{"id":"https://openalex.org/W831335085","doi":null,"title":"Development of a mouse model for the study of osteoarthritis pain","display_name":"Development of a mouse model for the study of osteoarthritis pain","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W831335085","mag":"831335085"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:21153","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/21153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057736012","display_name":"Chancie Knights","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chancie Knights","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057736012"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis-pain","display_name":"osteoarthritis pain","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7570000290870667},{"id":"https://openalex.org/keywords/partial-medial-meniscectomy","display_name":"partial medial meniscectomy","score":1.0},{"id":"https://openalex.org/keywords/mechanical-hyperalgesia","display_name":"mechanical hyperalgesia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cold-allodynia","display_name":"cold allodynia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vocalizations","display_name":"vocalizations","score":0.6759999990463257},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.8180000185966492},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.781000018119812},{"id":"https://openalex.org/keywords/endogenous-opioids","display_name":"endogenous opioids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.609000027179718},{"id":"https://openalex.org/keywords/genetically-modified-mice","display_name":"genetically modified mice","score":0.7289999723434448},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7167524695396423},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4415375590324402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40486931800842285},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3773302435874939},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.35762932896614075},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.22140148282051086},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08472791314125061}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:21153","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/21153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},{"id":"mag:831335085","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628049","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":257,"referenced_works":["https://openalex.org/W14496186","https://openalex.org/W42442342","https://openalex.org/W56207713","https://openalex.org/W60522490","https://openalex.org/W69766374","https://openalex.org/W86325689","https://openalex.org/W176814618","https://openalex.org/W194903029","https://openalex.org/W1487036716","https://openalex.org/W1551310212","https://openalex.org/W1594150142","https://openalex.org/W1594770614","https://openalex.org/W1596758664","https://openalex.org/W1782095941","https://openalex.org/W1840804593","https://openalex.org/W1845054049","https://openalex.org/W1878998678","https://openalex.org/W1896731805","https://openalex.org/W1915946375","https://openalex.org/W1937888893","https://openalex.org/W1942930266","https://openalex.org/W1956547950","https://openalex.org/W1959157182","https://openalex.org/W1959229569","https://openalex.org/W1965948569","https://openalex.org/W1966917600","https://openalex.org/W1967132326","https://openalex.org/W1968061311","https://openalex.org/W1968879356","https://openalex.org/W1970141662","https://openalex.org/W1971759646","https://openalex.org/W1972592953","https://openalex.org/W1973910337","https://openalex.org/W1974759500","https://openalex.org/W1976037358","https://openalex.org/W1976473344","https://openalex.org/W1978829341","https://openalex.org/W1979246434","https://openalex.org/W1980241739","https://openalex.org/W1980359398","https://openalex.org/W1980798939","https://openalex.org/W1980885430","https://openalex.org/W1982303210","https://openalex.org/W1982534244","https://openalex.org/W1984096754","https://openalex.org/W1984252894","https://openalex.org/W1984271619","https://openalex.org/W1984832858","https://openalex.org/W1985340342","https://openalex.org/W1985670285","https://openalex.org/W1985761943","https://openalex.org/W1987836761","https://openalex.org/W1989050612","https://openalex.org/W1989198317","https://openalex.org/W1989833758","https://openalex.org/W1990078084","https://openalex.org/W1991488724","https://openalex.org/W1992121047","https://openalex.org/W1992400477","https://openalex.org/W1994593694","https://openalex.org/W1994618304","https://openalex.org/W1995330222","https://openalex.org/W1995463676","https://openalex.org/W1996213831","https://openalex.org/W1997140718","https://openalex.org/W1997637714","https://openalex.org/W1998482813","https://openalex.org/W1999087512","https://openalex.org/W1999484572","https://openalex.org/W1999860802","https://openalex.org/W2000492372","https://openalex.org/W2000519148","https://openalex.org/W2002251686","https://openalex.org/W2002534005","https