{"id":"https://openalex.org/W82385358","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","title":"Acetyl\u2010CoA carboxylases are checkpoints in adipocyte differentiation","display_name":"Acetyl\u2010CoA carboxylases are checkpoints in adipocyte differentiation","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W82385358","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","mag":"82385358"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.641.4","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028588057","display_name":"Elizabeth Lyn Cordonier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Lyn Cordonier","raw_affiliation_strings":["Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104353483","display_name":"Daniel C\u00e2mara Teixeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Camara Teixeira","raw_affiliation_strings":["Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046272211","display_name":"Zhonghi Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]},{"id":"https://openalex.org/I2802450327","display_name":"University of Nebraska System","ror":"https://ror.org/0238rvs44","country_code":"US","type":"education","lineage":["https://openalex.org/I2802450327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhonghi Han","raw_affiliation_strings":["Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE","Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901","https://openalex.org/I2802450327"]},{"raw_affiliation_string":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056977278","display_name":"Angela K. Pannier","orcid":"https://orcid.org/0000-0002-7589-9351","observed_orcids":["https://orcid.org/0000-0002-7589-9351"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]},{"id":"https://openalex.org/I2802450327","display_name":"University of Nebraska System","ror":"https://ror.org/0238rvs44","country_code":"US","type":"education","lineage":["https://openalex.org/I2802450327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela K Pannier","raw_affiliation_strings":["Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901","https://openalex.org/I2802450327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044003397","display_name":"Janos Zempleni","orcid":"https://orcid.org/0000-0001-5492-4661","observed_orcids":["https://orcid.org/0000-0001-5492-4661"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janos Zempleni","raw_affiliation_strings":["Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00483413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.3125,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase-1","display_name":"acetyl-CoA carboxylase 1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase-2","display_name":"acetyl-CoA carboxylase 2","score":1.0},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/malonyl-coa","display_name":"malonyl-CoA","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/human-mesenchymal-stem-cells","display_name":"human mesenchymal stem cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/grape-leaf-extract","display_name":"grape leaf extract","score":0.9300000071525574},{"id":"https://openalex.org/keywords/soraphen-a","display_name":"soraphen A","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fabp4","display_name":"FABP4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.5569999814033508},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.7598263025283813},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.5723372101783752},{"id":"https://openalex.org/C2780806160","wikidata":"https://www.wikidata.org/wiki/Q132442","display_name":"Oil Red O","level":4,"score":0.5346355438232422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49913454055786133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4839458763599396},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.47819116711616516},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4267909526824951},{"id":"https://openalex.org/C2779318131","wikidata":"https://www.wikidata.org/wiki/Q21199067","display_name":"Acetyl-CoA carboxylase","level":4,"score":0.4178923964500427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38994598388671875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37212276458740234},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.31777292490005493},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.23753637075424194},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16415488719940186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13770461082458496},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.641.4","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.641.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:digitalcommons.unl.edu:biosysengfacpub-1423","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/biosysengfacpub/421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biological Systems Engineering: Papers and Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337693","display_name":"Agricultural Research Division, Institute of Agriculture and Natural Resources","ror":"https://ror.org/043mer456"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1468455817","https://openalex.org/W2319529420","https://openalex.org/W4231163208","https://openalex.org/W4252353898","https://openalex.org/W4249829475","https://openalex.org/W3018819938","https://openalex.org/W147859989","https://openalex.org/W1484401753","https://openalex.org/W2015449720","https://openalex.org/W2098789722"],"abstract_inverted_index":{"Acetyl\u2010CoA":[0],"carboxylases":[1],"(ACC)":[2],"1":[3],"and":[4,12,25,36,53,60,85,98,120,194,210],"2":[5],"depend":[6],"on":[7],"biotin":[8],"as":[9],"a":[10,29],"coenzyme":[11],"catalyze":[13],"the":[14,91,109,115,134,176,180],"carboxylation":[15],"of":[16,39,70,93,101,117,122,130,148,175,197],"acetyl\u2010CoA":[17],"to":[18,64,153,172],"malonyl\u2010CoA.":[19],"Malonyl\u2010CoA":[20],"produced":[21],"by":[22,73,83,114,143,163],"cytoplasmic":[23],"ACC1":[24],"mitochondrial":[26,40],"ACC2":[27,71],"is":[28,179],"precursor":[30],"in":[31,50,75,183,191],"fatty":[32],"acid":[33],"(FA)":[34],"synthesis":[35],"an":[37],"inhibitor":[38,137],"FA":[41],"oxidation,":[42],"respectively.":[43],"We":[44,185],"hypothesized":[45],"that":[46,187,195],"ACCs":[47,178,188],"are":[48,189],"checkpoints":[49,190],"adipocyte":[51,94,192],"differentiation,":[52,141],"used":[54],"human":[55],"mesenchymal":[56],"stem":[57],"cells":[58,132],"(hMSC)":[59],"murine":[61],"3T3\u2010L1":[62,131],"preadipocytes":[63],"test":[65],"our":[66],"hypothesis.":[67],"The":[68],"expression":[69],"increased":[72],"1500%":[74],"differentiating":[76],"hMSC":[77],"compared":[78],"with":[79,103,125,133,158],"non\u2010differentiating":[80],"hMSC,":[81],"judged":[82,113,142],"qRT\u2010PCR":[84],"western":[86],"blot.":[87],"This":[88],"increase":[89,92],"preceded":[90],"marker":[95],"genes":[96],"FABP4":[97],"PPARy.":[99],"Treatment":[100,147],"hMSCs":[102],"grape":[104],"leaf":[105],"extract":[106],"(GLE)":[107],"inhibited":[108,140],"differentiation":[110,193],"into":[111],"adipocytes":[112],"abundance":[116],"PPARy/FABP4":[118],"mRNA":[119],"staining":[121],"lipid":[123,145],"droplets":[124],"Oil":[126],"Red\u2010O.":[127],"Likewise,":[128],"treatment":[129],"microbial":[135],"ACC":[136,198],"soraphen":[138],"A":[139],"decreased":[144,160],"accumulation.":[146],"transgenic":[149],"fruit":[150],"flies,":[151],"predisposed":[152],"storing":[154],"excess":[155],"body":[156,161,201],"lipids,":[157],"GLE":[159],"lipids":[162],"~50%.":[164],"In":[165],"future":[166],"studies,":[167],"we":[168],"will":[169],"use":[170],"mutagenesis":[171],"determine":[173],"which":[174],"two":[177],"critical":[181],"checkpoint":[182],"differentiation.":[184],"conclude":[186],"manipulation":[196],"activity":[199],"decreases":[200],"fat.":[202],"Grant":[203],"Funding":[204],"Source":[205],":":[206],"ARD":[207],"Hatch,":[208],"NIFA,":[209],"NIH":[211]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}