{"id":"https://openalex.org/W8327150","doi":"https://doi.org/10.1007/978-1-59259-383-5_11","title":"Targeting the Apoptotic Machinery as a Potential Antileukemic Strategy","display_name":"Targeting the Apoptotic Machinery as a Potential Antileukemic Strategy","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W8327150","doi":"https://doi.org/10.1007/978-1-59259-383-5_11","mag":"8327150"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-383-5_11","doi":"https://doi.org/10.1007/978-1-59259-383-5_11","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-383-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologic Therapy of Leukemia","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4406322647","display_name":"Biologic Therapy of Leukemia"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-1-59259-383-5_11","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108461583","display_name":"Benjamin M. F. Mow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin M. F. Mow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054370710","display_name":"Scott H. Kaufmann","orcid":"https://orcid.org/0000-0002-4900-7145","observed_orcids":["https://orcid.org/0000-0002-4900-7145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott H. Kaufmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4387,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54939759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"163","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.671999990940094},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/membrane-blebbing","display_name":"membrane blebbing","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8530627489089966},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8263331651687622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7621617317199707},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.711192786693573},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6563223600387573},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6238820552825928},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5907130241394043},{"id":"https://openalex.org/C45413362","wikidata":"https://www.wikidata.org/wiki/Q6013254","display_name":"Prophase","level":4,"score":0.5700913071632385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48723307251930237},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46433010697364807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3478730320930481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19474637508392334},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08139145374298096},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06022605299949646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-59259-383-5_11","doi":"https://doi.org/10.1007/978-1-59259-383-5_11","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-383-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologic Therapy of Leukemia","raw_type":"book-chapter"},{"id":"doi:10.1385/1-59259-383-6:163","doi":"https://doi.org/10.1385/1-59259-383-6:163","is_oa":false,"landing_page_url":"http://doi.org/10.1385/1-59259-383-6:163","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologic Therapy of Leukemia","raw_type":"book-chapter"},{"id":"mag:8327150","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-383-5_11.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/978-1-59259-383-5_11","doi":"https://doi.org/10.1007/978-1-59259-383-5_11","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-383-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologic Therapy of Leukemia","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W19487332","https://openalex.org/W29766578","https://openalex.org/W85529956","https://openalex.org/W122353466","https://openalex.org/W146240628","https://openalex.org/W180295822","https://openalex.org/W286443710","https://openalex.org/W1211118294","https://openalex.org/W1483995411","https://openalex.org/W1484817497","https://openalex.org/W1487506158","https://openalex.org/W1492587973","https://openalex.org/W1504057655","https://openalex.org/W1512072225","https://openalex.org/W1513007231","https://openalex.org/W1515269506","https://openalex.org/W1527712367","https://openalex.org/W1535874622","https://openalex.org/W1543358981","https://openalex.org/W1545446999","https://openalex.org/W1547637047","https://openalex.org/W1551972473","https://openalex.org/W1553544241","https://openalex.org/W1560001018","https://openalex.org/W1560035984","https://openalex.org/W1565563441","https://openalex.org/W1589415602","https://openalex.org/W1591166893","https://openalex.org/W1591646293","https://openalex.org/W1598719623","https://openalex.org/W1601836981","https://openalex.org/W1611726375","https://openalex.org/W1618299283","https://openalex.org/W1845459216","https://openalex.org/W1857665725","https://openalex.org/W1908051699","https://openalex.org/W1912789001","https://openalex.org/W1913661233","https://openalex.org/W1964165239","https://openalex.org/W1966565183","https://openalex.org/W1967564946","https://openalex.org/W1967912613","https://openalex.org/W1969150166","https://openalex