{"id":"https://openalex.org/W82869636","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","title":"Functional and Molecular Adaptation of Lymphatic Vessels","display_name":"Functional and Molecular Adaptation of Lymphatic Vessels","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W82869636","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","mag":"82869636"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.392.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Emily Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Wilson","raw_affiliation_strings":["Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014212911","display_name":"Glen A. Laine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glen Laine","raw_affiliation_strings":["Veterinary Physiology and Pharmacology Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology and Pharmacology Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014572356","display_name":"Christopher M. Quick","orcid":"https://orcid.org/0000-0002-0221-1755","observed_orcids":["https://orcid.org/0000-0002-0221-1755"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Quick","raw_affiliation_strings":["Veterinary Physiology and Pharmacology Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology and Pharmacology Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008368282","display_name":"Joanne Hardy","orcid":"https://orcid.org/0000-0003-3341-0084","observed_orcids":["https://orcid.org/0000-0003-3341-0084"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Hardy","raw_affiliation_strings":["Veterinary Physiology and Pharmacology Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology and Pharmacology Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040963576","display_name":"Bruce Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Ngo","raw_affiliation_strings":["Veterinary Physiology and Pharmacology Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology and Pharmacology Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000327598","display_name":"David Carl Zawieja","orcid":"https://orcid.org/0000-0002-2644-6524","observed_orcids":["https://orcid.org/0000-0002-2644-6524"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dave Zawieja","raw_affiliation_strings":["Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084004072","display_name":"Anatoliy A. Gashev","orcid":"https://orcid.org/0000-0002-1503-5500","observed_orcids":["https://orcid.org/0000-0002-1503-5500"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoliy Gashev","raw_affiliation_strings":["Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biolgy and Translational Medicine Texas A&M Health Science Center College Station TX","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012678106","display_name":"Randolph H. Stewart","orcid":"https://orcid.org/0000-0002-3867-1016","observed_orcids":["https://orcid.org/0000-0002-3867-1016"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randolph Stewart","raw_affiliation_strings":["Veterinary Physiology and Pharmacology Texas A&M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology and Pharmacology Texas A&M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00932326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lymphatic-smooth-muscle","display_name":"lymphatic smooth muscle","score":0.5960000157356262},{"id":"https://openalex.org/keywords/lymphatic-contractility","display_name":"lymphatic contractility","score":0.5849999785423279},{"id":"https://openalex.org/keywords/gene-expression-adaptation","display_name":"gene expression adaptation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/actin-isoforms","display_name":"actin isoforms","score":0.9729999899864197},{"id":"https://openalex.org/keywords/smooth-muscle-alpha-actin","display_name":"smooth muscle actin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/intestinal-edema","display_name":"intestinal edema","score":0.6779999732971191},{"id":"https://openalex.org/keywords/lymphatic-dysfunction","display_name":"lymphatic dysfunction","score":0.3959999978542328},{"id":"https://openalex.org/keywords/bovine-model","display_name":"bovine model","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.7279070615768433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4486067295074463},{"id":"https://openalex.org/C2780965494","wikidata":"https://www.wikidata.org/wiki/Q11238641","display_name":"Lymphatic vessel","level":4,"score":0.42268243432044983},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.42082226276397705},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41349104046821594},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.384838342666626},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3591894209384918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33777672052383423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23364248871803284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21500754356384277},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.392.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.392.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.7900000214576721}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5544355707","display_name":null,"funder_award_id":"623086","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"}],"funders":[{"id":"https://openalex.org/F4320310164","display_name":"Texas A and M University","ror":"https://ror.org/01f5ytq51"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320332871","display_name":"Life Sciences Institute","ror":"https://ror.org/00jmfr291"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071257280","https://openalex.org/W2009125745","https://openalex.org/W3174159652","https://openalex.org/W3167052665","https://openalex.org/W3174968912","https://openalex.org/W2123317934","https://openalex.org/W4225396503","https://openalex.org/W2277523999","https://openalex.org/W2002951717","https://openalex.org/W1990634815"],"abstract_inverted_index":{"We":[0,127],"developed":[1],"a":[2,47,204,220],"bovine":[3],"model":[4,31],"of":[5,24,71,113,134,213],"mesenteric":[6,12,26,38,74],"venous":[7,144],"hypertension":[8],"(MVH)by":[9],"surgically":[10],"occluding":[11],"veins":[13],"for":[14],"3":[15],"days":[16],"to":[17,43,55,67,143,184,199],"investigate":[18],"the":[19,25,114,123,132,165],"functional":[20,193],"and":[21,58,84,101,151,153,158,177,194,227],"molecular":[22,195],"adaptations":[23],"lymphatic":[27,75,139,190],"vessels.":[28],"The":[29,146],"MVH":[30,108],"was":[32,217],"characterized":[33,129],"by":[34,173,219],"an":[35,59],"increase":[36,60],"in":[37,49,61,107,125,131,138,141,162,182,197,201,203,211],"vein":[39],"pressure":[40,91],"from":[41,53,65,164,223],"10":[42],"30":[44],"mm":[45],"Hg,":[46],"decrease":[48],"lymph":[50],"protein":[51,169],"concentration":[52],"6":[54],"5":[56],"g/dL":[57],"intestinal":[62],"water":[63],"content":[64],"72":[66],"78%.":[68],"After":[69],"3\u2010days":[70],"MVH,":[72],"isolated":[73],"vessels":[76,191],"demonstrated":[77],"decreased":[78,81,85,161],"contraction":[79],"frequency,":[80],"ejection":[82],"fraction":[83],"stroke":[86],"volume":[87],"at":[88],"each":[89],"transmural":[90],"tested.":[92],"Microarray":[93],"analysis":[94,176],"revealed":[95,178],"that":[96,189,207],"117":[97],"genes":[98,103,116],"were":[99,104,156,171],"upregulated":[100],"79":[102],"down":[105],"regulated":[106,115],"lymphatics.":[109],"A":[110],"large":[111],"number":[112],"are":[117],"muscle":[118,140,148],"contractile":[119],"proteins,":[120],"consistent":[121],"with":[122],"changes":[124,130,181,200],"function.":[126],"further":[128],"mRNA":[133],"actin":[135,155,160],"isoforms":[136],"expressed":[137],"response":[142,183,198],"hypertension.":[145],"smooth":[147],"actins":[149],"(alpha":[150],"gamma)":[152],"skeletal":[154],"increased":[157],"cardiac":[159],"lymphatics":[163],"MHV":[166],"model.":[167],"Actin":[168],"levels":[170],"analyzed":[172],"western":[174],"blot":[175],"similar":[179],"directional":[180],"MHV.":[185],"These":[186],"data":[187],"suggest":[188],"undergo":[192],"adaptation":[196],"lymphdynamics":[202],"time":[205],"frame":[206],"may":[208],"be":[209],"important":[210],"resolution":[212],"edema.":[214],"This":[215],"work":[216],"supported":[218],"LSI":[221],"grant":[222,229],"Texas":[224],"A&M":[225],"University":[226],"CDC":[228],"623086.":[230]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}