{"id":"https://openalex.org/W83537016","doi":null,"title":"Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition","display_name":"Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W83537016","mag":"83537016"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-206069","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206069","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206069","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024050557","display_name":"Alfhild Gr\u00f6nbladh","orcid":"https://orcid.org/0000-0001-9780-4168","observed_orcids":["https://orcid.org/0000-0001-9780-4168"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alfhild Gr\u00f6nbladh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9780-4168","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024050557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anabolic-androgenic-steroids","display_name":"anabolic steroids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nandrolone-decanoate","display_name":"nandrolone decanoate","score":1.0},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7459999918937683},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.921999990940094},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9750000238418579},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8450000286102295},{"id":"https://openalex.org/keywords/growth-hormone-receptor","display_name":"growth hormone receptor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neurochemistry","display_name":"neurochemistry","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-induced-cognitive-impairment","display_name":"drug-induced cognitive impairment","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.7156339883804321},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.7046105265617371},{"id":"https://openalex.org/C2908663871","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Anabolic-Androgenic Steroids","level":3,"score":0.5688738226890564},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5679188370704651},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5652874708175659},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5598609447479248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5399333238601685},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.49645572900772095},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4875776171684265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44406843185424805},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3541562259197235},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2683972716331482},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.19191962480545044}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-206069","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206069","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:83537016","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:643425","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-206069","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206069","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":252,"referenced_works":["https://openalex.org/W22860145","https://openalex.org/W1483365010","https://openalex.org/W1488424161","https://openalex.org/W1524314405","https://openalex.org/W1529983368","https://openalex.org/W1535834717","https://openalex.org/W1542371499","https://openalex.org/W1571586310","https://openalex.org/W1581458838","https://openalex.org/W1591517178","https://openalex.org/W1654156243","https://openalex.org/W1686581241","https://openalex.org/W1864437270","https://openalex.org/W1964056343","https://openalex.org/W1964122573","https://openalex.org/W1967383091","https://openalex.org/W1968827204","https://openalex.org/W1970235212","https://openalex.org/W1970996040","https://openalex.org/W1971085935","https://openalex.org/W1971468043","https://openalex.org/W1971755585","https://openalex.org/W1972011011","https://openalex.org/W1972270480","https://openalex.org/W1973015253","https://openalex.org/W1973859796","https://openalex.org/W1974483157","https://openalex.org/W1974892244","https://openalex.org/W1976113375","https://openalex.org/W1976276194","https://openalex.org/W1977747054","https://openalex.org/W1977913176","https://openalex.org/W1978905596","https://openalex.org/W1979434195","https://openalex.org/W1980504779","https://openalex.org/W1980563645","https://openalex.org/W1982685226","https://openalex.org/W1984214648","https://openalex.org/W1984414350","https://openalex.org/W1984620374","https://openalex.org/W1986161955","https://openalex.org/W1987910229","https://openalex.org/W1988366400","https://openalex.org/W1988812517","https://openalex.org/W1989002274","https://openalex.org/W1989448227","https://openalex.org/W1990076171","https://openalex.org/W1990355134","https://openalex.org/W1990367576","https://openalex.org/W1991205571","https://openalex.org/W1992622058","https://openalex.org/W1995216212","https://openalex.org/W1995321663","https://openalex.org/W1995486400","https://openalex.org/W1995958227","https://openalex.org/W1996554590","https://openalex.org/W1997425589","https://openalex.org/W1998468933","https://openalex.org/W2000125000","https://openalex.org/W2000754762","https://