{"id":"https://openalex.org/W829806972","doi":null,"title":"Characterization of the Anti-angiogenic Properties of KDR-Ig4-7 and its Variants as Potential Anti-cancer Therapeutics","display_name":"Characterization of the Anti-angiogenic Properties of KDR-Ig4-7 and its Variants as Potential Anti-cancer Therapeutics","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W829806972","mag":"829806972"},"language":"en","primary_location":{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1161","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/161","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/161","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tigerprints.clemson.edu/all_dissertations/161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026424090","display_name":"Jang Pyo Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jang Pyo Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026424090"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.6359999775886536},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8349999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4860000014305115},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.6779999732971191},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8894566297531128},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.6588643789291382},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5623825788497925},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5513368844985962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5435689091682434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5390192270278931},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5290963649749756},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5070321559906006},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4907039403915405},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44967371225357056},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4342016875743866},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.41060325503349304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15967482328414917},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0872901976108551},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1161","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/161","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/161","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"pmh:oai:open.clemson.edu:all_dissertations-1161","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/161","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"mag:829806972","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/161/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1161","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/161","pdf_url":"https://tigerprints.clemson.edu/all_dissertations/161","source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W829806972.pdf","grobid_xml":"https://content.openalex.org/works/W829806972.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W56534538","https://openalex.org/W75273126","https://openalex.org/W582962088","https://openalex.org/W636264593","https://openalex.org/W1489873347","https://openalex.org/W1494571575","https://openalex.org/W1502515987","https://openalex.org/W1531079490","https://openalex.org/W1570971207","https://openalex.org/W1579297325","https://openalex.org/W1593130318","https://openalex.org/W1670891845","https://openalex.org/W1679229092","https://openalex.org/W1756894428","https://openalex.org/W1845506541","https://openalex.org/W1863396779","https://openalex.org/W1963876488","https://openalex.org/W1964389139","https://openalex.org/W1966091070","https://openalex.org/W1966535797","https://openalex.org/W1966931906","https://openalex.org/W1967587727","https://openalex.org/W1969695473","https://openalex.org/W1970614272","https://openalex.org/W1973918329","https://openalex.org/W1974188350","https://openalex.org/W1977776349","https://openalex.org/W1978139448","https://openalex.org/W1978340181","https://openalex.org/W1980701140","https://openalex.org/W1982246723","https://openalex.org/W1982912692","https://openalex.org/W1985359220","https://openalex.org/W1985712533","https://openalex.org/W1986412618","https://openalex.org/W1986559037","https://openalex.org/W1987306181","https://openalex.org/W1987454669","https://openalex.org/W1990624032","https://openalex.org/W1991123816","https://openalex.org/W1991958278","https://openalex.org/W1992101966","https://openalex.org/W1995857537","https://openalex.org/W1999600810","https://openalex.org/W2000064849","https://openalex.org/W2000196730","https://openalex.org/W2000292756","https://openalex.org/W2000307014","https://openalex.org/W2001658518","https://openalex.org/W2002408287","https://openalex.org/W2003686790","https://openalex.org/W2004907588","https://openalex.org/W2004918005","https://openalex.org/W2005994924","https://openalex.org/W2008786326","https://openalex.org/W2008830445","https://openalex.org/W2009968499","https://openalex.org/W2009997132","https://openalex.org/W2010092400","https://openalex.org/W2012607934","https://openalex.org/W2013041233","https://openalex.org/W2013818100","https://openalex.org/W2014133561","https://openalex.org/W2019426369","https://openalex.org/W2022163230","https://openalex.org/W2023052504","https://openalex.org/W2025173623","https://openalex.org/W2025600570","https://openalex.org/W2025933554","https://openalex.org/W2026038921","https://openalex.org/W2029521699","https://openalex.org/W2031061373","https://openalex.org/W2033759107","https://openalex.org/W2034269086","https://openalex.org/W2034448175","https://openalex.org/W2035127867","https://openalex.org/W2035595755","https://openalex.org/W2035693645","https://openalex.org/W2040972148","https://openalex.org/W2041323282","https://openalex.org/W2041609936","https://openalex.org/W2041816417","https://openalex.org/W2043508733","https://openalex.org/W2045247659","https://openalex.org/W2046516822","https://openalex.org/W2047470479","https://openalex.org/W2048141128","https://openalex.org/W2049612319","https://openalex.org/W2049852228","https://openalex.org/W2050499474","https://openalex.org/W2053221827","https://openalex.org/W2053473403","https://openalex.org/W2054154416","https://openalex.org/W2054979979","https://openalex.org/W2055515174","https://openalex.org/W2058268622","https://openalex.org/W2060118799","https://openalex.org/W2062679525","https://openalex.org/W2063883918","https://openalex.org/W2064623632","https://openalex.org/W2065240552","https://openalex.org/W2072928113","https://openalex.org/W2076415360","https://openalex.org/W2076820945","https://openalex.org/W2078676742","https://openalex.org/W2078868629","https://openalex.org/W2080237506","https://openalex.org/W2080881382","https://openalex.org/W2081143051","https://openalex.org/W2082240332","https://openalex.org/W2083157562","https://openalex.org/W2084740377","https://openalex.org/W2088255586","https://openalex.org/W2089861713","https://openalex.org/W2090028833","https://openalex.org/W2090134402","https://openalex.org/W2091774189","https://openalex.org/W2091818331","https://openalex.org/W2092118563","https://openalex.org/W2093498435","https://openalex.org/W2095445691","https://openalex.org/W2095882207","https://openalex.org/W2097731330","https://openalex.org/W2105064556","https://openalex.org/W2107919129","https://openalex.org/W2110173413","https://openalex.org/W2111707754","https://openalex.org/W2112264347","https://openalex.org/W2118378313","https://openalex.org/W2123424871","https://openalex.org/W2123840402","https://openalex.org/W2127463799","https://openalex.org/W2131798870","https://openalex.org/W2131899324","https://openalex.org/W2134891742","https://openalex.org/W2137473984","https://openalex.org/W2141046053","https://openalex.org/W2143659344","https://openalex.org/W2144026946","https://openalex.org/W2147066580","https://openalex.org/W2147153812","https://openalex.org/W2148130479","https://openalex.org/W2150108534","https://openalex.org/W2150156158","https://openalex.org/W2150732175","https://openalex.org/W2151752381","https://openalex.org/W2153003431","https://openalex.org/W2155591311","https://openalex.org/W2156113162","https://openalex.org/W2158965678","https://openalex.org/W2159241628","https://openalex.org/W2167298186","https://openalex.org/W2168736535","https://openalex.org/W2171998177","https://openalex.org/W2176758753","https://openalex.org/W2202356825","https://openalex.org/W2530014580","https://openalex.org/W2793323124"],"related_works":["https://openalex.org/W2070807808","https://openalex.org/W1997431163","https://openalex.org/W2322614519","https://openalex.org/W1580854977","https://openalex.org/W2142785166","https://openalex.org/W2125233609","https://openalex