org/W2099751670","https://openalex.org/W2099817249","https://openalex.org/W2100622130","https://openalex.org/W2101120467","https://openalex.org/W2101272820","https://openalex.org/W2102350205","https://openalex.org/W2102746137","https://openalex.org/W2103124900","https://openalex.org/W2103358577","https://openalex.org/W2103376979","https://openalex.org/W2103903744","https://openalex.org/W2104037158","https://openalex.org/W2105043986","https://openalex.org/W2105108085","https://openalex.org/W2105329815","https://openalex.org/W2105776288","https://openalex.org/W2106317612","https://openalex.org/W2106519203","https://openalex.org/W2106694537","https://openalex.org/W2106829739","https://openalex.org/W2107352655","https://openalex.org/W2107594154","https://openalex.org/W2107677337","https://openalex.org/W2108018752","https://openalex.org/W2108975442","https://openalex.org/W2109276717","https://openalex.org/W2109744701","https://openalex.org/W2109843135","https://openalex.org/W2110065044","https://openalex.org/W2110221742","https://openalex.org/W2111416182","https://openalex.org/W2111458006","https://openalex.org/W2111858111","https://openalex.org/W2113256118","https://openalex.org/W2113678392","https://openalex.org/W2113820646","https://openalex.org/W2116329881","https://openalex.org/W2116531370","https://openalex.org/W2116844657","https://openalex.org/W2116872861","https://openalex.org/W2117463772","https://openalex.org/W2117727476","https://openalex.org/W2118526609","https://openalex.org/W2118695222","https://openalex.org/W2120423769","https://openalex.org/W2120529603","https://openalex.org/W2120700667","https://openalex.org/W2122047626","https://openalex.org/W2122421045","https://openalex.org/W2122435279","https://openalex.org/W2123366827","https://openalex.org/W2124006710","https://openalex.org/W2124351063","https://openalex.org/W2124937554","https://openalex.org/W2125145071","https://openalex.org/W2125498037","https://openalex.org/W2125826054","https://openalex.org/W2125934305","https://openalex.org/W2126012074","https://openalex.org/W2126570610","https://openalex.org/W2127508137","https://openalex.org/W2127634163","https://openalex.org/W2127922913","https://openalex.org/W2128114769","https://openalex.org/W2129297365","https://openalex.org/W2129785704","https://openalex.org/W2129994723","https://openalex.org/W2130077037","https://openalex.org/W2130596438","https://openalex.org/W2130984115","https://openalex.org/W2131123698","https://openalex.org/W2131150306","https://openalex.org/W2131902769","https://openalex.org/W2131988453","https://openalex.org/W2134416902","https://openalex.org/W2135164316","https://openalex.org/W2135256281","https://openalex.org/W2135465392","https://openalex.org/W2135526183","https://openalex.org/W2135747924","https://openalex.org/W2136325639","https://openalex.org/W2136879569","https://openalex.org/W2137653635","https://openalex.org/W2137844026","https://openalex.org/W2138084574","https://openalex.org/W2138253380","https://openalex.org/W2138492548","https://openalex.org/W2139346593","https://openalex.org/W2139607253","https://openalex.org/W2139828607","https://openalex.org/W2139941178","https://openalex.org/W2140492232","https://openalex.org/W2141846515","https://openalex.org/W2142149155","https://openalex.org/W2142503351","https://openalex.org/W2142536690","https://openalex.org/W2144568881","https://openalex.org/W2145336165","https://openalex.org/W2145664556","https://openalex.org/W2145817938","https://openalex.org/W2146074997","https://openalex.org/W2146301357","https://openalex.org/W2146401071","https://openalex.org/W2146516445","https://openalex.org/W2146615689","https://openalex.org/W2147618390","https://openalex.org/W2147619435","https://openalex.org/W2147783737","https://openalex.org/W2148790592","https://openalex.org/W2148908418","https://openalex.org/W2149348195","https://openalex.org/W2151141101","https://openalex.org/W2151532303","https://openalex.org/W2151579021","https://openalex.org/W2151742889","https://openalex.org/W2152054335","https://openalex.org/W2152076149","https://openalex.org/W2152417392","https://openalex.org/W2152555393","https://openalex.org/W2152805980","https://openalex.org/W2152997725","https://openalex.org/W2153456263","https://openalex.org/W2153896859","https://openalex.org/W2154026962","https://openalex.org/W2154969423","https://openalex.org/W2155770880","https://openalex.org/W2155776392","https://openalex.org/W2155806125","https://openalex.org/W2157016955","https://openalex.org/W2157071436","https://openalex.org/W2157800726","https://openalex.org/W2158795865","https://openalex.org/W2158885600","https://openalex.org/W2158887145","https://openalex.org/W2159482