openalex.org/W2001091045","https://openalex.org/W2002109161","https://openalex.org/W2002748611","https://openalex.org/W2003656057","https://openalex.org/W2005355707","https://openalex.org/W2006072112","https://openalex.org/W2006485431","https://openalex.org/W2006629782","https://openalex.org/W2007570747","https://openalex.org/W2008158760","https://openalex.org/W2008418293","https://openalex.org/W2008521981","https://openalex.org/W2010715554","https://openalex.org/W2010735689","https://openalex.org/W2011645297","https://openalex.org/W2013733809","https://openalex.org/W2014156441","https://openalex.org/W2014309820","https://openalex.org/W2017120126","https://openalex.org/W2017793291","https://openalex.org/W2020033147","https://openalex.org/W2020229546","https://openalex.org/W2020764643","https://openalex.org/W2022219818","https://openalex.org/W2022376135","https://openalex.org/W2022541264","https://openalex.org/W2023055302","https://openalex.org/W2023471562","https://openalex.org/W2024394264","https://openalex.org/W2025206161","https://openalex.org/W2025864476","https://openalex.org/W2025974332","https://openalex.org/W2026577028","https://openalex.org/W2029783241","https://openalex.org/W2030037258","https://openalex.org/W2030236055","https://openalex.org/W2030288866","https://openalex.org/W2030997373","https://openalex.org/W2032673083","https://openalex.org/W2033040272","https://openalex.org/W2033503688","https://openalex.org/W2033630088","https://openalex.org/W2033702782","https://openalex.org/W2033964653","https://openalex.org/W2034323087","https://openalex.org/W2034446662","https://openalex.org/W2035000549","https://openalex.org/W2035069150","https://openalex.org/W2035854501","https://openalex.org/W2036007062","https://openalex.org/W2036371043","https://openalex.org/W2038425446","https://openalex.org/W2038874446","https://openalex.org/W2039490460","https://openalex.org/W2040649843","https://openalex.org/W2040888475","https://openalex.org/W2040999909","https://openalex.org/W2041292180","https://openalex.org/W2041908043","https://openalex.org/W2043077389","https://openalex.org/W2043688619","https://openalex.org/W2045517212","https://openalex.org/W2046044139","https://openalex.org/W2047102142","https://openalex.org/W2049141458","https://openalex.org/W2049511526","https://openalex.org/W2049830756","https://openalex.org/W2049986534","https://openalex.org/W2050581082","https://openalex.org/W2052225445","https://openalex.org/W2052376299","https://openalex.org/W2054229227","https://openalex.org/W2055243341","https://openalex.org/W2055488174","https://openalex.org/W2056716856","https://openalex.org/W2058849359","https://openalex.org/W2059506882","https://openalex.org/W2062033941","https://openalex.org/W2062967169","https://openalex.org/W2063972644","https://openalex.org/W2064715640","https://openalex.org/W2066991732","https://openalex.org/W2068187158","https://openalex.org/W2069842478","https://openalex.org/W2070009149","https://openalex.org/W2070160790","https://openalex.org/W2070645131","https://openalex.org/W2071253111","https://openalex.org/W2071595515","https://openalex.org/W2072235551","https://openalex.org/W2072357288","https://openalex.org/W2073152302","https://openalex.org/W2074071945","https://openalex.org/W2074257075","https://openalex.org/W2074417504","https://openalex.org/W2074826984","https://openalex.org/W2074840300","https://openalex.org/W2076101724","https://openalex.org/W2077462719","https://openalex.org/W2080403057","https://openalex.org/W2080710150","https://openalex.org/W2082023748","https://openalex.org/W2082047348","https://openalex.org/W2082072773","https://openalex.org/W2082445013","https://openalex.org/W2082573808","https://openalex.org/W2083240331","https://openalex.org/W2083954196","https://openalex.org/W2085124463","https://openalex.org/W2086099814","https://openalex.org/W2086452840","https://openalex.org/W2087675056","https://openalex.org/W2089845502","https://openalex.org/W2089846692","https://openalex.org/W2091664769","https://openalex.org/W2092483615","https://openalex.org/W2093730240","https://openalex.org/W2096931520","https://openalex.org/W2098735718","https://openalex.org/W2099976824","https://openalex.org/W2102123572","https://openalex.org/W2102385712","https://openalex.org/W2102420653","https://openalex.org/W2103997244","https://openalex.org/W2105508233","https://openalex.org/W2107366093","https://openalex.org/W2108482445","https://openalex.org/W2108529838","https://openalex.org/W2109494488","https://openalex.org/W2110469184","https://openalex.org/W2112267904","https://openalex.org/W2115235046","https://openalex.org/W2118726420","https://openalex.org/W2118775306","https://openalex.org/W2119593044","https://openalex.org/W2119788334","https://openalex.org/W2120108803","https://openalex.org/W2121855288","https://openalex.org/W2124483177","https://openalex.org/W2124517960","https://openalex.org/W2125450316","https://openalex.org/W2126846194","https://openalex.org/W2128594541","https://openalex.org/W2128801271","https://openalex.org/W2129143684","https://openalex.org/W2130222325","https://openalex.org/W2130414446","https://openalex.org/W2132540129","https://openalex.org/W2132957638","https://openalex.org/W2133969927","https://openalex.org