{"id":"https://openalex.org/W832052764","doi":null,"title":"Bacteria as drug delivery vehicles","display_name":"Bacteria as drug delivery vehicles","publication_year":2014,"publication_date":"2014-12-19","ids":{"openalex":"https://openalex.org/W832052764","mag":"832052764"},"language":"en","primary_location":{"id":"pmh:oai:krex.k-state.edu:2097/18804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/18804","pdf_url":"http://hdl.handle.net/2097/18804","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2097/18804","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088342196","display_name":"Sebastian O. Wendel","orcid":"https://orcid.org/0000-0002-5515-0968","observed_orcids":["https://orcid.org/0000-0002-5515-0968"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wendel, Sebastian Oliver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088342196"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8939999938011169},{"id":"https://openalex.org/keywords/phagocytes","display_name":"phagocytes","score":0.6980000138282776},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7540000081062317},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.847000002861023},{"id":"https://openalex.org/keywords/mycobacterium-luteum","display_name":"Mycobacterium luteum","score":0.8740000128746033},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dp44mt","display_name":"Dp44mT","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chlorhexidine","display_name":"chlorhexidine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.652999997138977},{"id":"https://openalex.org/keywords/intracellular-drug-delivery","display_name":"intracellular drug delivery","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5252613425254822},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5210968255996704},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41457870602607727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3068833351135254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25309479236602783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2130546271800995},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.17630070447921753},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10080409049987793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08686551451683044}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:krex.k-state.edu:2097/18804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/18804","pdf_url":"http://hdl.handle.net/2097/18804","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"pmh:oai:krex.k-state.edu:2097/18804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/18804","pdf_url":"http://hdl.handle.net/2097/18804","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W832052764.pdf","grobid_xml":"https://content.openalex.org/works/W832052764.grobid-xml"},"referenced_works_count":219,"referenced_works":["https://openalex.org/W140062039","https://openalex.org/W635031084","https://openalex.org/W1484334610","https://openalex.org/W1486740674","https://openalex.org/W1503426422","https://openalex.org/W1508126216","https://openalex.org/W1511703157","https://openalex.org/W1518490346","https://openalex.org/W1558366281","https://openalex.org/W1560466618","https://openalex.org/W1561168111","https://openalex.org/W1566772021","https://openalex.org/W1578283200","https://openalex.org/W1597610606","https://openalex.org/W1665704747","https://openalex.org/W1682474579","https://openalex.org/W1706123544","https://openalex.org/W1776418785","https://openalex.org/W1850522356","https://openalex.org/W1869550436","https://openalex.org/W1884780861","https://openalex.org/W1918322381","https://openalex.org/W1924296019","https://openalex.org/W1930683464","https://openalex.org/W1938224578","https://openalex.org/W1955161937","https://openalex.org/W1964321121","https://openalex.org/W1966305351","https://openalex.org/W1966445054","https://openalex.org/W1967128858","https://openalex.org/W1968461095","https://openalex.org/W1968736434","https://openalex.org/W1969849879","https://openalex.org/W1971863203","https://openalex.org/W1971964548","https://openalex.org/W1972677660","https://openalex.org/W1973155262","https://openalex.org/W1974855616","https://openalex.org/W1974935001","https://openalex.org/W1976646654","https://openalex.org/W1977373583","https://openalex.org/W1978083259