{"id":"https://openalex.org/W828906101","doi":null,"title":"Die Bedeutung des Arylhydrocarbon Rezeptors f\u00fcr die Reifung und Funktion epidermaler Langerhans-Zellen","display_name":"Die Bedeutung des Arylhydrocarbon Rezeptors f\u00fcr die Reifung und Funktion epidermaler Langerhans-Zellen","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W828906101","mag":"828906101"},"language":"de","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:6854","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=6854","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080805055","display_name":"Bettina Jux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bettina Jux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080805055"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epidermal-langerhans-cells","display_name":"epidermal Langerhans cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/langerhans-cell-maturation","display_name":"Langerhans cell maturation","score":0.843999981880188},{"id":"https://openalex.org/keywords/tcdd","display_name":"TCDD","score":0.5220000147819519},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.8999999761581421},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.847000002861023},{"id":"https://openalex.org/keywords/haptens","display_name":"haptens","score":0.8410000205039978},{"id":"https://openalex.org/keywords/allergic-contact-dermatitis","display_name":"allergic contact dermatitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/phagosome-maturation","display_name":"phagosome maturation","score":0.45399999618530273},{"id":"https://openalex.org/keywords/phagosome-lysosome-fusion","display_name":"phagosome-lysosome fusion","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6917440891265869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6179661750793457},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.34811365604400635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16562369465827942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1377565860748291}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:6854","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=6854","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:828906101","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=6854","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1192919539","https://openalex.org/W2319714405","https://openalex.org/W2800649718","https://openalex.org/W3214409508","https://openalex.org/W7213479875","https://openalex.org/W1943478621","https://openalex.org/W2972187080","https://openalex.org/W1410997911","https://openalex.org/W819918528","https://openalex.org/W2971460795"],"abstract_inverted_index":{"Der":[0,23],"Arylhydrocarbon":[1],"Rezeptor":[2],"(AHR)":[3],"ist":[4,82],"ein":[5],"Liganden-aktivierter":[6],"Transkriptionsfaktor,":[7],"welcher":[8],"unter":[9,31,290],"anderem":[10,32,291],"die":[11,58,83,104,145,151,229,253],"Expression":[12,105],"Fremdstoff-metabolisierender":[13],"Enzyme":[14],"und":[15,38,73,85,179,191,232,236,245,318],"damit":[16],"den":[17],"Abbau":[18],"niedermolekularer":[19],"chemischer":[20],"Substanzen":[21,53,141,170,326],"reguliert.":[22],"AHR":[24,61,88,107,187,207,287,305],"nimmt":[25],"daruber":[26],"hinaus":[27],"auch":[28,211,268],"physiologische":[29,184,310],"Aufgaben":[30],"in":[33,54,62,89,108,156,188,204,306],"der":[34,39,63,90,97,189,240,304,307,313],"Regulation":[35,314],"des":[36,60,87,106,131,153,163,186,257,286,292,315],"Zellzyklus":[37],"Zelldifferenzierung":[40],"wahr.":[41],"Die":[42,273],"Haut":[43,64,91,308],"kommt":[44],"als":[45],"Barriereorgan":[46],"mit":[47,67],"einer":[48,77,120,198],"Vielzahl":[49],"an":[50],"niedermolekularen":[51,139,169],"chemischen":[52,140],"Kontakt.":[55],"Weiterhin":[56],"fuhrt":[57],"Aktivierung":[59,283],"durch":[65,125,136,269,282],"Exposition":[66],"exogenen":[68],"AHR-Liganden":[69],"wie":[70],"polychlorierten":[71],"Biphenylen":[72],"2,3,7,8-Tetrachlordibenzo-p-dioxin":[74],"(TCDD)":[75],"zu":[76],"Reihe":[78],"von":[79,138,175,193,214,295],"Effekten.":[80],"Dennoch":[81],"Auspragung":[84,130],"Funktion":[86,192],"bisher":[92],"nur":[93],"unzureichend":[94],"untersucht.\r":[95],"In":[96,197],"vorliegenden":[98],"Arbeit":[99],"konnte":[100,124,150,182],"um":[101],"ersten":[102],"Mal":[103],"Langerhans":[109],"Zellen":[110,217,230],"(LZ)":[111],"nachgewiesen":[112,195],"werden.":[113,134,196],"Uberraschenderweise":[114],"blieben":[115],"LZ":[116,157,176,194,254],"jedoch":[117],"inert":[118],"gegenuber":[119,167],"TCDD-induzierten":[121],"Genexpression.":[122],"Dies":[123],"eine":[126,146,158,183,270,281,319],"ungewohnlich":[127],"hohe":[128],"konstitutive":[129],"AHR-Repressors":[132],"erklart":[133],"Da":[135],"Metabolisierung":[137],"Haptene":[142],"entstehen":[143],"konnten,":[144],"Kontaktdermatitis":[147],"auslosen":[148],"konnen,":[149],"Blockierung":[152],"AHR-abhangigen":[154],"Fremdstoffmetabolismus":[155,316],"mogliche":[159,320],"Strategie":[160,322],"zur":[161,264],"Vermeidung":[162],"Risikos":[164],"allergischer":[165],"Reaktionen":[166],"harmlosen":[168],"darstellen.":[171],"Im":[173],"Vergleich":[174],"aus":[177],"Wildtyp-":[178],"AHR-defizienten":[180],"Mausen":[181],"Rolle":[185],"Reifung":[190,265],"Genexpressionsanalyse":[199],"zeigten":[200,220],"sich":[201,225,267,277,301],"127":[202],"Gene":[203,213],"Abhangigkeit":[205],"vom":[206],"differenziell":[208],"reguliert,":[209],"darunter":[210],"22":[212],"immunologischer":[215],"Relevanz.":[216],"AHR-defizienter":[218],"Mause":[219],"einen":[221],"unreifen":[222],"Phanotyp,":[223],"was":[224],"darin":[226],"auserte,":[227],"dass":[228,303],"kleiner":[231],"weniger":[233,255],"granular":[234],"waren":[235],"deutlich":[237],"geringere":[238],"Mengen":[239],"ko-stimulatorischen":[241],"Molekule":[242],"CD24a,":[243],"CD40":[244],"CD80":[246],"auf":[247,280],"ihrer":[248],"Oberflache":[249],"auspragten.":[250],"Ebenfalls":[251],"hatten":[252],"Transkripte":[256],"immunregulatorischen":[258],"Gens":[259],"IDO.":[260],"Eine":[261],"verminderte":[262],"Fahigkeit":[263],"zeigte":[266],"erhohte":[271],"Phagozytosekapazitat.":[272],"beobachteten":[274],"Effekte":[275],"liesen":[276],"zum":[278],"Teil":[279],"oder":[284],"Fehlen":[285],"veranderte":[288],"Zytokin-expression,":[289],"Wachstumsfaktors":[293],"GM-CSF":[294],"Keratinozyten":[296],"erklaren.":[297],"Zusammenfassend":[299],"lasst":[300],"sagen,":[302],"wesentliche":[309],"Funktionen":[311],"jenseits":[312],"erfullt":[317],"immunsuppressive":[321],"gegen":[323],"harmlose":[324],"niedermolekulare":[325],"darstellt.":[327]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}
