{"id":"https://openalex.org/W833051036","doi":null,"title":"The Identification and Characterisation of Novel Proteins and Metabolic Signalling Pathways that Regulate TRAIL-Induced Apoptosis","display_name":"The Identification and Characterisation of Novel Proteins and Metabolic Signalling Pathways that Regulate TRAIL-Induced Apoptosis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W833051036","mag":"833051036"},"language":"en","primary_location":{"id":"pmh:oai:lra.le.ac.uk:2381/10196","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/10196","pdf_url":"http://hdl.handle.net/2381/10196","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2381/10196","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064030048","display_name":"Gemma L. Robinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gemma L. Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064030048"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9210000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/death-inducing-signalling-complex","display_name":"death-inducing signalling complex","score":0.9599999785423279},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8450000286102295},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.9369999766349792},{"id":"https://openalex.org/keywords/transferrin-receptor-1","display_name":"transferrin receptor 1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/trail-receptors","display_name":"TRAIL receptors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7929999828338623},{"id":"https://openalex.org/keywords/abt-737","display_name":"ABT-737","score":0.8479999899864197},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.7931764125823975},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6201099753379822},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5519730448722839},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.550957977771759},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.531972348690033},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5251398086547852},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212308168411255},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4911303222179413},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.4281274080276489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4173656404018402},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.352297306060791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3467123508453369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2642202377319336},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1438833773136139},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08992907404899597}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:lra.le.ac.uk:2381/10196","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/10196","pdf_url":"http://hdl.handle.net/2381/10196","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/992016","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/992016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:figshare.com:article/10104872","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_Identification_and_Characterisation_of_Novel_Proteins_and_Metabolic_Signalling_Pathways_that_Regulate_TRAIL-Induced_Apoptosis/10104872","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:833051036","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lra.le.ac.uk:2381/10196","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/10196","pdf_url":"http://hdl.handle.net/2381/10196","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W833051036.pdf","grobid_xml":"https://content.openalex.org/works/W833051036.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1532865172","https://openalex.org/W1965827991","https://openalex.org/W2002134084","https://openalex.org/W2015533291","https://openalex.org/W2015805559","https://openalex.org/W2024475665","https://openalex.org/W2053894359","https://openalex.org/W2083560313","https://openalex.org/W2094570524","https://openalex.org/W2130846759"],"related_works":["https://openalex.org/W826786236","https://openalex.org/W200158592","https://openalex.org/W1967637444","https://openalex.org/W2169693674","https://openalex.org/W2624907825","https://openalex.org/W2017338209","https://openalex.org/W1964840905","https://openalex.org/W2032077813","https://openalex.org/W2392431971","https://openalex.org/W142277243"],"abstract_inverted_index":{"TNF-related":[0],"apoptosis":[1,26,133],"inducing":[2],"ligand":[3],"(TRAIL)":[4],"is":[5,11,22],"a":[6,30,40,91,162,200,210,231],"putative":[7],"anti-cancer":[8],"cytokine":[9],"that":[10,114,142],"relatively":[12],"specific":[13],"for":[14,98],"transformed":[15],"cells":[16,188,197,222],"however":[17],"Mantle":[18],"Cell":[19],"Lymphoma":[20],"(MCL)":[21],"resistant.":[23],"TRAIL":[24,83],"induces":[25],"through":[27,63],"formation":[28],"of":[29,39,46,60,82,161,185,227],"Death-Inducing":[31],"Signalling":[32],"Complex":[33],"(DISC)":[34],"and":[35,56,67,101,156,206,214],"the":[36,44,54,61,88,115,122,126,143,159,183,225],"successive":[37],"activation":[38],"caspase":[41],"cascade.":[42],"Therefore,":[43],"aims":[45],"this":[47,109,157],"thesis":[48],"were":[49,177,218],"two-fold:":[50],"firstly":[51],"to":[52,69,86,154,173,192,203],"examine":[53],"known":[55,144],"novel":[57,163],"protein":[58],"components":[59],"DISC":[62,89,145,164],"mass":[64,106],"spectrometry":[65],"analysis":[66,104],"second":[68],"determine":[70],"how":[71],"cellular":[72],"metabolism,":[73],"specifically":[74,124],"glucose-deprivation,":[75],"influences":[76],"TRAIL-induced":[77,132,193],"apoptosis.":[78,194],"A":[79],"tagged":[80],"variant":[81],"was":[84,112,140,148,189],"used":[85],"capture":[87],"from":[90],"TRAIL-sensitive":[92],"MCL-derived":[93],"cell":[94],"line":[95],"(Z138)":[96],"allowing":[97],"its":[99],"purification":[100],"subsequent":[102],"proteomic":[103],"by":[105],"spectrometry.":[107],"From":[108],"study,":[110],"it":[111,129,139],"found":[113],"transferrin":[116],"receptor":[117],"(TFR1)":[118],"may":[119],"interact":[120],"with":[121,125],"DISC,":[123],"TRAIL-receptors,":[127],"where":[128],"potentially":[130],"modulates":[131],"and/or":[134],"receptor-mediated":[135],"endocytosis.":[136],"In":[137,171],"addition,":[138],"observed":[141],"component":[146],"FADD":[147],"present":[149],"in":[150,182,224],"sub-stoichiometric":[151],"amounts":[152],"compared":[153],"caspase-8":[155,168],"permitted":[158],"identification":[160],"structure":[165],"based":[166],"on":[167,220],"chain":[169],"formation.":[170],"parallel":[172],"this,":[174],"glucose-deprivation":[175],"studies":[176,217],"performed,":[178],"which":[179,229],"showed":[180,199],"that,":[181],"absence":[184,226],"glucose,":[186,228],"Z138":[187,221],"less":[190],"sensitive":[191],"Furthermore,":[195],"these":[196],"also":[198],"reduced":[201],"sensitivity":[202],"both":[204],"ABT-737":[205],"x-ray":[207],"radiation.":[208],"As":[209],"result,":[211],"proteomic,":[212],"ultra-structural":[213],"gene":[215],"profiling":[216],"performed":[219],"cultured":[223],"demonstrated":[230],"switch":[232],"towards":[233],"an":[234],"anti-apoptotic/pro-survival":[235],"phenotype.":[236]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
