{"id":"https://openalex.org/W828079486","doi":null,"title":"Vitamin D Supplementation and Immune Response to Antarctic Winter","display_name":"Vitamin D Supplementation and Immune Response to Antarctic Winter","publication_year":2011,"publication_date":"2011-04-11","ids":{"openalex":"https://openalex.org/W828079486","mag":"828079486"},"language":"en","primary_location":{"id":"mag:828079486","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20110008643/downloads/20110008643.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014977670","display_name":"Sara R. Zwart","orcid":"https://orcid.org/0000-0001-8694-0180","observed_orcids":["https://orcid.org/0000-0001-8694-0180"]},"institutions":[{"id":"https://openalex.org/I1329765538","display_name":"Universities Space Research Association","ror":"https://ror.org/043pgqy52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1329765538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara R. Zwart","raw_affiliation_strings":["Universities Space Research Association Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0001-8694-0180","affiliations":[{"raw_affiliation_string":"Universities Space Research Association Houston, TX, United States","institution_ids":["https://openalex.org/I1329765538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020203646","display_name":"Satish Kumar Mehta","orcid":"https://orcid.org/0000-0003-4198-3261","observed_orcids":["https://orcid.org/0000-0003-4198-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satish Mehta","raw_affiliation_strings":["Enterprise Advisory Services, Inc. Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0003-4198-3261","affiliations":[{"raw_affiliation_string":"Enterprise Advisory Services, Inc. Houston, TX, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008461870","display_name":"Robert J. Ploutz-Snyder","orcid":"https://orcid.org/0000-0002-8503-2073","observed_orcids":["https://orcid.org/0000-0002-8503-2073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Ploutz\u2010Snyder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8503-2073","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111966571","display_name":"Y. Bourbeau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Bourbeau","raw_affiliation_strings":["Enterprise Advisory Services, Inc. Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterprise Advisory Services, Inc. Houston, TX, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003083708","display_name":"James P. Locke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Locke","raw_affiliation_strings":["NASA Johnson Space Center Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center Houston, TX, United States","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623804","display_name":"D. L. Pierson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Pierson","raw_affiliation_strings":["NASA Johnson Space Center Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center Houston, TX, United States","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075879804","display_name":"Scott M. Smith","orcid":"https://orcid.org/0000-0001-9313-7900","observed_orcids":["https://orcid.org/0000-0001-9313-7900"]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Smith","raw_affiliation_strings":["NASA Johnson Space Center Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0001-9313-7900","affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center Houston, TX, United States","institution_ids":["https://openalex.org/I4210149382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vitamin-d-status","display_name":"vitamin D status","score":0.7749999761581421},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.921999990940094},{"id":"https://openalex.org/keywords/epstein-barr-virus-reactivation","display_name":"Epstein-Barr virus reactivation","score":0.824999988079071},{"id":"https://openalex.org/keywords/latent-viral-reactivation","display_name":"latent viral reactivation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.6790000200271606},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.921999990940094},{"id":"https://openalex.org/keywords/antarctic-winter","display_name":"Antarctic winter","score":0.6290000081062317},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.8082493543624878},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.7172358632087708},{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.7116153240203857},{"id":"https://openalex.org/C170853661","wikidata":"https://www.wikidata.org/wiki/Q193788","display_name":"Sunlight","level":2,"score":0.6614531874656677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5803107023239136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5690983533859253},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5037986636161804},{"id":"https://openalex.org/C2776941976","wikidata":"https://www.wikidata.org/wiki/Q139307","display_name":"Calcifediol","level":4,"score":0.5028805136680603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49372825026512146},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.4835740923881531},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3446189761161804},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3395724296569824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27978891134262085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18661954998970032},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:828079486","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20110008643/downloads/20110008643.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2134833875"],"related_works":["https://openalex.org/W2151911148","https://openalex.org/W2134833875","https://openalex.org/W3173712437","https://openalex.org/W3160885189","https://openalex.org/W1997091814","https://openalex.org/W72429652","https://openalex.org/W2101209314","https://openalex.org/W2806705195","https://openalex.org/W2546117747","https://openalex.org/W2944915359"],"abstract_inverted_index":{"Maintaining":[0],"vitamin":[1,38,42,79,107,224,243,254],"D":[2,43,103,108,225,244],"status":[3,44,226,245],"without":[4,9],"sunlight":[5,232],"exposure":[6,60],"is":[7],"difficult":[8],"supplementation.":[10],"This":[11],"study":[12],"was":[13,239],"designed":[14],"to":[15,135,148,210,231],"better":[16],"understand":[17],"interrelationships":[18],"between":[19],"periodic":[20],"cholecalciferol(vitamin":[21],"D3)":[22],"supplementation":[23,40,193],"and":[24,45,96,99,109,112,142,158,236,246],"immune":[25,48],"function":[26,49],"in":[27,52,54,88,155,187,214,227,269],"Antarctic":[28],"workers.":[29],"The":[30,220,248],"effect":[31,162],"of":[32,37,47,106,262],"2":[33],"oral":[34],"dosing":[35],"regimens":[36],"D3":[39,80,126,189,206],"on":[41],"markers":[46,105],"were":[50,65,92,116,207],"evaluated":[51],"people":[53],"Antarctica":[55],"with":[56,170,199,257],"no":[57],"ultraviolet":[58],"light":[59],"for":[61,82,233],"6":[62,83,100,119,191,234],"mo.":[63,101],"Participants":[64,169,198],"given":[66,222],"a":[67,86,171,184],"2,000-IU":[68],"(50":[69],"g)":[70,76],"daily":[71],"(n=15)":[72],"or":[73,132,138,145,151],"10,000-IU":[74],"(250":[75],"weekly":[77],"(n=14)":[78],"supplement":[81],"mo":[84,120,192],"during":[85,266],"winter":[87,268],"Antarctica.":[89,270],"Biological":[90],"samples":[91],"collected":[93],"at":[94,97],"baseline":[95,242],"3":[98],"Vitamin":[102],"intake,":[104],"bone":[110],"metabolism,":[111],"latent":[113,263],"virus":[114,213,264],"reactivation":[115,265],"determined.":[117],"After":[118],"the":[121,156,237,267],"mean":[122],"(SD)":[123],"serum":[124,201,204],"25-hydroxyvitamin":[125,188,205],"concentration":[127],"increased":[128],"from":[129],"56":[130],"plus":[131,137,144,150],"minus":[133,139,146,152],"17":[134],"79":[136],"16":[140],"nmol/L":[141,154],"52":[143],"10":[147],"69":[149],"9":[153],"2,000-IU/d":[157],"10,000-IU/wk":[159],"groups":[160],"(main":[161],"over":[163],"time":[164],"P":[165],"less":[166,195,208,217],"than":[167,196,218],"0.001).":[168],"greater":[172],"BMI":[173,175],"(participant":[174],"range":[176],"=":[177],"19-43":[178],"grams":[179],"per":[180],"square":[181],"meter)":[182],"had":[183],"smaller":[185],"increase":[186],"after":[190],"(P":[194,216],"0.05).":[197,219],"high":[200],"cortisoland":[202],"higher":[203],"likely":[209],"shed":[211],"Epstein-Barr":[212],"saliva":[215],"doses":[221],"raised":[223],"participants":[228],"not":[229],"exposed":[230],"mo,":[235],"efficacy":[238],"influenced":[240],"by":[241],"BMI.":[247],"data":[249],"also":[250],"provide":[251],"evidence":[252],"that":[253],"D,":[255],"interacting":[256],"stress,":[258],"can":[259],"reduce":[260],"risk":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}