{"id":"https://openalex.org/W832655052","doi":"https://doi.org/10.1016/j.apjtm.2015.06.013","title":"Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice","display_name":"Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W832655052","doi":"https://doi.org/10.1016/j.apjtm.2015.06.013","mag":"832655052","pmid":"https://pubmed.ncbi.nlm.nih.gov/26276283"},"language":"en","primary_location":{"id":"doi:10.1016/j.apjtm.2015.06.013","doi":"https://doi.org/10.1016/j.apjtm.2015.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtm.2015.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S203437272","display_name":"Asian Pacific Journal of Tropical Medicine","issn_l":"1995-7645","issn":["1995-7645","2352-4146"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.apjtm.2015.06.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084247296","display_name":"Ali Berraaouan","orcid":"https://orcid.org/0000-0001-8705-3516","observed_orcids":["https://orcid.org/0000-0001-8705-3516"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ali Berraaouan","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037858688","display_name":"Abderrahim Ziyyat","orcid":"https://orcid.org/0000-0001-6384-2537","observed_orcids":["https://orcid.org/0000-0001-6384-2537"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ziyyat Abderrahim","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085718136","display_name":"Hassane Mekhfi","orcid":"https://orcid.org/0000-0003-1295-9588","observed_orcids":["https://orcid.org/0000-0003-1295-9588"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mekhfi Hassane","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071751917","display_name":"Abdelkhaleq Legssyer","orcid":"https://orcid.org/0000-0002-3220-9429","observed_orcids":["https://orcid.org/0000-0002-3220-9429"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Legssyer Abdelkhaleq","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107520356","display_name":"Mohammed Aziz","orcid":"https://orcid.org/0000-0003-2273-2889","observed_orcids":["https://orcid.org/0000-0003-2273-2889"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Aziz Mohammed","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086459012","display_name":"Mohamed Bnouham","orcid":"https://orcid.org/0000-0001-9473-1290","observed_orcids":["https://orcid.org/0000-0001-9473-1290"]},"institutions":[{"id":"https://openalex.org/I4210108110","display_name":"Mohamed I University","ror":"https://ror.org/01ejxf797","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210108110"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Bnouham Mohamed","raw_affiliation_strings":["Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco. Electronic address: mbnouham@yahoo.fr","Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco. Electronic address: mbnouham@yahoo.fr","institution_ids":["https://openalex.org/I4210108110"]},{"raw_affiliation_string":"Laboratory of Physiology and Ethnopharmacology-URAC40, Mohammed First University, Faculty of Sciences, Oujda, Morocco","institution_ids":["https://openalex.org/I4210108110"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086459012"],"corresponding_institution_ids":["https://openalex.org/I4210108110"],"apc_list":null,"apc_paid":null,"fwci":3.5019,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.92739446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"532","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12330","display_name":"Botanical Research and Applications","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opuntia-ficus-indica","display_name":"Opuntia ficus-indica","score":1.0},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pancreatic-histopathology","display_name":"pancreatic histopathology","score":0.746999979019165},{"id":"https://openalex.org/keywords/chemically-induced-diabetes","display_name":"chemically induced diabetes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/diabetes-prevention","display_name":"diabetes prevention","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.9536494016647339},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.728470504283905},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.7193588018417358},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5634666085243225},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5266171097755432},{"id":"https://openalex.org/C2775874295","wikidata":"https://www.wikidata.org/wiki/Q568694","display_name":"PEAR","level":2,"score":0.5229887962341309},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5114649534225464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.491375595331192},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.35654622316360474},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3556289076805115},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35172349214553833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3077217936515808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2818787395954132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2806028723716736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23307842016220093}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.apjtm.2015.06.013","doi":"https://doi.org/10.1016/j.apjtm.2015.