{"id":"https://openalex.org/W82814575","doi":"https://doi.org/10.1023/a:1006969008056","title":"Induction of TNF\u03b1 in macrophages by vanadate is dependent on activation of transcription factor NF-\u03baB and free radical reactions","display_name":"Induction of TNF\u03b1 in macrophages by vanadate is dependent on activation of transcription factor NF-\u03baB and free radical reactions","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W82814575","doi":"https://doi.org/10.1023/a:1006969008056","mag":"82814575","pmid":"https://pubmed.ncbi.nlm.nih.gov/10497896"},"language":"en","primary_location":{"id":"doi:10.1023/a:1006969008056","doi":"https://doi.org/10.1023/a:1006969008056","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006969008056","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076653687","display_name":"Jianping Ye","orcid":"https://orcid.org/0000-0003-3875-365X","observed_orcids":["https://orcid.org/0000-0003-3875-365X"]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianping Ye","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101643409","display_name":"Ming Ding","orcid":"https://orcid.org/0000-0002-6264-2709","observed_orcids":["https://orcid.org/0000-0002-6264-2709"]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Ding","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]},{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449427","display_name":"Xiaoying Zhang","orcid":"https://orcid.org/0009-0009-0232-1936","observed_orcids":["https://orcid.org/0009-0009-0232-1936"]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoying Zhang","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]},{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080894648","display_name":"Yon Rojanasakul","orcid":"https://orcid.org/0000-0002-8839-6462","observed_orcids":["https://orcid.org/0000-0002-8839-6462"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yon Rojanasakul","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013001925","display_name":"Sergei A. Nedospasov","orcid":"https://orcid.org/0000-0001-5818-2829","observed_orcids":["https://orcid.org/0000-0001-5818-2829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergei Nedospasov","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, National University, Cancer Institute, Frederick, MD, USA","Laboratory of Molecular Immunoregulation, National University, Cancer Institute, Frederick, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, National University, Cancer Institute, Frederick, MD, USA","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, National University, Cancer Institute, Frederick, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060892607","display_name":"Val Vallyathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val Vallyathan","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]},{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114256988","display_name":"Vincent Castranova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Castranova","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]},{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085452040","display_name":"Xinglin Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinglin Shi","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]},{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, USA","institution_ids":["https://openalex.org/I198423848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.3845,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.79176755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"198","issue":"1-2","first_page":"193","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.968999981880188},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.9559999704360962},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sn50","display_name":"SN50","score":0.7360000014305115},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.7250000238418579},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.8880000114440918},{"id":"https://openalex.org/keywords/respiratory-diseases","display_name":"respiratory diseases","score":0.5799999833106995},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.940117597579956},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.616521954536438},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5497848391532898},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.508080244064331},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.46661749482154846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4584465026855469},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.45230013132095337},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4494131803512573},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.44391563534736633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4289971590042114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4005661606788635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27136558294296265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2706206440925598},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26597505807876587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15785586833953857}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1006969008056","doi":"https://doi.org/10.1023/a:1006969008056","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006969008056","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:10497896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10497896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1496485913","https://openalex.org/W1498787374","https://openalex.org/W1564792690","https://openalex.org/W1568529372","https://openalex.org/W1584114579","https://openalex.org/W1584234581","https://openalex.org/W1613287901","https://openalex.org/W1727750278","https://openalex.org/W1868478050","https://openalex.org/W1947030034","https://openalex.org/W1964689096","https://openalex.org/W1965583590","https://openalex.org/W1969108518","https://openalex.org/W1984380214","https://openalex.org/W2005258621","https://openalex.org/W2026832750","https://openalex.org/W2027632610","https://openalex.org/W2030592815","https://openalex.org/W2039081691","https://openalex.org/W2039167252","https://openalex.org/W2063081233","https://openalex.org/W2066898553","https://openalex.org/W2069099949","https://openalex.org/W2070073216","https://openalex.org/W2075593542","https://openalex.org/W2077076178","https://openalex.org/W2080200553","https://openalex.org/W2082865189","https://openalex.org/W2096678608","https://openalex.org/W2105415988","https://openalex.org/W2112139849","https://openalex.org/W2122808153","https://openalex.org/W2132304605","https://openalex.org/W2132470279","https://openalex.org/W2146963242","https://openalex.org/W2158834797","https://openalex.org/W2163092949","https://openalex.org/W2165626613","https://openalex.org/W2170618588","https://openalex.org/W2204123985","https://openalex.org/W2291043664","https://openalex.org/W2412297678","https://openalex.org/W2417434381"],"related_works":["https://openalex.org/W1946450549","https://openalex.org/W2091928006","https://openalex.org/W110280024","https://openalex.org/W2122948215","https://openalex.org/W43886454","https://openalex.org/W2065032678","https://openalex.org/W7095887182","https://openalex.org/W2079308092","https://openalex.org/W2294286315","https://openalex.org/W2091290146"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}