.org/W2353085321","https://openalex.org/W1977614672","https://openalex.org/W1604140953","https://openalex.org/W2080098573"],"abstract_inverted_index":{"Beginning":[0],"with":[1],"the":[2,33,46,75,102,108,138,153,173,265,270,274,292,299,304,310,318,326,334,349],"development":[3],"of":[4,24,35,66,77,82,97,121,124,152,267,276,284,294,312,329,336],"an":[5,14,70],"embryo":[6],"and":[7,20,54,62,90,116,141,197,202,225,247,254,315,353],"throughout":[8],"one's":[9],"adult":[10],"life":[11],"angiogenesis":[12,67,83],"plays":[13],"essential":[15],"role":[16],"for":[17,73,137,143,204,273],"organ":[18],"growth":[19,61,76,87],"repair.":[21],"The":[22,95,118,281],"balancing":[23],"pro-angiogenic":[25],"factors":[26,29],"to":[27,99,112,134,172,177,215,218,233,241,378],"anti-angiogenic":[28,207],"is":[30,40,132,374],"what":[31],"regulates":[32],"process":[34],"angiogenesis.":[36],"When":[37],"this":[38,189],"balance":[39],"disrupted":[41],"in":[42,58,105,129,228,289,317,333],"one":[43],"direction":[44],"or":[45],"other,":[47],"numerous":[48],"disorders":[49],"can":[50],"occur":[51],"including":[52],"ocular":[53],"inflammatory":[55],"diseases":[56],"and,":[57],"particular,":[59],"tumor":[60],"metastasis.":[63],"Therefore,":[64],"inhibition":[65,275],"has":[68],"become":[69],"effective":[71],"therapy":[72],"arresting":[74],"tumors.":[78],"A":[79],"key":[80],"regulator":[81],"involves":[84],"vascular":[85],"endothelial":[86,222,235],"factor":[88],"(VEGF)":[89],"its":[91,231],"receptor,":[92],"VEGFR-2":[93],"(KDR).":[94],"binding":[96,140,171],"VEGF":[98,184,341],"KDR":[100,122,154,168,176,180,192],"activates":[101],"receptor":[103,144,319],"which,":[104],"turn,":[106],"initiates":[107],"signaling":[109],"cascade":[110],"leading":[111],"cell":[113,277],"proliferation,":[114,251],"migration,":[115],"survival.":[117],"extracellular":[119,155],"portion":[120],"consists":[123],"seven":[125],"Ig-like":[126],"domains":[127,313],"(Ig1-7),":[128],"which":[130,308,338,347],"Ig1-3":[131],"believed":[133],"be":[135],"responsible":[136],"ligand":[139],"Ig4-7":[142],"dimerization.":[145],"We":[146,209],"hypothesized":[147],"that":[148,158,211,264,325,340,372],"a":[149,160,167,179,344,375],"soluble":[150],"fragment":[151],"domain":[156,163],"(KDR-Ig4-7)":[157],"lacks":[159],"tyrosine":[161],"kinase":[162],"may":[164],"serve":[165],"as":[166],"antagonist":[169,377],"by":[170,279],"membrane":[174],"bound":[175],"form":[178],"dimer":[181],"thus":[182],"preventing":[183],"induced":[185],"signal":[186],"transduction.":[187],"In":[188,355,367],"study":[190],"various":[191,245],"proteins":[193],"(KDR-Ig4-7,":[194],"KDR-Ig4-6,":[195],"KDR-Ig5-7":[196],"KDR-Ig5-6)":[198],"were":[199],"produced,":[200],"purified":[201],"characterized":[203],"their":[205],"potential":[206],"ability.":[208],"demonstrated":[210],"KDR-Ig4-7":[212,238,330,352,362,373],"was":[213,239,269,286,303,331,364],"able":[214,240],"specifically":[216,227],"bind":[217],"human":[219],"umbilical":[220],"vein":[221],"cells":[223,262],"(HUVEC),":[224],"accumulated":[226],"tumors":[229],"indicating":[230],"ability":[232],"target":[234],"cells.":[236],"Furthermore,":[237],"inhibit":[242],"HUVEC":[243],"(and":[244],"breast":[246],"leukemic":[248],"cancer":[249],"cells)":[250],"tube":[252],"formation":[253],"migration.":[255],"An":[256],"apoptosis":[257,268],"assay":[258],"conducted":[259],"using":[260],"T47-D":[261],"revealed":[263],"induction":[266],"likely":[271],"mechanism":[272],"proliferation":[278],"KDR-Ig4-7.":[280],"inhibitory":[282,327],"effect":[283],"KDR-Ig-4-7":[285,302],"at":[287],"least,":[288],"part,":[290],"through":[291],"blocking":[293],"ERK":[295],"phosphorylation.":[296],"Among":[297],"all":[298],"variants":[300],"tested,":[301],"most":[305],"potent":[306],"inhibitor,":[307],"suggested":[309,339],"involvement":[311],"Ig4":[314],"Ig7":[316],"dimerization":[320],"process.":[321],"Moreover,":[322],"we":[323],"found":[324],"activity":[328],"enhanced":[332],"presence":[335],"VEGF,":[337],"might":[342],"induce":[343],"conformational":[345],"change":[346],"favors":[348],"interaction":[350],"between":[351],"KDR.":[354,379],"our":[356,369],"4T1":[357],"xenograft":[358],"animal":[359],"studies,":[360],"however,":[361],"treatment":[363],"not":[365],"effective.":[366],"summary,":[368],"results":[370],"suggest":[371],"functional":[376]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
