{"id":"https://openalex.org/W82626080","doi":null,"title":"PULMONARY ENDOTHELIUM AND THE ROLE OF ZINC IN HYPOXIA INDUCED VASOCONSTRICTION","display_name":"PULMONARY ENDOTHELIUM AND THE ROLE OF ZINC IN HYPOXIA INDUCED VASOCONSTRICTION","publication_year":2010,"publication_date":"2010-08-19","ids":{"openalex":"https://openalex.org/W82626080","mag":"82626080"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9158","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084252128","display_name":"Paula Jimena Bernal","orcid":"https://orcid.org/0009-0002-2421-302X","observed_orcids":["https://orcid.org/0009-0002-2421-302X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paula J. Bernal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084252128"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxic-pulmonary-vasoconstriction","display_name":"hypoxic pulmonary vasoconstriction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pulmonary-endothelium","display_name":"pulmonary endothelium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.906000018119812},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9440000057220459},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endothelial-cell-contraction","display_name":"endothelial cell contraction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.9660000205039978},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphatase","display_name":"myosin light chain phosphatase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pkc-epsilon","display_name":"protein kinase C epsilon","score":0.527999997138977},{"id":"https://openalex.org/keywords/isolated-perfused-lung","display_name":"isolated perfused lung","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gas-exchange","display_name":"gas exchange","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C29323129","wikidata":"https://www.wikidata.org/wiki/Q3504897","display_name":"Hypoxic pulmonary vasoconstriction","level":3,"score":0.7545684576034546},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6313621401786804},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6194705963134766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5019254684448242},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49466535449028015},{"id":"https://openalex.org/C2779938346","wikidata":"https://www.wikidata.org/wiki/Q1956701","display_name":"Myosin-light-chain phosphatase","level":4,"score":0.4925282895565033},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.4831544756889343},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.4803010821342468},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.463215172290802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4600827991962433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4507350027561188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43707460165023804},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4100605249404907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.388255774974823},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.354006826877594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12276938557624817},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10090285539627075},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9158","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:82626080","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9158/1/BERNALPJ%2DETD2010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9158","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/9158/1/BERNALPJ-ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W82626080.pdf","grobid_xml":"https://content.openalex.org/works/W82626080.grobid-xml"},"referenced_works_count":299,"referenced_works":["https://openalex.org/W17183735","https://openalex.org/W89952529","https://openalex.org/W99737500","https://openalex.org/W129191972","https://openalex.org/W140048875","https://openalex.org/W189158296","https://openalex.org/W1250641235","https://openalex.org/W1514734464","https://openalex.org/W1523601423","https://openalex.org/W1526317775","https://openalex.org/W1535873009","https://openalex.org/W1551747958","https://openalex.org/W1579639018","https://openalex.org/W1582074497","https://openalex.org/W1582753616","https://openalex.org/W1584876031","https://openalex.org/W1587199968","https://openalex.org/W1589364751","https://openalex.org/W1590514634","https://openalex.org/W1591568506","https://openalex.org/W1619234695","https://openalex.org/W1649021695","https://openalex.org/W1678800844","https://openalex.org/W1754980219","https://openalex.org/W1787172519","https://openalex.org/W1790607182","https://openalex.org/W1795275022","https://openalex.org/W1822066871","https://openalex.org/W1842611921","https://openalex.org/W1848141627","https://openalex.org/W1857294168","https://openalex.org/W1874327812","https://openalex.org/W1902718532","https://openalex.org/W1925247835","https://openalex.org/W1928961235","https://openalex.org/W1929009802","https://openalex.org/W1946266499","https://openalex.org/W1951323910","https://openalex.org/W1963760549","https://openalex.org/W1964428172","https://openalex.org/W1965130327","https://openalex.org/W1967418013","https://openalex.org/W1967605013","https://openalex.org/W1967683969","https://openalex.org/W1969448383","https://openalex.org/W1970884474","https://openalex.org/W1971692939","https://openalex.org/W1972443719","https://openalex.org/W1973624889","https://openalex.org/W1975386643","https://openalex.org/W1975502948","https://openalex.org/W1978298108","https://openalex.org/W1980638138","https://openalex.org/W1981120411","https://openalex.org/W1981845473","https://openalex.org/W1982896936","https://openalex.org/W1985188216","https://openalex.org/W1985502400","https://openalex.org/W1986171863","https://openalex.org/W1986349419","https://openalex.org/W1987354436","https://openalex.org/W1987374310","https://openalex.org/W1987410396","https://openalex.org/W1987682986","https://openalex.org/W1987734763","https://openalex.org/W1988862154","https://openalex.org/W1991385395","https://openalex.org/W1991386525","https://openalex.org/W1992036449","https://openalex.org/W1992240624","https://openalex.org/W1992256486","https://openalex.org/W1992534903","https://openalex.org/W1992706834","https://openalex.org/W1993056616","https://openalex.org/W1995272882","https://openalex.org/W1995757732","https://openalex.org/W1996001348","https://openalex.org/W1996202093","https://openalex.org/W1996827095","https://openalex.org/W1998398302","https://openalex.org/W2002028073","https://openalex.org/W2002791925","https://openalex.org/W2004902531","https://openalex.org/W2006830036","https://openalex.org/W2007529137","https://openalex.org/W2008752288","https://openalex.org/W2009601307","https://openalex.org/W2010274527","https://openalex.org/W2011040878","https://openalex.org/W2011588737","https://openalex.org/W2014431633","https://openalex.org/W2016189603","https://openalex.org/W2016348467","https://openalex.org/W2018190245","https://openalex.org/W2018485343","https://openalex.org/W2019814232","https://openalex.org/W2021861995","https://openalex.org/W2022669318","https://openalex.org/W2023351764","https://openalex.org/W2023882972","https://openalex.org/W2025307456","https://openalex.org/W2025973200","https://openalex.org/W2027817420","https://openalex.org/W2028019527","https://openalex.org/W2028047084","https://openalex.org/W2029426689","https://openalex.org/W2030142800","https://openalex.org/W2030307890","https://openalex.org/W2030576423","https://openalex.org/W2030763573","https://openalex.org/W2031254143","https://openalex.org/W2032295238","https://openalex.org/W2032443618","https://openalex.org/W2032545428","https://openalex.org/W2033353305","https://openalex.org/W2035508242","https://openalex.org/W2036137960","https://openalex.org/W2037680600","https://openalex.org/W2039152425","https://openalex.org/W2041724214","https://openalex.org/W2042322531","https://openalex.org/W2043487692","https://openalex.org/W2043930136","https://openalex.org/W2044175451","https://openalex.org/W2044528288","https://openalex.org/W2045441833","https://openalex.org/W2047687026","https://openalex.org/W2050551315","https://openalex.org/W2050612706","https://openalex.org/W2053417711","https://openalex.org/W2054691861","https://openalex.org/W2054818418","https://openalex.org/W2058062846","https://openalex.org/W2058137293","https://openalex.org/W2058836844","https://openalex.org/W2059070349","https://openalex.org/W2060189631","https://openalex.org/W2061534579","https://openalex.org/W2061543832","https://openalex.org/W2062220400","https://openalex.org/W2062314949","https://openalex.org/W2062382507","https://openalex.org/W2063792345","https://openalex.org/W2063833124","https://openalex.org/W2064686740","https://openalex.org/W2064889608","https://openalex.org/W2065081217","https://openalex.org/W2065767835","https://openalex.org/W2