/W2135470636","https://openalex.org/W2136108338","https://openalex.org/W2136309995","https://openalex.org/W2136833539","https://openalex.org/W2139287811","https://openalex.org/W2139502395","https://openalex.org/W2139676310","https://openalex.org/W2140041042","https://openalex.org/W2140991966","https://openalex.org/W2141685811","https://openalex.org/W2144897021","https://openalex.org/W2145235967","https://openalex.org/W2145988372","https://openalex.org/W2146145065","https://openalex.org/W2149900811","https://openalex.org/W2150759685","https://openalex.org/W2151025762","https://openalex.org/W2151061730","https://openalex.org/W2154104720","https://openalex.org/W2155518354","https://openalex.org/W2155552431","https://openalex.org/W2156869534","https://openalex.org/W2156908503","https://openalex.org/W2157252436","https://openalex.org/W2159074414","https://openalex.org/W2159853544","https://openalex.org/W2161322400","https://openalex.org/W2163552968","https://openalex.org/W2163815564","https://openalex.org/W2163865122","https://openalex.org/W2165867905","https://openalex.org/W2166935415","https://openalex.org/W2169473035","https://openalex.org/W2171140194","https://openalex.org/W2171880836","https://openalex.org/W2172138018","https://openalex.org/W2172256092","https://openalex.org/W2318782547","https://openalex.org/W2410446460","https://openalex.org/W2472179893","https://openalex.org/W2749190633","https://openalex.org/W4388158039"],"related_works":["https://openalex.org/W2016787502","https://openalex.org/W2023704305","https://openalex.org/W2321224022","https://openalex.org/W2076414649","https://openalex.org/W2095958739","https://openalex.org/W7008148765","https://openalex.org/W2388435933","https://openalex.org/W211520144","https://openalex.org/W581104131","https://openalex.org/W2042300641"],"abstract_inverted_index":{"Growth":[0],"hormone":[1],"(GH)":[2],"stimulates":[3],"growth":[4],"and":[5,21,23,43,57,60,87,91,98,107,143,191,204,222,227,240,266,271,292],"metabolism":[6],"but":[7,164],"also":[8,156,205],"displays":[9],"profound":[10],"effects":[11,181,186,237],"on":[12,89,182,187,195,244,263],"the":[13,32,72,83,99,137,146,158,166,174,179,188,196,207,213,218,224,232,264,281,297,303],"central":[14],"nervous":[15],"system":[16],"(CNS).":[17],"GH":[18,59,86,96,122,133,155,180,239,270,288,306],"affects":[19,293],"neurogenesis":[20],"neuroprotection,":[22],"has":[24],"been":[25],"shown":[26],"to":[27,65,80,113,199],"counteract":[28],"drug-induced":[29,309],"apoptosis":[30],"in":[31,71,108,127,145,150,173,212,231,296],"brain.":[33,175,214],"Anabolic":[34],"androgenic":[35],"steroids":[36],"(AAS),":[37],"mainly":[38],"abused":[39],"for":[40,148],"their":[41],"anabolic":[42],"performance-enhancing":[44],"properties,":[45],"can":[46,307],"cause":[47],"several":[48,68],"adverse":[49],"effects,":[50],"such":[51],"as":[52,250,252],"cardiovascular":[53],"complications,":[54],"sterility,":[55],"depression,":[56],"aggression.":[58],"AAS":[61,88,285],"are":[62,278],"both":[63],"believed":[64],"interact":[66],"with":[67,110,153,260,300],"signaling":[69,294],"systems":[70,295],"CNS.":[73],"The":[74,116,274],"aim":[75],"of":[76,85,121,136,178,202,238,269,284],"this":[77,257],"thesis":[78,258],"was":[79],"further":[81,261,312],"investigate":[82],"impact":[84],"neurochemistry":[90],"cognitive":[92,265],"functions.":[93],"Recombinant":[94],"human":[95],"(rhGH)":[97],"steroid":[100,246],"nandrolone":[101],"decanoate":[102],"(ND)":[103],"were":[104,242],"administered,":[105],"separately":[106],"combination":[109],"each":[111],"other,":[112],"male":[114],"rats.":[115],"results":[117],"demonstrated":[118],"that":[119,305],"administration":[120],"improved":[123],"spatial":[124],"memory,":[125],"assessed":[126],"a":[128],"water":[129],"maze":[130],"test.":[131],"Furthermore,":[132,215],"induced":[134],"alterations":[135],"GABAB":[138,189,208],"receptor":[139,171,209],"mRNA":[140,210,229],"expression,":[141],"density,":[142],"functionality":[144,172],"brain,":[147],"example":[149],"regions":[151],"associated":[152,299],"cognition.":[154],"altered":[157,206],"mu":[159],"opioid":[160,168],"peptide":[161,169],"(MOP)":[162],"receptor,":[163],"not":[165],"delta":[167],"(DOP)":[170],"Thus,":[176],"some":[177],"cognition":[183],"may":[184],"involve":[185],"receptors":[190],"MOP":[192],"receptors.":[193],"ND,":[194],"contrary,":[197],"seemed":[198],"induce":[200],"impairments":[201,310],"memory":[203,290],"expression":[211,230],"ND":[216,241,272,277],"lowered":[217],"IGF-1":[219],"plasma":[220,245],"concentrations":[221],"attenuated":[223],"IGF-1,":[225],"IGF-2,":[226],"GHR":[228],"pituitary.":[233],"In":[234,255],"addition,":[235],"significant":[236],"found":[243],"concentrations,":[247],"organ":[248],"weight,":[249],"well":[251],"body":[253],"weight.":[254],"conclusion,":[256],"contributes":[259],"knowledge":[262],"neurochemical":[267],"consequences":[268],"use.":[273],"findings":[275],"regarding":[276],"worrying":[279],"considering":[280],"common":[282],"use":[283],"among":[286],"adolescents.":[287],"improves":[289],"functions":[291],"brain":[298],"cognition,":[301],"hence":[302],"hypothesis":[304],"reverse":[308],"is":[311],"strengthened.":[313]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
