{"id":"https://openalex.org/W8330563","doi":null,"title":"The separate impact of tight control schemes and disease activity on quality of life in patients with early rheumatoid arthritis: results from the CAMERA trials.","display_name":"The separate impact of tight control schemes and disease activity on quality of life in patients with early rheumatoid arthritis: results from the CAMERA trials.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W8330563","mag":"8330563","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564933"},"language":"en","primary_location":{"id":"pmid:24564933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113730040","display_name":"Maud S. Jurgens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M S Jurgens","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. mjurgens@umcutrecht.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. mjurgens@umcutrecht.nl","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073590530","display_name":"Paco M J Welsing","orcid":"https://orcid.org/0000-0003-2361-2803","observed_orcids":["https://orcid.org/0000-0003-2361-2803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M J Welsing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070570826","display_name":"Rinie Geenen","orcid":"https://orcid.org/0000-0002-6615-6708","observed_orcids":["https://orcid.org/0000-0002-6615-6708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Geenen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021951199","display_name":"Marije F. Bakker","orcid":"https://orcid.org/0000-0002-9287-8827","observed_orcids":["https://orcid.org/0000-0002-9287-8827"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Bakker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111888390","display_name":"Y Schenk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Schenk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108527622","display_name":"Ya\u00ebl A de Man","orcid":"https://orcid.org/0000-0001-7591-0840","observed_orcids":["https://orcid.org/0000-0001-7591-0840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y A de Man","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063928355","display_name":"J. W. J. Bijlsma","orcid":"https://orcid.org/0000-0002-0128-8451","observed_orcids":["https://orcid.org/0000-0002-0128-8451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W J Bijlsma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113758008","display_name":"Floris P. J. G. Lafeber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P J G Lafeber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008286981","display_name":"Johannes W. G. Jacobs","orcid":"https://orcid.org/0000-0002-7438-3468","observed_orcids":["https://orcid.org/0000-0002-7438-3468","https://orcid.org/0000-0003-1584-6933","https://orcid.org/0000-0002-8583-7277","https://orcid.org/0009-0003-7427-5883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W G Jacobs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1587,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76034995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"32","issue":"3","first_page":"369","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9520000219345093},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.984000027179718},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.8309999704360962},{"id":"https://openalex.org/keywords/usual-care","display_name":"usual care","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.943710207939148},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6795858144760132},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6484852433204651},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5625457167625427},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.5313433408737183},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.511816680431366},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5092538595199585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.489255428314209},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4532145857810974},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4452454447746277},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.43325915932655334},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.42801064252853394},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.4131092429161072},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1499922275543213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09083300828933716},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013813","descriptor_name":"Therapy, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:24564933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/395546","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/395546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/395546","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/395546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Experimental Rheumatology, 32(3), 369. Clinical and Experimental Rheumatology S.A.S.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:8330563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2053420045"],"related_works":["https://openalex.org/W2330973721","https://openalex.org/W1578184230","https://openalex.org/W7219201762","https://openalex.org/W2335052360","https://openalex.org/W2131553420","https://openalex.org/W133959754","https://openalex.org/W2134171514","https://openalex.org/W2434375890","https://openalex.org/W2036902803","https://openalex.org/W2025669550"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1,99],"examine":[2],"in":[3,33,95,179,185,224],"patients":[4,38],"with":[5,39,124,127,183],"early":[6,40],"rheumatoid":[7,159],"arthritis":[8],"(RA)":[9],"whether":[10],"quality":[11],"of":[12,16,49,104,151,170,188,195,222],"life":[13],"(QoL),":[14],"independently":[15],"disease":[17,42,97,138,211],"activity,":[18],"is":[19],"affected":[20],"by":[21],"tight":[22,58,80,198,226],"control":[23,59,81,199,227],"treatment":[24,135,172],"strategy":[25,60,82,93,136,228],"schemes.":[26],"METHODS:":[27],"In":[28,85],"the":[29,90,102,128,171,186,196,220],"Computer":[30],"Assisted":[31],"Management":[32],"Early":[34],"RA":[35],"(CAMERA)":[36],"trials,":[37],"RA,":[41],"duration":[43],"<1":[44],"year,":[45],"no":[46,165],"prior":[47],"use":[48],"DMARDs)":[50],"had":[51],"been":[52],"randomised":[53],"to":[54,67,77,89],"a":[55,78,177,209,225],"methotrexate":[56],"(MTX)-based":[57],"or":[61,66,71,219],"usual":[62],"care":[63],"(CAMERA":[64],"study)":[65],"10":[68],"mg/d":[69],"prednisone":[70,223],"placebo":[72],"both":[73],"added":[74],"from":[75],"start":[76],"MTX-based":[79],"(CAMERA-II":[83],"study).":[84],"either":[86,169],"study,":[87],"randomisation":[88],"more":[91],"intensive":[92],"resulted":[94],"lower":[96],"activity.":[98],"assess":[100],"QoL,":[101,175],"'Influence":[103],"Rheumatic":[105],"Diseases":[106],"on":[107,202],"General":[108],"Health":[109],"and":[110,117,134,137,154,174],"Lifestyle'":[111],"questionnaire":[112],"(IRGL)":[113],"was":[114,164,181,204,208],"used.":[115],"Baseline":[116],"1-":[118],"and/or":[119],"2-year":[120],"measurements":[121],"were":[122],"analysed":[123],"regression":[125],"analyses":[126],"IRGL":[129],"(sub)scales":[130],"as":[131,144],"outcome":[132],"variables":[133],"activity":[139,212],"assessing":[140],"28":[141],"joints":[142],"(DAS28)":[143],"independent":[145,193],"variables,":[146],"correcting":[147],"for":[148],"baseline":[149],"values":[150],"each":[152],"scale":[153],"possible":[155],"confounders":[156],"(gender,":[157],"age,":[158],"factor":[160],"status).":[161],"RESULTS:":[162],"There":[163],"clear":[166,210],"association":[167],"between":[168],"strategies":[173,200],"but":[176],"decrease":[178],"DAS28":[180],"associated":[182],"improvement":[184],"majority":[187],"QoL":[189,203],"(sub)scales.":[190],"CONCLUSIONS:":[191],"No":[192],"effect":[194],"specific":[197],"schemes":[201],"found,":[205],"while":[206],"there":[207],"related":[213],"effect.":[214],"Thus":[215],"frequent":[216],"outpatient":[217],"visits":[218],"inclusion":[221],"did":[229],"not":[230],"negatively":[231],"influence":[232],"QoL.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}