{"id":"https://openalex.org/W83068226","doi":"https://doi.org/10.1007/978-1-59259-479-5_3","title":"Cell Swelling in Cerebral Ischemia","display_name":"Cell Swelling in Cerebral Ischemia","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W83068226","doi":"https://doi.org/10.1007/978-1-59259-479-5_3","mag":"83068226"},"language":"sl","primary_location":{"id":"doi:10.1007/978-1-59259-479-5_3","doi":"https://doi.org/10.1007/978-1-59259-479-5_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-479-5_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Ischemia","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4255737951","display_name":"Cerebral Ischemia"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114011818","display_name":"Harold K. Kimelberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Harold K. Kimelberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5114011818"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6234,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.66563728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"45","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-swelling","display_name":"cell swelling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/charge-neutrality","display_name":"charge neutrality","score":0.7760000228881836},{"id":"https://openalex.org/keywords/semipermeable-membranes","display_name":"semipermeable membranes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7757805585861206},{"id":"https://openalex.org/C94421946","wikidata":"https://www.wikidata.org/wiki/Q17043863","display_name":"Donnan potential","level":4,"score":0.7576910853385925},{"id":"https://openalex.org/C107511713","wikidata":"https://www.wikidata.org/wiki/Q866317","display_name":"Semipermeable membrane","level":3,"score":0.7497960329055786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7323671579360962},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6014298796653748},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.5728098154067993},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5637080073356628},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5386471748352051},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4970727264881134},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.4529409408569336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2244662344455719},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.18140703439712524},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.09206128120422363},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.08816808462142944},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-479-5_3","doi":"https://doi.org/10.1007/978-1-59259-479-5_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-479-5_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Ischemia","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W171292496","https://openalex.org/W171346032","https://openalex.org/W210515338","https://openalex.org/W402438237","https://openalex.org/W420743000","https://openalex.org/W422189603","https://openalex.org/W566333469","https://openalex.org/W603717701","https://openalex.org/W841526488","https://openalex.org/W1497027759","https://openalex.org/W1543868776","https://openalex.org/W1552492984","https://openalex.org/W1591646146","https://openalex.org/W1592818492","https://openalex.org/W1674335052","https://openalex.org/W1844768017","https://openalex.org/W1900227502","https://openalex.org/W1936866440","https://openalex.org/W1967925024","https://openalex.org/W1968928244","https://openalex.org/W1976754780","https://openalex.org/W1981133890","https://openalex.org/W1981513754","https://openalex.org/W1982632034","https://openalex.org/W1988052349","https://openalex.org/W1988147297","https://openalex.org/W1988606081","https://openalex.org/W1989155697","https://openalex.org/W1989868065","https://openalex.org/W1991701465","https://openalex.org/W1991853401","https://openalex.org/W1994137439","https://openalex.org/W1996196738","https://openalex.org/W2003410399","https://openalex.org/W2004904688","https://openalex.org/W2006681786","https://openalex.org/W2009788226","https://openalex.org/W2015794252","https://openalex.org/W2016575029","https://openalex.org/W2017086759","https://openalex.org/W2018075479","https://openalex.org/W2018795711","https://openalex.org/W2022889768","https://openalex.org/W2024422704","https://openalex.org/W2027006803","https://openalex.org/W2028840842","https://openalex.org/W2032827072","https://openalex.org/W2034275018","https://openalex.org/W2034454128","https://openalex.org/W2036511400","https://openalex.org/W2049685486","https://openalex.org/W2050432103","https://openalex.org/W2062238583","https://openalex.org/W2063504319","https://openalex.org/W2065500785","https://openalex.org/W2066419715","https://openalex.org/W2068095864","https://openalex.org/W2068427906","https://openalex.org/W2074