://openalex.org/W2003066952","https://openalex.org/W2003542915","https://openalex.org/W2004087885","https://openalex.org/W2006864238","https://openalex.org/W2007034094","https://openalex.org/W2007390402","https://openalex.org/W2007888083","https://openalex.org/W2008127512","https://openalex.org/W2008442706","https://openalex.org/W2009524387","https://openalex.org/W2009747539","https://openalex.org/W2009967312","https://openalex.org/W2010067410","https://openalex.org/W2011909645","https://openalex.org/W2014159435","https://openalex.org/W2014163423","https://openalex.org/W2015463772","https://openalex.org/W2015734868","https://openalex.org/W2016183904","https://openalex.org/W2016896506","https://openalex.org/W2017579145","https://openalex.org/W2017869529","https://openalex.org/W2019336825","https://openalex.org/W2019639349","https://openalex.org/W2019972898","https://openalex.org/W2022031142","https://openalex.org/W2022219238","https://openalex.org/W2022497559","https://openalex.org/W2023538813","https://openalex.org/W2026057304","https://openalex.org/W2027782457","https://openalex.org/W2028186017","https://openalex.org/W2028339112","https://openalex.org/W2028920679","https://openalex.org/W2029993965","https://openalex.org/W2030665584","https://openalex.org/W2031788545","https://openalex.org/W2032186105","https://openalex.org/W2032306447","https://openalex.org/W2035257142","https://openalex.org/W2035413305","https://openalex.org/W2037043363","https://openalex.org/W2037186296","https://openalex.org/W2037208185","https://openalex.org/W2038089520","https://openalex.org/W2038255710","https://openalex.org/W2038932665","https://openalex.org/W2038975231","https://openalex.org/W2039871355","https://openalex.org/W2040299229","https://openalex.org/W2040977107","https://openalex.org/W2041173066","https://openalex.org/W2043431908","https://openalex.org/W2043883181","https://openalex.org/W2045145665","https://openalex.org/W2045592577","https://openalex.org/W2045960213","https://openalex.org/W2047734268","https://openalex.org/W2051115280","https://openalex.org/W2052893433","https://openalex.org/W2058435889","https://openalex.org/W2058500772","https://openalex.org/W2058878920","https://openalex.org/W2059478187","https://openalex.org/W2059524959","https://openalex.org/W2062897333","https://openalex.org/W2063347675","https://openalex.org/W2064441047","https://openalex.org/W2064765332","https://openalex.org/W2065261838","https://openalex.org/W2066666725","https://openalex.org/W2067346310","https://openalex.org/W2068485217","https://openalex.org/W2068735758","https://openalex.org/W2070325241","https://openalex.org/W2071216905","https://openalex.org/W2071441738","https://openalex.org/W2071531474","https://openalex.org/W2071718640","https://openalex.org/W2071893619","https://openalex.org/W2073162601","https://openalex.org/W2074726858","https://openalex.org/W2075100277","https://openalex.org/W2075371618","https://openalex.org/W2075711985","https://openalex.org/W2075715972","https://openalex.org/W2075981875","https://openalex.org/W2077116297","https://openalex.org/W2077885131","https://openalex.org/W2078972659","https://openalex.org/W2081055505","https://openalex.org/W2082241876","https://openalex.org/W2082908786","https://openalex.org/W2085185063","https://openalex.org/W2087333063","https://openalex.org/W2087665027","https://openalex.org/W2088311820","https://openalex.org/W2088858180","https://openalex.org/W2091129286","https://openalex.org/W2092073393","https://openalex.org/W2092980618","https://openalex.org/W2094660330","https://openalex.org/W2095108162","https://openalex.org/W2097584864","https://openalex.org/W2099427592","https://openalex.org/W2104338235","https://openalex.org/W2104721296","https://openalex.org/W2106097986","https://openalex.org/W2106478572","https://openalex.org/W2106522962","https://openalex.org/W2106572941","https://openalex.org/W2107063571","https://openalex.org/W2107362722","https://openalex.org/W2109109035","https://openalex.org/W2109827203","https://openalex.org/W2109879418","https://openalex.org/W2110213068","https://openalex.org/W2112374588","https://openalex.org/W2113737911","https://openalex.org/W2114716950","https://openalex.org/W2115369213","https://openalex.org/W2115376597","https://openalex.org/W2115601182","https://openalex.org/W2117040516","https://openalex.org/W2118900213","https://openalex.org/W2118996750","https://openalex.org/W2120229762","https://openalex.org/W2120884990","https://openalex.org/W2122828560","https://openalex.org/W2122883560","https://openalex.org/W2124355299","https://openalex.org/W2124420763","https://openalex.org/W2127635545","https://openalex.org/W2128380002","https://openalex.org/W2129326126","https://openalex.org/W2130420429","https://openalex.org/W2132260835","https://openalex.org/W2133316133","https://openalex.org/W2133540538","https://openalex.org/W2134283897","https://openalex.org/W2134905207","https://openalex.org/W2135119721","https://openalex.org/W2136754136","https://openalex.org/W2137445147","https://openalex.org/W2139361583","https://openalex.org/W2141363952","https://openalex.org/W2