{"id":"https://openalex.org/W83193468","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","title":"LMWH inhibits anterior chamber inflammation after extra capsular lens extraction through down regulation of bFGF content in aqueous humor.","display_name":"LMWH inhibits anterior chamber inflammation after extra capsular lens extraction through down regulation of bFGF content in aqueous humor.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W83193468","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","mag":"83193468","pmid":"https://pubmed.ncbi.nlm.nih.gov/22937500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3428536"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2430747","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3428536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3428536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035598952","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0003-4118-6289","observed_orcids":["https://orcid.org/0000-0003-4118-6289"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ming Wang","raw_affiliation_strings":["Department of Ophthalmology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662485","display_name":"Lei Xiong","orcid":"https://orcid.org/0000-0003-3799-7679","observed_orcids":["https://orcid.org/0000-0003-3799-7679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013781784","display_name":"Quanchen Xiong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quan-Chen Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078112607","display_name":"Ya-Zhi Fan","orcid":"https://orcid.org/0000-0002-9150-1470","observed_orcids":["https://orcid.org/0000-0002-9150-1470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Zhi Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2823,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59744158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"4","first_page":"430","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anterior-chamber-inflammation","display_name":"anterior chamber inflammation","score":0.847000002861023},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postoperative-inflammatory-response","display_name":"postoperative inflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.8849999904632568},{"id":"https://openalex.org/keywords/aqueous-flare","display_name":"aqueous flare","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cataract-surgery","display_name":"cataract surgery","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.790175199508667},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.7367266416549683},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.7040295600891113},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5748167037963867},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5515331625938416},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.46298539638519287},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3443829417228699},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32464364171028137},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2011108696460724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16134268045425415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15834546089172363},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2430747","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3428536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22937500","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22937500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3428536","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3428536/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Ophthalmol","raw_type":"Text"},{"id":"mag:2511849071","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/60944X/201204/1003039085.html","pdf_url":null,"source":{"id":"https://openalex.org/S2481947471","display_name":"International Journal of Ophthalmology","issn_l":"2222-3959","issn":["2222-3959","2227-4898"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311965","host_organization_name":"Press of International Journal of Ophthalmology (IJO PRESS)","host_organization_lineage":["https://openalex.org/P4310311965"],"host_organization_lineage_names":["Press of International Journal of Ophthalmology (IJO PRESS)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u56fd\u9645\u773c\u79d1\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:83193468","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22937500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2430747","doi":"https://doi.org/10.3980/j.issn.2222-3959.2012.04.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3428536","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W14719812","https://openalex.org/W176971745","https://openalex.org/W2409946976","https://openalex.org/W2427459423"],"related_works":["https://openalex.org/W2511849071","https://openalex.org/W2391942384","https://openalex.org/W2391349054","https://openalex.org/W2183537171","https://openalex.org/W2364263021","https://openalex.org/W3028701710","https://openalex.org/W2409946976","https://openalex.org/W2031679750","https://openalex.org/W175968254","https://openalex.org/W2391059076"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"observe":[2],"the":[3,24,71,76,141,185,200,226,259,274],"changes":[4],"of":[5,26,73,78,85,112,121,145,153,193,223,276,298],"basic":[6],"fibroblast":[7],"growth":[8],"factor":[9],"(bFGF)":[10],"content":[11,204,236,300],"in":[12,49,61,80,123,147,160,168,195,211,219,225,237,245,289,301],"anterior":[13,33,68,281],"chamber":[14,34,69,282],"before":[15],"and":[16,44,90,107,158,177,266],"after":[17,130,231,250,284],"extra":[18,285],"capsular":[19,53,286],"lens":[20,54,287],"extraction":[21,55,288],"for":[22,139],"investigating":[23],"mechanism":[25],"low":[27],"molecular":[28],"weight":[29],"heparin":[30],"(LMWH)":[31],"inhibiting":[32],"inflammation.":[35],"METHODS:":[36],"Eighty-four":[37],"rabbits":[38,48],"were":[39,92,115,126,132,137,163,240,256],"randomly":[40],"divided":[41],"into":[42,67],"control":[43,169,220,238],"experimental":[45,81,161,212,246],"group,":[46,213],"42":[47],"each":[50,62,113,117],"group.":[51,82,221],"Extra":[52],"was":[56,65,182],"done":[57],"on":[58,98,172,207,215,262],"unilateral":[59],"eye":[60],"rabbit.":[63],"LMWH":[64,272],"perfused":[66],"by":[70,128,273],"concentration":[72,275],"50U/mL":[74,277],"at":[75,116,188,199],"end":[77],"operation":[79],"The":[83,151,234],"degrees":[84,152],"corneal":[86,154],"edema,":[87,155],"aqueous":[88,124,148,156,196,302],"flare":[89,157],"fibrin":[91,159],"evaluated":[93],"with":[94,271],"slit":[95],"lamp":[96],"microscope":[97],"postoperative":[99,173,208,216,263],"day":[100,174,209,217,264],"1,":[101,175],"3,":[102],"6,":[103,178],"15,":[104],"30,":[105],"45":[106,265],"60,":[108,267],"respectively.":[109,179,268],"Six":[110],"eyes":[111,136],"group":[114,162,170,239,247],"time":[118],"point.":[119],"Contents":[120,192,222],"bFGF":[122,146,194,203,224,235,299],"humor":[125,197],"determined":[127],"ELISA":[129],"animals":[131],"killed.":[133],"Another":[134],"six":[135],"used":[138],"determining":[140],"base":[142],"line":[143],"level":[144],"humor.":[149,303],"RESULTS:":[150],"significantly":[164,241,279],"lighter":[165],"than":[166,243],"those":[167],"(P<0.01)":[171],"3":[176],"No":[180,253],"difference":[181],"showed":[183],"between":[184,258],"two":[186,227,260],"groups":[187,228,261],"other":[189],"point":[190],"time.":[191,202],"increased":[198],"same":[201],"reached":[205],"peak":[206],"1":[210],"while":[214],"6":[218],"declined":[229],"slowly":[230],"reaching":[232],"peak.":[233],"higher":[242],"that":[244],"1-30":[248],"days":[249],"surgery":[251],"(P<0.05).":[252],"significant":[254],"differences":[255],"shown":[257],"CONCLUSION:":[269],"Perfusion":[270],"can":[278],"reduce":[280],"inflammation":[283],"rabbits,":[290],"which":[291],"may":[292],"be":[293],"related":[294],"to":[295],"down":[296],"regulation":[297]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}