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtm.2015.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S203437272","display_name":"Asian Pacific Journal of Tropical Medicine","issn_l":"1995-7645","issn":["1995-7645","2352-4146"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Medicine","raw_type":"journal-article"},{"id":"pmid:26276283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26276283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of tropical medicine","raw_type":"Journal Article"},{"id":"mag:3143726449","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/71792X/201507/89848289504849534855484854.html","pdf_url":null,"source":{"id":"https://openalex.org/S203437272","display_name":"Asian Pacific Journal of Tropical Medicine","issn_l":"1995-7645","issn":["1995-7645","2352-4146"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e9a\u592a\u70ed\u5e26\u533b\u836f\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.apjtm.2015.06.013","doi":"https://doi.org/10.1016/j.apjtm.2015.06.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtm.2015.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S203437272","display_name":"Asian Pacific Journal of Tropical Medicine","issn_l":"1995-7645","issn":["1995-7645","2352-4146"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323771","display_name":"Centre National pour la Recherche Scientifique et Technique","ror":"https://ror.org/00675rp98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W51641643","https://openalex.org/W97620924","https://openalex.org/W592106610","https://openalex.org/W629979786","https://openalex.org/W1937085541","https://openalex.org/W1971674535","https://openalex.org/W1972426232","https://openalex.org/W1975536395","https://openalex.org/W1980400496","https://openalex.org/W1981933434","https://openalex.org/W1987823762","https://openalex.org/W1994567337","https://openalex.org/W2038098721","https://openalex.org/W2045757770","https://openalex.org/W2049701947","https://openalex.org/W2050289279","https://openalex.org/W2052750222","https://openalex.org/W2053809430","https://openalex.org/W2065906579","https://openalex.org/W2076627209","https://openalex.org/W2077758083","https://openalex.org/W2087440370","https://openalex.org/W2099540110","https://openalex.org/W2108250096","https://openalex.org/W2117801971","https://openalex.org/W2124344880","https://openalex.org/W2130189158","https://openalex.org/W2140502478","https://openalex.org/W2147993424","https://openalex.org/W2161849974","https://openalex.org/W2164330387","https://openalex.org/W2321497603","https://openalex.org/W2770105844","https://openalex.org/W2955504961","https://openalex.org/W4248753582","https://openalex.org/W4302338290","https://openalex.org/W6602059047","https://openalex.org/W6604065466"],"related_works":["https://openalex.org/W3143726449","https://openalex.org/W2365778194","https://openalex.org/W2052750222","https://openalex.org/W7126405794","https://openalex.org/W2150010312","https://openalex.org/W2356426827","https://openalex.org/W2101602552","https://openalex.org/W2356860792","https://openalex.org/W2386505247","https://openalex.org/W2363990122"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2,88],"the":[3,103],"in":[4,27,31,98,118,157],"vitro":[5,32],"antioxidant":[6,33,96],"power":[7],"of":[8,35,83,105,123,131],"cactus":[9],"pear":[10],"seed":[11],"oil":[12],"[Opuntia":[13],"ficus-indica":[14],"L.":[15],"MILL.":[16],"(CPSO)]":[17],"and":[18,61,74,80,113,153],"its":[19],"protective":[20],"effect":[21,34,46,97],"against":[22,133],"chemically":[23],"induced":[24],"diabetes":[25],"mellitus":[26],"mice.":[28,120],"METHODS:":[29],"The":[30,44],"CPSO":[36,55,93,106,127,142],"was":[37,47,85],"evaluated":[38],"using":[39],"2,2-diphenyl-1-picrylhydrazyl":[40],"(DPPH)":[41],"scavenging":[42,100],"assay.":[43,101],"preventive":[45],"conducted":[48],"on":[49,139],"Swiss":[50],"albino":[51],"mice":[52],"treated":[53,119],"with":[54],"(2":[56,107],"mL/kg,":[57],"per":[58],"os),":[59],"before":[60],"after":[62],"a":[63],"single":[64],"intraperitoneal":[65],"alloxan":[66,134,152],"administration":[67,104],"(100":[68],"mg/kg).":[69],"Survival":[70],"rate,":[71],"body":[72],"weight":[73],"fasting":[75],"blood":[76],"glucose":[77],"were":[78],"measured":[79],"histopathological":[81],"analysis":[82],"pancreas":[84,124],"performed":[86],"to":[87],"alloxan-induced":[89,111],"tissue":[90,155],"injuries.":[91],"RESULTS:":[92],"exhibited":[94],"an":[95],"DPPH":[99],"Moreover,":[102],"mL/kg)":[108],"significantly":[109,128],"attenuated":[110],"death":[112],"hyperglycemia":[114],"(P":[115],"<":[116],"0.001)":[117],"Morphometric":[121],"study":[122],"revealed":[125],"that":[126],"protected":[129],"islets":[130],"langerhans":[132],"induced-tissue":[135],"alterations.":[136],"CONCLUSIONS:":[137],"Based":[138],"theses":[140],"results,":[141],"can":[143],"prevente":[144],"alloxan-induced-diabetes":[145],"by":[146,151],"quenching":[147],"free":[148],"radicals":[149],"produced":[150],"inhibiting":[154],"injuries":[156],"pancreatic":[158],"\u03b2-cells.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}