065773243","https://openalex.org/W2066474065","https://openalex.org/W2066953042","https://openalex.org/W2067637944","https://openalex.org/W2068048197","https://openalex.org/W2068053418","https://openalex.org/W2068431117","https://openalex.org/W2068620549","https://openalex.org/W2069753164","https://openalex.org/W2070733563","https://openalex.org/W2071561430","https://openalex.org/W2072304029","https://openalex.org/W2077298757","https://openalex.org/W2078315848","https://openalex.org/W2079754680","https://openalex.org/W2080312195","https://openalex.org/W2080495541","https://openalex.org/W2085052540","https://openalex.org/W2086710730","https://openalex.org/W2087926587","https://openalex.org/W2088071645","https://openalex.org/W2088116933","https://openalex.org/W2088903728","https://openalex.org/W2088928790","https://openalex.org/W2088975387","https://openalex.org/W2089742414","https://openalex.org/W2090458427","https://openalex.org/W2093382413","https://openalex.org/W2093788858","https://openalex.org/W2094121810","https://openalex.org/W2095896860","https://openalex.org/W2096202298","https://openalex.org/W2096327838","https://openalex.org/W2096791952","https://openalex.org/W2098544308","https://openalex.org/W2098866409","https://openalex.org/W2099891637","https://openalex.org/W2100642038","https://openalex.org/W2103748251","https://openalex.org/W2104089533","https://openalex.org/W2104764272","https://openalex.org/W2105043010","https://openalex.org/W2107821473","https://openalex.org/W2107836548","https://openalex.org/W2108247020","https://openalex.org/W2108740616","https://openalex.org/W2110112605","https://openalex.org/W2110829214","https://openalex.org/W2111116475","https://openalex.org/W2112634792","https://openalex.org/W2114875967","https://openalex.org/W2116709740","https://openalex.org/W2116954627","https://openalex.org/W2117948621","https://openalex.org/W2118023300","https://openalex.org/W2118033887","https://openalex.org/W2119225742","https://openalex.org/W2119228425","https://openalex.org/W2120062906","https://openalex.org/W2120369875","https://openalex.org/W2120971413","https://openalex.org/W2123179186","https://openalex.org/W2123579381","https://openalex.org/W2124143346","https://openalex.org/W2126938649","https://openalex.org/W2127162829","https://openalex.org/W2127218310","https://openalex.org/W2128231056","https://openalex.org/W2130887632","https://openalex.org/W2131364104","https://openalex.org/W2132486325","https://openalex.org/W2132924014","https://openalex.org/W2134107900","https://openalex.org/W2134288604","https://openalex.org/W2134643192","https://openalex.org/W2136557068","https://openalex.org/W2138230673","https://openalex.org/W2138742704","https://openalex.org/W2139012310","https://openalex.org/W2139214427","https://openalex.org/W2140377941","https://openalex.org/W2140703192","https://openalex.org/W2141109284","https://openalex.org/W2141174309","https://openalex.org/W2141768942","https://openalex.org/W2146267072","https://openalex.org/W2146795759","https://openalex.org/W2147415675","https://openalex.org/W2150700731","https://openalex.org/W2151308522","https://openalex.org/W2151570078","https://openalex.org/W2151767234","https://openalex.org/W2151978982","https://openalex.org/W2152462023","https://openalex.org/W2153329657","https://openalex.org/W2154366496","https://openalex.org/W2155461712","https://openalex.org/W2155802295","https://openalex.org/W2156103849","https://openalex.org/W2156715387","https://openalex.org/W2157236140","https://openalex.org/W2157430977","https://openalex.org/W2157810907","https://openalex.org/W2158253639","https://openalex.org/W2160606731","https://openalex.org/W2161146119","https://openalex.org/W2162230936","https://openalex.org/W2163003098","https://openalex.org/W2164258188","https://openalex.org/W2164716310","https://openalex.org/W2165137873","https://openalex.org/W2165222034","https://openalex.org/W2165863663","https://openalex.org/W2167666911","https://openalex.org/W2171906125","https://openalex.org/W2176238459","https://openalex.org/W2182340497","https://openalex.org/W2184088679","https://openalex.org/W2186451348","https://openalex.org/W2189756124","https://openalex.org/W2215538315","https://openalex.org/W2223649658","https://openalex.org/W2233163131","https://openalex.org/W2252348067","https://openalex.org/W2264997947","https://openalex.org/W2269312913","https://openalex.org/W2278328423","https://openalex.org/W2285731352","https://openalex