","https://openalex.org/W1978139448","https://openalex.org/W1981825588","https://openalex.org/W1985804036","https://openalex.org/W1986129921","https://openalex.org/W1986312299","https://openalex.org/W1990523202","https://openalex.org/W1990983926","https://openalex.org/W1992803165","https://openalex.org/W1993470602","https://openalex.org/W1996385548","https://openalex.org/W1998176651","https://openalex.org/W1998253311","https://openalex.org/W1999645926","https://openalex.org/W1999903411","https://openalex.org/W2001275742","https://openalex.org/W2002157461","https://openalex.org/W2002516695","https://openalex.org/W2003630286","https://openalex.org/W2003652884","https://openalex.org/W2004329358","https://openalex.org/W2004681222","https://openalex.org/W2005659583","https://openalex.org/W2006318766","https://openalex.org/W2006529110","https://openalex.org/W2012686340","https://openalex.org/W2013470095","https://openalex.org/W2014698797","https://openalex.org/W2017691475","https://openalex.org/W2018004211","https://openalex.org/W2018695684","https://openalex.org/W2019227458","https://openalex.org/W2021771515","https://openalex.org/W2025036947","https://openalex.org/W2025882541","https://openalex.org/W2027213295","https://openalex.org/W2028427446","https://openalex.org/W2029210239","https://openalex.org/W2030892741","https://openalex.org/W2030975847","https://openalex.org/W2032050847","https://openalex.org/W2032151198","https://openalex.org/W2033204353","https://openalex.org/W2034042483","https://openalex.org/W2035270506","https://openalex.org/W2036965645","https://openalex.org/W2039350685","https://openalex.org/W2039796373","https://openalex.org/W2040992800","https://openalex.org/W2041195097","https://openalex.org/W2041759339","https://openalex.org/W2044352000","https://openalex.org/W2044851945","https://openalex.org/W2044905143","https://openalex.org/W2050896001","https://openalex.org/W2051247819","https://openalex.org/W2051771286","https://openalex.org/W2051948180","https://openalex.org/W2052904729","https://openalex.org/W2054472394","https://openalex.org/W2057572412","https://openalex.org/W2059149560","https://openalex.org/W2059294866","https://openalex.org/W2059541587","https://openalex.org/W2059597289","https://openalex.org/W2061916358","https://openalex.org/W2064680267","https://openalex.org/W2065569312","https://openalex.org/W2066444468","https://openalex.org/W2066515050","https://openalex.org/W2066836516","https://openalex.org/W2066880239","https://openalex.org/W2067165996","https://openalex.org/W2068307966","https://openalex.org/W2069578064","https://openalex.org/W2069689127","https://openalex.org/W2070595030","https://openalex.org/W2070980168","https://openalex.org/W2071170624","https://openalex.org/W2071410533","https://openalex.org/W2073344259","https://openalex.org/W2073417537","https://openalex.org/W2073779267","https://openalex.org/W2074544404","https://openalex.org/W2079301298","https://openalex.org/W2079511965","https://openalex.org/W2080838408","https://openalex.org/W2088024377","https://openalex.org/W2088402600","https://openalex.org/W2090563089","https://openalex.org/W2090732350","https://openalex.org/W2091039183","https://openalex.org/W2091637866","https://openalex.org/W2095033519","https://openalex.org/W2098888044","https://openalex.org/W2100568503","https://openalex.org/W2100711575","https://openalex.org/W2100953649","https://openalex.org/W2101799341","https://openalex.org/W2104934425","https://openalex.org/W2105489185","https://openalex.org/W2107854895","https://openalex.org/W2108836062","https://openalex.org/W2109342699","https://openalex.org/W2109930846","https://openalex.org/W2110216592","https://openalex.org/W2110444464","https://openalex.org/W2110843516","https://openalex.org/W2111379647","https://openalex.org/W2111650618","https://openalex.org/W2111922520","https://openalex.org/W2111960266","https://openalex.org/W2113990199","https://openalex.org/W2114443210","https://openalex.org/W2114691036","https://openalex.org/W2115222882","https://openalex.org/W2115504037","https://openalex.org/W2115993724","https://openalex.org/W2121429936","https://openalex.org/W2125841464","https://openalex.org/W2125894404","https://openalex.org/W2135212691","https://openalex.org/W2136558504","https://openalex.org/W2136786497","https://openalex.org/W2137271839","https://openalex.org/W2137403734","https://openalex.org/W2140333493","https://openalex.org/W2141085937","https://openalex.org/W2142197209","https://openalex.org/W2142471033","https://openalex.org/W2144080981","https://openalex.org/W2145789959","https://openalex.org/W2146172570","https://openalex.org/W2147188864","https://openalex.org/W2150181623","https://openalex.org/W2150500173","https://openalex.org/W2152783510","https://openalex.org/W2152853086","https://openalex.org/W2153731253","https://openalex.org/W2153965661","https://openalex.org/W2155360682","https://openalex.org/W2157567077","https://openalex.org/W2157607856","https://openalex.org/W2158449037","https://openalex.org/W2158580948","https://openalex.org/W2158762036","https://openalex.org/W2159309054","https://openalex.org/W2160479880","https://openalex.org/W2161756312","https://openalex.org/W2161885008","https://openalex.org/W2162100134","https://openalex.org/W2162373031","https://openalex.org/W2163581770","https://openalex.org/W2164032940","https://openalex.org/W2164498267","https://openalex.org/W2166731734","https://openalex.org/W2167363836","https://openalex.org/W2168454302","https://openalex.org/W2169647073","https://openalex.org/W2169965478","https://openalex.org/W2171559922","https://openalex.org/W2171649560","https://openalex.org/W2178778111","https://openalex.org/W2187465619","https://openalex.org/W2190350017","https://openalex.org/W2218961515","https://openalex.org/W2279506517","https://openalex.org/W2279693978","https://openalex.org/W2318605753","https://openalex.org/W2319178856","https://openalex.org/W2323027157","https://openalex.org/W2335698550","https://openalex.org/W2339247442","https://openalex.org/W2341769195","https://openalex.org/W2416366182","https://openalex.org/W2571488753","https://openalex.org/W2804842145","https://openalex.org/W3148661256"],"related_works":["https://openalex.org/W2623873539","https://openalex.org/W7049284681","https://openalex.org/W7037762973","https://openalex.org/W2286137604","https://openalex.org/W4297399481","https://openalex.org/W2244000233","https://openalex.org/W6959392267","https://openalex.org/W2625744228","https://openalex.org/W2585389534","https://openalex.org/W2063521895"],"abstract_inverted_index":{"Both":[0],"chemotherapy":[1],"for":[2,8,101],"cancer":[3,173],"treatment":[4],"and":[5,17,51,96,104,118,144,151],"antibiotic":[6],"therapy":[7],"bacterial":[9],"infections":[10],"require":[11],"systemic":[12,19,153],"applications":[13],"of":[14,27,41,116,155,171,180],"the":[15,39,44,67,77,84,102,111,120,124,129,148,169,178],"drug":[16,33,121,135,165],"a":[18,25,31,56,156,161],"application":[20],"is":[21,89,108],"always":[22],"linked":[23],"to":[24,49,91,110,175],"number":[26],"disadvantages.To":[28],"circumvent":[29],"these":[30],"targeted":[32],"delivery":[34,136,166],"system":[35,48,137,167],"was":[36,61,138],"developed.It":[37],"utilizes":[38],"ability":[40],"phagocytes":[42,92],"from":[43],"hosts":[45],"own":[46],"immune":[47],"recognize":[50],"internalize":[52],"antigens.Deactivated":[53],"M.":[54,126],"luteus,":[55],"non-pathogenic":[57],"gram":[58],"positive":[59],"bacteria":[60,88],"loaded":[62],"with":[63,83,123],"high":[64],"concentrations":[65],"(exceeding":[66],"IC50":[68],"at":[69],"least":[70],"60":[71],"fold":[72],"in":[73,142,145,160,183],"local":[74],"intracellular":[75],"concentration)":[76],"chemotherapeutics":[78],"doxorubicin":[79,164],"or":[80,82,94,114],"DP44mt":[81],"bactericidal":[85],"chlorhexidine.The":[86],"modified":[87],"fed":[90],"(Monocytes/Macrophages":[93],"neutrophils)":[95],"serves":[97],"as":[98],"protective":[99],"shell":[100],"transporting":[103],"targeting":[105],"phagocyte.The":[106],"phagocyte":[107],"recruited":[109],"tumor":[112],"site":[113,115],"infection":[117,159],"releases":[119],"along":[122],"processed":[125],"luteus":[127],"via":[128],"exosome":[130],"pathway":[131],"upon":[132],"arrival.The":[133],"chlorhexidine":[134],"successfully":[139],"tested":[140],"both":[141],"vitro":[143],"vivo,":[146],"reducing":[147],"pathogen":[149],"count":[150],"preventing":[152],"spread":[154],"F.":[157],"necrophorum":[158],"mouse":[162],"model.The":[163],"reduced":[168],"viability":[170],"4T1":[172],"cells":[174],"20%":[176],"over":[177],"course":[179],"four":[181],"days":[182],"vitro.":[184]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}
