{"id":"https://openalex.org/W832745930","doi":null,"title":"Role of CD31 Binding Partners in Viable Leukocyte Detachment from Macrophages","display_name":"Role of CD31 Binding Partners in Viable Leukocyte Detachment from Macrophages","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W832745930","mag":"832745930"},"language":"en","primary_location":{"id":"pmh:hdl:10068/998048","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/998048","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/998048","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040070178","display_name":"Kim Wilkinson","orcid":"https://orcid.org/0000-0002-0793-3159","observed_orcids":["https://orcid.org/0000-0002-0793-3159"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kim Wilkinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0793-3159","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040070178"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.734000027179718},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.8379999995231628},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/itim","display_name":"ITIM","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tpr-motif","display_name":"TPR motif","score":0.6470000147819519},{"id":"https://openalex.org/keywords/14-3-3epsilon","display_name":"14-3-3\u03b5","score":0.8069999814033508},{"id":"https://openalex.org/keywords/eif3","display_name":"eIF3","score":0.8989999890327454},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cytoplasmic-domain","display_name":"cytoplasmic domain","score":0.5889999866485596},{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.5519999861717224},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.531000018119812},{"id":"https://openalex.org/keywords/homophilic-interactions","display_name":"homophilic interactions","score":0.5820000171661377},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.5431565046310425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4645741879940033},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.43538427352905273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3786695599555969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32738786935806274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32012224197387695},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/998048","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/998048","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:era.ed.ac.uk:1842/1973","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1842/1973","pdf_url":null,"source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:832745930","doi":null,"is_oa":false,"landing_page_url":"https://era.ed.ac.uk/bitstream/1842/1973/1/Wilkinson_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/998048","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/998048","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2007701848","https://openalex.org/W2073513377","https://openalex.org/W2092590506","https://openalex.org/W2104485568","https://openalex.org/W2108241942","https://openalex.org/W2170020426"],"related_works":["https://openalex.org/W1968736434","https://openalex.org/W4234909838","https://openalex.org/W2001081096","https://openalex.org/W2133885225","https://openalex.org/W2141908703","https://openalex.org/W3023014613","https://openalex.org/W2404821003","https://openalex.org/W2055970438","https://openalex.org/W1607157162","https://openalex.org/W7098557846"],"abstract_inverted_index":{"CD31":[0,63,119,187,214,242,256,331,364,393,423],"mediates":[1],"homophilic":[2],"interactions":[3],"between":[4,182],"leukocytes":[5],"and":[6,14,29,132,142,204,275,304,352,383,394,434],"macrophages":[7],"during":[8],"inflammation,":[9],"apoptotic":[10,133,155],"cells":[11,19],"remain":[12],"attached":[13],"are":[15],"engulfed":[16],"whereas":[17,227],"viable":[18,43,70,131],"actively":[20],"detach.":[21],"We":[22,135,175],"hypothesised":[23],"that":[24,137,363,390],"differential":[25],"recruitment":[26,81,139],"of":[27,41,62,82,118,130,140,160,186,213,216,239,255,262,272,279