845","https://openalex.org/W2159590190","https://openalex.org/W2159748283","https://openalex.org/W2160251091","https://openalex.org/W2161645441","https://openalex.org/W2161817666","https://openalex.org/W2162266792","https://openalex.org/W2162578061","https://openalex.org/W2163287630","https://openalex.org/W2164640614","https://openalex.org/W2165065263","https://openalex.org/W2165067288","https://openalex.org/W2165407078","https://openalex.org/W2165924947","https://openalex.org/W2166130574","https://openalex.org/W2166171121","https://openalex.org/W2167730457","https://openalex.org/W2167766152","https://openalex.org/W2168542758","https://openalex.org/W2169330513","https://openalex.org/W2170024099","https://openalex.org/W2171571559","https://openalex.org/W2173924792","https://openalex.org/W2177846120","https://openalex.org/W2187883617","https://openalex.org/W2206647875","https://openalex.org/W2277430674","https://openalex.org/W2321525077","https://openalex.org/W2331725203","https://openalex.org/W2335836975","https://openalex.org/W2341427843","https://openalex.org/W2462261126","https://openalex.org/W2612494021","https://openalex.org/W2930291257","https://openalex.org/W4229591924","https://openalex.org/W7063219147"],"related_works":["https://openalex.org/W2569342617","https://openalex.org/W4255311902","https://openalex.org/W3154018397","https://openalex.org/W190399827","https://openalex.org/W4230519615","https://openalex.org/W6929447624","https://openalex.org/W2164640614","https://openalex.org/W2611697575","https://openalex.org/W2069894149","https://openalex.org/W2085654814"],"abstract_inverted_index":{"The":[0,18,61,165],"nosocomial":[1],"pathogen":[2],"Clostridium":[3,64,163,202],"difficile":[4],"is":[5,68,88,121],"normally":[6],"unable":[7],"to":[8,15,85,130,160,172,223],"thrive":[9],"in":[10,228],"the":[11,21,41,86,95,100,112,115,118,123,126,131,135,148,151,168,174,218,225,233,240,245],"human":[12],"gut":[13],"due":[14],"colonisation":[16,58,161],"resistance.":[17],"presence":[19],"of":[20,40,44,50,94,99,104,117,125,134,153,167,176,179,210,235,239,247],"normal":[22],"intestinal":[23,211,226],"bacteria":[24,227],"prevents":[25],"its":[26],"proliferation":[27],"through":[28],"competition":[29],"for":[30,79,92,258],"nutrients,":[31],"or":[32],"via":[33],"other":[34,97],"mechanisms":[35],"as":[36,47,107],"yet":[37,108],"unknown.":[38],"Disruption":[39],"standard":[42],"flora":[43,152],"an":[45,89],"individual":[46],"a":[48,73,141,177,229],"result":[49],"antibiotic":[51],"administration":[52],"attenuates":[53],"this":[54],"resistance":[55],"such":[56],"that":[57,122],"can":[59],"occur.":[60],"resultant":[62],"infection,":[63],"difficile-associated":[65],"disease":[66],"(CDAD),":[67],"potentially":[69],"life-threatening,":[70],"and":[71,76,102,184,204,250],"represents":[72],"considerable":[74],"financial":[75],"logistical":[77],"burden":[78],"healthcare":[80],"institutions.":[81],"\\n":[82],"While":[83],"exposure":[84],"microbe":[87],"absolute":[90],"pre-requisite":[91],"development":[93,246],"disease,":[96],"aspects":[98],"epidemiology":[101],"pathogenesis":[103],"CDAD":[105],"are":[106,157],"incompetely":[109],"defined.":[110],"However,":[111],"hypothesis":[113],"at":[114],"core":[116],"current":[119,169],"research":[120,170,241],"composition":[124],"microbiota":[127,175],"may":[128,139],"contribute":[129],"multifactorial":[132],"nature":[133],"infection:":[136],"certain":[137],"individuals":[138,180],"have":[140],"microbiotic":[142],"fingerprint":[143],"which":[144],"confers":[145],"protection":[146],"against":[147],"pathogen,":[149],"while":[150],"others":[154],"means":[155],"they":[156],"more":[158],"susceptible":[159],"by":[162,201],"difficile.\\n":[164],"aim":[166],"was":[171,221],"investigate":[173],"number":[178],"treated":[181],"with":[182,254],"antibiotics":[183],"subsequently":[185],"falling":[186],"into":[187],"3":[188],"distinct":[189],"groups;":[190],"those":[191,195,205],"who":[192,196,206],"contracted":[193],"CDAD;":[194],"developed":[197],"diarrhoea":[198],"not":[199],"caused":[200],"difficile;":[203],"displayed":[207],"no":[208],"evidence":[209],"disruption.":[212],"To":[213],"identify":[214],"substantive":[215],"differences":[216],"between":[217],"groups":[219],"it":[220],"essential":[222],"characterise":[224],"comprehensive":[230],"manner,":[231],"beyond":[232],"potential":[234],"existing":[236],"techniques.":[237],"Achievement":[238],"objective":[242],"thus":[243],"necessitated":[244],"novel":[248],"array":[249],"sequencing":[251],"approaches,":[252],"along":[253],"complementary":[255],"bioinformatic":[256],"pipelines":[257],"analysis.":[259]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}