{"id":"https://openalex.org/W82831963","doi":null,"title":"The Association Between Body Composition, Mitochondrial Function and Fatigability and Physical Function in Older Adults","display_name":"The Association Between Body Composition, Mitochondrial Function and Fatigability and Physical Function in Older Adults","publication_year":2013,"publication_date":"2013-06-27","ids":{"openalex":"https://openalex.org/W82831963","mag":"82831963"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:18621","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18621/1/SantanastoAJ_ETD_06_12_13.pdf","pdf_url":"https://d-scholarship.pitt.edu/18621/1/SantanastoAJ_ETD_06_12_13.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043967551","display_name":"Adam J. Santanasto","orcid":"https://orcid.org/0000-0002-6912-2909","observed_orcids":["https://orcid.org/0000-0002-6912-2909"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam J. Santanasto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6912-2909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043967551"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00991338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8190000057220459},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.9700000286102295},{"id":"https://openalex.org/keywords/fatigability","display_name":"fatigability","score":0.8159999847412109},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9940000176429749},{"id":"https://openalex.org/keywords/skeletal-muscle-energetics","display_name":"skeletal muscle energetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/intermuscular-adipose-tissue","display_name":"intermuscular adipose tissue","score":0.8600000143051147},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.9760000109672546},{"id":"https://openalex.org/keywords/weight-loss-interventions","display_name":"weight loss interventions","score":0.6460000276565552},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/phosphocreatine-recovery","display_name":"phosphocreatine recovery","score":0.9520000219345093},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.9160000085830688},{"id":"https://openalex.org/keywords/walking-performance","display_name":"walking performance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/perceived-exertion","display_name":"perceived exertion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/age-related-disability","display_name":"age-related disability","score":0.6959999799728394},{"id":"https://openalex.org/keywords/mobility-impairment","display_name":"mobility impairment","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5713536739349365},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5167088508605957},{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.4910028278827667},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48122596740722656},{"id":"https://openalex.org/C2778310968","wikidata":"https://www.wikidata.org/wiki/Q14536140","display_name":"Exertion","level":2,"score":0.45037826895713806},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.44593197107315063},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4359099566936493},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4305359125137329},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3859637379646301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24375370144844055},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.08228209614753723},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:18621","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18621/1/SantanastoAJ_ETD_06_12_13.pdf","pdf_url":"https://d-scholarship.pitt.edu/18621/1/SantanastoAJ_ETD_06_12_13.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:82831963","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/18621/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2951306207","https://openalex.org/W2067042054","https://openalex.org/W2337039471","https://openalex.org/W4387061920","https://openalex.org/W3135944630","https://openalex.org/W1982216425","https://openalex.org/W1974625402","https://openalex.org/W3189076549","https://openalex.org/W4403632249","https://openalex.org/W4205497510"],"abstract_inverted_index":{"The":[0,19,43,299],"39":[1],"million":[2],"Americans":[3],"over":[4],"the":[5,13,36,84,117,183,287],"age":[6],"of":[7,12,24,45,68,86,154,289,301],"65":[8],"accounted":[9],"for":[10,80,100],"13%":[11],"United":[14],"States":[15],"population":[16],"in":[17,48,124,133,138,149,182,195,221,246,292,344],"2008.":[18],"absolute":[20],"and":[21,54,74,103,128,131,140,160,204,226,269,276,309,317,323,333],"relative":[22],"number":[23],"older":[25,49,107,134,224,227,304,345],"adults":[26,51,225,228,305],"(age":[27],"\u226565":[28],"years)":[29],"is":[30,52,55,63,94,104,297,306,310],"starting":[31],"to":[32,40,88,112,166,169,197,201,218,235,251,294,329,341],"rise":[33],"rapidly":[34],"as":[35,61,144,146,286],"baby":[37],"boomers":[38],"begin":[39],"turn":[41],"65.":[42],"prevalence":[44,300],"mobility":[46],"disability":[47,62,102,291,302],"(30%)":[50],"high":[53,249,308],"a":[56,152,158,211],"large":[57,282],"public":[58,283,320],"health":[59,71,284,314,321],"concern":[60],"associated":[64,311],"with":[65,248,312],"lower":[66,245],"quality":[67],"life,":[69],"higher":[70,222],"care":[72,315],"costs,":[73],"mortality.":[75,318],"There":[76],"are":[77],"many":[78],"reasons":[79],"age-related":[81,290],"disability,":[82],"however;":[83],"role":[85],"changes":[87,123],"skeletal":[89,120,295,339],"muscle":[90,121,150,296,340],"remains":[91],"unclear.":[92,298],"Fatigue":[93],"also":[95,243],"an":[96,147,186],"independent":[97],"risk":[98],"factor":[99],"physical":[101,129,161,171],"common":[105],"among":[106,303],"adults.":[108,135,346],"This":[109,254],"dissertation":[110],"aimed":[111],"provide":[113],"novel":[114,257],"insight":[115],"into":[116],"association":[118],"between":[119],"energetics,":[122],"regional":[125],"body":[126],"composition":[127],"function":[130,215,241,260,271,275,343],"fatigability":[132,207],"First,":[136],"decreases":[137],"visceral":[139],"intermuscular":[141],"adipose":[142],"tissue":[143],"well":[145],"increase":[148],"density,":[151],"marker":[153],"intramyocellular":[155],"fat,":[156],"following":[157,185,210],"weight-loss":[159],"activity":[162],"intervention,":[163],"were":[164,230],"shown":[165],"be":[167,262],"related":[168,217],"improved":[170,263],"performance.":[172],"Next,":[173],"mitochondrial":[174,270],"function,":[175],"measured":[176],"by":[177,264],"phosphocreatine":[178],"recovery":[179],"(mM":[180],"ATP/s)":[181],"quadriceps":[184],"exercise-bout":[187],"using":[188],"31P":[189],"magnetic":[190],"resonance":[191],"spectroscopy,":[192],"was":[193,216,242],"examined":[194],"relation":[196],"walking":[198,219],"performance":[199,206,220],"(time":[200],"walk":[202],"400m)":[203],"perceived":[205],"(perceived":[208],"exertion":[209],"0.67ms":[212],"treadmill-walk).":[213],"Mitochondrial":[214,240],"functioning":[223],"who":[229],"functionally":[231],"impaired":[232],"but":[233],"able":[234],"ambulate":[236],"400m":[237],"without":[238],"discomfort.":[239],"significantly":[244],"those":[247],"compared":[250],"low":[252],"fatigability.":[253,277],"research":[255,335],"provides":[256],"evidence":[258],"that":[259],"can":[261,325],"targeting":[265],"specific":[266],"fat":[267],"depots":[268],"may":[272],"impact":[273],"overall":[274],"These":[278],"findings":[279],"could":[280],"have":[281],"implications,":[285],"etiology":[288],"regard":[293],"quite":[307],"increased":[313],"costs":[316],"Clinicians,":[319],"professionals":[322],"researchers":[324],"use":[326],"this":[327],"information":[328],"design":[330],"interventions,":[331],"treatments":[332],"future":[334],"studies":[336],"focused":[337],"on":[338],"improve":[342]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
