{"id":"https://openalex.org/W82279447","doi":null,"title":"Monitoreo de la actividad despigmentante de la idebenoma","display_name":"Monitoreo de la actividad despigmentante de la idebenoma","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W82279447","mag":"82279447"},"language":"es","primary_location":{"id":"mag:82279447","doi":null,"is_oa":false,"landing_page_url":"https://www.medigraphic.com/pdfs/cutanea/mc-2008/mc084c.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210238548","display_name":"Revista Medicina Cut\u00e1nea Ibero-Latino-Americana","issn_l":"0210-5187","issn":["0210-5187","1989-8932"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Medicina Cut\u00e1nea Ibero-Latino-Americana","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113667070","display_name":"Martin Laguens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Laguens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032960237","display_name":"G. Zeitune","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Zeitune","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091013027","display_name":"M. Reigosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Reigosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Cebri\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Cebri\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010928208","display_name":"V. Labarta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Labarta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053615113","display_name":"N. Almi\u00f1ana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Almi\u00f1ana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00825309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"3","first_page":"183","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idebenone","display_name":"idebenone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/depigmenting-agents","display_name":"depigmenting agents","score":0.7990000247955322},{"id":"https://openalex.org/keywords/melanogenesis-inhibition","display_name":"melanogenesis inhibition","score":0.9100000262260437},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hydroquinone","display_name":"hydroquinone","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.843999981880188},{"id":"https://openalex.org/keywords/skin-lightening","display_name":"skin lightening","score":0.6330000162124634},{"id":"https://openalex.org/keywords/pigmentary-disorders","display_name":"skin pigmentation disorders","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.8509085774421692},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.7884737849235535},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4009559750556946}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:82279447","doi":null,"is_oa":false,"landing_page_url":"https://www.medigraphic.com/pdfs/cutanea/mc-2008/mc084c.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210238548","display_name":"Revista Medicina Cut\u00e1nea Ibero-Latino-Americana","issn_l":"0210-5187","issn":["0210-5187","1989-8932"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista Medicina Cut\u00e1nea Ibero-Latino-Americana","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W46474434","https://openalex.org/W60324179","https://openalex.org/W66952839","https://openalex.org/W122145733","https://openalex.org/W1966102109","https://openalex.org/W1967711597","https://openalex.org/W1968089096","https://openalex.org/W1970526961","https://openalex.org/W1993820899","https://openalex.org/W2004808760","https://openalex.org/W2038415004","https://openalex.org/W2055984976","https://openalex.org/W2074923371","https://openalex.org/W2075402686","https://openalex.org/W2077893977","https://openalex.org/W2080885807","https://openalex.org/W2132936062","https://openalex.org/W2320681122","https://openalex.org/W2321406830","https://openalex.org/W2414219681"],"related_works":["https://openalex.org/W3200694252","https://openalex.org/W2950617707","https://openalex.org/W2730514399","https://openalex.org/W7120319417","https://openalex.org/W2025392464","https://openalex.org/W2272150713","https://openalex.org/W3213834026","https://openalex.org/W2123314546","https://openalex.org/W2952232932","https://openalex.org/W2079956604"],"abstract_inverted_index":{"Introduccion:Existen":[0],"numerosos":[1],"compuestos":[2,184],"que":[3,21,166],"presentan":[4],"capacidad":[5,58,89],"depigmentante,":[6],"pero":[7,172],"su":[8],"uso":[9],"presenta":[10,179],"ciertos":[11],"riesgos":[12],"de":[13,31,39,49,55,59,62,67,84,90,92,100,107,115,124,154,186,195,201,206,222,228,231],"toxicidad":[14],"local":[15],"y":[16,75,126,209],"even-tualmente":[17],"sistemica,":[18],"por":[19,169],"lo":[20],"se":[22,69,110,143],"hace":[23],"necesario":[24],"buscar":[25],"nuevas":[26],"alternativas":[27,41],"terapeuticas":[28],"para":[29,198,225],"desordenes":[30,230],"la":[32,44,50,57,60,65,94,122,127,152,167,170,187,199,207,210,217,232],"pigmentacion":[33,233],"o":[34],"nuevos":[35],"agentes":[36],"blan-queadores.":[37],"Una":[38],"estas":[40],"puede":[42],"ser":[43],"idebenona,":[45],"una":[46,79],"analogo":[47],"sintetico":[48],"coenzima":[51],"Q10.Con":[52],"el":[53,71,226],"objeto":[54],"evaluar":[56],"idebenona":[61,101,150,178],"inhibir":[63],"especificamente":[64],"sintesis":[66,91,153],"melanina,":[68,93],"realizo":[70],"siguiente":[72],"experimento:":[73],"Materiales":[74],"metodo:":[76],"Se":[77],"utilizo":[78],"linea":[80,224],"celular":[81],"continua":[82],"obtenida":[83],"melanoma":[85],"humano":[86],"(SK-MEL28)":[87],"con":[88,173,183,193],"quese":[95],"expuso":[96],"a":[97,216],"diferentes":[98],"concentraciones":[99],"durante":[102],"5":[103],"dias.":[104],"Al":[105],"cabo":[106],"este":[108],"tiempo":[109],"midieron":[111],"las":[112,220],"densidades":[113],"opticas":[114],"los":[116,131,229],"sobrenadantescon":[117],"un":[118,134],"espectrofotometro,":[119],"determinandose":[120],"asi":[121],"concentracion":[123],"melanina":[125,155],"viabilidad":[128],"celular,":[129],"expresandose":[130],"resultados":[132],"como":[133,234,236],"porcentajede":[135],"cultivos":[136],"controles":[137],"sin":[138],"tratar.":[139],"Como":[140],"control":[141],"comparativo":[142],"corrieron":[144],"experimentos":[145],"en":[146,156,159],"paralelo":[147],"utilizando":[148],"hidroquinona.Resultados:La":[149],"inhibe":[151],"celulas":[157],"SK-MEL28":[158],"forma":[160],"dosis-dependiente,":[161],"siendo":[162],"esta":[163],"inhibicion":[164],"mayor":[165],"produ-cida":[168],"hidroquinona,":[171],"menos":[174],"efectos":[175],"citotoxicos.":[176],"Comentario:La":[177],"cierta":[180],"analogia":[181,190],"estructural":[182],"inhibidores":[185],"melanogenesis.":[188],"Esta":[189],"podria":[191],"interferir":[192],"laactividad":[194],"tirosinasa":[196],"necesaria":[197],"produccion":[200],"melanina.":[202],"La":[203],"alta":[204],"seguridad":[205],"droga":[208],"eficacia":[211],"demostrada":[212],"aqui":[213],"podrian":[214],"poner":[215],"idebe-nona":[218],"entre":[219],"moleculas":[221],"primera":[223],"tratamiento":[227],"tambien":[235],"agente":[237],"blanqueador.":[238]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
