{"id":"https://openalex.org/W832470632","doi":null,"title":"PPAR-g Regulatory Networks in Bone Metabolism And Mineralization","display_name":"PPAR-g Regulatory Networks in Bone Metabolism And Mineralization","publication_year":2015,"publication_date":"2015-06-16","ids":{"openalex":"https://openalex.org/W832470632","mag":"832470632"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004396257","display_name":"Claudia Bruedigam","orcid":"https://orcid.org/0000-0002-9580-1446","observed_orcids":["https://orcid.org/0000-0002-9580-1446"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claudia Bruedigam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9580-1446","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004396257"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9459999799728394},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":1.0},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/osteopetrosis","display_name":"osteopetrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sclerosteosis","display_name":"sclerosteosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/van-buchem-disease","display_name":"van Buchem disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/skeletal-dysplasia","display_name":"skeletal dysplasia","score":0.859000027179718},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.8646219968795776},{"id":"https://openalex.org/C12021080","wikidata":"https://www.wikidata.org/wiki/Q4941580","display_name":"Bone remodeling period","level":4,"score":0.7690188884735107},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.751846432685852},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7177265286445618},{"id":"https://openalex.org/C2781078528","wikidata":"https://www.wikidata.org/wiki/Q1755568","display_name":"Osteopetrosis","level":2,"score":0.6611751317977905},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5055766105651855},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4959736764431},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48822715878486633},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.4620036780834198},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.45055484771728516},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4453434348106384},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.439340204000473},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.43254998326301575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4256152808666229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.384246289730072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36982613801956177},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.32190656661987305},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23898404836654663},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14375606179237366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08828002214431763},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06306985020637512},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:78274","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/78274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:78274","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/78274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:832470632","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/78274/150616_Bruedigam-Claudia.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/87eb8ea5-8abf-476f-8a3d-fd0e05088f77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7023812094","https://openalex.org/W2159061765","https://openalex.org/W2057946516","https://openalex.org/W4235917234","https://openalex.org/W2801436026","https://openalex.org/W4389006545","https://openalex.org/W2978311966","https://openalex.org/W2595492331","https://openalex.org/W4393378499","https://openalex.org/W2388539709"],"abstract_inverted_index":{"__Abstract__":[0],"\\n":[1],"\\nBone":[2],"is":[3,9,44,51,87,102,150,159],"a":[4,115,151,214],"highly":[5],"dynamic":[6],"tissue":[7],"that":[8,43,69,144,158,193],"permanently":[10],"remodeled":[11],"as":[12],"an":[13,121],"intrinsic":[14],"mechanism":[15],"\\nto":[16],"regenerate":[17],"bone":[18,29,34,42,49,83,105,130,142,163,191],"during":[19],"life,":[20],"to":[21,26,108,138,189],"accomplish":[22],"longitudinal":[23],"growth,":[24],"and":[25,65,75,92,114,132,165,176,197,206],"generate":[27],"new":[28],"\\nduring":[30],"fracture":[31,167],"repair.":[32],"As":[33],"formation":[35,64,133,185],"must":[36],"match":[37],"closely":[38],"the":[39,54,63,73,90,99,124,127,156,180],"amount":[40],"of":[41,57,67,77,94,98,117,123,216],"\\nresorbed":[45],"at":[46,79],"each":[47],"site,":[48],"remodeling":[50,80],"controlled":[52],"by":[53,161,213],"coupled":[55],"actions":[56],"osteoclasts":[58,68,86],"\\nand":[59],"osteoblasts.":[60,95],"Osteoblasts":[61],"control":[62],"activity":[66,93],"are":[70],"\\nresponsible":[71],"for":[72,104],"initiation":[74],"execution":[76],"resorption":[78,131],"sites.":[81],"The":[82],"resorbed":[84],"\\nby":[85],"replaced":[88],"through":[89],"differentiation":[91],"This":[96],"\\ncoupling":[97],"two":[100],"processes":[101],"essential":[103],"balance.":[106],"Due":[107],"age,":[109],"sex":[110],"hormone":[111],"status,":[112],"\\ncancer":[113],"variety":[116,215],"diseases":[118],"associated":[119,171],"with":[120,172],"activation":[122],"immune":[125],"system,":[126],"balance":[128],"\\nbetween":[129],"can":[134,186,209],"be":[135,211],"shifted":[136],"leading":[137],"local":[139],"or":[140,222],"systemic":[141],"\\nloss":[143],"ultimately":[145],"results":[146],"in":[147],"osteoporosis.":[148],"Osteoporosis":[149],"prevalent":[152],"skeletal":[153],"disorder":[154],"\\nin":[155],"elderly":[157],"characterized":[160],"impaired":[162],"strength":[164],"increased":[166,177],"risk.":[168],"It":[169],"\\nis":[170],"reduced":[173],"life":[174],"quality":[175],"mortality.":[178],"On":[179],"other":[181],"hand,":[182],"excessive":[183],"\\nbone":[184],"give":[187],"rise":[188],"sclerosing":[190],"disorders":[192],"include":[194],"many":[195],"rare":[196],"\\noften":[198],"hereditary":[199],"osteochondrodysplasias":[200],"(e.g.":[201],"osteopetrosis,":[202],"Van":[203],"Buchem":[204],"disease":[205],"sclerosteosis),":[207],"\\nbut":[208],"also":[210],"caused":[212],"dietary,":[217],"metabolic,":[218],"endocrine,":[219],"hematologic,":[220],"\\ninfectious":[221],"neoplastic":[223],"disorders.":[224]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}