.org/W1970408491","https://openalex.org/W1970460848","https://openalex.org/W1971670779","https://openalex.org/W1971967721","https://openalex.org/W1973109581","https://openalex.org/W1973166702","https://openalex.org/W1973931901","https://openalex.org/W1974980101","https://openalex.org/W1983547790","https://openalex.org/W1983601044","https://openalex.org/W1984547206","https://openalex.org/W1985411011","https://openalex.org/W1988356885","https://openalex.org/W1991865867","https://openalex.org/W1993129579","https://openalex.org/W1993669933","https://openalex.org/W1994611236","https://openalex.org/W1998397035","https://openalex.org/W2000623989","https://openalex.org/W2002645985","https://openalex.org/W2006917576","https://openalex.org/W2007522168","https://openalex.org/W2012513927","https://openalex.org/W2013801793","https://openalex.org/W2015362281","https://openalex.org/W2016656445","https://openalex.org/W2017102177","https://openalex.org/W2017631156","https://openalex.org/W2020262557","https://openalex.org/W2023997192","https://openalex.org/W2028526641","https://openalex.org/W2036822121","https://openalex.org/W2038114873","https://openalex.org/W2038118195","https://openalex.org/W2041204531","https://openalex.org/W2043051754","https://openalex.org/W2043141000","https://openalex.org/W2047571097","https://openalex.org/W2055946816","https://openalex.org/W2056961869","https://openalex.org/W2061690334","https://openalex.org/W2065482981","https://openalex.org/W2067686281","https://openalex.org/W2069990321","https://openalex.org/W2074156234","https://openalex.org/W2074678011","https://openalex.org/W2075352602","https://openalex.org/W2077754831","https://openalex.org/W2078818685","https://openalex.org/W2080166898","https://openalex.org/W2082801302","https://openalex.org/W2083173501","https://openalex.org/W2083272027","https://openalex.org/W2084733813","https://openalex.org/W2093791243","https://openalex.org/W2096008106","https://openalex.org/W2099611934","https://openalex.org/W2101689120","https://openalex.org/W2101730597","https://openalex.org/W2102986716","https://openalex.org/W2104979289","https://openalex.org/W2106284224","https://openalex.org/W2108307486","https://openalex.org/W2112127173","https://openalex.org/W2112968535","https://openalex.org/W2113999599","https://openalex.org/W2117820574","https://openalex.org/W2118310862","https://openalex.org/W2122051507","https://openalex.org/W2123513769","https://openalex.org/W2127048642","https://openalex.org/W2127868048","https://openalex.org/W2129683520","https://openalex.org/W2132411546","https://openalex.org/W2136269288","https://openalex.org/W2142498284","https://openalex.org/W2142618806","https://openalex.org/W2147787249","https://openalex.org/W2151501496","https://openalex.org/W2152247516","https://openalex.org/W2157740207","https://openalex.org/W2157805786","https://openalex.org/W2157999078","https://openalex.org/W2162517036","https://openalex.org/W2163634416","https://openalex.org/W2167434038","https://openalex.org/W2167490100","https://openalex.org/W2168656373","https://openalex.org/W2169205569","https://openalex.org/W2207944816","https://openalex.org/W2208136208","https://openalex.org/W2227735896","https://openalex.org/W2290539832","https://openalex.org/W2314938037","https://openalex.org/W2315310434","https://openalex.org/W2316285318","https://openalex.org/W2318309282","https://openalex.org/W2321334283","https://openalex.org/W2322349519","https://openalex.org/W2337577525","https://openalex.org/W2398378119","https://openalex.org/W2400694579","https://openalex.org/W2409163532","https://openalex.org/W2415881972"],"related_works":["https://openalex.org/W2060180453","https://openalex.org/W2086803177","https://openalex.org/W2087652708","https://openalex.org/W2272781862","https://openalex.org/W2089618519","https://openalex.org/W2170400693","https://openalex.org/W2052842511","https://openalex.org/W2057387238","https://openalex.org/W1994293796","https://openalex.org/W2024445545"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1,21],"a":[2],"morphologically":[3],"and":[4,15,31,77],"biochemically":[5],"distinctive":[6],"cell":[7,35],"death":[8],"process":[9],"that":[10,69],"occurs":[11],"under":[12],"several":[13],"physiologic":[14],"pathologic":[16],"conditions":[17],"(1,2).":[18],"Morphologically,":[19],"apoptosis":[20],"characterized":[22],"by":[23,28,44],"plasma":[24],"membrane":[25],"blebbing":[26],"followed":[27],"chromatin":[29],"condensation":[30],"disassembly":[32],"of":[33,64],"the":[34,62],"into":[36],"multiple":[37],"membrane-enclosed":[38],"fragments,":[39],"which":[40],"are":[41,54],"then":[42],"engulfed":[43],"neighboring":[45],"cells":[46],"or":[47],"professional":[48],"phagocytes":[49],"(2).":[50],"These":[51],"biochemical":[52],"changes":[53],"believed":[55],"to":[56],"reflect,":[57],"at":[58],"least":[59],"in":[60],"part,":[61],"action":[63],"caspases,":[65],"unique":[66],"intracellular":[67],"proteases":[68],"digest":[70],"critical":[71],"polypeptides":[72],"required":[73],"for":[74],"cellular":[75],"integrity":[76],"survival":[78],"(3,4).":[79]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