.org/W2304915751","https://openalex.org/W2311577107","https://openalex.org/W2316325194","https://openalex.org/W2320516100","https://openalex.org/W2327169971","https://openalex.org/W2327665598","https://openalex.org/W2343122702","https://openalex.org/W2402079920","https://openalex.org/W2404855608","https://openalex.org/W2406843742","https://openalex.org/W2410891731","https://openalex.org/W2413085142","https://openalex.org/W2413153618","https://openalex.org/W2413324085","https://openalex.org/W2416565140","https://openalex.org/W2416757916","https://openalex.org/W2418638936","https://openalex.org/W2430702987","https://openalex.org/W2987070645","https://openalex.org/W3135166507","https://openalex.org/W4246461005","https://openalex.org/W4247088117","https://openalex.org/W4301375977"],"related_works":["https://openalex.org/W2289160967","https://openalex.org/W2307667970","https://openalex.org/W2098866409","https://openalex.org/W2028417012","https://openalex.org/W2265649062","https://openalex.org/W2293043009","https://openalex.org/W1864352741","https://openalex.org/W3174907359","https://openalex.org/W3174882934","https://openalex.org/W2113158482"],"abstract_inverted_index":{"Hypoxic":[0],"pulmonary":[1,88,301],"vasoconstriction":[2,94],"(HPV)":[3],"is":[4,55],"a":[5,33,137,215,257],"unique":[6],"physiological":[7],"response":[8,126,140,230,244,270,299],"of":[9,43,68,80,87,95,108,119,124,133,181,192,201,210,226,252,256],"the":[10,41,69,125,157,177,190,227,241,266,287],"lung":[11],"that":[12,58,167,265],"acts":[13],"to":[14,31,93,141,213,231,271,294],"optimize":[15],"gas":[16],"exchange":[17],"by":[18,116,222,240],"diverting":[19],"blood":[20],"flow":[21],"from":[22],"poorly":[23],"ventilated":[24],"regions.":[25],"The":[26,106],"endothelium":[27],"has":[28],"been":[29],"thought":[30],"play":[32,214],"mostly":[34],"modulatory":[35],"role":[36,216],"in":[37,63,77,100,112,127,136,143,152,174,176,217,229,236,245,269,275,282,300],"this":[38,109,218],"phenomenon":[39],"through":[40,189,278],"synthesis":[42,121],"vasoactive":[44],"agents":[45],"such":[46],"as":[47,220],"nitric":[48],"oxide":[49],"(NO),":[50],"prostacyclin,":[51],"and":[52,91,122,160,179,206,224,239,290],"endothelin.":[53],"Data":[54],"provided":[56],"showing":[57],"acute":[59],"hypoxia":[60,142,169,233,272],"induces":[61],"increases":[62,175,235,274],"NO":[64,120,267],"biosynthesis,":[65],"promoting":[66],"S-nitrosation":[67],"metal":[70],"binding":[71],"protein":[72],"metallothionein":[73],"(MT),":[74],"which":[75,134,198,281],"resulted":[76,135,173],"intracellular":[78,153],"release":[79],"zinc.":[81],"Hypoxia":[82],"released":[83,268],"zinc":[84,154,172],"induced":[85],"contraction":[86],"endothelial":[89,247],"cells":[90,248],"contributed":[92],"small,":[96],"non-muscularized":[97],"intra-acinar":[98],"arteries":[99],"isolated":[101,246],"perfused":[102],"mouse":[103],"lungs":[104],"(IPL).":[105],"relevance":[107],"NO/MT/Zn":[110],"pathway":[111],"HPV":[113],"was":[114,165],"illustrated":[115],"pharmacological":[117,250],"inhibition":[118,191,251],"analysis":[123],"MT":[128],"knockout":[129],"(MT-/-)":[130],"mice,":[131],"both":[132,232],"blunted":[138,242],"pressure":[139],"IPL.":[144],"Signaling":[145],"pathways":[146],"were":[147,187],"delineated,":[148],"indicating":[149],"how":[150],"changes":[151,186],"can":[155],"alter":[156],"actin":[158,182],"cytoskeleton":[159],"promote":[161],"cellular":[162],"contraction.":[163],"It":[164],"found":[166],"either":[168],"or":[170,254],"exogenous":[171],"formation":[178],"alignment":[180],"stress":[183],"fibers.":[184],"These":[185,262],"mediated":[188],"myosin":[193,202],"light":[194,203],"chain":[195,204],"phosphatase":[196],"(MLCP),":[197],"promoted":[199],"phosphorylation":[200,277],"(MLC)":[205],"tension":[207],"generation.":[208],"Activation":[209],"PKC":[211,253],"appeared":[212],"process,":[219],"indicated":[221],"activation":[223],"translocation":[225],"enzyme":[228],"and/or":[234],"labile":[237],"zinc,":[238],"contractile":[243,298],"following":[249],"utilization":[255],"PCK\u03b5":[258],"dominant":[259],"negative":[260],"construct.":[261],"data":[263],"suggest":[264],"promotes":[273],"MLC":[276],"zinc-dependent":[279],"pathways,":[280],"turn":[283],"are":[284],"responsible":[285],"for":[286],"force":[288],"induction":[289],"cell":[291],"stability":[292],"necessary":[293],"elicit":[295],"an":[296],"active":[297],"endothelium.":[302]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