488489","https://openalex.org/W2074792377","https://openalex.org/W2079344865","https://openalex.org/W2079569777","https://openalex.org/W2090544950","https://openalex.org/W2091079769","https://openalex.org/W2092892837","https://openalex.org/W2094038479","https://openalex.org/W2099712604","https://openalex.org/W2099790144","https://openalex.org/W2105056821","https://openalex.org/W2114131838","https://openalex.org/W2114504271","https://openalex.org/W2115638394","https://openalex.org/W2115891269","https://openalex.org/W2129692557","https://openalex.org/W2139155172","https://openalex.org/W2141946911","https://openalex.org/W2142503237","https://openalex.org/W2160588083","https://openalex.org/W2179555289","https://openalex.org/W2180104442","https://openalex.org/W2209526247","https://openalex.org/W2290010678","https://openalex.org/W2316634253","https://openalex.org/W2330540255","https://openalex.org/W2331872561","https://openalex.org/W2398443655","https://openalex.org/W2400044024","https://openalex.org/W2400918729","https://openalex.org/W2403340116","https://openalex.org/W2408194645","https://openalex.org/W2411019228","https://openalex.org/W2416874786","https://openalex.org/W2419508362","https://openalex.org/W2422404462","https://openalex.org/W2500246241","https://openalex.org/W2768556492","https://openalex.org/W2887646526","https://openalex.org/W2983864680","https://openalex.org/W2985956097","https://openalex.org/W4210982669","https://openalex.org/W4240366224","https://openalex.org/W4300784327","https://openalex.org/W6633017383","https://openalex.org/W6633058493"],"related_works":["https://openalex.org/W4319599617","https://openalex.org/W981839311","https://openalex.org/W12454575","https://openalex.org/W2942040335","https://openalex.org/W2134866582","https://openalex.org/W2343007549","https://openalex.org/W4248274913","https://openalex.org/W4400585227","https://openalex.org/W2046292218","https://openalex.org/W7097000967"],"abstract_inverted_index":{"The":[0,90],"simplest":[1],"mechanism":[2],"for":[3],"cell":[4,79,183,229,239],"swelling":[5,9],"is":[6,29,80,155,164,169,188,268],"termed":[7],"Donnan":[8,55],"in":[10,121,213],"which":[11,120],"cells":[12],"are":[13,86,230],"simply":[14],"viewed":[15],"as":[16,31,73,276],"collections":[17],"of":[18,59,62,67,132,177,198,220,249],"predominantly":[19],"anionic":[20],"macromolecules":[21],"surrounded":[22],"by":[23,259,263],"a":[24,49,112,243],"semipermeable":[25],"lipid":[26],"membrane.":[27],"This":[28,266],"speculated":[30],"being":[32],"the":[33,60,65,78,87,94,100,103,109,130,133,141,153,159,182,185,195,204,211,218,228,238,247,250,264,271,277],"prototypic":[34],"cell\u2014a":[35],"spontaneously":[36],"forming":[37],"phospholipid":[38],"bilayer":[39],"membrane":[40,95,104,114,145,154,186],"enclosing":[41],"enough":[42],"protein":[43],"and":[44,75,125,179,200,223,226,261,270],"nucleic":[45],"acids":[46],"to":[47,108,158,193,242],"form":[48],"nonequilibrium,":[50],"self-replicating":[51],"entity":[52],"(Tosteson,":[53],"1963b).":[54],"forces":[56],"arise":[57],"because":[58,184],"principle":[61],"electroneutrality.":[63],"Thus":[64],"number":[66],"small,":[68],"presumed":[69],"membrane-permeable":[70],"anions":[71,135,180,199,224,252],"such":[72],"Cl\u00af":[74],"HCO3\u00af":[76],"inside":[77,93,225],"less":[81,189],"than":[82,191,203],"outside,":[83],"where":[84],"they":[85],"only":[88,106,235],"anions.":[89],"membrane-permeant":[91],"cations":[92,160,178,222],"generally":[96],"equal":[97],"those":[98],"on":[99],"outside.":[101],"If":[102],"were":[105,257],"permeable":[107,157,221],"small":[110],"anions,":[111],"Nernstian":[113],"potential":[115,146,163,187],"would":[116,127],"be":[117,148,175,274],"set":[118],"up":[119],"sign":[122],"(inside":[123],"negative)":[124,151],"magnitude":[126],"exactly":[128],"oppose":[129],"movement":[131,176],"permeant":[134],"down":[136],"their":[137],"concentration":[138,248],"gradients":[139],"into":[140,181],"cells.":[142],"However,":[143,232],"this":[144,167,233],"will":[147,173,215,234],"reduced":[149],"(less":[150],"when":[152,237],"also":[156],"whose":[161],"equilibrium":[162,206],"zero.":[165],"Thus,":[166],"situation":[168],"not":[170,262],"stable;":[171],"there":[172],"always":[174],"negative":[190,202],"needed":[192],"balance":[194],"net":[196],"influx":[197],"more":[201],"cation":[205],"potential.":[207],"To":[208],"reach":[209],"equilibrium,":[210],"cell,":[212],"theory,":[214],"swell":[216],"until":[217],"concentrations":[219],"outside":[227],"equal.":[231],"occur":[236],"has":[240],"swollen":[241],"size":[244],"that":[245],"makes":[246],"impermeant":[251],"vanishingly":[253],"small.":[254],"These":[255],"keywords":[256,272],"added":[258],"machine":[260],"authors.":[265],"process":[267],"experimental":[269],"may":[273],"updated":[275],"learning":[278],"algorithm":[279],"improves.":[280]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}