{"id":"https://openalex.org/W83296873","doi":"https://doi.org/10.1055/s-1999-170","title":"Das NO/cGMP-Signaltransduktionssystem: Ein zentraler Angriffspunkt von An\u00e4sthetika?","display_name":"Das NO/cGMP-Signaltransduktionssystem: Ein zentraler Angriffspunkt von An\u00e4sthetika?","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W83296873","doi":"https://doi.org/10.1055/s-1999-170","mag":"83296873","pmid":"https://pubmed.ncbi.nlm.nih.gov/10189520"},"language":"de","primary_location":{"id":"doi:10.1055/s-1999-170","doi":"https://doi.org/10.1055/s-1999-170","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1999-170","pdf_url":null,"source":{"id":"https://openalex.org/S131562361","display_name":"AINS - An\u00e4sthesiologie \u00b7 Intensivmedizin \u00b7 Notfallmedizin \u00b7 Schmerztherapie","issn_l":"0939-2661","issn":["0939-2661","1439-1074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ains \u00b7 An\u00e4sthesiologie \u00b7 Intensivmedizin \u00b7 Notfallmedizin \u00b7 Schmerztherapie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017553592","display_name":"Peter Hans Tonner","orcid":"https://orcid.org/0000-0002-8862-3530","observed_orcids":["https://orcid.org/0000-0002-8862-3530"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. H. Tonner","raw_affiliation_strings":["Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg. tonner@uke.uni-hamburg.de","Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg. tonner@uke.uni-hamburg.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054758916","display_name":"J. Scholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Scholz","raw_affiliation_strings":["Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr An\u00e4sthesiologie, Universit\u00e4ts-Krankenhaus Eppendorf, Hamburg","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.01154957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"2","first_page":"78","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/no-cgmp-signaling","display_name":"NO/cGMP signaling","score":0.902999997138977},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8149999976158142},{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.6610000133514404},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intravenous-anesthetics","display_name":"intravenous anesthetics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8429999947547913},{"id":"https://openalex.org/keywords/no-synthase-inhibitors","display_name":"NO synthase inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.7649999856948853},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.7271263003349304},{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.6317076683044434},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6288735866546631},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5869680047035217},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.5631025433540344},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4636100232601166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4618268609046936},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.45221367478370667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44952598214149475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4457189738750458},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42141348123550415},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36945992708206177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33728262782096863},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2779881954193115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16996726393699646},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.09041696786880493}],"mesh":[{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-1999-170","doi":"https://doi.org/10.1055/s-1999-170","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1999-170","pdf_url":null,"source":{"id":"https://openalex.org/S131562361","display_name":"AINS - An\u00e4sthesiologie \u00b7 Intensivmedizin \u00b7 Notfallmedizin \u00b7 Schmerztherapie","issn_l":"0939-2661","issn":["0939-2661","1439-1074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ains \u00b7 An\u00e4sthesiologie \u00b7 Intensivmedizin \u00b7 Notfallmedizin \u00b7 Schmerztherapie","raw_type":"journal-article"},{"id":"pmid:10189520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10189520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1607164635","https://openalex.org/W2093625880","https://openalex.org/W2046868278","https://openalex.org/W1985881424","https://openalex.org/W2161530914","https://openalex.org/W2415711653","https://openalex.org/W2413495330","https://openalex.org/W2078283568","https://openalex.org/W1590567489","https://openalex.org/W4386470026"],"abstract_inverted_index":{"The":[0,80,92],"identity":[1],"and":[2,12,55,96,173,201],"physiologic":[3],"function":[4],"of":[5,26,43,67,75,94,120,128,130,154,161,169,179,186,197,227],"nitric":[6],"oxide":[7],"(NO)":[8],"as":[9,87,89,99,101,108],"an":[10],"intra-":[11],"intercellular":[13],"transmitter":[14],"substance":[15],"have":[16,46],"only":[17],"been":[18,47,113],"recognized":[19],"during":[20],"the":[21,38,49,52,56,60,68,133,141,145,149,155,159,167,177,183,214,225],"last":[22],"years.":[23],"A":[24],"variety":[25],"tissues":[27],"including":[28],"neuronal":[29,57,198],"tissue":[30],"is":[31,83,158,189],"able":[32],"to":[33,64,115,213],"synthesize":[34],"NO":[35,62,81],"catalysed":[36],"by":[37,85,123],"enzyme":[39,45,69],"NO-synthase.":[40,58],"Three":[41],"isoforms":[42],"this":[44],"described:":[48],"endothelial":[50],"NO-synthase,":[51,54,146],"immunologic":[53],"Within":[59],"cell":[61],"binds":[63],"a":[65],"haeme-moiety":[66],"guanylyl":[70,150],"cyclase":[71],"thus":[72],"increasing":[73],"concentrations":[74],"cyclic":[76],"guanosine":[77],"monophosphate":[78],"(cGMP).":[79],"metabolism":[82],"influenced":[84],"volatile":[86],"well":[88,100],"intravenous":[90,97],"anaesthetics.":[91,229],"action":[93,185,226],"inhalational":[95],"anesthetics":[98],"other":[102,216],"substances":[103],"with":[104,132,206],"hypnotic":[105],"properties":[106],"such":[107],"alpha":[109],"2-adrenoceptor":[110],"agonists":[111],"has":[112],"demonstrated":[114],"be":[116],"increased":[117],"after":[118],"disruption":[119],"NO-synthase":[121,124,199,207],"activity":[122,168,200],"inhibitors.":[125],"Different":[126],"mechanisms":[127],"interaction":[129],"anaesthetics":[131,188],"NO/cGMP":[134,156],"signal":[135,217],"transduction":[136,218],"pathway":[137,157],"are":[138,222],"conceivable:":[139],"at":[140,144,148],"receptor":[142],"level,":[143],"or":[147],"cyclase.":[151],"Common":[152],"denominator":[153],"control":[160],"cGMP.":[162],"This":[163],"second":[164],"messenger":[165],"regulates":[166],"protein":[170],"kinases,":[171],"phosphodiesterases,":[172],"ion":[174],"channels.":[175],"However,":[176],"relevance":[178],"these":[180],"structures":[181],"for":[182,224],"hypnotic-anaesthetic":[184],"general":[187,228],"currently":[190],"unclear.":[191],"Recent":[192],"findings":[193],"in":[194,202,211],"mice":[195],"deficient":[196],"animals":[203],"chronically":[204],"treated":[205],"inhibitors":[208],"suggest":[209],"that":[210,221],"addition":[212],"NO/cGMP-metabolism":[215],"pathways":[219],"exist":[220],"necessary":[223]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}