{"id":"https://openalex.org/W833135644","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","title":"Hyaluronan Mediates Cardiac Myocyte Phenotypic Response","display_name":"Hyaluronan Mediates Cardiac Myocyte Phenotypic Response","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W833135644","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","mag":"833135644"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.25.1_supplement.1128.1","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Victor Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Lin","raw_affiliation_strings":["Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038484024","display_name":"Anant Chopra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anant Chopra","raw_affiliation_strings":["Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028268542","display_name":"Paul A. Janmey","orcid":"https://orcid.org/0000-0002-3495-3286","observed_orcids":["https://orcid.org/0000-0002-3495-3286"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Janmey","raw_affiliation_strings":["University of PennsylvaniaPhiladelphiaPA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of PennsylvaniaPhiladelphiaPA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072324498","display_name":"J. Yasha Kresh","orcid":"https://orcid.org/0000-0001-5573-6507","observed_orcids":["https://orcid.org/0000-0001-5573-6507"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Yasha Kresh","raw_affiliation_strings":["Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic SurgeryDrexel University College of MedicinePhiladelphiaPA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06634916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.30149999260902405,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.09309999644756317,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neonatal-cardiomyocytes","display_name":"neonatal cardiomyocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cardiac-extracellular-matrix","display_name":"cardiac extracellular matrix","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/biomimetic-microenvironment","display_name":"biomimetic microenvironment","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myofibril-assembly","display_name":"myofibril assembly","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cardiomyocyte-phenotype","display_name":"cardiomyocyte phenotype","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8510000109672546},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-contractility","display_name":"cell contractility","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7462971806526184},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6943057179450989},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.6755877733230591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.403203547000885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40210914611816406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38271626830101013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3802868723869324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23687103390693665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0625283420085907}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.25.1_supplement.1128.1","doi":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.25.1_supplement.1128.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029971013","https://openalex.org/W2917923254","https://openalex.org/W1970846029","https://openalex.org/W3176668341","https://openalex.org/W392953181","https://openalex.org/W7133538343","https://openalex.org/W259124171","https://openalex.org/W49280995","https://openalex.org/W1969364165","https://openalex.org/W2885607631"],"abstract_inverted_index":{"Hyaluronan":[0],"(HA)":[1],"has":[2],"been":[3],"used":[4],"extensively":[5],"for":[6,10,83,119,187],"tissue":[7],"engineering":[8],"approaches":[9],"organ":[11],"repair,":[12],"enhancing":[13],"cellular":[14],"response":[15,37,137],"and":[16,53,71,81,87,98,107,142,157,170,175],"wound":[17],"healing.":[18],"Hyaluronic":[19],"acid":[20],"is":[21],"also":[22],"the":[23,27,36,84,94,150,165],"major":[24],"glycosaminoglycan":[25],"of":[26,38,76,96,117,167],"early":[28],"cardiac":[29,41],"extracellular":[30],"matrix":[31],"(ECM).":[32],"This":[33],"study":[34],"investigated":[35],"neonatal":[39],"ventricular":[40],"myocytes":[42],"(NVRM)":[43],"to":[44,60,92,124,133,144],"HA":[45,56,147,178],"gels":[46,57,131,148,179],"conjugated":[47],"with":[48,181],"ECM":[49,183],"proteins":[50,184],"like":[51],"gelatin":[52],"fibronectin":[54],"(Fbn).":[55],"were":[58,79],"designed":[59],"act":[61],"as":[62,103,105],"a":[63,114,189],"biomimetic":[64],"microenvironment":[65],"aimed":[66],"at":[67],"improving":[68],"myocyte":[69,173],"structure":[70],"function.":[72],"After":[73],"48":[74],"hours":[75],"culture,":[77],"cells":[78],"fixed":[80],"stained":[82],"\u03b1-actinin,":[85],"f-actin,":[86],"CD44.":[88],"qRT-PCR":[89],"was":[90],"performed":[91],"analyze":[93],"expression":[95,118],"\u03b1":[97,123],"\u03b2":[99,128],"myosin":[100,120,125],"heavy":[101,121,126],"chains":[102],"well":[104],"CD44":[106],"integrin":[108],"beta":[109],"1.":[110],"Our":[111],"results":[112,163],"show":[113],"higher":[115],"ratio":[116],"chain":[122,127],"on":[129,172],"Fbn-HA":[130],"compared":[132],"other":[134],"substrates.":[135],"The":[136],"(cell":[138],"shape,":[139],"myofibril":[140,155],"assembly":[141],"organization)":[143],"Fbn":[145],"coated":[146],"exhibited":[149],"largest":[151],"spread":[152],"area,":[153],"organized":[154],"formation,":[156],"contractile":[158],"function":[159],"(105%":[160],"increase).":[161],"These":[162],"implicate":[164],"importance":[166],"ligand":[168],"type":[169],"activity":[171],"remodeling":[174],"suggest":[176],"that":[177],"bound":[180],"specific":[182],"are":[185],"crucial":[186],"inducing/preserving":[188],"normal":[190],"cardiomyocyte":[191],"phenotype.":[192]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}