{"id":"https://openalex.org/W83198737","doi":"https://doi.org/10.17077/etd.80r5ugyv","title":"Age and Sex-Related Differences in Dental Pulp Stem Cells","display_name":"Age and Sex-Related Differences in Dental Pulp Stem Cells","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W83198737","doi":"https://doi.org/10.17077/etd.80r5ugyv","mag":"83198737"},"language":"en","primary_location":{"id":"doi:10.17077/etd.80r5ugyv","doi":"https://doi.org/10.17077/etd.80r5ugyv","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.80r5ugyv","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730684520002771/13730718760002771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046907642","display_name":"Rene Chu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rene Chu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001369345","display_name":"Liu Hong","orcid":"https://orcid.org/0000-0003-0308-5049","observed_orcids":["https://orcid.org/0000-0003-0308-5049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu Hong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0308-5049","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080471775","display_name":"Anne E. Williamson","orcid":"https://orcid.org/0000-0002-7421-9625","observed_orcids":["https://orcid.org/0000-0002-7421-9625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne E. Williamson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012130474","display_name":"William T. Johnson","orcid":"https://orcid.org/0000-0002-6485-9274","observed_orcids":["https://orcid.org/0000-0002-6485-9274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William T. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046907642"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-pulp-stem-cells","display_name":"dental pulp stem cells","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.984000027179718},{"id":"https://openalex.org/keywords/proliferative-potential","display_name":"proliferative capacity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":1.0},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.8920000195503235},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stro-1","display_name":"STRO-1","score":0.7720000147819519},{"id":"https://openalex.org/keywords/regenerative-dentistry","display_name":"regenerative dentistry","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2777400515","wikidata":"https://www.wikidata.org/wiki/Q5259430","display_name":"Dental pulp stem cells","level":3,"score":0.6578102111816406},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5747914910316467},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4862424433231354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35211390256881714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30431681871414185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16073957085609436}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.17077/etd.80r5ugyv","doi":"https://doi.org/10.17077/etd.80r5ugyv","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.80r5ugyv","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},{"id":"pmh:oai:alma.01IOWA_INST:11730684530002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/graduate/Age-and-Sex-Related-Differences-in-Dental/9983777107402771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730684520002771/13730718760002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},{"id":"pmh:oai:ir.uiowa.edu:etd-4830","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/cgi/viewcontent.cgi?article=4830&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4377196317","display_name":"Iowa Research Online (University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:alma.01IOWA_INST:11730684530002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/graduate/Age-and-Sex-Related-Differences-in-Dental/9983777107402771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730684520002771/13730718760002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W83198737.pdf","grobid_xml":"https://content.openalex.org/works/W83198737.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107235618","https://openalex.org/W2898330566","https://openalex.org/W2584265157","https://openalex.org/W7144193307","https://openalex.org/W2169726287","https://openalex.org/W7135038524","https://openalex.org/W4231780900","https://openalex.org/W2021381900","https://openalex.org/W7017116164","https://openalex.org/W2095714762"],"abstract_inverted_index":{"Objective:":[0],"An":[1],"in":[2,18,95,180,196,198,217],"vitro":[3],"study":[4],"to":[5,20,46,104,128,192,200,208],"determine":[6],"the":[7,57,66,86,181,185],"age":[8,45,225],"and":[9,23,31,81,93,107,119,132,141,147,172,184,203,220,232],"gender":[10,212],"related":[11,213],"changes":[12],"of":[13,44,49,63,68,72,116,187],"dental":[14],"pulp":[15],"stem":[16],"cells":[17,118,136],"regards":[19,199,207],"proliferative":[21,167,201,230],"capacity":[22,171,202],"lineage":[24,233],"dependent":[25,234],"effects":[26,235],"on":[27,236],"differentiation":[28,129,204,238],"capabilities.":[29],"Material":[30],"Methods:":[32],"Specimens":[33],"have":[34],"been":[35],"collected":[36,55,84],"from":[37,41,56,85],"a":[38,165,228],"population":[39],"ranging":[40],"16":[42],"yrs":[43,48],"78":[47],"age.":[50],"Intact,":[51],"non-carious":[52],"teeth":[53],"were":[54,75,78,113,122,126,137],"oral":[58],"surgery":[59],"department":[60],"at":[61,65],"College":[62],"Dentistry":[64],"University":[67],"Iowa.":[69],"A":[70,210],"total":[71],"20":[73],"specimens":[74],"collected.":[76],"Teeth":[77],"collected,":[79],"sectioned":[80],"pulpal":[82,89],"tissue":[83,90,100],"specimens.":[87],"The":[88,99,124,135],"was":[91,101,215],"cut":[92],"stored":[94],"phosphate":[96],"buffered":[97],"saline.":[98],"then":[102],"subjected":[103,127],"enzymatic":[105],"digestion":[106],"DPSC":[108,125,188,237],"isolation.":[109],"Subsequently":[110],"cell":[111],"cultures":[112],"grown,":[114],"percentage":[115,186],"Stro-1+":[117],"proliferation":[120],"rate":[121],"measured.":[123],"via":[130],"osteogenic":[131,140,170,218],"adipogenic":[133,142,182],"medium.":[134],"assessed":[138],"for":[139,246],"characteristics":[143],"using":[144,151],"RT-":[145],"PCR":[146],"also":[148],"replicative":[149],"senescence":[150],"telomere":[152,174,221],"length":[153],"ratio":[154],"measurement.":[155],"Results:":[156],"Data":[157],"suggests":[158],"that":[159],"with":[160,206],"increasing":[161],"age,":[162],"there":[163],"is":[164,177],"decreased":[166,169,229],"capacity,":[168],"shortened":[173],"length.":[175,222],"There":[176,190],"no":[178,194],"difference":[179,195],"potential":[183,205,219],"present.":[189],"appears":[191],"be":[193,244],"DPSCs":[197],"gender.":[209],"possible":[211],"effect":[214,231],"noted":[216],"Conclusion:":[223],"Increasing":[224],"has":[226],"both":[227],"potential.":[239],"Thus":[240],"this":[241],"relationship":[242],"must":[243],"accounted":[245],"when":[247],"developing":[248],"future":[249],"regenerative":[250],"therapies.":[251]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}