{"id":"https://openalex.org/W823979986","doi":"https://doi.org/10.25772/6vdg-6383","title":"ATM, BRCA1, and Aurora A: Mechanisms of G2/M Checkpoint Control in Human Embryonic Stem Cells","display_name":"ATM, BRCA1, and Aurora A: Mechanisms of G2/M Checkpoint Control in Human Embryonic Stem Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W823979986","doi":"https://doi.org/10.25772/6vdg-6383","mag":"823979986"},"language":"en","primary_location":{"id":"pmh:oai:scholarscompass.vcu.edu:etd-4478","doi":null,"is_oa":false,"landing_page_url":"https://scholarscompass.vcu.edu/etd/3477","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25772/6vdg-6383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066345126","display_name":"Jason M. Beckta","orcid":"https://orcid.org/0000-0003-0756-6173","observed_orcids":["https://orcid.org/0000-0003-0756-6173"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Beckta, Jason","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066345126"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02591541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.796999990940094},{"id":"https://openalex.org/keywords/mitotic-entry","display_name":"mitotic entry","score":0.7269999980926514},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.4429999887943268},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.5529999732971191},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7701592445373535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48572880029678345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42520707845687866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2027190923690796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1146073043346405}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarscompass.vcu.edu:etd-4478","doi":null,"is_oa":false,"landing_page_url":"https://scholarscompass.vcu.edu/etd/3477","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"mag:823979986","doi":null,"is_oa":false,"landing_page_url":"https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=4478&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.25772/6vdg-6383","doi":"https://doi.org/10.25772/6vdg-6383","is_oa":true,"landing_page_url":"https://doi.org/10.25772/6vdg-6383","pdf_url":null,"source":{"id":"https://openalex.org/S7407053258","display_name":"VCULIBRARIES","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"doi:10.25772/6vdg-6383","doi":"https://doi.org/10.25772/6vdg-6383","is_oa":true,"landing_page_url":"https://doi.org/10.25772/6vdg-6383","pdf_url":null,"source":{"id":"https://openalex.org/S7407053258","display_name":"VCULIBRARIES","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054791794","https://openalex.org/W2410119563","https://openalex.org/W2047955983","https://openalex.org/W1977075613","https://openalex.org/W2014385950","https://openalex.org/W2595277879","https://openalex.org/W7095529931","https://openalex.org/W1968144787","https://openalex.org/W2037798154","https://openalex.org/W2397455836"],"abstract_inverted_index":{"When":[0],"cultured":[1],"in":[2,99,156,199],"vitro,":[3],"human":[4],"embryonic":[5],"stem":[6],"cells":[7,131],"(hESCs)":[8],"acquire":[9],"genetic":[10,29],"abnormalities":[11],"that":[12,50,64,90,119,163],"have":[13,20,52],"slowed":[14],"their":[15],"therapeutic":[16],"use.":[17],"As":[18],"hESCs":[19,51,98,110],"a":[21,53,135,148,179,189],"\u201cleaky\u201d":[22],"G1/S":[23],"boundary,":[24],"the":[25,33,65,72,122,157],"pressure":[26],"of":[27,92,103,130,137,151],"ensuring":[28],"integrity":[30],"falls":[31],"on":[32,84,177],"G2/M":[34,73,158],"checkpoint,":[35,56],"which":[36,140,193],"can":[37],"be":[38],"activated":[39,164],"by":[40,192],"failed":[41],"chromosomal":[42],"decatenation":[43,55,74,93],"(among":[44],"other":[45],"stimuli).":[46],"It":[47],"is":[48,141,145,153],"hypothesized":[49],"deficient":[54],"but":[57],"little":[58],"data":[59,187],"supports":[60],"this.":[61],"Evidence":[62],"suggests":[63],"ataxia":[66],"telangiectasia":[67],"mutated":[68],"(ATM)":[69],"kinase":[70],"controls":[71],"and":[75,96,174],"DNA":[76,138],"damage":[77],"checkpoints,":[78],"though":[79],"previous":[80],"reports":[81],"are":[82],"conflicting":[83],"this":[85,107,186],"point.":[86],"My":[87],"work":[88],"demonstrates":[89],"inhibition":[91,102],"activates":[94],"ATM":[95,104,165,194],"arrests":[97],"G2.":[100],"Pharmacologic":[101],"(ATMi)":[105],"abrogates":[106],"arrest,":[108],"allowing":[109],"to":[111,126],"enter":[112],"mitosis.":[113,128],"Live":[114],"cell":[115],"imaging":[116],"studies":[117],"reveal":[118],"ATMi":[120,133,144],"increases":[121],"time":[123],"it":[124],"takes":[125],"complete":[127],"Culture":[129],"under":[132],"causes":[134],"gain":[136],"content,":[139],"reversed":[142],"once":[143],"relieved.":[146],"BRCA1,":[147,167],"known":[149],"target":[150],"ATM,":[152],"also":[154],"involved":[155],"checkpoint.":[159],"Experimental":[160],"evidence":[161],"reveals":[162],"phosphorylates":[166],"preventing":[168],"Aurora":[169],"A":[170],"from":[171],"interacting":[172],"with":[173],"phosphorylating":[175],"BRCA1":[176],"S308,":[178],"modification":[180],"necessary":[181],"for":[182],"mitotic":[183],"entry.":[184],"Together,":[185],"illuminates":[188],"novel":[190],"pathway":[191],"activation":[195],"mediates":[196],"G2":[197],"arrest":[198],"hESCs.":[200]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}