{"id":"https://openalex.org/W822649166","doi":null,"title":"TLR4-mediated calvarial bone repair: investigating its role and potential use for regenerative medicine","display_name":"TLR4-mediated calvarial bone repair: investigating its role and potential use for regenerative medicine","publication_year":2015,"publication_date":"2015-05-22","ids":{"openalex":"https://openalex.org/W822649166","mag":"822649166"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:24639","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100411833","display_name":"Dan Michelle Wang","orcid":"https://orcid.org/0000-0002-5934-9085","observed_orcids":["https://orcid.org/0000-0002-5934-9085","https://orcid.org/0000-0002-0646-7141"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0646-7141","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100411833"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.37720000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/craniofacial-trauma","display_name":"craniofacial trauma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5799999833106995},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/myd88-signaling","display_name":"MyD88 signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-graft-remodeling","display_name":"bone graft remodeling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tlr4-knockout-mice","display_name":"TLR4 knockout mice","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7332847118377686},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.687795877456665},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.6559885740280151},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.5946036577224731},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5708168745040894},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5640360713005066},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5530658960342407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4555590748786926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4203995168209076},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4200440049171448},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4149004817008972},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4091823101043701},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.303097128868103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21258315443992615},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19191902875900269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17258232831954956},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1365625262260437},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:24639","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:822649166","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/24639/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:24639","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","pdf_url":"http://d-scholarship.pitt.edu/24639/1/wangd_etd2015.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W822649166.pdf","grobid_xml":"https://content.openalex.org/works/W822649166.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W18760785","https://openalex.org/W121232295","https://openalex.org/W147822272","https://openalex.org/W1491977827","https://openalex.org/W1499883890","https://openalex.org/W1509907951","https://openalex.org/W1511602449","https://openalex.org/W1591714343","https://openalex.org/W1595293335","https://openalex.org/W1607201914","https://openalex.org/W1696233391","https://openalex.org/W1828000364","https://openalex.org/W1944035943","https://openalex.org/W1965098739","https://openalex.org/W1965175560","https://openalex.org/W1969323709","https://openalex.org/W1970144926","https://openalex.org/W1970853163","https://openalex.org/W1972228155","https://openalex.org/W1972623289","https://openalex.org/W1978172024","https://openalex.org/W1980051005","https://openalex.org/W1981740757","https://openalex.org/W1983231547","https://openalex.org/W1983265746","https://openalex.org/W1985109410","https://openalex.org/W1986876798","https://openalex.org/W1988782375","https://openalex.org/W1990574061","https://openalex.org/W1990709710","https://openalex.org/W1997700476","https://openalex.org/W1997839876","https://openalex.org/W2004487653","https://openalex.org/W2004706898","https://openalex.org/W2005726028","https://openalex.org/W2006532804","https://openalex.org/W2007409890","https://openalex.org/W2011509273","https://openalex.org/W2011897320","https://openalex.org/W2012330620","https://openalex.org/W2013106780","https://openalex.org/W2014353292","https://openalex.org/W2016849440","https://openalex.org/W2018544354","https://openalex.org/W2020778747","https://openalex.org/W2020995185","https://openalex.org/W2023715743","https://openalex.org/W2028798894","https://openalex.org/W2033023829","https://openalex.org/W2033185128","https://openalex.org/W2034543757","https://openalex.org/W2035510188","https://openalex.org/W2036123574","https://openalex.org/W2037219613","https://openalex.org/W2037690890","https://openalex.org/W2041590882","https://openalex.org/W2041591721","https://openalex.org/W2042436346","https://openalex.org/W2042804590","https://openalex.org/W2043414447","https://openalex.org/W2043806266","https://openalex.org/W2050262218","https://openalex.org/W2052057624","https://openalex.org/W2053570594","https://openalex.org/W2057578757","https://openalex.org/W2061626698","https://openalex.org/W2063998346","https://openalex.org/W2064374431","https://openalex.org/W2065295375","https://openalex.org/W2067371230","https://openalex.org/W2070793750","https://openalex.org/W2070807248","https://openalex.org/W2071439944","https://openalex.org/W2071726878","https://openalex.org/W2071846904","https://openalex.org/W2075196631","https://openalex.org/W2081561119","https://openalex.org/W2081703144","https://openalex.org/W2082385204","https://openalex.org/W2083339409","https://openalex.org/W2084711904","https://openalex.org/W2086005288","https://openalex.org/W2087624286","https://openalex.org/W2088846947","https://openalex.org/W2089790133","https://openalex.org/W2091892084","https://openalex.org/W2091969371","https://openalex.org/W2094646915","https://openalex.org/W2098301173","https://openalex.org/W2100820895","https://openalex.org/W2102047286","https://openalex.org/W2102445800","https://openalex.org/W2102948981","https://openalex.org/W2103924961","https://openalex.org/W2104760558","https://openalex.org/W2105090945","https://openalex.org/W2106149734","https://openalex.org/W2108388278","https://openalex.org/W2109293470","https://openalex.org/W2109415016","https://openalex.org/W2109937981","https://openalex.org/W2110341920","https://openalex.org/W2110720586","https://openalex.org/W2112174625","https://openalex.org/W2113672914","https://openalex.org/W2121023034","https://openalex.org/W2125683619","https://openalex.org/W2127085755","https://openalex.org/W2129319296","https://openalex.org/W2130186203","https://openalex.org/W2130293973","https://openalex.org/W2131498101","https://openalex.org/W2131626977","https://openalex.org/W2132865159","https://openalex.org/W2132868508","https://openalex.org/W2133819222","https://openalex.org/W2134237608","https://openalex.org/W2139697507","https://openalex.org/W2140709802","https://openalex.org/W2140739060","https://openalex.org/W2142480686","https://openalex.org/W2144158814","https://openalex.org/W2144675149","https://openalex.org/W2145431360","https://openalex.org/W2146122622","https://openalex.org/W2148582980","https://openalex.org/W2149161988","https://openalex.org/W2153588066","https://openalex.org/W2157476969","https://openalex.org/W2159314490","https://openalex.org/W2160830589","https://openalex.org/W2161175463","https://openalex.org/W2163768016","https://openalex.org/W2164598272","https://openalex.org/W2164714222","https://openalex.org/W2171944569","https://openalex.org/W2180472307","https://openalex.org/W2261783944","https://openalex.org/W2317279002","https://openalex.org/W2332677061","https://openalex.org/W2415144256","https://openalex.org/W4408335546"],"related_works":["https://openalex.org/W2315155322","https://openalex.org/W2603791773","https://openalex.org/W7099170689","https://openalex.org/W2740741358","https://openalex.org/W3173957466","https://openalex.org/W2991066534","https://openalex.org/W4416397784","https://openalex.org/W7120355465","https://openalex.org/W4399727916","https://openalex.org/W2800170182"],"abstract_inverted_index":{"Abstract:":[0],"Injuries":[1],"to":[2,34,57,73,95,143,295,308],"the":[3,54,145,154,162,224],"craniofacial":[4,23,41],"skeleton":[5],"have":[6,31],"a":[7,79,87,117,167,218,282],"tremendous":[8],"economical":[9],"and":[10,17,28,36,69,122,136,177,232,253,270],"social":[11],"impact":[12],"on":[13],"our":[14],"healthcare":[15],"system":[16],"society.":[18],"Presently,":[19],"clinical":[20,310],"management":[21],"of":[22,89,99,147,158,164,191,226,256,289],"trauma":[24],"remains":[25],"highly":[26],"challenging":[27],"various":[29,129],"efforts":[30],"been":[32],"undertaken":[33],"develop":[35],"improve":[37,309],"existing":[38],"therapies":[39],"for":[40,105,120,134,197],"reconstruction.":[42],"Among":[43],"these":[44,264],"efforts,":[45],"mounting":[46],"evidence":[47],"has":[48,77],"demonstrated":[49],"that":[50,92,187,267],"inflammation":[51,65,72,96,148],"is":[52,86,93,116],"among":[53],"first":[55],"events":[56],"determine":[58],"fracture":[59],"healing":[60,68,152,213,231,298],"outcome.":[61],"Thus,":[62],"understanding":[63],"how":[64],"affects":[66],"bone":[67,75,151,159,165,199,212,227,230,260,300,305],"subsequently":[70],"modulating":[71],"enhance":[74],"regeneration":[76],"become":[78],"promising":[80],"strategy.":[81],"Toll-like":[82],"receptor":[83],"4":[84],"(TLR4)":[85],"member":[88],"TLR":[90],"family":[91],"central":[94],"by":[97],"virtue":[98],"its":[100,137,271],"involvement":[101],"in":[102,149,153,182,205,210,223,239,258,279,285,299,304],"host":[103],"defense":[104],"microbial":[106],"infection":[107],"as":[108,110,141],"well":[109],"tissue":[111],"regeneration.":[112],"As":[113],"such,":[114],"TLR4":[115,135,203,240,245,257,268,290],"potential":[118,283],"candidate":[119],"investigation":[121],"subsequent":[123],"immune":[124],"modulation.":[125],"This":[126],"work":[127],"utilized":[128],"knockout":[130],"(KO)":[131],"mouse":[132],"models":[133],"associated":[138],"inflammatory":[139],"mediators":[140,273],"tools":[142],"study":[144],"role":[146,255,278],"calvarial":[150,198,219],"absence":[155,163],"or":[156,243,302],"presence":[157,225],"grafts.":[160],"In":[161,201],"graft,":[166,228],"similar":[168],"accelerated":[169,211],"phenotype":[170],"was":[171,195,237,247],"observed":[172,238],"between":[173],"MyD88":[174,193],"KO":[175,179,241],"mice":[176,242],"DC-TLR4":[178],"(TLR4":[180],"depleted":[181],"dendritic":[183,188],"cells)":[184],"mice,":[185],"indicating":[186],"cell":[189],"expression":[190],"TLR4-mediated":[192],"signaling":[194,246,269,291],"detrimental":[196],"healing.":[200],"addition,":[202],"depletion":[204],"myeloid":[206],"cells":[207],"also":[208],"resulted":[209],"via":[214],"enhanced":[215],"osteoclastogenesis":[216],"within":[217],"defect":[220],"model.":[221],"However,":[222],"inhibited":[229],"decreased":[233],"osteoclast-mediated":[234],"graft":[235],"remodeling":[236],"when":[244],"locally":[248],"inhibited,":[249],"establishing":[250],"an":[251,275],"important":[252,276],"novel":[254],"graft-based":[259],"repair.":[261],"Taken":[262],"together,":[263],"data":[265],"demonstrate":[266],"pathway":[272],"play":[274],"regulatory":[277],"osteoclastogenesis,":[280],"highlighting":[281],"opportunity":[284],"which":[286],"appropriate":[287],"modulation":[288],"can":[292],"be":[293],"used":[294],"initiate":[296],"early":[297],"defects":[301],"assist":[303],"graft-mediated":[306],"therapy":[307],"outcomes.":[311]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}