,319,330,343,349,410,422],"signalling":[28],"adapter":[30],"molecules":[31],"to":[32,87,97,120,178,224,231,241,245,298,361,371,397,429],"the":[33,39,42,60,65,80,115,138,161,183,217,252,280,293,300,320,327,335,341,374],"cytoplasmic":[34,116,184,253,281,328],"domain":[35,117,185,254,282,329],"were":[36,144,176],"responsible":[37],"for":[38,69,79,109,287],"disengagement":[40],"leukocyte":[44,66,395,432],"from":[45,128,436],"macrophages.":[46,437],"Investigation":[47],"with":[48,188,313,337,373],"a":[49,56,77,104,209,248,259,267,305,344,407,426],"static":[50],"attachment":[51],"assay":[52],"using":[53],"THP-1":[54],"as":[55,103,208,406],"macrophage":[57],"model":[58],"showed":[59],"ITIM":[61,149,233],"on":[64,146],"was":[67,243,365],"important":[68],"cell":[71,156],"detachment.":[72],"Our":[73],"data":[74],"also":[75,101,339,380],"implicated":[76],"role":[78],"SHP-2":[83,143],"which":[84,122,257,309,332,379],"we":[85,113,123],"attempted":[86],"knock-down":[88],"by":[89,92,202],"siRNA":[90],"delivered":[91],"lentivirus.":[93],"SHP-2,":[94],"in":[95,125,162,169,172],"addition":[96],"its":[98],"phosphatase":[99,170],"activity,":[100],"acts":[102],"docking":[105],"protein.":[106],"To":[107],"examine":[108],"potential":[110],"interacting":[111],"partners":[112,191,421],"fused":[114],"GST":[121],"used":[124],"pulldown":[126],"assays":[127],"lysates":[129,157],"leukocytes.":[134],"demonstrated":[136],"SHP-1":[141],"dependent":[145],"an":[147,167,180,232,387],"intact":[148],"(immunoreceptor":[150],"tyrosine-based":[151],"inhibitory":[152],"motif).":[153],"Interestingly,":[154],"promoted":[158],"dephosphorylation":[159],"vitro":[163],"phosphorylated":[164,225],"GST-CD31,":[165],"suggesting":[166],"increase":[168],"activity":[171],"aged":[173],"neutrophils.":[174],"unable":[177],"demonstrate":[179],"interaction":[181,336],"putative":[189,321],"binding":[190,211,238,285,302,420],"\u03b2-catenin,":[192],"src,":[193],"RasGAPp120,":[194],"RhoGAPp190,":[195],"talin":[196],"or":[197],"calmodulin.":[198],"A":[199],"proteomic":[200],"approach":[201],"MALDI-TOF":[203],"MS/MS":[205],"identified":[206,418],"Hsp90":[207,240,338],"novel":[210,306,419],"partner":[212],"irrespective":[215],"phosphorylation":[218],"state.":[219],"In":[220],"contrast,":[221],"14-3-3\u03b5":[222,351,382],"bound":[223,230],"CD31,":[226],"eIF3":[228,353,385],"specifically":[229,289],"double":[234],"tyrosine":[235],"mutant.":[236],"The":[237,347],"proposed":[244],"occur":[246],"via":[247],"TPR":[249,345],"motif":[250],"within":[251,326,368],"comprises":[258],"surface":[260],"fold":[261],"basic":[263,322],"amino":[264,324],"acids":[265,325],"complexing":[266],"highly":[268],"acidic":[269],"carboxy":[270],"tail":[271],"Hsp90.":[273,384],"Truncation":[274],"site":[276],"directed":[277],"mutagenesis":[278,318],"revealed":[283],"multiple":[284],"sites":[286],"Hsp90;":[288],"two":[290],"regions":[291],"containing":[292],"sequences":[294],"(KAFYLRKAKAK),":[295],"previously":[296],"shown":[297],"be":[299,404],"calmodulin":[301],"region,":[303],"area":[307],"(SNNEKMSDMEANSHY)":[308],"has":[310],"significant":[311],"homology":[312],"other":[314],"TPR-containing":[315],"proteins.":[316],"Systematic":[317],"charged":[323],"may":[333,391,424],"mediate":[334],"supports":[340],"presence":[342],"motif.":[346],"importance":[348],"Hsp90,":[350],"is":[354,359,386],"currently":[355],"unknown,":[356],"although":[357],"it":[358],"interesting":[360],"note":[362],"recently":[366],"found":[367],"this":[369],"laboratory":[370],"associate":[372],"voltage-gated":[375],"potassium":[376],"channel":[377],"HERG":[378],"binds":[381],"RNA":[388],"helicase":[389],"link":[392],"motility":[396,402,433],"spreading":[398],"initiation":[399],"centres":[400],"where":[401],"can":[403],"viewed":[405],"rapid":[408],"turnover":[409],"focal":[411],"adhesion":[412],"complexes.":[413],"Together,":[414],"these":[415],"studies":[416],"have":[417],"form":[425],"macromolecular":[427],"complex":[428],"promote":[430],"CD31-dependent":[431],"detachment":[435]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}