141609058","https://openalex.org/W2142925530","https://openalex.org/W2144421372","https://openalex.org/W2147503051","https://openalex.org/W2148195877","https://openalex.org/W2148575622","https://openalex.org/W2149290144","https://openalex.org/W2149855043","https://openalex.org/W2152064724","https://openalex.org/W2152484263","https://openalex.org/W2153763507","https://openalex.org/W2155524482","https://openalex.org/W2155671648","https://openalex.org/W2156733405","https://openalex.org/W2157672175","https://openalex.org/W2158622693","https://openalex.org/W2159980203","https://openalex.org/W2160611045","https://openalex.org/W2160779124","https://openalex.org/W2161934021","https://openalex.org/W2164042844","https://openalex.org/W2164863281","https://openalex.org/W2166622977","https://openalex.org/W2167792025","https://openalex.org/W2169782271","https://openalex.org/W2171633908","https://openalex.org/W2172146727","https://openalex.org/W2172201406","https://openalex.org/W2248077625","https://openalex.org/W2256167805","https://openalex.org/W2336588424","https://openalex.org/W2337527034","https://openalex.org/W2340946487","https://openalex.org/W2408708585","https://openalex.org/W2408776802","https://openalex.org/W2414373265","https://openalex.org/W4406059077"],"related_works":["https://openalex.org/W1972810913","https://openalex.org/W2023519783","https://openalex.org/W3184924296","https://openalex.org/W2039871355","https://openalex.org/W2048811067","https://openalex.org/W2153600755","https://openalex.org/W7062604706","https://openalex.org/W2051948028","https://openalex.org/W2910914601","https://openalex.org/W2071171984"],"abstract_inverted_index":{"Murine":[0],"models":[1,27,31],"of":[2,46,54,106,150,178,223,236,249,261,274,286,310,313,321],"osteoarthritis":[3],"(OA)":[4],"provide":[5],"a":[6,68,175,304],"potentially":[7],"powerful":[8],"tool":[9,306],"to":[10,89,136,155,244,302],"elucidate":[11],"mechanisms":[12],"responsible":[13],"for":[14,49,92,153,170,307,318],"OA":[15,26,38,254,262,279,287,314],"pain.":[16,225],"However,":[17],"few":[18],"studies":[19],"have":[20],"examined":[21],"pain":[22,180,189,241,251,255,276,280,315],"behaviours":[23,190],"in":[24,28,67,87,114,134,140,144,253,258,278,283],"relevant":[25],"mice.":[29],"Several":[30],"including":[32],"spontaneous,":[33],"surgical":[34],"and":[35,85,128,131,158,203,269,294,316],"chemically":[36],"induced":[37],"were":[39,101,256,281],"explored":[40],"before":[41],"selecting":[42],"partial":[43],"medial":[44,298],"meniscectomy":[45,299],"C57BI/6":[47],"mice":[48],"in-depth":[50],"study.":[51,108],"The":[52,247,272],"development":[53],"degenerative":[55],"joint":[56],"disease":[57],"was":[58,73,112,159,242],"confirmed":[59],"using":[60,263,288],"histology":[61],"which":[62],"illustrated":[63],"progressive":[64],"cartilage":[65],"damage":[66],"time":[69],"dependent":[70],"manner.":[71],"Pain":[72,167,214],"assessed":[74],"by":[75,161,174,194,234],"monitoring":[76],"weight":[77,98],"bearing,":[78],"mechanical":[79,83,110,126],"hyperalgesia,":[80],"cold":[81,129],"allodynia,":[82,130],"allodynia":[84,111],"vocalisation":[86,133],"response":[88,135],"knee":[90,137],"compression":[91,138],"12":[93],"weeks":[94,121,157,172,183],"post-surgery.":[95,184],"No":[96],"significant":[97],"bearing":[99],"deficits":[100],"observed":[102],"during":[103,216],"the":[104,107,115,141,217,308,311,319],"course":[105],"Significant":[109],"present":[113],"ipsilateral":[116,142],"hind":[117],"limb":[118,125,143],"from":[119],"9":[120],"following":[122],"surgery.":[123],"Hind":[124],"hyperalgesia":[127],"increased":[132],"developed":[139],"two":[145,212],"phases.":[146],"An":[147],"early":[148],"phase":[149,177,219],"hypersensitivities":[151,230],"lasted":[152],"up":[154],"3":[156],"reversed":[160,193],"treatment":[162],"with":[163,220],"an":[164],"NSAID,":[165],"diclofenac.":[166],"then":[168],"resolved":[169],"several":[171],"followed":[173],"second":[176,218],"NSAID-insensitive":[179],"after":[181],"6":[182],"During":[185],"this":[186,259,284],"phase,":[187],"all":[188],"could":[191,231],"be":[192,232,303],"morphine.":[195],"In":[196],"contrast,":[197],"other":[198],"analgesic":[199],"drugs":[200],"(paracetamol,":[201],"gabapentin":[202],"tramadol)":[204],"had":[205],"selective":[206],"effects":[207],"on":[208],"only":[209],"one":[210],"or":[211],"modalities.":[213],"fluctuated":[215],"transient":[221],"periods":[222],"reduced":[224,240],"At":[226],"these":[227],"times":[228],"underlying":[229],"unmasked":[233],"administration":[235],"naloxone":[237],"indicating":[238],"that":[239],"due":[243],"endogenous":[245],"opioids.":[246],"role":[248,273],"specific":[250,275],"receptors":[252,277],"investigated":[257,282],"model":[260,285],"genetically":[264,289],"modified":[265,290],"mice,":[266,291],"novel":[267,292],"analgesics":[268,293],"calcium":[270,295],"imaging.":[271,296],"Partial":[297],"has":[300],"proven":[301],"useful":[305],"investigation":[309],"pathophysiology":[312],"also":[317],"discovery":[320],"potential":[322],"new":[323],"therapeutics.":[324]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
