{"id":"https://openalex.org/W82616469","doi":null,"title":"[Infant leukemia with t(1;22) presenting proliferation of erythroid and megakaryocytic cell lineages].","display_name":"[Infant leukemia with t(1;22) presenting proliferation of erythroid and megakaryocytic cell lineages].","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W82616469","mag":"82616469","pmid":"https://pubmed.ncbi.nlm.nih.gov/10222631"},"language":"ja","primary_location":{"id":"pmid:10222631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10222631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Oshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155507","display_name":"Ibaraki Children's Hospital","ror":"https://ror.org/052rymf92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155507"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Oshima","raw_affiliation_strings":["Department of Pediatrics, Ibaraki Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ibaraki Children's Hospital","institution_ids":["https://openalex.org/I4210155507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198096","display_name":"Toshihiro Fukushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fukushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103633328","display_name":"K Koike","orcid":"https://orcid.org/0000-0002-6796-5785","observed_orcids":["https://orcid.org/0000-0002-6796-5785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Koike","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005730516","display_name":"C Hoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Hoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091108111","display_name":"Ichiro Izumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Izumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110539359","display_name":"Masamichi TSUCHIDA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tsuchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00657895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"3","first_page":"230","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.08659999817609787,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infant-leukemia","display_name":"infant leukemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/acute-megakaryoblastic-leukemia","display_name":"acute megakaryoblastic leukemia","score":0.824999988079071},{"id":"https://openalex.org/keywords/m7","display_name":"M7","score":0.6600000262260437},{"id":"https://openalex.org/keywords/erythroid-lineage","display_name":"erythroid lineage","score":0.7419999837875366},{"id":"https://openalex.org/keywords/megakaryocytic-lineage","display_name":"megakaryocytic lineage","score":0.9419999718666077},{"id":"https://openalex.org/keywords/erythroblasts","display_name":"erythroblasts","score":0.6790000200271606},{"id":"https://openalex.org/keywords/megakaryoblasts","display_name":"megakaryoblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cd41","display_name":"CD41","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glycophorin-a","display_name":"glycophorin A","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bone-marrow-relapse","display_name":"bone marrow relapse","score":0.8289999961853027},{"id":"https://openalex.org/keywords/common-progenitor-cell","display_name":"common progenitor cell","score":0.640999972820282},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.4189999997615814},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7896339893341064},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.673678457736969},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.5856640934944153},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5250656008720398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4559936225414276},{"id":"https://openalex.org/C2909030593","wikidata":"https://www.wikidata.org/wiki/Q3296909","display_name":"Erythroblast","level":4,"score":0.4500494599342346},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4325041174888611},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4070030748844147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27246350049972534},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.11369386315345764}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004900","descriptor_name":"Erythroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007947","descriptor_name":"Leukemia, Megakaryoblastic, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007947","descriptor_name":"Leukemia, Megakaryoblastic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10222631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10222631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"Case Reports"},{"id":"mag:82616469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10222631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W133388127","https://openalex.org/W2410865127","https://openalex.org/W2045315598","https://openalex.org/W1999152383","https://openalex.org/W2414889300","https://openalex.org/W2009643085","https://openalex.org/W1971815840","https://openalex.org/W301939461","https://openalex.org/W2087211810","https://openalex.org/W2419357590"],"abstract_inverted_index":{"We":[0,81,140],"report":[1],"a":[2,143,151],"case":[3],"of":[4,10,30,112],"infant":[5],"leukemia":[6,136,144],"with":[7,45,77],"the":[8,28,90,106,110],"proliferation":[9],"both":[11,21,157],"erythroblast":[12],"and":[13,23,48,57,74,96,159],"megakaryoblast":[14],"lineages.":[15,161],"The":[16],"blasts":[17,113],"became":[18],"double-positive":[19],"for":[20,133],"erythroblastic":[22],"megakaryoblastic":[24,135],"surface":[25],"markers":[26],"at":[27,150],"time":[29],"bone":[31,60,107],"marrow":[32,61,108],"relapse.":[33],"A":[34,59],"9-month-old":[35],"girl":[36],"was":[37],"admitted":[38],"to":[39,116,130,156],"our":[40],"hospital":[41],"presenting":[42],"chiefly":[43],"poor":[44],"weight":[46],"gain":[47],"anemia.":[49],"She":[50],"also":[51],"had":[52,114,145],"splenomegaly,":[53],"pleural":[54],"effusion,":[55],"leukocytosis,":[56],"thrombocytopenia.":[58],"specimen":[62],"showed":[63,120],"53.2%":[64],"erythroblasts":[65],"(PAS":[66],"positive,":[67,69],"alpha-NA":[68],"CD41":[70],"negative,":[71],"MPO":[72],"negative)":[73],"20.4%":[75],"megakaryoblasts":[76],"marked":[78],"cytoplasmic":[79],"blebs.":[80],"examined":[82],"specimens":[83],"by":[84],"two-color":[85],"flow":[86],"cytometric":[87],"analysis.":[88],"At":[89,105],"onset,":[91],"CD41+":[92],"glycophorin":[93,98],"A-":[94],"fraction":[95,100],"CD41-":[97],"A+":[99],"were":[101],"two":[102],"major":[103],"components.":[104],"relapse,":[109],"majority":[111],"altered":[115],"double-positive.":[117],"Chromosomal":[118],"analysis":[119],"t":[121],"(1;":[122],"22)":[123],"(p13;":[124],"q13),":[125],"which":[126],"has":[127],"been":[128],"reported":[129],"be":[131],"specific":[132],"acute":[134],"(M7)":[137],"in":[138,147],"infants.":[139],"reasoned":[141],"that":[142],"occurred":[146],"this":[148],"patient":[149],"progenitor":[152],"cell":[153],"level":[154],"common":[155],"erythroid":[158],"megakaryocytic":[160]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}